Activities in Family	α-1,3-L-galactosidase (EC 3.2.1.-); α-1,4-L-fucosidase (EC 3.2.1.-); α-L-galactosidase (EC 3.2.1.-); α-L-glucosidase (EC 3.2.1.-); α-1,3-L-fucosidase (EC 3.2.1.111); α-1,6-L-fucosidase (EC 3.2.1.127); α-L-fucosidase (EC 3.2.1.51); α-1,2-L-fucosidase (EC 3.2.1.63);
Mechanism	Retaining e
Clan	GH-R
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Asp (experimental)
Catalytic Proton Donor	Asp (experimental)
External resources	CAZypedia; PROSITE; SMART;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (12481); Uniprot accession (65); PDB accession (74); 3D entries (19); cryst (0)

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Archaea
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
α-L-fucosidase (Ss?Fuc; FucA1; E04; SSO11867 + SSO3060)	3.2.1.51	pubmed	Saccharolobus solfataricus P2	AAK43159.1 AAK43160.1 CAC24067.1 NP_344369.1 NP_344370.1	Q97UG1 Q97UG2
Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
α-L-fucosidase (F07; ACP_3283)	3.2.1.51	pubmed	Acidobacterium capsulatum ATCC 51196	ACO33974.1
α-fucosidase (AmGH29A; F01; Amuc_0010)	3.2.1.51	pubmed	Akkermansia muciniphila ATCC BAA-835	ACD03857.1 QTD80689.1
α-fucosidase (AmGH29B; Amuc_0146)	3.2.1.51	pubmed	Akkermansia muciniphila ATCC BAA-835	ACD03990.1 QTD80813.1
α-fucosidase (AmGH29C; Amuc_0392)	3.2.1.51	pubmed	Akkermansia muciniphila ATCC BAA-835	ACD04231.1 QTD81045.1
α-fucosidase (AmGH29D; Amuc_0846)	3.2.1.51	pubmed	Akkermansia muciniphila ATCC BAA-835	ACD04679.1 QTD81467.1		8AYR[A,B]
α-L-fucosidase (A05; Murru_0070)	3.2.1.51	pubmed	Allomuricauda ruestringensis DSM 13258	AEM69128.1
α-L-fucosidase (C02; HMPREF9154_0311)	3.2.1.51	pubmed	Arachnia propionica F0230a	AFN47394.1
α-L-fucosidase (BF0028)	3.2.1.51	pubmed	Bacteroides fragilis NCTC 9343	CAH05807.1	Q5LJ69
α-L-fucosidase (BF0810)	3.2.1.51	pubmed	Bacteroides fragilis NCTC 9343	CAH06554.1	Q5LH32
α-L-fucosidase (BF3242)	3.2.1.51	pubmed	Bacteroides fragilis NCTC 9343	CAH08937.1	Q5LAD6
α-1,3-L-fucosidase (BF3591)	3.2.1.111 3.2.1.-	pubmed pubmed	Bacteroides fragilis NCTC 9343	CAH09273.1	Q5L9F5
α-L-fucosidase (BT1625; BT_1625)	3.2.1.51	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO76732.1 NP_810538.1	Q8A7A0
α-1,3/1,4-L-fucosidase / α-galactosidase (BT2192; BT_2192)	3.2.1.111 3.2.1.-	pubmed pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO77299.1 NP_811105.1	Q8A5P6	3EYP[A,B] 4OUE[A,B] 4OZO[A,B]
