Glycoside Hydrolase Family 29

Known Activities	α-L-fucosidase (EC 3.2.1.51)
Mechanism	Retaining
3D Structure Status	( β / α ) ₈
Catalytic Nucleophile/Base	Asp (experimental)
Catalytic Proton Donor	Glu (experimental)
External resources	CAZypedia; InterPro; PFAM; PROSITE; SMART;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (474); Uniprot accession (161); PDB accession (20); 3D entries (4); cryst (0)

Summary

All (295) Archaea (9) Bacteria (244) Eukaryota (42) Structure (4 ) Characterized (11)

Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
α-L-fucosidase (FucA1;SSO11867 + SSO3060)	3.2.1.51	Sulfolobus solfataricus P2	AAK43159.1 AAK43160.1 CAC24067.1 NP_344369.1 NP_344370.1	Q97UG1 Q97UG2
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
α-L-fucosidase (Fuc2970;BT2970)	3.2.1.51	Bacteroides thetaiotaomicron VPI-5482	AAO78076.1 NP_811882.1		2WVS[A,B,C,D] 2WVT[A,B] 2WVU[A,B,C,D] 2WVV[A,B,C,D]
α-1,3/4-L-fucosidase (AfcB)	3.2.1.51	Bifidobacterium bifidum JCM 1254	BAH80310.1
α-L-fucosidase	3.2.1.51	Streptomyces sp. 142	AAD10477.1	Q9Z4I9
α-L-fucosidase (TM0306)	3.2.1.51	Thermotoga maritima MSB8	AAD35394.1 NP_228118.1	Q9WYE2	1HL8[A,B] 1HL9[A,B] 1ODU[A,B] 2WSP[A,B] 2ZWY[A,B] 2ZWZ[A,B] 2ZX5[A,B] 2ZX6[A,B] 2ZX7[A,B] 2ZX8[A,B] 2ZX9[A,B] 2ZXA[A,B] 2ZXB[A,B] 2ZXD[A,B]
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
α-1,3/4-L-fucosidase 1 (AtFUC1;At2g28100)	3.2.1.51	Arabidopsis thaliana	AAC98456.1 BAC43615.1 NP_180377.1 NP_180377.2	Q8GW72 Q9ZUV2
α-L-fucosidase	3.2.1.51	Canis lupus familiaris	AAB17401.1 AAB17403.1 CAA63197.1 CAA63362.1	P48300
α-L-fucosidase	3.2.1.51	Dictyostelium discoideum	AAO51149.1 CAA68800.1	P10901.1
α-L-fucosidase (FucA2;Mgc1314;dJ20N2.5)	3.2.1.51	Homo sapiens	AAH03060.1 AAH51268.1 AAQ51311.1 AAQ88915.1 AAR67756.1 AAS23605.1 AAS33131.1 AAU96025.1 AAV25913.1 AAW11558.1 AAW13887.1 AAW14386.1 AAW18914.1 AAX07037.1 AAY11234.1 AAY11614.1 AAY73794.1 ABA68606.1 ABC13938.1 ABC14003.1 ABE12077.1 ABH71498.1 ABH87348.1 ABH98705.1 ABI01123.1 ABI12087.1 ABJ28887.1 ABL21707.1 ABX93825.1 ABX96118.1 ABX96428.1 ABX96738.1 ABY04892.1 ABY16611.1 ABY18628.1 ACC07443.1 ACC17161.1 ACC22663.1 ACC28029.1 ACC30821.1 ACE08619.1 ACE15066.1 ACG89530.1 ACJ99825.1 ACM94936.1 ACP73691.1 ACS06317.1 ACW19785.1 BAC11633.1 BAG59123.1 CAB53746.1 CAC39765.1 CAD92494.1 CAD92495.1 CAI72136.1 NP_114409.2	Q7Z6V2 Q9BTY2.1
α-L-fucosidase (FucA1)	3.2.1.51	Homo sapiens	AAA35519.1 AAA52481.1 AAA52482.1 AAH17338.1 ABA67657.1 BAC04002.1 BAE45738.1 BAG37210.1 BAH12098.1 BAH13453.1 CAA25646.1 CAH74004.1 CAH74004.2 NP_000138.1	P04066.4 Q8NAC2
α-L-fucosidase (Fuca1;FucA)	3.2.1.51	Rattus norvegicus	AAH81844.1 CAA34268.1 NP_036694.1	P17164.1

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.