Glycoside Hydrolase Family 39

Activities in Familyα-L-iduronidase (EC 3.2.1.76); β-xylosidase (EC 3.2.1.37); α-L-arabinofuranosidase (EC 3.2.1.55); β-glucosidase (EC 3.2.1.21); β-galactosidase (EC 3.2.1.23)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (3687); Uniprot accession (270); PDB accession (30); 3D entries (11); cryst (0)
All (3623) Archaea (13) Bacteria (3432) Eukaryota (169) Viruses (1) unclassified (8) Structure (11) Characterized (23)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 BcellWH2_03314 (GH39wh2)   Bacteroides cellulosilyticus WH2 ALJ60547.1  
5JVK[A,B,C] 1.65
 β-xylosidase II (XynB2;CcXynB2;CC2357) 3.2.1.37 Caulobacter vibrioides CB15 AAK24328.1
NP_421160.1
Q9A5U0
4EKJ[A] 1.95
4M29[A] 1.60
 glucosidase A9D14_15590 3.2.1.21 Croceicoccus marinus E4A9 ARU17782.1  
5Z3K[A,B] 1.68
  β-xylosidase (DICTH_1792) 3.2.1.37 Dictyoglomus thermophilum H-6-12 ACI18502.1 B5YB78
6YYH[A,B] 1.55
6YYI[A,B] β-D-Xylp
2.25
 β-xylosidase (XynB;XynB1;HUS_CDS69) 3.2.1.37 Geobacillus stearothermophilus T-6 NCIMB 40222 ABI49941.1
AAC98129.1
Q9ZFM2
1W91[A,B,C,D,E,F,G,H] 1.60
2BFG[A,B,C,D,E,F,G,H] L-1-deoxy-Xylp
α-D-Xylp-(1-4)-GLU
β-D-Xylp-(1-1)-<non_carb>
1.65
2BS9[A,B,C,D,E,F,G,H] NMR
 exopolysaccharide Psl biosynthetic/hydrolytic enzyme (PslG;PA2237) 2.4.1.-
3.2.1.-
Pseudomonas aeruginosa PAO1 AAG05625.1
NP_250927.1
Q9I1N2
4ZN2[A,B,C,D] 1.60
5BX9[A] 1.49
5BXA[A] α-D-Manp
1.35
 α-L-iduronidase (BAE36_24485)   Rhizobium leguminosarum bv. trifolii OBY04744.1  
5NDX[A] α-L-IdopA-(1-1)-<non_carb>
2.50
 β-xylosidase (XynB) 3.2.1.37 Thermoanaerobacterium saccharolyticum B6A-RI AAA27369.1 P36906
1PX8[A,B] β-D-Xylp
1.60
1UHV[A,B,C,D] α-D-Xylp2F-(1-4)-GLU
2.10
 XAC4058 (XynB) 3.2.1.37 Xanthomonas citri pv. citri str. 306 AAM38893.1
NP_644357.1
Q8PFC5
6UQJ[A] 2.29
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 α-L-iduronidase (IduA) 3.2.1.76 Homo sapiens AAA81589.1
AAA51698.1
AAE53576.1
AAE72581.1
AAH29959.1
AAN25812.1
AAQ32908.1
AAQ46779.1
AAT18792.1
AAY01759.1
ABH73761.1
ABL21590.1
ACG93377.1
ACH14961.1
ACK10791.1
AFR32586.1
ASX95248.1
ASX95249.1
BAD92138.1
BAF84505.1
BAG54168.1
NP_000194.1
XP_042678.2
P35475
3W81[A,B] 1.90
3W82[A] α-L-IdopA
0.96
4JXO[A,B] 1.46
4JXP[A] 2.69
4KGJ[A,B] α-L-IdopA1F
2.00
4KGL[A,B] 2.00
4KH2[A,B] β-L-IdopA2F-(1-4)-GLU
2.797
4MJ2[A,B] 2.01
4MJ4[A] 1.95
4OBR[A,B] α-L-IdopA
0.98
4OBS[A] 2.00
6I6R[A,B] 2.28
6I6X[A,B] 1.99
 α-L-(β-1,2)-arabinofuranobiosidase (NF2152) 3.2.1.55 Neocallimastix frontalis ASF57707.1  
5U22[A] 2.40
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