Glycoside Hydrolase Family 39

Activities in Family	3-O-β-L-arabinopyranosyl-α-L-arabinofuranosidase (EC 3.2.1.-); Endo-α-L-rhamnosidase (EC 3.2.1.-); β-glucosidase (EC 3.2.1.21); 3-O-α-D-galactosyl-α-L-arabinofuranosidase (EC 3.2.1.215); β-galactosidase (EC 3.2.1.23); Xylan β-1,4-xylosidase (EC 3.2.1.37); Exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); α-L-iduronidase (EC 3.2.1.76);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) ₈ barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
External resources	CAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)	PROZOMIX;
Statistics	GenBank accession (5752); Uniprot accession (45); PDB accession (29); 3D entries (10); cryst (0)

Summary

Download GH39 (6131) Taxonomic display Structure (10) Characterized (29)


Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
3-O-α-D-galactosyl-α-L-arabinofuranosidase (GAfase; BLGA_00340)	3.2.1.215	pubmed	Bifidobacterium longum subsp. longum JCM 7052	BBV22623.1	A0A7I6W7X7
3-O-β-L-arabinopyranosyl-α-L-arabinofuranosidase (AAfase; MCC10289_0425)	3.2.1.-	pubmed	Bifidobacterium pseudocatenulatum MCC10289	WP_065438160.1 BDV32471.1
β-1,4-xylosidase (CoXylA;Calow_0126)	3.2.1.37	pubmed	Caldicellulosiruptor owensensis OL	ADQ03734.1	E4Q2A6
β-xylosidase B (XynB;Orf5)	3.2.1.37	pubmed	Caldicellulosiruptor saccharolyticus	AAA23063.1 AAB87376.1	P23552
β-xylosidase D (XynD)	3.2.1.37	pubmed	Caldicellulosiruptor saccharolyticus	AAB87373.1	O30428
β-xylosidase (XynD;Csac_2409)	3.2.1.37	pubmed	Caldicellulosiruptor saccharolyticus DSM 8903	ABP67986.1 ABP67986.2	A4XM51
β-xylosidase II (XynB2;CcXynB2;CC2357)	3.2.1.37	pubmed	Caulobacter vibrioides CB15	AAK24328.1 NP_421160.1	Q9A5U0	4EKJ[A] 4M29[A]
β-xylosidase (Xln-DT)	3.2.1.37	pubmed	Dictyoglomus thermophilum DSM 3960	ARO76324.1	A0A1W6S724
β-xylosidase (DtXyl; DICTH_1792)	3.2.1.37	pubmed	Dictyoglomus thermophilum H-6-12	ACI18502.1	B5YB78	6YYH[A,B] 6YYI[A,B]
[ulvan] endo-α-L-rhamnosidase (BN863_22200)	3.2.1.-	pubmed	Formosa agariphila KMM 3901	CDF79932.1	T2KM23
β-xylosidase	3.2.1.37	pubmed	Geobacillus sp. WSUCF1	WP_020755811.1	A0A1V9CR85 A0A7H1RXW2 S7STZ0
β-xylosidase (XynB;XynB1;HUS_CDS69)	3.2.1.37	pubmed	Geobacillus stearothermophilus T-6 NCIMB 40222	ABI49941.1 AAC98129.1	Q9ZFM2	1W91[A,B,C,D,E,F,G,H] 2BFG[A,B,C,D,E,F,G,H] 2BS9[A,B,C,D,E,F,G,H]
β-xylosidase (BHXyl39;Bxyl;BH1068)	3.2.1.37	pubmed	Halalkalibacterium halodurans C-125	BAB04787.1 NP_241934.1	Q9KDZ3
exopolysaccharide Psl biosynthetic/hydrolytic enzyme (PslG; PA2237)	3.2.1.21	pubmed	Pseudomonas aeruginosa PAO1	AAG05625.1 NP_250927.1	Q9I1N2	4ZN2[A,B,C,D] 5BX9[A] 5BXA[A]
exo-oligoxylanase (XuaG; Ccel_1259)	3.2.1.37	pubmed	Ruminiclostridium cellulolyticum H10	ACL75615.1
β-xylosidase (JB13GH39)	3.2.1.37	pubmed	Sphingomonas sp. JB13	AZC12019.1
xylan 1,4-β-xylosidase (SlXyn39; Slin_3934)	3.2.1.37	pubmed	Spirosoma linguale DSM 74	ADB39924.1	D2QHX5
β-xylosidase (XynB)	3.2.1.37	pubmed	Thermoanaerobacterium saccharolyticum B6A-RI	AAA27369.1	P36906	1PX8[A,B] 1UHV[A,B,C,D]
β-xylosidase (XylB;Tsac_1452)	3.2.1.37	pubmed	Thermoanaerobacterium saccharolyticum JW/SL-YS485	AFK86459.1 AAB68820.1	I3VVB4 O30360
β-xylosidase A (BxlA) (Bxl39A)	3.2.1.37	pubmed	Thermoclostridium stercorarium NCIMB 11745	CAD48308.1	Q8GJ43
β-xylosidase (Bxl39A; BxlA; Cst_c08910)	3.2.1.37	pubmed	Thermoclostridium stercorarium subsp. stercorarium DSM 8532	AGI38931.1 AGC67890.1	L7VIK2
β-xylosidase (Xyl21)	3.2.1.37	doi	uncultured bacterium	APG32530.1	A0A1L3GYC8
xylan 1,4-β-xylosidase (XylP81) (fragment)	3.2.1.37	pubmed	uncultured bacterium	QPG93045.1	A0A8E4REG4
β-xylosidase (XynB; XacXynB; XAC4058)	3.2.1.37	pubmed	Xanthomonas citri pv. citri str. 306	AAM38893.1 NP_644357.1	Q8PFC5	6UQJ[A]
Eukaryota
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
α-L-iduronidase (IduA)	3.2.1.76	pubmed	Canis lupus familiaris	AAA51455.1	Q01634
α-L-iduronidase (IduA;IDUA)	3.2.1.76	pubmed	Felis catus	AIT52923.1	A0A097HWG4
α-L-iduronidase (IduA)	3.2.1.76	pubmed	Homo sapiens	AAA81589.1 AAA51698.1 AAE53576.1 AAE72581.1 AAH29959.1 AAN25812.1 AAQ32908.1 AAQ46779.1 AAT18792.1 AAY01759.1 ABH73761.1 ABL21590.1 ACG93377.1 ACH14961.1 ACK10791.1 AFR32586.1 ASX95248.1 ASX95249.1 BAD92138.1 BAF84505.1 BAG54168.1 NP_000194.1 XP_042678.2	A0A286RYY1 A0A286RZ47 A8K701 J9QQV7 P35475 Q56A80 Q59H58	3W81[A,B] 3W82[A,B] 4JXO[A,B] 4JXP[A] 4KGJ[A,B] 4KGL[A,B] 4KH2[A,B] 4MJ2[A,B] 4MJ4[A] 4OBR[A,B] 4OBS[A] 6I6R[A,B] 6I6X[A,B]
α-L-iduronidase (IduA)	3.2.1.76	pubmed	Mus musculus	AAC42044.1 AAH57935.1 BAC27393.1 BAC32313.1 BAE33353.1 BAE41504.1 NP_032351.1	P48441 Q3TDU4 Q3U1Z0 Q6PEP9 Q8BLF6 Q8BMG0
multifunctional β-glycoside hydrolase (Bgxg1)	3.2.1.21 3.2.1.23 3.2.1.74	pubmed pubmed pubmed	Orpinomyces sp. C1A	ALT07805.1	A0A0U3AYH9
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