Glycoside Hydrolase Family 28

Activities in Familypolygalacturonase (EC 3.2.1.15); exo-polygalacturonase (EC 3.2.1.67); exo-polygalacturonosidase (EC 3.2.1.82); rhamnogalacturonase (EC 3.2.1.171); rhamnogalacturonan α-1,2-galacturonohydrolase (EC 3.2.1.173); xylogalacturonan hydrolase (EC 3.2.1.-)
Mechanism Inverting
ClanGH-N
3D Structure Statusparallel β-helix
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (13683); Uniprot accession (176); PDB accession (21); 3D entries (18); cryst (3)
| 1 | 2 |
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 polygalacturonase (PehA) 3.2.1.15 pubmed
Agrobacterium vitis CG49 AAB51699.1 P77818 1ZFW[nd]
 exo-polygalacturonosidase (Peh358) 3.2.1.82 pubmed
Bacillus sp. KSM-P358 / P-358 BAB85762.1 Q8RR74  
 homogalacturonan specific α-galacturonidase / exo-polygalacturonase (BT4155;BT_4155) 3.2.1.67 pubmed
Bacteroides thetaiotaomicron VPI-5482 AAO79260.1
NP_813066.1
Q8A066 5OLP[A,B]
 α-galacturonidase (BT4123;BT_4123) 3.2.1.67 pubmed
Bacteroides thetaiotaomicron VPI-5482 AAO79228.1
NP_813034.1
Q8A098  
 RGI specific α-galacturonidase (BT4149;BT_4149) (fragment) 3.2.1.173 pubmed
Bacteroides thetaiotaomicron VPI-5482 AAO79254.1
NP_813060.1
Q8A072  
 RGI-disaccharide specific α-galacturonidase (BT4146;BT_4146) 3.2.1.173 pubmed
Bacteroides thetaiotaomicron VPI-5482 AAO79251.1
NP_813057.1
Q8A075  
 α-galacturonidase (cleaves D-GalpA-α-1,4-D-GalpA; BT1018) 3.2.1.67 pubmed
Bacteroides thetaiotaomicron VPI-5482 AAO76125.1
NP_809931.1
Q8A8Z9  
 RGI-specific α-galacturonidase (BT4153;BT_4153) 3.2.1.173 pubmed
Bacteroides thetaiotaomicron VPI-5482 AAO79258.1
NP_813064.1
Q8A068  
 polygalacturonase (PehA) (Peh28A) 3.2.1.15 pubmed
Burkholderia cepacia ATCC 25416 AAB46984.1 P94293  
 exo-polygalacturonosidase (PehX) 3.2.1.82 pubmed
Dickeya chrysanthemi EC16 AAA24842.1 P15922  
 polygalacturonase (PehN;Dda3937_04155) 3.2.1.15 pubmed
Dickeya dadantii 3937 ADM97429.1
CAC83614.1
E0SDX9
Q8KKH7
 
 exo-polygalacturonosidase (PehX;Dda3937_00261) 3.2.1.82 pubmed
Dickeya dadantii 3937 ADN00467.1
CAB99320.1
E0SKR4
Q9K5A0
 
 exo-polygalacturonosidase (PehW;Dda3937_00262) 3.2.1.82 pubmed
Dickeya dadantii 3937 ADN00466.1
CAB99319.1
E0SKR3
Q9K5A1
 
 exo-polygalacturonosidase (PehV;Dda3937_00263) 3.2.1.82 pubmed
Dickeya dadantii 3937 ADN00465.1
CAB99318.1
E0SKR2
Q9K5A2
 