α-L-fucosidase (Fuc2970; C12; BtFuc2970; BT2970; BT_2970)	3.2.1.51	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO78076.1 NP_811882.1	Q8A3I4	2WVS[A,B,C,D] 2WVT[A,B] 2WVU[A,B,C,D] 2WVV[A,B,C,D] 2XIB[A,B,C,D] 2XII[A,B] 4J27[A,B] 4J28[A,B] 4JFS[A,B] 4JFT[A,B] 4JFU[A,B] 4JFV[A,B,C,D] 4JFW[A,B,C,D] 4JL1[A,B] 4JL2[A,B] 4PCS[A,B,C,D] 4PCT[A,B,C,D] 4PEE[A,B,C,D] 4WSJ[A,B,C,D] 4WSK[A,B,C,D] 5HDR[A,B,C,D] 5I5R[A,B,C,D] 6HZY[A,B]
α-fucosidase (BT4136)	3.2.1.51	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO79241.1 NP_813047.1	Q8A085
α-L-fucosidase (C06; BT3798)	3.2.1.51	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO78903.1 NP_812709.1		3GZA[A,B]
α-L-fucosidase (BT3665)	3.2.1.51	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO78770.1 NP_812576.1
antigen α-1,6-fucosidase (TT1819;GYM67_05190)	3.2.1.127		Bifidobacterium asteroides ESL0447	QYN60528.1		8P1R[A,B,C,D,E,F]
α-1,3/4-L-fucosidase (AfcB;BbAfcB)	3.2.1.111 3.2.1.-	pubmed pubmed	Bifidobacterium bifidum JCM 1254	BAH80310.1	C5NS94
α-1,3/1,4-L-fucosidase (BiAfcB;Blon_2336)	3.2.1.51 3.2.1.111 3.2.1.-	pubmed pubmed pubmed	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	ACJ53394.1	B7GNN8	3MO4[A,B] 3UES[A,B] 3UET[A,B]
α-L-fucosidase (Blon_0248)	3.2.1.51	pubmed	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	ACJ51376.1	B7GTT5
α-1,6-L-fucosidase (Blon_0426)	3.2.1.51 3.2.1.127	pubmed pubmed	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	ACJ51546.1	B7GN40
α-L-fucosidase (D11; BLIJ_2413)	3.2.1.51	pubmed	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	BAJ69990.1
α-L-fucosidase (E01; WESB_1689)	3.2.1.51	pubmed	Brachyspira pilosicoli WesB	CCG57154.1
α-L-fucosidase (H06; Coch_2160)	3.2.1.51	pubmed	Capnocytophaga ochracea DSM 7271	ACU93704.1
α-L-glucosidase 29A (ClAgl29A; B879_03288)	3.2.1.-	pubmed	Cecembia lonarensis	WP_009186306.1		7XSF[A,B]
α-L-glucosidase 29B (ClAgl29B; B879_03287)	3.2.1.-	pubmed	Cecembia lonarensis	WP_009186305.1		7XSG[A,B] 7XSH[A,B]
α-L-fucosidase (E03; Celal_2470)	3.2.1.51	pubmed	Cellulophaga algicola DSM 14237	ADV49759.1
α-1,3/1,4-L-fucosidase (Afc2;CPF_2130)	3.2.1.111 3.2.1.-	pubmed pubmed	Clostridium perfringens ATCC 13124	ABG83106.1	A0A0H2YQI3 Q0TP82
α-L-fucosidase (C03; CPE0324)	3.2.1.51	pubmed	Clostridium perfringens str. 13	BAB80030.1 NP_561240.1
α-L-glycosidase (Caka_0074)	3.2.1.51 3.2.1.-	pubmed pubmed pubmed	Coraliomargarita akajimensis DSM 45221	ADE53103.1
