Glycoside Hydrolase Family 38

Activities in Familyα-mannosidase (EC 3.2.1.24); mannosyl-oligosaccharide α-1,2-mannosidase (EC 3.2.1.113); mannosyl-oligosaccharide α-1,3-1,6-mannosidase (EC 3.2.1.114); α-2-O-mannosylglycerate hydrolase (EC 3.2.1.170); mannosyl-oligosaccharide α-1,3-mannosidase (EC 3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 7
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorNot known
External resourcesCAZypedia; MEGAZYME;
Statistics GenBank accession (3793); Uniprot accession (537); PDB accession (63); 3D entries (7); cryst (2)
All (3427) Archaea (59) Bacteria (2963) Eukaryota (403) unclassified (2) Structure (7 - 2 cryst) Characterized (45)
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-mannosidase (ManA;PTO0091) 3.2.1.24 Picrophilus torridus DSM 9790 AAT42676.1 Q6L2X5  
 α-mannosidase (ManA;LMann;SsLMann;SSO3006) 3.2.1.24 Sulfolobus solfataricus P2 AAK43108.1
AIX48014.1
CAC24028.1
NP_344318.1
Q97UK5  
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-mannosidase 3.2.1.24 Bacillus sp. GL1 BAB40444.2 Q9AJR6  
 α-mannosidase / α-1,P-mannosidase (BT3774) 3.2.1.113
3.2.1.-
Bacteroides thetaiotaomicron VPI-5482 AAO78879.1
NP_812685.1
Q8A192  
 mannosylglycerate hydrolase / 2-O-(6-P-mannosyl)-glycerate α-mannosidase (MngB;YbgG;b0732) 3.2.1.170 Escherichia coli str. K-12 substr. MG1655 AAC73826.1
AAT26309.1
AIZ92134.1
ALI41472.1
AMC97960.1
NP_415260.1
P54746  
 α-mannosidase (Rv0648) 3.2.1.24 Mycobacterium tuberculosis H37Rv CAB07105.1
AFN48518.1
CCP43391.1
NP_215162.1
P96937  
 mannosyl-oligosaccharide α-1,3-mannosidase (SPy1604) 3.2.1.- Streptococcus pyogenes M1 GAS AAK34381.1
NP_269660.1
Q99YP5 2WYH[A,B]
2WYI[A,B]
 α-mannosidase (SCO0948;SCM11.03c) 3.2.1.24 Streptomyces coelicolor A3(2) CAB61914.1
NP_625245.1
Q9RIV8  
 α-mannosidase (cytosolic) (TM1851;Tmari_1866) 3.2.1.24 Thermotoga maritima MSB8 AAD36913.1
AGL50790.1
AHD18252.1
AKE29607.1
NP_229647.1
Q9X2G6 cryst
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-mannosidase II (AtGMII;At5g14950) 3.2.1.114 Arabidopsis thaliana CAC01814.1
AAK96611.1
AAL38616.1
AAY90120.1
AED92095.1
CAH33905.1
CBA12844.1
CBA34884.1
NP_196999.1
Q940T6
Q9LFR0
 
 α-mannosidase (Man2B1;ManB) (lysosomal) 3.2.1.24 Bos taurus AAC48763.1
AAB67726.2
NP_776986.2
Q29451 1O7D[A,B,C,D,E]
 α-mannosidase 3.2.1.24 Bos taurus AAE61905.1    
 α-mannosidase (Aman-3;F48C1.1) 3.2.1.24 Caenorhabditis elegans Bristol N2 AAB52345.2
AAM81094.1
CCD62468.1
NP_491568.1
NP_740847.1
NP_740848.1
O01574  
 α-mannosidase (Aman-1;F55D10.1) (lysosomal) 3.2.1.24 Caenorhabditis elegans Bristol N2 AAA81731.2
CCD67087.1
NP_508811.1
Q20829  
 α-mannosidase II (Aman-2;F58H1.1) 3.2.1.114 Caenorhabditis elegans Bristol N2 CAJ55257.1
CAB00104.1
CAH33906.1
CBA12845.1
CBA34885.1
NP_505995.1
Q21010
Q2PJ74
 
