Activities in Family	Exo-α-sialidase (EC 3.2.1.18);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; HOMSTRAD; ProteinSpotlight;
Statistics	GenBank accession (139011); Uniprot accession (46); PDB accession (250); 3D entries (58); cryst (0)

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Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
neuraminidase (NA)		Influenza A virus A/Humboldt penguin/Antofagasta/236063-2/2023	WPS69898.1
neuraminidase (NA)		Influenza A virus A/Hydroprogne caspia/Atyrau/25/2022	WFS86952.1
neuraminidase (NA)		Influenza A virus A/Hyogo/DS2-331/2012	BBF41015.1
neuraminidase (NA)		Influenza A virus A/Hyogo/DS3-310/2013	BBF40973.1
neuraminidase (NA)		Influenza A virus A/Hyogo/DS3-369/2013	BBF40982.1
neuraminidase (NA)		Influenza A virus A/Hyogo/DS3-441/2013	BBF40937.1
neuraminidase (NA)		Influenza A virus A/Hyogo/DS4-216/2014	BBF41191.1
neuraminidase (NA)		Influenza A virus A/Hyogo/DS4-244/2014	BBF41031.1
neuraminidase (NA)		Influenza A virus A/Hyogo/DS5-282/2015	BBF41053.1
neuraminidase (NA)		Influenza A virus A/Hyogo/DS7-284/2017	BBF41133.1
neuraminidase (NA)		Influenza A virus A/Hyogo/DS7-305/2017	BBF41141.1
neuraminidase (NA)		Influenza A virus A/Iceland Gull/DE/819/2022	WCJ14979.1
neuraminidase (NA)		Influenza A virus A/Iceland Gull/DE/821/2022	WCJ14938.1
neuraminidase (NA)		Influenza A virus A/Iceland Gull/DE/826/2022	WCJ17401.1
neuraminidase (NA)		Influenza A virus A/Iceland Gull/DE/831/2022	WDY61435.1
neuraminidase (NA)		Influenza A virus A/Iceland gull/Iceland/4266/2015	AYN81359.1
neuraminidase (NA)		Influenza A virus A/Iceland gull/Iceland/4402/2015	AYN81366.1
neuraminidase (NA)		Influenza A virus A/Idaho/01/2018	AVP03586.1
neuraminidase (NA)		Influenza A virus A/Idaho/01/2019	QBP38510.1 QCW14183.1
neuraminidase (NA)		Influenza A virus A/Idaho/01/2021	UPP05389.1
neuraminidase (NA)		Influenza A virus A/Idaho/01/2021	UZO39792.1
neuraminidase (NA)		Influenza A virus A/Idaho/01/2022	UZO36363.1
neuraminidase (NA)		Influenza A virus A/Idaho/01/2023	WES76917.1
neuraminidase (NA)		Influenza A virus A/Idaho/02/2018	AVP04012.1
neuraminidase (NA)		Influenza A virus A/Idaho/02/2019	QBP37745.1
neuraminidase (NA)		Influenza A virus A/Idaho/02/2021	UPP05401.1
neuraminidase (NA)		Influenza A virus A/Idaho/02/2021	UZO39804.1
neuraminidase (NA)		Influenza A virus A/Idaho/02/2022	UZO36353.1
neuraminidase (NA)		Influenza A virus A/Idaho/02/2023	WES76929.1
neuraminidase (NA)		Influenza A virus A/Idaho/03/2018	AXQ12642.1
neuraminidase (NA)		Influenza A virus A/Idaho/03/2019	QBP37756.1
neuraminidase (NA)		Influenza A virus A/Idaho/03/2020	QIQ46292.1 QKS74163.1
neuraminidase (NA)		Influenza A virus A/Idaho/03/2021	UPP05413.1
neuraminidase (NA)		Influenza A virus A/Idaho/03/2021	UZO39816.1
neuraminidase (NA)		Influenza A virus A/Idaho/03/2022	UPP05425.1
neuraminidase (NA)		Influenza A virus A/Idaho/03/2022	UTR03080.1
neuraminidase (NA)		Influenza A virus A/Idaho/03/2023	WES76941.1
neuraminidase (NA)		Influenza A virus A/Idaho/04/2018	AVR40900.1
neuraminidase (NA)		Influenza A virus A/Idaho/04/2019	QBQ86440.1
neuraminidase (NA)		Influenza A virus A/Idaho/04/2022	UPP05437.1
neuraminidase (NA)		Influenza A virus A/Idaho/04/2022	UTR03092.1
neuraminidase (NA)		Influenza A virus A/Idaho/04/2023	WES76953.1
neuraminidase (NA)		Influenza A virus A/Idaho/05/2018	AVX28791.1
neuraminidase (NA)		Influenza A virus A/Idaho/05/2019	QBS20112.1 QDX12448.1
neuraminidase (NA)		Influenza A virus A/Idaho/05/2020	QIV19735.1 QJA11184.1
neuraminidase (NA)		Influenza A virus A/Idaho/05/2022	UPP04227.1
neuraminidase (NA)		Influenza A virus A/Idaho/05/2022	UTR03104.1
