Activities in Family	α-1,3-L-galactosidase (EC 3.2.1.-); α-1,4-L-fucosidase (EC 3.2.1.-); α-L-galactosidase (EC 3.2.1.-); α-L-glucosidase (EC 3.2.1.-); α-1,3-L-fucosidase (EC 3.2.1.111); α-1,6-L-fucosidase (EC 3.2.1.127); α-L-fucosidase (EC 3.2.1.51); α-1,2-L-fucosidase (EC 3.2.1.63);
Mechanism	Retaining e
Clan	GH-R
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Asp (experimental)
Catalytic Proton Donor	Asp (experimental)
External resources	CAZypedia; PROSITE; SMART;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (12481); Uniprot accession (65); PDB accession (74); 3D entries (19); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
α-fucosidase (AmGH29D; Amuc_0846)	3.2.1.51	Akkermansia muciniphila ATCC BAA-835	ACD04679.1 QTD81467.1		8AYR[A,B] 2.70
Bovatus_01698		Bacteroides ovatus ATCC 8483	ALJ46339.1		4ZRX[A] 1.59
α-1,3/1,4-L-fucosidase / α-galactosidase (BT2192; BT_2192)	3.2.1.111 3.2.1.-	Bacteroides thetaiotaomicron VPI-5482	AAO77299.1 NP_811105.1	Q8A5P6	3EYP[A,B] 1.90 4OUE[A,B] β-D-Galp1S-(1-1)-<non_carb> 2.35 4OZO[A,B] β-D-Galp-(1-1)-<non_carb> 2.60
α-L-fucosidase (Fuc2970; C12; BtFuc2970; BT2970; BT_2970)	3.2.1.51	Bacteroides thetaiotaomicron VPI-5482	AAO78076.1 NP_811882.1	Q8A3I4	2WVS[A,B,C,D] β-L-Fucp2F β-L-Fucp2F-(1-4)-ASP 2.19 2WVT[A,B] <carb_like_FHN> 1.80 2WVU[A,B,C,D] α-L-Fucp-(1-1)-<non_carb> 1.95 2WVV[A,B,C,D] 1.73 2XIB[A,B,C,D] <carb_like_DFU> 2.20 2XII[A,B] <carb_like_TA9> 1.80 4J27[A,B] 1.59 4J28[A,B] <carb_like_EAT> 1.73 4JFS[A,B] <carb_like_16Z> 2.00 4JFT[A,B] <carb_like_1KN> 2.10 4JFU[A,B] <carb_like_K80> 1.66 4JFV[A,B,C,D] <carb_like_H57> 1.88 4JFW[A,B,C,D] <carb_like_H58> 2.10 4JL1[A,B] <carb_like_LM5> 1.68 4JL2[A,B] <carb_like_LM5> 1.70 4PCS[A,B,C,D] <carb_like_2M7> 1.77 4PCT[A,B,C,D] <carb_like_H76> 2.10 4PEE[A,B,C,D] <carb_like_2OX> 1.95 4WSJ[A,B,C,D] <carb_like_3U3> 1.64 4WSK[A,B,C,D] <carb_like_3U2> 1.92 5HDR[A,B,C,D] 2.30 5I5R[A,B,C,D] 2.10 6HZY[A,B] α-L-Fucp1N-(1-1)-<non_carb> β-L-Fucp1N-(1-1)-<non_carb> 1.70
α-L-fucosidase (C06; BT3798)	3.2.1.51	Bacteroides thetaiotaomicron VPI-5482	AAO78903.1 NP_812709.1		3GZA[A,B] 1.60
antigen α-1,6-fucosidase (TT1819;GYM67_05190)	3.2.1.127	Bifidobacterium asteroides ESL0447	QYN60528.1		8P1R[A,B,C,D,E,F] 1.66
α-1,3/1,4-L-fucosidase (BiAfcB;Blon_2336)	3.2.1.51 3.2.1.111 3.2.1.-	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	ACJ53394.1	B7GNN8	3MO4[A,B] 1.90 3UES[A,B] <carb_like_DFU> 1.60 3UET[A,B] α-L-Fucp-(1-4)[β-D-Galp-(1-3)]-β-D-GlcpNAc 2.10
α-L-glucosidase 29A (ClAgl29A; B879_03288)	3.2.1.-	Cecembia lonarensis	WP_009186306.1		7XSF[A,B] 2.01
α-L-glucosidase 29B (ClAgl29B; B879_03287)	3.2.1.-	Cecembia lonarensis	WP_009186305.1		7XSG[A,B] 1.61 7XSH[A,B] β-L-Glcp 1.71
