| Activities in Family | α-mannosidase (EC 3.2.1.24); mannosyl-oligosaccharide α-1,2-mannosidase (EC 3.2.1.113); mannosyl-oligosaccharide α-1,3-1,6-mannosidase (EC 3.2.1.114); mannosyl-oligosaccharide α-1,3-mannosidase (EC 3.2.1.207); mannosyl-oligosaccharide α-1,6-mannosidase / exo-α-1,6-mannosidase (EC 3.2.1.163) |
|---|---|
| Mechanism | Retaining a |
| 3D Structure Status | mannosidase fold |
| Catalytic Nucleophile/Base | Asp |
| Catalytic Proton Donor | Not known |
| External resources | CAZypedia; |
| Commercial Enzyme Provider(s) | MEGAZYME; |
| Statistics | GenBank accession (11060); Uniprot accession (89); PDB accession (82); 3D entries (13); cryst (2) |
| Archaea | |||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | |
| α-mannosidase (ManA;PTO0091) | 3.2.1.24 | pubmed |
Picrophilus torridus DSM 9790 | AAT42676.1 | Q6L2X5 | ||
| α-mannosidase (ManA;LMann;SsLMann;SSO3006) | 3.2.1.24 | pubmed |
Saccharolobus solfataricus P2 | AAK43108.1 AIX48014.1 CAC24028.1 NP_344318.1 |
Q97UK5 | ||
| Bacteria | |||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | |
| [xanthan] α-mannosidase | 3.2.1.24 | pubmed |
Bacillus sp. GL1 | BAB40444.2 | Q9AJR6 | ||
| α-mannosidase / α-1,P-mannosidase (BT3774) | 3.2.1.113 3.2.1.- |
pubmed pubmed |
Bacteroides thetaiotaomicron VPI-5482 | AAO78879.1 NP_812685.1 |
Q8A192 | ||
| mannosyl-oligosaccharide α-1,6-mannosidase (Bl_Man38A; BL1327) | 3.2.1.114 | pubmed |
Bifidobacterium longum NCC2705 | AAN25127.1 NP_696491.1 |
7UFR[A,B,C,D] 7UFU[A,B,C,D] |
||
| mannosyl-oligosaccharide α-1,2-mannosidase (Bl_Man38B; BL1328) | 3.2.1.113 | pubmed |
Bifidobacterium longum NCC2705 | AAN25128.1 NP_696492.1 |
7UFS[A,B,C,D] | ||
| mannosyl-oligosaccharide exo-α-1,2-mannosidase (Bl_Man38C; BL1329) | 3.2.1.113 | pubmed |
Bifidobacterium longum NCC2705 | AAN25129.1 NP_696493.1 |
7UFT[A,B,C,D] | ||
| [xanthan] α-mannosidase (AB663_001101) | 3.2.1.24 | pubmed |
Microbacterium sp. XT11 | AMB17208.1 | |||
| α-mannosidase (Rv0648) | 3.2.1.24 | pubmed pubmed |
Mycobacterium tuberculosis H37Rv | WP_003917325.1 AFN48518.1 CAB07105.1 CCP43391.1 NP_215162.1 |
P96937 | ||
| α-mannosidase (Rv0648) | 3.2.1.24 | pubmed pubmed |
Mycobacterium tuberculosis H37Rv | WP_003917325.1 AFN48518.1 CAB07105.1 CCP43391.1 NP_215162.1 |
P96937 | ||
| mannosyl-oligosaccharide α-1,3-mannosidase (SPy1604) | 3.2.1.- | pubmed |
Streptococcus pyogenes M1 GAS SF370 | AAK34381.1 NP_269660.1 |
Q99YP5 | 2WYH[A,B] 2WYI[A,B] |
|
| α-mannosidase (SCO0948;SCM11.03c) | 3.2.1.24 | pubmed |
Streptomyces coelicolor A3(2) | CAB61914.1 NP_625245.1 |
Q9RIV8 | ||
| α-mannosidase (cytosolic) (TM1851;Tmari_1866) | 3.2.1.24 | pubmed |
Thermotoga maritima MSB8 | AAD36913.1 AGL50790.1 AHD18252.1 AKE29607.1 NP_229647.1 |
Q9X2G6 R4NSK1 |
cryst | |
| Eukaryota | |||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | |
| α-mannosidase II (AtGMII;At5g14950) | 3.2.1.114 | pubmed |
Arabidopsis thaliana | CAC01814.1 AAK96611.1 AAL38616.1 AAY90120.1 AED92095.1 CAH33905.1 CBA12844.1 CBA34884.1 NP_196999.1 |