α-L-fucosidase (Caka_0506)	3.2.1.51	pubmed	Coraliomargarita akajimensis DSM 45221	ADE53531.1
α-L-glucosidase (Caka_0522)	3.2.1.-	pubmed	Coraliomargarita akajimensis DSM 45221	ADE53547.1
α-L-fucosidase (Caka_0523)	3.2.1.51	pubmed	Coraliomargarita akajimensis DSM 45221	ADE53548.1
α-L-glucosidase (Caka_0536)	3.2.1.-	pubmed	Coraliomargarita akajimensis DSM 45221	ADE53561.1
α-L-fucosidase (C11; TIA2EST22_03065)	3.2.1.51	pubmed	Cutibacterium acnes TypeIA2 P.acn17	AEW80941.1
[N-glycan] core α-1,3-L-fucosidase I (cFase I; M876_10910)	3.2.1.111 3.2.1.-	pubmed pubmed	Elizabethkingia anophelis FMS-007	AKH95075.1 WP_047034007.1
α-L-fucosidase (EntFuc; AL523_01335)	3.2.1.51	pubmed	Enterococcus gallinarum FDAARGOS_163	AVC42161.1 WP_016612761.1
α-L-fucosidase (C01; EHR_02410)	3.2.1.51	pubmed	Enterococcus hirae ATCC 9790	AFM69462.1
α-L-fucosidase (OUC-Jdch16)	3.2.1.51	pubmed	Flavobacterium algicola CGMCC 12076	QYJ10021.1
α-L-fucosidase (D08; Fjoh_2040)	3.2.1.51	pubmed	Flavobacterium johnsoniae UW101	ABQ05071.1
α-L-fucosidase (A03; Isop_3607)	3.2.1.51	pubmed	Isosphaera pallida ATCC 43644	ADV64164.1
α-L-fucosidase (A04; LCBD_2849)	3.2.1.51	pubmed	Lacticaseibacillus casei BD-II	AEA58343.1
α-1,6-L-fucosidase A (AlfA; A02; LCABL_20390)	3.2.1.127	pubmed	Lacticaseibacillus casei BL23	CAQ67115.1	B3W8U6
α-L-fucosidase B (AlfB;LCABL_28270)	3.2.1.111 3.2.1.-	pubmed pubmed	Lacticaseibacillus casei BL23	CAQ67877.1	B3WB08
α-1,6-L-fucosidase C (AlfC; A01; LCABL_29340)	3.2.1.127	pubmed	Lacticaseibacillus casei BL23	CAQ67984.1	B3WBB5	6O18[A,B,C,D] 6O1A[A,B,C,D] 6O1C[A,B,C,D,E,F,G,H] 6O1I[A,B,C,D] 6O1J[A,B,C,D,E,F,G,H] 6OHE[A,B,C,D]
α-L-fucosidase (B02; Lbys_1665)	3.2.1.51	pubmed	Leadbetterella byssophila DSM 17132	ADQ17372.1
α-L-fucosidase (A07; Lbys_2883)	3.2.1.51	pubmed	Leadbetterella byssophila DSM 17132	ADQ18545.1
α-fucosidase (TT1817;GLA29479_3805)	3.2.1.51	doi	Lysobacter antibioticus ATCC 29479	ALN64656.1
α-L-fucosidase (RUMGNA_03833; RGna_04325)	3.2.1.51	pubmed	Mediterraneibacter gnavus ATCC 29149	QHB22774.1
multi-functionnal antigen exo-α-1,3-fucosidase and antigen exo-α-1,4-fucosidase (CDL26_02305)	3.2.1.111 3.2.1.-	pubmed pubmed	Mediterraneibacter gnavus RJX1124	PLT74914.1	A0A2N5PIE7	6TR3[A] 6TR4[A,B]
α-L-fucosidase (C05; MLP_07550)	3.2.1.51	pubmed	Microlunatus phosphovorus NM-1	BAK33769.1
α-L-fucosidase (E09; Niako_0681)	3.2.1.51	pubmed	Niastella koreensis GR20-10	AEV97064.1