 exo-polygalacturonase B (PguB;exo-PGU B) 3.2.1.67 pubmed
Klebsiella sp. CGMCC 4433 / Y1 AFQ23185.1 J9QQ32  
 polygalacturonase-2 (PehA) 3.2.1.15 pubmed
Pectobacterium carotovorum SCC3193 CAA35998.1 P26509 1BHE[A]
 polygalacturonase-1 (Peh1;Peh-1;Peh) 3.2.1.15 pubmed
Pectobacterium carotovorum SUBSP. CAROTOVORA 71 / SCRI193 CAA37119.1
AAA03624.1
AAA57139.1
P18192  
 polygalacturonase (PglA) 3.2.1.15 pubmed
Ralstonia solanacearum AW1 AAA25931.1 P20041  
 exo-polygalacturonosidase (PehB) 3.2.1.82 pubmed
Ralstonia solanacearum K60 AAC46001.1 Q53241  
 exo-polygalacturonase (GalU;PelB;ExoPG;TM0437;TM_0437;Tmari_0434) 3.2.1.67 pubmed
Thermotoga maritima MSB8 AAD35522.1
AGL49359.1
AHD17805.1
AKE28230.1
NP_228247.1
G4FE33
Q9WYR8
3JUR[A,B,C,D]
 endo-polygalacturonase (pectinase; JKR01;RB1) 3.2.1.15 pubmed
uncultured bacterium ACL36472.1
AHG55466.1
B8YJC4  
 polygalacturonase (Pg_4) 3.2.1.15 pubmed
uncultured bacterium AFU91007.1 K4KA83  
 polygalacturonase (PglA;XCC2266) 3.2.1.15 pubmed
Xanthomonas campestris pv. campestris str. ATCC 33913 AAM41545.1
NP_637621.1
Q8P8H5  
 polygalacturonase (Peh-1;XCC3459) 3.2.1.15 pubmed
Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42729.1
NP_638805.1
Q8P582  
 exo-polygalacturonosidase (PehX) (YeGH28) 3.2.1.82 pubmed
Yersinia enterocolitica ATCC 9610D AAC15064.1 O68975 2UVE[A,B]
2UVF[A,B]
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 endo-polygalacturonase I (PgI;Endo-PG I) 3.2.1.15 pubmed
Achaetomium sp. Xz-8 / Xz8 AGR51994.1 S5MK25  
 polygalacturonase 1 (PG-1;AaPG-1) 3.2.1.15 pubmed
Alternaria alternata AC325 BAB32924.1 Q9C4A0  
 polygalacturonase 1 (PG-1;AcPG-1) 3.2.1.15 pubmed
Alternaria citri BAB32923.1
AXB87857.1
URD30975.1
Q9C4A1  
 polygalacturonase (ADPG1;At3g57510) 3.2.1.15 pubmed
Arabidopsis thaliana AAC98923.1
AAO63440.1
AEE79664.1
BAC42580.1
CAA05525.1
CAB66108.1
CAD5326090.1
NP_191310.1
A0A178V9D7
A0A7G2EYK0
O23147
 