Q940T6 Q9LFR0 |
||
| α-mannosidase (Man2B1;ManB) (lysosomal) | 3.2.1.24 | pubmed |
Bos taurus | AAC48763.1 AAB67726.2 NP_776986.2 |
Q29451 | 1O7D[A,B,C,D,E] | |
| α-mannosidase | 3.2.1.24 | pubmed |
Bos taurus | AAE61905.1 | |||
| α-mannosidase (Aman-3;F48C1.1) | 3.2.1.24 | pubmed |
Caenorhabditis elegans Bristol N2 | AAB52345.2 AAM81094.1 CCD62468.1 NP_491568.1 NP_740847.1 NP_740848.1 |
O01574 | ||
| α-mannosidase (Aman-1;F55D10.1) (lysosomal) | 3.2.1.24 | pubmed |
Caenorhabditis elegans Bristol N2 | AAA81731.2 CCD67087.1 NP_508811.1 |
Q20829 | ||
| α-mannosidase II (Aman-2;F58H1.1) | 3.2.1.114 | pubmed |
Caenorhabditis elegans Bristol N2 | CAJ55257.1 CAB00104.1 CAH33906.1 CBA12845.1 CBA34885.1 NP_505995.1 |
Q21010 Q2PJ74 |
||
| α-1,2/3/6-mannosidase (JBM;JBAM) (peptide sequencing) (partial) | 3.2.1.113 3.2.1.114 3.2.1.24 |
pubmed pubmed pubmed pubmed |
Canavalia ensiformis | C0HJB3 | 6B9O[A,B] 6B9P[A,B] |
||
| lysosomal α-mannosidase (Man2b1;LAM;chLAM) | 3.2.1.24 | pubmed |
Capra hircus | AEZ02307.1 | J7F5B7 | ||
| α-mannosidase (α-Man) | 3.2.1.24 | pubmed |
Capsicum annuum | ADU20406.1 | E7BYE5 | ||
| α-mannosidase (ManB;LMann;CpLMann) (lysosomal) | 3.2.1.24 | pubmed |
Cavia porcellus | AAL58982.1 AIX48009.1 |
Q8VHC8 | ||
| α-mannosidase (ManA;LMann;DdLMann) | 3.2.1.114 | pubmed |
Dictyostelium discoideum | AAA33224.1 AIX48007.1 |
P34098 | ||
| Golgi α-mannosidase IIb (Mα-Man-IIb;GMIIb;CG4606;Dmel_CG4606) | 3.2.1.114 | pubmed |
Drosophila melanogaster | BAA75817.1 AAF55228.2 AAM49872.1 AGB95994.1 AGW52177.1 AHN57340.1 BAC92711.1 NP_650494.2 |
O97043 Q75WP2 Q8MSX9 Q9VF33 |
||
| GlcNAcMan5GlcNAc2 α-1,6-mannosidase / GlcNAcMan4GlcNAc2 α-1,3-mannosidase / α-mannosidase II (GMII;α-Man-II;CG18474) | 3.2.1.114 | pubmed |
Drosophila melanogaster | CAA54732.1 AAF54375.1 AAF54376.1 AAM50118.1 AGB95795.1 CAA10755.1 CAH33908.1 CBA12847.1 CBA34887.1 NP_524291.2 |
A0A0B4KFG0 Q24451 |
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|
|
| lysosomal α-mannosidase (LManII;dLM408;CG6206;Dmel_CG6206) | 3.2.1.24 | pubmed |
Drosophila melanogaster | AAD38576.1 AAF52958.1 AAF52958.2 AAN10754.1 NP_609408.1 NP_723591.1 |
Q8IPB7 Q9VKV1 |
cryst | |
| α-mannosidase (lysosomal) | 3.2.1.24 | pubmed |
Felis catus | AAB97672.1 | O46432 | ||
| α-1,2-mannosidase (LMann;GmLMann;LOC100806748) | 3.2.1.113 | pubmed |
Glycine max | XP_003548841.1 AIX48008.1 |
I1MN42 | ||
| α-mannosidase II (Man2A1;ManA2) | 3.2.1.114 | pubmed |
Homo sapiens | AAC50302.1 AAH43416.1 AAI42657.1 AAI42697.1 ACM84601.1 BAA10017.1 CAH33909.1 CAL47687.1 CBA12848.1 CBA34888.1 NP_002363.1 |
A5PKX5 Q16706 |
||
| α-mannosidase a (Man2B1;ManB;LaMan;LMann;HsLMann) (lysosomal) | 3.2.1.113 3.2.1.24 |
pubmed |
Homo sapiens | AAC51362.1 AAB03816.1 AAC34130.1 AAC50811.1 AAC50812.1 AAH00736.1 ABA84560.1 ACM80454.1 ACM82884.1 AIX48010.1 BAD93158.1 BAF84261.1 BAG64471.1 CAD68121.1 CAH33914.1 CBA12853.1 CBA34893.1 NP_000519.1 |
A8K6A7 B4E0K9 O00754 Q59E90 Q93093 |