α-L-fucosidase (B06; AAur_3800)	3.2.1.51	pubmed	Paenarthrobacter aurescens TC1	ABM09785.1
α-L-fucosidase (aLfuk1; A08)	3.2.1.51	pubmed	Paenibacillus thiaminolyticus CCM 3599	CBM40947.1	E3PQQ9	6GN6[A,B,C,D,E,F]
α-1,3-L-galactosidase active on porphyrooligosaccharides desulfated at the non-reducing end (BpGH29; BACPLE_01702)	3.2.1.-	pubmed	Phocaeicola plebeius DSM 17135	EDY95436.1	B5CYA5	7LJJ[A] 7LK7[A] 7LNP[A,B,C,D] 7SNK[A]
α-L-fucosidase (A06; BVU_1745)	3.2.1.51	pubmed	Phocaeicola vulgatus ATCC 8482	ABR39421.1
antigen exo-α-1,3/4-fucosidase (TT1377;PGN_1690)	3.2.1.111 3.2.1.-	doi doi	Porphyromonas gingivalis ATCC 33277	BAG34209.1 AUR49171.1
α-L-fucosidase (G04; PG1884)	3.2.1.51	pubmed	Porphyromonas gingivalis W83	AAQ66868.1 NP_905969.1
α-L-fucosidase (E07; HMPREF0659_A6969)	3.2.1.51	pubmed	Prevotella melaninogenica ATCC 25845	ADK97204.1
α-L-fucosidase (PsaFuc; Fuc)	3.2.1.51	doi	Pseudoalteromonas sp. OU03	WEV90146.1
exo-α-1,2-fucosidase (TT1379;ROI_24740)	3.2.1.63	doi	Roseburia intestinalis M50/1	CBL09437.1
α-1,4-fucosidase (RiFuc29; EEG94253.1+EEG94252.1)	3.2.1.111 3.2.1.-	pubmed pubmed	Roseburia inulinivorans DSM 16841	EEG94252.1 EEG94253.1	C0FT23 C0FT24
α-L-fucosidase (H04; CK1_28620)	3.2.1.51	pubmed	Ruminococcus sp. SR1/5	CBL20742.1
α-L-fucosidase (D02; Runsl_2271)	3.2.1.51	pubmed	Runella slithyformis DSM 19594	AEI48683.1
α-L-fucosidase (F11; Sph21_0657)	3.2.1.51	pubmed	Sphingobacterium sp. 21	ADZ77236.1
α-L-fucosidase (E05; Sph21_2863)	3.2.1.51	pubmed	Sphingobacterium sp. 21	ADZ79410.1
α-L-fucosidase (SlFuc29; Slin_1127)	3.2.1.51	pubmed	Spirosoma linguale DSM 74	ADB37178.1	D2QK56
antigen exo-α-1,3-fucosidase (TT1380;smi_2019)	3.2.1.111	doi	Streptococcus mitis B6	CBJ23255.1
α-1,3/1,4-L-fucosidase (SpGH29; SP_2146)	3.2.1.111 3.2.1.-	pubmed pubmed	Streptococcus pneumoniae TIGR4	AAK76203.1 ABA35887.1 NP_346563.1	A0A0H2US78 Q97NA6	6OR4[A,B] 6ORF[A,B] 6ORG[A,B] 6ORH[A,B]
α-L-fucosidase (G03; SCAB_0631)	3.2.1.51	pubmed	Streptomyces scabiei 87.22	CBG67291.1
α-1,3/1,4-L-fucosidase (TT1385)	3.2.1.111 3.2.1.-	pubmed pubmed	Streptomyces sp. 142	AAD10477.1	Q9Z4I9
α-L-fucosidase (C04; Strvi_5589)	3.2.1.51	pubmed	Streptomyces violaceusniger Tu 4113	AEM85108.1
α-1,2-L-fucosidase (Fuc1; TfFuc1; BFO_2737)	3.2.1.63	pubmed	Tannerella forsythia 92A2	AEW21393.1	G8UMQ6
α-L-fucosidase (H01; AciPR4_3782)	3.2.1.51	pubmed	Terriglobus saanensis SP1PR4	ADV84531.1