 α-1,2/3/6-mannosidase (JBM;JBAM) (peptide sequencing) (partial) 3.2.1.113
3.2.1.114
3.2.1.24
Canavalia ensiformis   C0HJB3  
 lysosomal α-mannosidase (Man2b1;LAM;chLAM) 3.2.1.24 Capra hircus AEZ02307.1    
 α-mannosidase (α-Man) 3.2.1.24 Capsicum annuum ADU20406.1    
 α-mannosidase (ManB;LMann;CpLMann) (lysosomal) 3.2.1.24 Cavia porcellus AAL58982.1
AIX48009.1
Q8VHC8  
 α-mannosidase (ManA;LMann;DdLMann) 3.2.1.114 Dictyostelium discoideum AAA33224.1
AIX48007.1
P34098  
 Golgi α-mannosidase IIb (Mα-Man-IIb;GMIIb;CG4606;Dmel_CG4606) 3.2.1.114 Drosophila melanogaster BAA75817.1
AAF55228.2
AAM49872.1
AGB95994.1
AGW52177.1
AHN57340.1
BAC92711.1
NP_650494.2
O97043
Q8MSX9
Q9VF33
 
 GlcNAcMan5GlcNAc2 α-1,6-mannosidase / GlcNAcMan4GlcNAc2 α-1,3-mannosidase / α-mannosidase II (GMII;α-Man-II;CG18474) 3.2.1.114 Drosophila melanogaster CAA54732.1
AAF54375.1
AAF54376.1
AAM50118.1
AGB95795.1
CAA10755.1
CAH33908.1
CBA12847.1
CBA34887.1
NP_524291.2
Q24451 1HTY[A]
1HWW[A]
1HXK[A]
1PS3[A]
1QWN[A]
1QWU[A]
1QX1[A]
1R33[A]
1R34[A]
1TQS[A]
1TQT[A]
1TQU[A]
1TQV[A]
1TQW[A]
2ALW[A]
2F18[A]
2F1A[A]
2F1B[A]
2F7O[A]
2F7P[A]
2F7Q[A]
2F7R[A]
2FYV[A]
2OW6[A]
2OW7[A]
3BLB[A]
3BUB[A]
3BUD[A]
3BUI[A]
3BUP[A]
3BUQ[A]
3BVT[A]
3BVU[A]
3BVV[A]
3BVW[A]
3BVX[A]
3CV5[A]
3CZN[A]
3CZS[A]
3D4Y[A]
3D4Z[A]
3D50[A]
3D51[A]
3D52[A]
3DDF[A]
3DDG[A]
3DX0[A]
3DX1[A]
3DX2[A]
3DX3[A]
3DX4[A]
3EJP[A]
3EJQ[A]
3EJR[A]
3EJS[A]
3EJT[A]
3EJU[A]
 lysosomal α-mannosidase (LManII;dLM408;CG6206;Dmel_CG6206) 3.2.1.24 Drosophila melanogaster AAD38576.1
AAF52958.1
AAF52958.2
AAN10754.1
NP_609408.1
NP_723591.1
Q8IPB7
Q9VKV1
cryst
 α-mannosidase (lysosomal) 3.2.1.24 Felis catus AAB97672.1 O46432  
 α-1,2-mannosidase (LMann;GmLMann;LOC100806748) 3.2.1.113 Glycine max XP_003548841.1
AIX48008.1
   
 α-mannosidase II (Man2A1;ManA2) 3.2.1.114 Homo sapiens AAC50302.1
AAH43416.1
AAI42657.1
AAI42697.1
ACM84601.1
BAA10017.1
CAH33909.1
CAL47687.1
CBA12848.1
CBA34888.1
NP_002363.1
Q16706  
 α-mannosidase a (Man2B1;ManB;LaMan;LMann;HsLMann) (lysosomal) 3.2.1.113
3.2.1.24
Homo sapiens AAC51362.1
AAB03816.1
AAC34130.1
AAC50811.1
AAC50812.1
AAH00736.1
ABA84560.1
ACM80454.1
ACM82884.1
AIX48010.1
BAD93158.1
BAF84261.1
BAG64471.1
CAD68121.1
CAH33914.1
CBA12853.1
CBA34893.1
NP_000519.1
O00754
Q93093
 