 polygalacturonase 1 / polygalacturonase EPG M2 (Pg1;ePOL;E-PGALUSP) 3.2.1.15 pubmed
Aspergillus aculeatus CAE46193.1 O74213  
 polygalacturonase 2 (Pg2;PG2) 3.2.1.15 pubmed
Aspergillus aculeatus CAE46194.1 Q70HJ4  
 polygalacturonase (Pga1) 3.2.1.15 pubmed
Aspergillus aculeatus KSM 510 AAC23565.1 O74213 1IA5[A]
1IB4[A,B]
 rhamnogalacturonase A (RhgA) 3.2.1.171 pubmed
Aspergillus aculeatus KSM 510 / CBS 115.80 AAA64367.1
AAB35485.1
CAA58507.2
CAB58937.1
CAB58938.1
Q00001 1RMG[A]
 protopectinase-AS (Ppas) 3.2.1.15 pubmed
Aspergillus awamori BAA95408.1 Q9P358  
 polygalacturonase-X2 (Pgx2) 3.2.1.15 pubmed
Aspergillus awamori BAA95407.1 Q9P359  
 exo-polygalacturonase (NfPG4;NFIA_049320) 3.2.1.67 doi
Aspergillus fischeri NRRL 181 EAW15592.1
XP_001257489.1
A1DLC1  
 endo-polygalacturonase (NfPG5;NFIA_008150) 3.2.1.15 doi
Aspergillus fischeri NRRL 181 EAW22138.1
XP_001264035.1
A1D145  
 polygalacturonase A (PecA;P2c) 3.2.1.15 pubmed
Aspergillus flavus 70 AAA85279.1 P41749  
 polygalacturonase B (PecB) 3.2.1.15 pubmed
Aspergillus flavus 70 AAA85280.1 P41750  
 xylogalacturonase (Afu8g06890) 3.2.1.- pubmed
Aspergillus fumigatus Af293 EAL85450.1 Q4WBT4  
 polygalacturonase A / I (PgaA;Pg1;PG I) 3.2.1.15 pubmed
Aspergillus kawachii IFO 4308 BAC10596.1 Q8NK99  
 exo-polygalacturonase (AN8761.2) 3.2.1.67 pubmed
Aspergillus nidulans FGSC A4 EAA60554.1
ABF50895.1
Q5ASG9  
 rhamnogalacturonase (AN9134.2) 3.2.1.171 pubmed
Aspergillus nidulans FGSC A4 ABF50898.1
EAA61967.1
Q5ARE6  
 endo-polygalacturonase (PG1;AN4372.2) 3.2.1.15 pubmed
Aspergillus nidulans FGSC A4 ABF50868.1
EAA60289.1
Q5B508  
 exo-polygalacturonase (AN9045.2) 3.2.1.67 pubmed
Aspergillus nidulans FGSC A4 EAA64377.1
ABF50897.1
Q5ARN5  
 endo-polygalacturonase (AN8327.2) 3.2.1.15 pubmed
Aspergillus nidulans FGSC A4 EAA66950.1
ABF50893.1
Q5ATQ3  
 endo-polygalacturonase D (PgaD) 3.2.1.15 pubmed
Aspergillus niger CBS 120.49 / N400 CAB72931.1 Q9P4W2  
 endo-polygalacturonase A (PgaA;PGA) 3.2.1.15 pubmed
Aspergillus niger CBS 120.49 / N400 CAB72125.1 Q9P4W4  
 endo-polygalacturonase B (PgaB) 3.2.1.15 pubmed
Aspergillus niger CBS 120.49 / N400 CAB72126.1
AAR39811.1
Q9P4W3  
 polygalacturonase (PgaE) 3.2.1.15 pubmed
Aspergillus niger CBS 120.49 / N400 CAA74744.1 O42809  
 endopolygalacturonase-1 / I (PgaI;PgaA;AnPGI) 3.2.1.15 pubmed
Aspergillus niger CBS 120.49 / N400 CAA41693.1 P26213 1NHC[A,B,C,D,E,F]
 endopolygalacturonase-2 / II (PgaII;PgaB;AnPGII) 3.2.1.15 pubmed
Aspergillus niger CBS 120.49 / N400 CAA41694.1 P26214 1CZF[A,B]
 endopolygalacturonase C (PgaC) 3.2.1.15 pubmed
Aspergillus niger CBS 120.49 / N400 CAA45707.1 Q12554  
 rhamnogalacturonase A (RhgA) 3.2.1.171 pubmed
Aspergillus niger CBS 120.49 / N400 CAA63911.1 P87160  
 rhamnogalacturonase B (RhgB) 3.2.1.171 pubmed
Aspergillus niger CBS 120.49 / N400 CAA63912.1 P87161  
 exo-xylogalacturonan hydrolase (PgxA;An11g04040) 3.2.1.- pubmed
Aspergillus niger CBS 513.88 ABD61563.1
CAK48389.1
A2QW66
Q27UB2
 
 exopolygalacturonase (PgxB;An03g0674) 3.2.1.67 pubmed
Aspergillus niger CBS 513.88 ABD61564.1
CAK38430.1
A2QHG0
Q27UB1
 
 exopolygalacturonase (PgxC;An02g12450) 3.2.1.67 pubmed
Aspergillus niger CBS 513.88 ABD61565.1
CAK44512.1
A2QEW2
Q27UB0
 