α-L-fucosidase (B04; Tter_1903)	3.2.1.51	pubmed	Thermobaculum terrenum ATCC BAA-798	ACZ42809.1
α-L-fucosidase (TmaFuc; C09; TM0306; Tmari_0304)	3.2.1.51	pubmed	Thermotoga maritima MSB8	AAD35394.1 AGL49230.1 AHD17930.1 AKE28107.1 NP_228118.1	G4FHM0 Q9WYE2	1HL8[A,B] 1HL9[A,B] 1ODU[A,B] 2WSP[A,B] 2ZWY[A,B] 2ZWZ[A,B] 2ZX5[A,B] 2ZX6[A,B] 2ZX7[A,B] 2ZX8[A,B] 2ZX9[A,B] 2ZXA[A,B] 2ZXB[A,B] 2ZXD[A,B]
α-L-fucosidase (GH29)	3.2.1.51	pubmed	uncultured bacterium	AMO13190.1	A0A140HJ24
α-1,4-L-fucosidase (Fp231)	3.2.1.-	pubmed	uncultured bacterium	QTJ01947.1	A0A8A6LWW9
α-1,2/3-L-fucosidase (Fp239)	3.2.1.63 3.2.1.111	pubmed pubmed	uncultured bacterium	QTJ01948.1	A0A8A6LMS6
α-1,6-L-fucosidase (Fp284)	3.2.1.127	pubmed	uncultured bacterium	QTJ01951.1	A0A8A6LM44
α-L-fucosidase (Fp251)	3.2.1.51	pubmed	uncultured bacterium	QTJ01950.1	A0A8A6LSW7
α-L-fucosidase (Fp240)	3.2.1.51	pubmed	uncultured bacterium	QTJ01949.1	A0A8A6LXU3
α-L-fucosidase (Fuc25C)	3.2.1.51	doi	uncultured bacterium	WPO27446.1
α-L-fucosidase (Fuc25A)	3.2.1.51	doi	uncultured bacterium	WPO27445.1
α-L-fucosidase (Fuc25D)	3.2.1.51	doi	uncultured bacterium	WPO27447.1
α-L-fucosidase (Fuc25E)	3.2.1.51	doi	uncultured bacterium	WPO27449.2 WPO27449.1
α-L-fucosidase (Mfuc5)	3.2.1.51	pubmed	uncultured bacterium	AIC77302.1	A0A068B2Y3
α-L-fucosidase (Mfuc1)	3.2.1.51	pubmed	uncultured bacterium	AIC77298.1	A0A068B780
α-L-fucosidase (Mfuc2)	3.2.1.51	pubmed	uncultured bacterium	AIC77299.1	A0A068B4L8
α-L-fucosidase (Mfuc4)	3.2.1.51	pubmed	uncultured bacterium	AIC77301.1	A0A068B3H5
α-L-fucosidase (Mfuc6)	3.2.1.51	pubmed	uncultured bacterium	AIC77303.1	A0A068B783
α-L-fucosidase (Mfuc7)	3.2.1.51	pubmed	uncultured bacterium	AIC77304.1	A0A068B4M2
α-L-fucosidase (B12; A1_GH29)	3.2.1.51	pubmed	uncultured bacterium A1_9	AEW47938.1
α-L-fucosidase (VejFCD; VEJY3_11310)	3.2.1.51	pubmed	Vibrio sp. EJY3	AEX22740.1	A0A8I3AZV2	7DB5[A]
fucosidase 1 (Alf1; Alf1_Wf; AXE80_08860)	3.2.1.51	pubmed	Wenyingzhuangia fucanilytica CZ1127	ANW96380.1 ANS88313.1	A0A1B1NX89
α-L-fucosidase (FucWf2; AXE80_07410)	3.2.1.51	pubmed	Wenyingzhuangia fucanilytica CZ1127	ANW96113.1
α-L-fucosidase (FucWf1; AXE80_07450)	3.2.1.51	pubmed	Wenyingzhuangia fucanilytica CZ1127	ANW96121.1
α-L-fucosidase (FucWf3; AXE80_07380)	3.2.1.51	pubmed	Wenyingzhuangia fucanilytica CZ1127	ANW96108.1
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