 α-mannosidase IIx (Man2A2;Man2Ax) 3.2.1.114 Homo sapiens BAA09510.1
AAA92022.1
AAI36449.1
BAF82552.1
BAG57210.1
BAG58516.1
BAG61252.1
BAH14521.1
CAH33912.1
CBA12851.1
CBA34891.1
NP_006113.1
P49641  
 neutral α-mannosidase (Man2C1;6A8;6A8B) (cytosolic) 3.2.1.24 Homo sapiens AAC00190.2
AAC00568.1
AAH50550.1
AAH80191.1
ACM82923.1
AEE61026.1
BAD92378.1
BAG62758.1
CAB66810.1
CAH33915.1
CBA12854.1
CBA34894.1
NP_006706.1
Q13358
Q9NTJ4
 
 α-1,6-mannosidase (Man2B2;KIAA0935) 3.2.1.114 Homo sapiens CAD89971.1
AAH33307.1
AAH36836.1
AAH94773.1
BAA76779.1
BAA76779.2
BAG52093.1
BAH13490.1
CAF86562.1
NP_056089.1
XP_052620.6
Q9Y2E5
Q9Y2E5
 
 α-1,2-mannosidase (LMann;MtLMann;MtrDRAFT_AC148217g19v1) 3.2.1.113 Medicago truncatula ABE88173.1
AIX48011.1
XP_003629280.1
G7LB83  
 α-mannosidase (Man2c1;C330035A14;1110025H24) (cytosolic) 3.2.1.24 Mus musculus AAH16253.1
AAH39913.1
AAY53557.1
BAB23074.1
BAC33715.1
BAE32264.1
BAE42254.1
BAE42554.1
NP_082912.1
Q3ZCX9
Q80XU4
Q8BWY6
Q91W89
Q9CTD5
 
 α-mannosidase (Man2B2;Kiaa0935) 3.2.1.24 Mus musculus BAA24266.1
AAH66211.1
BAB23655.1
BAC30580.1
BAC53862.1
BAD32345.1
BAE30761.1
BAE31143.1
BAE38153.1
NP_032576.1
O54782  
 α-mannosidase (Man2b;LMann;MmLMann) (lysosomal) 3.2.1.24 Mus musculus NP_034894.2
AAC09470.1
AAC53369.1
AAC78560.1
AAH05430.1
AIX48012.1
BAB23588.1
BAE28235.1
BAE42071.1
BAE42288.1
BAE42419.1
NP_034894.1
O09159
Q3UGH3
 
 α-mannosidase II (Man2A1;ManA2) 3.2.1.114 Mus musculus CAA43480.1
AAI38373.1
BAC38329.1
CAH33910.1
CBA12849.1
CBA34889.1
NP_032575.1
P27046
Q8C4L1
 
 α-mannosidase IIx (Man2A2) 3.2.1.114 Mus musculus ABG02551.1
AAD20813.1
AAH55006.1
BAC31745.1
BAE36580.1
NP_766491.1
Q197W7
Q7TPQ0
Q8BRK9
Q9WU23
 
 α-mannosidase 1 (Man2C1) 3.2.1.24 Rattus norvegicus AAA41565.1
AAH86989.1
NP_640349.1
P21139  
 α-mannosidase 2 (fragment) 3.2.1.114 Rattus norvegicus AAA66457.1 P28494  
 α-mannosidase (Ams1;YGL156W;G1861) 3.2.1.24 Saccharomyces cerevisiae S288c CAA88536.1
AAA34422.1
AAA34423.1
CAA96868.1
NP_011359.1
P22855 5JM0[A]
 1,3-1,6-α-mannosidase (fragment) 3.2.1.114 Scherffelia dubia CAC20908.1 Q9FET3  
 α-mannosidase (Mns2;SPAC513.05) (ER) 3.2.1.24 Schizosaccharomyces pombe 972h- CAB58728.1
NP_593979.1
Q9UT61  
 α-mannosidase (α-Man;LMann;SlLMann;Loc100500729) 3.2.1.113
3.2.1.114
Solanum lycopersicum ADK66339.1
ABY83271.1
AIX48016.1
NP_001234851.1
D3TI68  
 α-mannosidase (Man2B2) 3.2.1.24 Sus scrofa BAA05877.1
AAX82987.1
AAX82988.1
AAX82989.1
ABY58116.1
ABY58117.1
ABY58118.1
ABY58119.1
ABY58120.1
Q28949  
 α-mannosidase (LMann;VvLMann;Loc100259071) 3.2.1.113
3.2.1.24
Vitis vinifera XP_002265360.1
AIX48017.1
   
 α-mannosidase 1 (Ama1) (fragment) 3.2.1.24 Zea mays BAA06405.1 Q43249  
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