 An01g11520 (PgaI) 3.2.1.15 pubmed
Aspergillus niger CBS 513.88 CAK44054.1 A2QAH3  
 An01g14670 (PgaE) 3.2.1.15 pubmed
Aspergillus niger CBS 513.88 CAK44164.1 A2QBB6  
 An02g04900 (PgaB) 3.2.1.15 pubmed
Aspergillus niger CBS 513.88 CAK47667.1 A2QCV8  
 endogalacturonase A (PgaA) 3.2.1.15 pubmed
Aspergillus niger JL-15 AGV40780.1 T2D2W8  
 polygalacturonase M1 (PG) 3.2.1.15 pubmed
Aspergillus niger RH5344 CAA37085.1
CAA02197.1
CAA02200.1
CAA38085.1
P0CU55  
 polygalacturonase (PG) 3.2.1.15 pubmed
Aspergillus oryzae KBN616 BAA03244.2 P35335  
 polygalacturonase B (PgaB) 3.2.1.15 pubmed
Aspergillus oryzae KBN616 BAA34782.1 O93789
Q2UHL4
 
 polygalacturonase (PG;AO090023000161) 3.2.1.15 pubmed
Aspergillus oryzae RIB40 BAE58737.1
ABO38858.1
P35335  
 polygalacturonase B (PgaB;AO090023000401) 3.2.1.15 pubmed
Aspergillus oryzae RIB40 BAE58951.1 Q2UHL4  
 xylogalacturonan hydrolase (XghA) 3.2.1.- pubmed
Aspergillus tubingensis CAB65657.1
CAC07733.1
Q9UUZ2 4C2L[A]
 exopolygalacturonase (PgaX;ExoPG) 3.2.1.67 pubmed
Aspergillus tubingensis CAA68128.1 Q00293  
 polygalacturonase II (PgaII;PG-II) 3.2.1.15 pubmed
Aspergillus tubingensis NW756 CAA41695.1 P0CU54
P19805
 
 polygalacturonase (Pgn1) 3.2.1.15 pubmed
Bipolaris zeicola SB111 AAA79885.1 P26215  
 endopolygalacturonase (Pga1) 3.2.1.15 doi
Bispora sp. MEY-1 ADZ99366.1 F2VRZ5  
 rhamnogalacturonase A (RhgA;BcRhgA) 3.2.1.171 pubmed
Botrytis cinerea ATCC 90870 AAB61358.1 P87247  
 endopolygalacturonase 1 (Pg1) 3.2.1.15 pubmed
Botrytis cinerea B05.10 AAV84613.1
CAM33462.1
A2VBD9
Q4G496
 
 endopolygalacturonase 2 (Pg2) 3.2.1.15 pubmed
Botrytis cinerea B05.10 AAV84614.1
CAM91324.1
Q4G495  
 endopolygalacturonase 3 (Pg3) 3.2.1.15 pubmed
Botrytis cinerea B05.10 AAV84615.1
CAM91243.1
A4VAU2
Q9Y7V9
 
 endopolygalacturonase 4 (Pg4) 3.2.1.15 pubmed
Botrytis cinerea B05.10 AAV84616.1
CAQ03414.1
B4ESG3
Q9Y7W0
 
 endopolygalacturonase 5 (Pg5) 3.2.1.15 pubmed
Botrytis cinerea B05.10 AAV84617.1
AFA52634.1
CAM33166.1
CAQ03437.1
CAQ03437.2
B4ESI3
H6W9D0
Q9Y7W1
 
