Glycoside Hydrolase Family 27

Activities in Familyα-galactosidase (EC 3.2.1.22); α-N-acetylgalactosaminidase (EC 3.2.1.49); isomalto-dextranase (EC 3.2.1.94); β-L-arabinopyranosidase (EC 3.2.1.88); galactan:galactan galactosyltransferase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteMechanistic commonality with family GH36 demonstrated by Comfort et al. (2007) Biochemistry 46:3319-3330 (PMID: 17323919).
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1788); Uniprot accession (327); PDB accession (47); 3D entries (14); cryst (0)
All (1532) Archaea (1) Bacteria (1142) Eukaryota (370) Viruses (1) unclassified (18) Structure (14) Characterized (70)
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-galactosidase (GalR) 3.2.1.22 synthetic construct QCC19990.1
QCC19991.1
   
 GH27_1, Alphα-galactosidase   uncultured organism VDS02529.1    
 GH27_1, Alphα-galactosidase   uncultured organism VDS02573.1    
 MedDCM-OCT-S04-C188-cds6 / ENSANGP00000020847 (fragment)   uncultured organism MedDCM-OCT-S04-C188 ADD95732.1 D6PJ31  
 E1750_16695   Flavobacterium sp. GS13 QBN20359.1    
 E1750_17270   Flavobacterium sp. GS13 QBN20465.1    
 E1750_17555   Flavobacterium sp. GS13 QBN20518.1    
 E1750_17300   Flavobacterium sp. GS13 QBN20471.1    
 E5673_05940   Sphingomonas sp. PAMC26645 QCB44255.1    
 E5225_17005   Cellulomonas sp. Z28 QCB95507.1    
 E5225_03940   Cellulomonas sp. Z28 QCB92829.1    
 E5554_11225   Sphingobium sp. PAMC28499 QCB40618.1    
 E7745_11680   Duncaniella sp. C9 QCD40129.1    
 FA702_20140   Novosphingobium sp. ABRDHK2 QCI96207.1    
 FCS00_03410   Elizabethkingia sp. 2-6 QCO45459.1    
 FDZ78_00825   Duncaniella sp. B8 QCP71216.1    
 C1N80_04220   Brachybacterium sp. SGAir0954 QCR52864.1    
 E6C60_1325   Paenibacillus sp. HB172198 QCT02041.1    
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