Glycoside Hydrolase Family 39

Known Activities	α-L-iduronidase (EC 3.2.1.76); β-xylosidase (EC 3.2.1.37).
Mechanism	Retaining
Clan	GH-A
3D Structure Status	( β / α ) ₈
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
External resources	CAZypedia; InterPro; PFAM; PRINTS; PROSITE;
Commercial Enzyme Provider(s)	PROZOMIX;
Statistics	GenBank accession (391); Uniprot accession (252); PDB accession (5); 3D entries (3); cryst (1)

Summary

All (344) Archaea (3) Bacteria (324) Eukaryota (17) Structure (3 - 1 cryst) Characterized (12)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
β-1,4-xylosidase (XysA)	3.2.1.37	Aeromonas caviae ME-1	BAA95685.1	Q9LBF2
β-xylosidase (XylBH39;Bxyl;BH1068)	3.2.1.37	Bacillus halodurans C-125	BAB04787.1 NP_241934.1	Q9KDZ3
β-xylosidase B (XynB;Orf5)	3.2.1.37	Caldicellulosiruptor saccharolyticus	AAA23063.1 AAB87376.1	P23552.1
β-xylosidase D (XynD)	3.2.1.37	Caldicellulosiruptor saccharolyticus	AAB87373.1	O30428
β-xylosidase (XynD;Csac_2409)	3.2.1.37	Caldicellulosiruptor saccharolyticus DSM 8903	ABP67986.1 ABP67986.2	A4XM51
β-xylosidase A (BxlA) (Bxl39A)	3.2.1.37	Clostridium stercorarium NCIMB 11745	CAD48308.1	Q8GJ43
β-xylosidase (XynB;XynB1)	3.2.1.37	Geobacillus stearothermophilus T-6 NCIMB 40222	AAC98129.1 ABI49941.1	Q9ZFM2	1W91[A,B,C,D,E,F,G,H] 2BFG[A,B,C,D,E,F,G,H] 2BS9[A,B,C,D,E,F,G,H]
β-xylosidase (XynB)	3.2.1.37	Thermoanaerobacterium saccharolyticum B6A-RI	AAA27369.1	P36906.1	1PX8[A,B] 1UHV[A,B,C,D]
β-xylosidase (XylB)	3.2.1.37	Thermoanaerobacterium sp. 'JW/SL YS485'	AAB68820.1	O30360.1
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
α-L-iduronidase (IduA)	3.2.1.76	Canis lupus familiaris	AAA51455.1	Q01634
α-L-iduronidase (IduA)	3.2.1.76	Homo sapiens	AAA51698.1 AAA81589.1 AAE53576.1 AAE72581.1 AAH29959.1 AAN25812.1 AAQ32908.1 AAQ46779.1 AAT18792.1 AAY01759.1 ABH73761.1 ABL21590.1 ACG93377.1 ACH14961.1 ACK10791.1 BAD92138.1 BAF84505.1 BAG54168.1 NP_000194.1 XP_042678.2	P35475.2	cryst
α-L-iduronidase (IduA)	3.2.1.76	Mus musculus	AAC42044.1 AAH57935.1 BAC27393.1 BAC32313.1 BAE33353.1 BAE41504.1 NP_032351.1	P48441 Q8BLF6 Q8BMG0

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.