 endopolygalacturonase 6 (Pg6) 3.2.1.15 pubmed
Botrytis cinerea B05.10 AAV84618.1 Q9Y7W2  
 endopolygalacturonase I (Pg1;endoPG I) 3.2.1.15 pubmed
Chondrostereum purpureum BAA08102.1
BAA96351.1
P79074 1K5C[A]
1KCC[A]
1KCD[A]
 polygalacturonase (EpgA) 3.2.1.15 pubmed
Chondrostereum purpureum AAF68401.1 Q9P8M5  
 endopolygalacturonase (EnPG-4;EndoPG IV;EndoPG IVa;EndoPG IVb) 3.2.1.15 doi
Chondrostereum purpureum ASP-4B BAE80700.1
BAE43407.1
Q2AAD7
Q400N6
 
 endopolygalacturonase 1 (Pect-1;CTR1) 3.2.1.15 pubmed
Chrysomela tremula ACP18831.2
ACP18831.1
C3UTC2  
 endopolygalacturonase (Gh28pect-2;CTR2) 3.2.1.- pubmed
Chrysomela tremula ADU33275.1 E7CIR3  
 endopolygalacturonase (Gh28pect-7;CTR7) 3.2.1.15 pubmed
Chrysomela tremula ADU33280.2
ADU33280.1
E7CIR8  
 polygalacturonase (Pg1) 3.2.1.15 pubmed
Claviceps purpurea T5 CAA71246.2 P78607  
 endopolygalacturonase (Pg2;Cgmpg2;CmpgII) 3.2.1.15 doi
Colletotrichum gloeosporioides f. sp. malvae CAC14022.1 Q9HFP1  
 endopolygalacturonase (Pg1) 3.2.1.15 pubmed
Colletotrichum lupini var. setosum (nom. inval.) SHK788 ABL01533.1 A1E266 2IQ7[A,B,C,D,E,F,G]
 polygalacturonase 3.2.1.15 pubmed
Cucumis melo AAC26512.1 O81246  
 oligogalacturonase (Gh28-3;DVI3) 3.2.1.- pubmed
Diabrotica virgifera virgifera AHJ09929.1 A0A088BZM3  
 endopolygalacturonase (Gh28-11;DVI11) 3.2.1.15 pubmed
Diabrotica virgifera virgifera AHJ09937.1 A0A088BZ31  
 endopolygalacturonase (PPSX1;SX1) 3.2.1.15 pubmed
Dipodascus klebahnii ATCC 42397 AAE82584.1   cryst
 polygalacturonase (PSE3;SE3) 3.2.1.15 pubmed
Dipodascus klebahnii B2 BAA20427.1
AAB46926.1
P87217 cryst
 exopolygalacturonase (TePG28a) 3.2.1.67 pubmed
Evansstolkia leycettana JCM 12802 ASM94208.1 A0A221LG01  
 endopolygalacturonase (TePG28b) 3.2.1.15 pubmed
Evansstolkia leycettana JCM 12802 ASM94209.1 A0A221LFZ6  
 endopolygalacturonase III (PgIII) 3.2.1.15 pubmed
Fusarium fujikuroi PD CAG27851.1 Q5W375  
 polygalacturonase (FgPG1;FGSG_11011;FG11011) 3.2.1.15 doi
Fusarium graminearum PH-1 CEF87240.1 I1S2L3  
 exopolygalacturonase (Pgx4; ExoPG1; Pgc2) 3.2.1.67 pubmed
Fusarium oxysporum f. sp. cubense RACE 1 / RACE 4 ACZ06598.1
ADA63833.1
ADA63834.1
D1MI97
D2KKQ2
 
 polygalacturonase 3.2.1.15 pubmed
Fusarium oxysporum f. sp. lycopersici AAC27792.1 O74244  
 polygalacturonase (Pg1) 3.2.1.15 pubmed
Fusarium oxysporum f. sp. lycopersici 42-87 AAC05015.1
BAD97400.1
BAD97401.1
BAD97402.1
BAD97403.1
BAE45845.1
O00094
Q3LHX1
Q53U77
Q53U78
Q53U79
Q53U80
 
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