Glycoside Hydrolase Family 38

Activities in Familyα-mannosidase (EC 3.2.1.24); mannosyl-oligosaccharide α-1,2-mannosidase (EC 3.2.1.113); mannosyl-oligosaccharide α-1,3-1,6-mannosidase (EC 3.2.1.114); α-2-O-mannosylglycerate hydrolase (EC 3.2.1.170); mannosyl-oligosaccharide α-1,3-mannosidase (EC 3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 7
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorNot known
External resourcesCAZypedia; MEGAZYME;
Statistics GenBank accession (3704); Uniprot accession (537); PDB accession (63); 3D entries (7); cryst (2)
All (3338) Archaea (59) Bacteria (2874) Eukaryota (403) unclassified (2) Structure (7 - 2 cryst) Characterized (45)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 α-mannosidase (EF1707;EF_1707)   Enterococcus faecalis V583 AAO81483.1
AAR57537.1
NP_815413.1
Q834E8
3LVT[A] 2.55
5KBP[A,B] 2.40
 mannosyl-oligosaccharide α-1,3-mannosidase (SPy1604) 3.2.1.- Streptococcus pyogenes M1 GAS AAK34381.1
NP_269660.1
Q99YP5
2WYH[A,B] 1.90
2WYI[A,B] <carb_like_SWA>
2.60
 α-mannosidase (cytosolic) (TM1851;Tmari_1866) 3.2.1.24 Thermotoga maritima MSB8 AAD36913.1
AGL50790.1
AHD18252.1
AKE29607.1
NP_229647.1
Q9X2G6
cryst    
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 α-mannosidase (Man2B1;ManB) (lysosomal) 3.2.1.24 Bos taurus AAC48763.1
AAB67726.2
NP_776986.2
Q29451
1O7D[A,B,C,D,E] 2.70
 GlcNAcMan5GlcNAc2 α-1,6-mannosidase / GlcNAcMan4GlcNAc2 α-1,3-mannosidase / α-mannosidase II (GMII;α-Man-II;CG18474) 3.2.1.114 Drosophila melanogaster CAA54732.1
AAF54375.1
AAF54376.1
AAM50118.1
AGB95795.1
CAA10755.1
CAH33908.1
CBA12847.1
CBA34887.1
NP_524291.2
Q24451
1HTY[A] 1.40
1HWW[A] <carb_like_SWA>
1.87
1HXK[A] <carb_like_DMJ>
1.50
1PS3[A] β-D-GlcpNAc
<carb_like_KIF>
1.80
1QWN[A] α-L-Gulp5F-(1-4)-ASP
1.20
1QWU[A] α-L-Gulp5F-(1-4)-ASP
2.03
1QX1[A] β-D-Manp2F-(1-4)-ASP
1.30
1R33[A] <carb_like_LKA>
1.80
1R34[A] <carb_like_LKS>
1.95
1TQS[A] <carb_like_SSO>
1.30
1TQT[A] <carb_like_SSD>
1.90
1TQU[A] <carb_like_GHA>
2.03
1TQV[A] <carb_like_SSE>
2.03
1TQW[A] 1.20
2ALW[A] <carb_like_MNM>
1.86
2F18[A] <carb_like_GB1>
1.30
2F1A[A] 1.45
2F1B[A] <carb_like_GB3>
1.45
2F7O[A] <carb_like_MSN>
1.43
2F7P[A] <carb_like_2SK>
1.28
2F7Q[A] <carb_like_AOL>
1.85
2F7R[A] <carb_like_SK3>
1.35
2FYV[A] <carb_like_W72>
1.90
2OW6[A] <carb_like_NK1>
1.19
2OW7[A] <carb_like_NK2>
1.77
3BLB[A] <carb_like_SWA>
1.30
3BUB[A] 1.38
3BUD[A] 1.85
3BUI[A] 1.25
3BUP[A] α-D-Manp
2.03
3BUQ[A] α-D-Manp
2.01
3BVT[A] α-D-Manp-(1-3)-α-D-Manp3S-(1-1)-methyl
1.30
3BVU[A] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp3S-(1-1)-methyl
1.12
3BVV[A] α-D-Manp6SH-(1-6)[α-D-Manp-(1-3)]-β-D-Manp-(1-1)-methyl
1.30
3BVW[A] α-D-Manp-(1-6)-α-D-Manp6SH-(1-6)[β-D-GlcpNAc-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-1)-methyl
1.20
3BVX[A] α-D-Manp-(1-6)-α-D-Manp-(1-6)[β-D-GlcpNAc-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-1)-methyl
1.10
3CV5[A] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)[α-D-Manp-(1-3)]-β-D-Manp
1.60
3CZN[A] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)[β-D-GlcpNAc-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-4)-α-D-GlcpNAc
1.40
3CZS[A] α-D-Manp
1.30
3D4Y[A] <carb_like_MVL>
1.52
3D4Z[A] <carb_like_GIM>
1.39
3D50[A] <carb_like_OEV>
1.79
3D51[A] <carb_like_GOX>
1.43
3D52[A] 1.60
3DDF[A] <carb_like_GB6>
1.20
3DDG[A] 1.74
3DX0[A] <carb_like_MSN>
1.70
3DX1[A] <carb_like_YHO>
1.21
3DX2[A] <carb_like_MZB>
1.40
3DX3[A] <carb_like_YTB>
1.42
3DX4[A] <carb_like_GOO>
1.38
3EJP[A] <carb_like_HN2>
1.32
3EJQ[A] <carb_like_HN3>
1.45
3EJR[A] <carb_like_HN4>
1.27
3EJS[A] <carb_like_HN5>
1.35
3EJT[A] <carb_like_HN6>
1.35
3EJU[A] <carb_like_HN7>
1.32
 lysosomal α-mannosidase (LManII;dLM408;CG6206;Dmel_CG6206) 3.2.1.24 Drosophila melanogaster AAD38576.1
AAF52958.1
AAF52958.2
AAN10754.1
NP_609408.1
NP_723591.1
Q8IPB7
Q9VKV1
cryst    
 α-mannosidase (Ams1;YGL156W;G1861) 3.2.1.24 Saccharomyces cerevisiae S288c CAA88536.1
AAA34422.1
AAA34423.1
CAA96868.1
NP_011359.1
P22855
5JM0[A] 6.30
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