α-1,6-L-fucosidase C (AlfC; A01; LCABL_29340)	3.2.1.127	Lacticaseibacillus casei BL23	CAQ67984.1	B3WBB5	6O18[A,B,C,D] 2.55 6O1A[A,B,C,D] β-L-Fucp 2.60 6O1C[A,B,C,D,E,F,G,H] α-L-Fucp-(1-1)-<non_carb> 2.60 6O1I[A,B,C,D] 3.55 6O1J[A,B,C,D,E,F,G,H] β-L-Fucp 2.00 6OHE[A,B,C,D] α-L-Fucp-(1-6)-β-D-GlcpNAc 3.14
multi-functionnal antigen exo-α-1,3-fucosidase and antigen exo-α-1,4-fucosidase (CDL26_02305)	3.2.1.111 3.2.1.-	Mediterraneibacter gnavus RJX1124	PLT74914.1	A0A2N5PIE7	6TR3[A] β-L-Fucp 1.70 6TR4[A,B] α-L-Fucp 1.45
α-L-fucosidase (aLfuk1; A08)	3.2.1.51	Paenibacillus thiaminolyticus CCM 3599	CBM40947.1	E3PQQ9	6GN6[A,B,C,D,E,F] α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp 2.20
α-1,3-L-galactosidase active on porphyrooligosaccharides desulfated at the non-reducing end (BpGH29; BACPLE_01702)	3.2.1.-	Phocaeicola plebeius DSM 17135	EDY95436.1	B5CYA5	7LJJ[A] 1.90 7LK7[A] α-L-Galp 2.19 7LNP[A,B,C,D] α-L-Galp-(1-1)-<non_carb> 2.70 7SNK[A] 2.00
α-1,3/1,4-L-fucosidase (SpGH29; SP_2146)	3.2.1.111 3.2.1.-	Streptococcus pneumoniae TIGR4	AAK76203.1 ABA35887.1 NP_346563.1	A0A0H2US78 Q97NA6	6OR4[A,B] α-L-Fucp-(1-4)[β-D-Galp-(1-3)]-β-D-GlcpNAc 2.10 6ORF[A,B] β-D-Galp-(1-4)[α-L-Fucp-(1-3)]-α-D-GlcpNAc 1.70 6ORG[A,B] 1.72 6ORH[A,B] α-L-Fucp-(1-2)-β-D-Galp-(1-4)[α-L-Fucp-(1-3)]-α-D-GlcpNAc 1.62
α-L-fucosidase (TmaFuc; C09; TM0306; Tmari_0304)	3.2.1.51	Thermotoga maritima MSB8	AAD35394.1 AGL49230.1 AHD17930.1 AKE28107.1 NP_228118.1	G4FHM0 Q9WYE2	1HL8[A,B] 2.4 1HL9[A,B] β-L-Fucp2F-(1-4)-ASP 2.25 1ODU[A,B] β-L-Fucp 2.8 2WSP[A,B] α-L-Fucp-(1-2)-β-L-Fucp1N-(1-1)-<non_carb> 2.65 2ZWY[A,B] 2.75 2ZWZ[A,B] <carb_like_ZWZ> 2.36 2ZX5[A,B] <carb_like_ZX5> 2.65 2ZX6[A,B] <carb_like_ZX6> 2.42 2ZX7[A,B] <carb_like_ZX7> 2.48 2ZX8[A,B] <carb_like_ZX8> 2.33 2ZX9[A,B] <carb_like_ZX9> 2.62 2ZXA[A,B] <carb_like_ZXA> 2.57 2ZXB[A,B] <carb_like_ZXB> 2.61 2ZXD[A,B] <carb_like_ZXD> 2.15
α-L-fucosidase (VejFCD; VEJY3_11310)	3.2.1.51	Vibrio sp. EJY3	AEX22740.1	A0A8I3AZV2	7DB5[A] 1.90
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
α-L-fucosidase (Fco1;FgFCO1;fg11254)	3.2.1.51	Fusarium graminearum PH-1	AFR68935.1 CEF87037.1	I1S384 J9UN47	4NI3[A,B] 1.40 4PSP[A,B] 1.56 4PSR[A,B] β-L-Fucp 1.38
α-L-fucosidase (FucA1; HsFucA1; B08)	3.2.1.51	Homo sapiens	AAA52481.1 AAA35519.1 AAA52482.1 AAH17338.1 ABA67657.1 BAC04002.1 BAE45738.1 BAG37210.1 BAH12098.1 BAH13453.1 CAH74004.1 CAH74004.2 NP_000138.1	B5MDC5 B7Z362 P04066 Q8NAC2	7PLS[A,B,C,D] 2.49 7PM4[A,B,C,D] <carb_like_DFU> 2.49
unclassified
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
GH29_0940 (partial)		unidentified			5K9H[A] 2.03
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