Activities in Family	Exo-α-sialidase (EC 3.2.1.18);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; HOMSTRAD; ProteinSpotlight;
Statistics	GenBank accession (139011); Uniprot accession (46); PDB accession (250); 3D entries (58); cryst (0)

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Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
neuraminidase (NA)		Influenza A virus A/Guinea fowl/South Africa/17080243/2017	AVV60737.1
neuraminidase (NA)		Influenza A virus A/Guinea fowl/South Africa/17080274/2017	AVV60749.1
neuraminidase (NA)		Influenza A virus A/guineafowl/France/170409/2017	QHA32630.1
neuraminidase (NA)		Influenza A virus A/guineafowl/India/1720888/2017	UXC94484.1
neuraminidase (NA)		Influenza A virus A/guineafowl/India/1720892/2017	UXC94496.1
neuraminidase (NA)		Influenza A virus A/guineafowl/India/1720917/2017	UXC94508.1
neuraminidase (NA)		Influenza A virus A/Gujarat/MCVR9981AC/2017	UYS78457.1
neuraminidase (NA)		Influenza A virus A/Gull/CHL/227023-2/2022	WDE94904.1
neuraminidase (NA)		Influenza A virus A/gull/Dagestan/397-2/2021	UXX33364.1
neuraminidase (NA)		Influenza A virus A/gull/Delaware Bay/501/2013	QBL97646.1
neuraminidase (NA)		Influenza A virus A/gull/Delaware/AI09-438/2009	AWV92225.1
neuraminidase (NA)		Influenza A virus A/gull/Delaware/AI09-453/2009	AWV92237.1
neuraminidase (NA)		Influenza A virus A/gull/Florida/W22-162/2022	UWI70041.1
neuraminidase (NA)		Influenza A virus A/gull/France/161176/2017	QHA32734.1
neuraminidase (NA)		Influenza A virus A/Gull/Massachusetts/14WP00028/2014	AZR39330.1
neuraminidase (NA)		Influenza A virus A/gull/New Jersey/UGAI15-3414/2015	AWV92249.1
neuraminidase (NA)		Influenza A virus A/gull/New Jersey/UGAI15-3416/2015	AWV92261.1
neuraminidase (NA)		Influenza A virus A/gull/New Jersey/UGAI15-3459/2015	AWV92273.1
neuraminidase (NA)		Influenza A virus A/gull/New Jersey/UGAI15-3728/2015	AWV92285.1
neuraminidase (NA)		Influenza A virus A/gull/New Jersey/UGAI15-3767/2015	AWV92297.1
neuraminidase (NA)		Influenza A virus A/gull/Russia/A_gull_Astrakhan_78-4/2003	UAR89071.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS2-487/2012	BBF40950.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS2-516/2012	BBF41000.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS3-2/2012	BBF40929.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS3-4/2012	BBF40943.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS3-51/2012	BBF40935.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS3-95/2013	BBF40944.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS5-126/2014	BBF41045.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS6-332/2016	BBF41202.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS7-107/2016	BBF41103.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS7-129/2016	BBF41166.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS7-350/2017	BBF41215.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS7-365/2017	BBF41218.1
neuraminidase (NA)		Influenza A virus A/Gunma/DS7-386/2017	BBF41222.1
neuraminidase (NA)		Influenza A virus A/Gwangju/1457/2018	QGW67105.1
neuraminidase (NA)		Influenza A virus A/Gwangju/766/2017	AZK15955.1
neuraminidase (NA)		Influenza A virus A/Gyeonbuk/1469/2018	QGW67116.1
neuraminidase (NA)		Influenza A virus A/Gyeongbuk/1301/2016	AVI14940.1
neuraminidase (NA)		Influenza A virus A/Gyeongbuk/745/2017	AZK15967.1
neuraminidase (NA)		Influenza A virus A/Gyeonggi/1304/2016	AVI14950.1
neuraminidase (NA)		Influenza A virus A/Harbor Seal/British Colombia/OTH-52-1/2021	UEA14146.1
neuraminidase (NA)		Influenza A virus A/harbor seal/New Hampshire/ES10B48H3/2019	QOL24086.1
neuraminidase (NA)		Influenza A virus A/harbor seal/New Hampshire/ES10B72H3/2019	QOL24056.1
neuraminidase (NA)		Influenza A virus A/harbor seal/New Hampshire/M11t72H3/2018	QOL23998.1
neuraminidase (NA)		Influenza A virus A/harbor seal/New Hampshire/M15t72H3/2018	QOL24039.1