neuraminidase (NA)		Influenza A virus A/Idaho/05/2023	WES71236.1
neuraminidase (NA)		Influenza A virus A/Idaho/06/2018	AXA18690.1
neuraminidase (NA)		Influenza A virus A/Idaho/06/2019	QBS20124.1 QDX12460.1
neuraminidase (NA)		Influenza A virus A/Idaho/06/2020	QIV19750.1 QJA11196.1
neuraminidase (NA)		Influenza A virus A/Idaho/06/2022	UUV89480.1
neuraminidase (NA)		Influenza A virus A/Idaho/06/2022	UXG51433.1
neuraminidase (NA)		Influenza A virus A/Idaho/06/2023	WES76965.1
neuraminidase (NA)		Influenza A virus A/Idaho/07/2018	QES86854.1 QMD04380.1
neuraminidase (NA)		Influenza A virus A/Idaho/07/2019	QBQ86451.1
neuraminidase (NA)		Influenza A virus A/Idaho/07/2020	QIV14317.1
neuraminidase (NA)		Influenza A virus A/Idaho/07/2022	UUV89492.1
neuraminidase (NA)		Influenza A virus A/Idaho/07/2022	UXG51445.1
neuraminidase (NA)		Influenza A virus A/Idaho/08/2018	AXY84511.1
neuraminidase (NA)		Influenza A virus A/Idaho/08/2019	QCG84466.1 QDE06847.1
neuraminidase (NA)		Influenza A virus A/Idaho/08/2020	QIV19758.1 QJA11208.1
neuraminidase (NA)		Influenza A virus A/Idaho/08/2022	UUV89504.1
neuraminidase (NA)		Influenza A virus A/Idaho/08/2022	UXG51457.1
neuraminidase (NA)		Influenza A virus A/Idaho/09/2018	AWI42468.1
neuraminidase (NA)		Influenza A virus A/Idaho/09/2019	QCG82996.1
neuraminidase (NA)		Influenza A virus A/Idaho/09/2020	QIZ32309.1
neuraminidase (NA)		Influenza A virus A/Idaho/09/2022	UUV89516.1
neuraminidase (NA)		Influenza A virus A/Idaho/09/2022	UXG51469.1
neuraminidase (NA)		Influenza A virus A/Idaho/10/2018	AWI46203.1 AXV44131.1
neuraminidase (NA)		Influenza A virus A/Idaho/10/2019	QCG83006.1
neuraminidase (NA)		Influenza A virus A/Idaho/10/2020	QIZ32318.1
neuraminidase (NA)		Influenza A virus A/Idaho/10/2022	UUV89528.1
neuraminidase (NA)		Influenza A virus A/Idaho/10/2022	UXG50130.1
neuraminidase (NA)		Influenza A virus A/Idaho/101/2022	WES76977.1
neuraminidase (NA)		Influenza A virus A/Idaho/11/2018	AWR88815.1
neuraminidase (NA)		Influenza A virus A/Idaho/11/2019	QCG84478.1 QDE06859.1
neuraminidase (NA)		Influenza A virus A/Idaho/11/2020	QIZ32329.1
neuraminidase (NA)		Influenza A virus A/Idaho/11/2022	UUV89540.1
neuraminidase (NA)		Influenza A virus A/Idaho/11/2022	UXG51481.1
neuraminidase (NA)		Influenza A virus A/Idaho/12/2018	AZF86961.1
neuraminidase (NA)		Influenza A virus A/Idaho/12/2020	QJA11218.1
neuraminidase (NA)		Influenza A virus A/Idaho/12/2022	UUV89552.1
neuraminidase (NA)		Influenza A virus A/Idaho/12/2022	UXG51493.1
neuraminidase (NA)		Influenza A virus A/Idaho/12636/2022	UUC11363.1
neuraminidase (NA)		Influenza A virus A/Idaho/13/2018	AYG77487.1
neuraminidase (NA)		Influenza A virus A/Idaho/13/2019	QCW11520.1
neuraminidase (NA)		Influenza A virus A/Idaho/13/2020	QJP02782.1
neuraminidase (NA)		Influenza A virus A/Idaho/13/2022	UUV89564.1
neuraminidase (NA)		Influenza A virus A/Idaho/13/2022	UXG50142.1
neuraminidase (NA)		Influenza A virus A/Idaho/14/2019	QCW14202.1 QDX12472.1
neuraminidase (NA)		Influenza A virus A/Idaho/14/2020	QJI52697.1
neuraminidase (NA)		Influenza A virus A/Idaho/14/2022	UUV89576.1
neuraminidase (NA)		Influenza A virus A/Idaho/14/2022	UXG51505.1
neuraminidase (NA)		Influenza A virus A/Idaho/15/2018	AXB50910.1
neuraminidase (NA)		Influenza A virus A/Idaho/15/2019	QCW11531.1
neuraminidase (NA)		Influenza A virus A/Idaho/15/2022	UUV89588.1
neuraminidase (NA)		Influenza A virus A/Idaho/16/2019	QCW14214.1
neuraminidase (NA)		Influenza A virus A/Idaho/16/2022	UUV89600.1
neuraminidase (NA)		Influenza A virus A/Idaho/16/2022	UYL65642.1
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