||
| α-mannosidase IIx (Man2A2;Man2Ax) | 3.2.1.24 | pubmed |
Homo sapiens | BAA09510.1 AAA92022.1 AAI36449.1 BAF82552.1 BAG57210.1 BAG58516.1 BAG61252.1 BAH14521.1 CAH33912.1 CBA12851.1 CBA34891.1 NP_006113.1 |
B4DEU9 B4DIK4 B4DRE0 B7ZA35 P49641 |
||
| neutral α-mannosidase (Man2C1;6A8;6A8B) (cytosolic) | 3.2.1.24 | pubmed |
Homo sapiens | AAC00190.2 AAC00568.1 AAH50550.1 AAH80191.1 ACM82923.1 AEE61026.1 BAD92378.1 BAG62758.1 CAB66810.1 CAH33915.1 CBA12854.1 CBA34894.1 NP_006706.1 |
A0A140VJN9 B4DVP6 Q13358 Q59GG8 Q9NTJ4 |
||
| α-1,6-mannosidase (Man2B2;KIAA0935) | 3.2.1.163 | pubmed |
Homo sapiens | CAD89971.1 AAH33307.1 AAH36836.1 AAH94773.1 ADO22337.1 BAA76779.1 BAA76779.2 BAG52093.1 BAH13490.1 CAF86562.1 NP_056089.1 XP_052620.6 |
A0A384NYH9 B3KQN1 B7Z754 Q05BN7 Q4VC00 Q9Y2E5 Q9Y2E5 |
||
| α-1,2-mannosidase (LMann;MtLMann;MtrDRAFT_AC148217g19v1) | 3.2.1.113 | pubmed |
Medicago truncatula | ABE88173.1 AIX48011.1 XP_003629280.1 |
G7LB83 | ||
| α-mannosidase (Man2c1;C330035A14;1110025H24) (cytosolic) | 3.2.1.24 | pubmed |
Mus musculus | AAH16253.1 AAH39913.1 AAY53557.1 BAB23074.1 BAC33715.1 BAE32264.1 BAE42254.1 BAE42554.1 NP_082912.1 |
Q3TAW2 Q3TBQ3 Q3ZCX9 Q80XU4 Q8BWY6 Q91W89 Q9CTD5 |
||
| α-mannosidase (Man2b;LMann;MmLMann) (lysosomal) | 3.2.1.24 | pubmed |
Mus musculus | NP_034894.2 AAC09470.1 AAC53369.1 AAC78560.1 AAH05430.1 AIX48012.1 BAB23588.1 BAE28235.1 BAE42071.1 BAE42288.1 BAE42419.1 NP_034894.1 |
O09159 Q3TB95 Q3TBM1 Q3UGH3 |
||
| α-mannosidase II (Man2A1;ManA2) | 3.2.1.114 | pubmed |
Mus musculus | CAA43480.1 AAI38373.1 BAC38329.1 CAH33910.1 CBA12849.1 CBA34889.1 NP_032575.1 |
P27046 Q8C4L1 |
||
| α-mannosidase IIx (Man2A2) | 3.2.1.114 | pubmed |
Mus musculus | ABG02551.1 AAD20813.1 AAH55006.1 BAC31745.1 BAE36580.1 NP_766491.1 |
Q197W7 Q3TSU5 Q7TPQ0 Q8BRK9 Q9WU23 |
||
| α-mannosidase 1 (Man2C1) | 3.2.1.24 | pubmed |
Rattus norvegicus | AAA41565.1 AAH86989.1 NP_640349.1 |
A0A0G2JWT2 P21139 Q5M9I2 |
||
| α-mannosidase 2 | 3.2.1.114 | pubmed |
Rattus norvegicus | AAA66457.1 | P28494 | ||
| α-mannosidase (Ams1;YGL156W;G1861) | 3.2.1.24 | pubmed |
Saccharomyces cerevisiae S288c | CAA88536.1 AAA34422.1 AAA34423.1 CAA96868.1 NP_011359.1 |
P22855 | 5JM0[A] | |
| α-mannosidase (weak activity) (Mns2;SPAC513.05) (ER) | 3.2.1.24 | pubmed |
Schizosaccharomyces pombe 972h- | CAB58728.1 NP_593979.1 |
Q9UT61 | 6LZ1[A,B,C,D] 7DD9[A,B] |
|
| α-mannosidase (α-Man;LMann;SlLMann;Loc100500729) | 3.2.1.113 3.2.1.114 |
pubmed pubmed |
Solanum lycopersicum | ADK66339.1 ABY83271.1 AIX48016.1 NP_001234851.1 |
D3TI68 E0XN34 |
||
| α-mannosidase (Man2B2) | 3.2.1.24 | pubmed |
Sus scrofa | BAA05877.1 AAX82987.1 AAX82988.1 AAX82989.1 ABY58116.1 ABY58117.1 ABY58118.1 ABY58119.1 ABY58120.1 |
B0FRA6 B0FRA7 B0FRA8 B0FRA9 Q28949 Q563W8 Q563W9 Q563X0 |
||
| α-mannosidase (LMann;VvLMann;Loc100259071) | 3.2.1.113 3.2.1.24 |
pubmed pubmed |
Vitis vinifera | XP_002265360.1 AIX48017.1 |
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