neuraminidase (NA)		Influenza A virus A/harbor seal/New Hampshire/SL06B48H3/2018	QOL23928.1
neuraminidase (NA)		Influenza A virus A/harbor seal/New Hampshire/SL06B72H3/2018	QOL23883.1
neuraminidase (NA)		Influenza A virus A/harbor seal/New Hampshire/UCD179629mdck/2017	QOL24169.1
neuraminidase (NA)		Influenza A virus A/Hartlaubs gull/South Africa/18040224/2018	QDH43296.1
neuraminidase (NA)		Influenza A virus A/Hartlaubs gull/South Africa/18040367/2018	QDH43320.1
neuraminidase (NA)		Influenza A virus A/Hawaii/01/2018	AVP03574.1
neuraminidase (NA)		Influenza A virus A/Hawaii/01/2019	QBM03577.1
neuraminidase (NA)		Influenza A virus A/Hawaii/01/2020	QIQ46244.1
neuraminidase (NA)		Influenza A virus A/Hawaii/01/2021	UZN91277.1
neuraminidase (NA)		Influenza A virus A/Hawaii/01/2021	UZO39538.1
neuraminidase (NA)		Influenza A virus A/Hawaii/01/2022	UXG51067.1
neuraminidase (NA)		Influenza A virus A/Hawaii/01/2022	UZO36462.1
neuraminidase (NA)		Influenza A virus A/Hawaii/01/2023	WES71214.1
neuraminidase (NA)		Influenza A virus A/Hawaii/02/2018	AVP03964.1
neuraminidase (NA)		Influenza A virus A/Hawaii/02/2019	QBS21151.1 QCW14075.1
neuraminidase (NA)		Influenza A virus A/Hawaii/02/2020	QIQ44783.1 QIZ32241.1
neuraminidase (NA)		Influenza A virus A/Hawaii/02/2021	UZN91289.1
neuraminidase (NA)		Influenza A virus A/Hawaii/02/2021	UZO39550.1
neuraminidase (NA)		Influenza A virus A/Hawaii/02/2022	UPP05353.1
neuraminidase (NA)		Influenza A virus A/Hawaii/02/2022	UTR03056.1
neuraminidase (NA)		Influenza A virus A/Hawaii/02/2023	WES76821.1
neuraminidase (NA)		Influenza A virus A/Hawaii/03/2018	AVR40856.1
neuraminidase (NA)		Influenza A virus A/Hawaii/03/2019	QBS20088.1 QDX11248.1
neuraminidase (NA)		Influenza A virus A/Hawaii/03/2020	QIQ46268.1
neuraminidase (NA)		Influenza A virus A/Hawaii/03/2021	UZN91301.1
neuraminidase (NA)		Influenza A virus A/Hawaii/03/2021	UZO39562.1
neuraminidase (NA)		Influenza A virus A/Hawaii/03/2022	UPP05365.1
neuraminidase (NA)		Influenza A virus A/Hawaii/03/2022	UTR02287.1
neuraminidase (NA)		Influenza A virus A/Hawaii/03/2023	WES76833.1
neuraminidase (NA)		Influenza A virus A/Hawaii/04/2018	AVR40868.1
neuraminidase (NA)		Influenza A virus A/Hawaii/04/2019	QBQ86145.1
neuraminidase (NA)		Influenza A virus A/Hawaii/04/2020	QIV19710.1 QJA11089.1
neuraminidase (NA)		Influenza A virus A/Hawaii/04/2021	UXG51409.1
neuraminidase (NA)		Influenza A virus A/Hawaii/04/2021	UZO39574.1
neuraminidase (NA)		Influenza A virus A/Hawaii/04/2022	UPP05377.1
neuraminidase (NA)		Influenza A virus A/Hawaii/04/2022	UTR03068.1
neuraminidase (NA)		Influenza A virus A/Hawaii/05/2018	AVR42121.1
neuraminidase (NA)		Influenza A virus A/Hawaii/05/2019	QBQ86429.1
neuraminidase (NA)		Influenza A virus A/Hawaii/05/2020	QIV14295.1
neuraminidase (NA)		Influenza A virus A/Hawaii/05/2021	UXG51421.1
neuraminidase (NA)		Influenza A virus A/Hawaii/05/2021	UZO39586.1
neuraminidase (NA)		Influenza A virus A/Hawaii/05/2022	UUV89408.1
neuraminidase (NA)		Influenza A virus A/Hawaii/05/2022	UYL65606.1
neuraminidase (NA)		Influenza A virus A/Hawaii/06/2018	AVR42137.1
neuraminidase (NA)		Influenza A virus A/Hawaii/06/2019	QBS20100.1 QDX12376.1
neuraminidase (NA)		Influenza A virus A/Hawaii/06/2020	QIV19722.1 QJA11103.1
neuraminidase (NA)		Influenza A virus A/Hawaii/06/2022	UUV89420.1
neuraminidase (NA)		Influenza A virus A/Hawaii/06/2022	UYL65618.1
neuraminidase (NA)		Influenza A virus A/Hawaii/07/2018	AVR40878.1
neuraminidase (NA)		Influenza A virus A/Hawaii/07/2019	QBY33969.1
neuraminidase (NA)		Influenza A virus A/Hawaii/07/2020	QIV14306.1
neuraminidase (NA)		Influenza A virus A/Hawaii/07/2022	UUV89432.1
neuraminidase (NA)		Influenza A virus A/Hawaii/07/2022	UYL65630.1
neuraminidase (NA)		Influenza A virus A/Hawaii/08/2018	AVR40889.1
neuraminidase (NA)		Influenza A virus A/Hawaii/08/2019	QBY32708.1 QCW14087.1
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