Glycoside Hydrolase Family 26

Activities in Familyβ-mannanase (EC 3.2.1.78); exo-β-1,4-mannobiohydrolase (EC 3.2.1.100); β-1,3-xylanase (EC 3.2.1.32); lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); mannobiose-producing exo-β-mannanase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family I.
External resourcesCAZypedia; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (4249); Uniprot accession (85); PDB accession (42); 3D entries (20); cryst (2)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 β-mannanase (Man;CtMan;CtManf;Cthe_0032) 3.2.1.78 pubmed
Acetivibrio thermocellus ATCC 27405 ABN51273.1 A3DBE4  
 β-mannanase (ManA;ManB;Cthe_2811) (Man26B) 3.2.1.78 pubmed
Acetivibrio thermocellus ATCC 27405 ABN54010.1 A3DJ81  
 β-mannanase 26B (Man26B) 3.2.1.78 pubmed
Acetivibrio thermocellus F1 BAB19050.1 Q9F1T9  
 endo-β-1,4-glucanase / β-1,3:1,4-glucanase H (CelH) (Lic26A;Cel5E) 3.2.1.73 pubmed
Acetivibrio thermocellus NCIB 10682 AAA23225.1 H6SHY4
P16218
2BV9[A]
2BVD[A]
2CIP[A]
2CIT[A]
2V3G[A]
2VI0[A]
6ZPL[C]
 β-mannanase A (ManA) (Man26A) 3.2.1.78 pubmed
Acetivibrio thermocellus YS CAB52403.1 Q9REC7  
 β-1,3-xylanase (TxyA;3xynAlc) 3.2.1.32 pubmed
Alcaligenes sp. XY-234 BAB88993.1 Q8RS40  
 endo-β-1,4-mannanase 3.2.1.78 pubmed
Bacillus amyloliquefaciens YB-1402 AIZ00503.1 A0A0A7H8N0  
 endo-β-1,4-mannanase (ManB;YdhT;BLi00735;BL00606) 3.2.1.78 pubmed
Bacillus licheniformis DSM 13 = ATCC 14580 AAU39670.1
AAU22320.1
AAU22321.2
Q65MP4 cryst
 endo-β-1,4-mannanase (ManB) 3.2.1.78 pubmed
Bacillus pumilus Nsic-2 AGI16498.1 M4WK58  
 β-mannanase 3.2.1.78 doi
Bacillus sp. (in: Bacteria) 5H BAA31711.1 O83011  
 endo-β-1,4-mannanase (ManA) 3.2.1.78 doi
Bacillus sp. (in: Bacteria) W-2 BAA21553.1 Q76N66  
 endo-β-1,4-mannanase (ManB-1601) 3.2.1.78 pubmed
Bacillus sp. CFR1601 AIY24429.1 A0A0A1E3J1  
 β-mannanase 26A (AmA) (alkaline) (Man26A) 3.2.1.78 pubmed
Bacillus sp. JAMB750 BAE80444.1 Q2ACI1 4YN5[A]
 β-mannanase (Bman26) 3.2.1.78 pubmed
Bacillus sp. MK-2(2016) ANG59296.1 A0A173DUJ6  
 endo-β-1,4-mannanase (Mans2) (partial) 3.2.1.78 pubmed
Bacillus sp. SWU60 BAS22086.1 A0A0K2S4R5  
 endo-β-1,4-mannanase 3.2.1.78 doi
Bacillus sp. YB-1401 AIZ00502.1 A0A0A7HAT5  
 β-mannanase (ManB36) 3.2.1.78 pubmed
Bacillus subtilis B36 ABC73065.1 Q2L7F9  
 endo-β-1,4-mannosidase (RMase24) 3.2.1.78 pubmed
Bacillus subtilis cAE24 AVG45451.1 A0A2L2DH00  
 endo-β-1,4-mannanase (ManaA) 3.2.1.78 pubmed
Bacillus subtilis G1 ABC61374.1 Q2LGZ6  
 β-mannanase (Man1) 3.2.1.78 pubmed
Bacillus subtilis HB002 AAK16706.1 Q9AGZ3  
 β-mannanase 3.2.1.78 pubmed
Bacillus subtilis MA139 ACH41133.1 B5LX62  
 β-mannanase (MannS) 3.2.1.78 pubmed
Bacillus subtilis MAFIC-S11 AFS64032.1 J9ZYE8  
 β-mannanase (ManA) 3.2.1.78 pubmed
Bacillus subtilis MUSc-1 / BCC41051 ADZ54787.1 F2VQ62  
 β-mannanase 3.2.1.78 pubmed
Bacillus subtilis NM-39 BAA07178.1 P55278  
 β-mannanase 26A (BsMan26A; YdhT; BSU05880) (Man26A) 3.2.1.78 pubmed
Bacillus subtilis subsp. subtilis str. 168 BAA19712.1
AIY91875.1
AQR80540.1
AQR84753.1
CAB12407.1
CAB12407.2
NP_388469.1
A0A6M3Z7Z2
O05512
2WHK[A]
3CBW[A,B]
 β-mannanase (ManA) 3.2.1.78 doi
Bacillus subtilis WL-3 AAZ95239.1 Q3S4E4  
 β-mannanase (ManA) 3.2.1.78 URL
Bacillus subtilis WL-7 AAT27435.1 Q6J4L3  
 β-1,4-mannanase (Man;BcMan) 3.2.1.78 pubmed
Bacillus subtilis Z-2 AAV84100.1 Q5PSP8 2QHA[A,B]
 exo-β-1,4-mannanase (mannobiose-producing) (ManA;BfMan26;BF0771) 3.2.1.100 pubmed
Bacteroides fragilis NCTC 9343 CAH06517.1 Q5LH69  
 exo-β-1,4-mannanase 26A (Mana_1;BoMan26A;Bovatus_02927;BACOVA_02092) (periplasmic) (Man26A) 3.2.1.100 pubmed
Bacteroides ovatus ATCC 8483 ALJ47536.1 A7LW88 4ZXO[A]
 β-1,4-mannanase 26B (Mana_2;BoMan26B;Bovatus_02928;BACOVA_02093) (Man26B) 3.2.1.78
3.2.1.100
pubmed
pubmed
Bacteroides ovatus ATCC 8483 ALJ47537.1 A7LW89 6HF2[A]
6HF4[A]
 β-mannanase (BaMan26A;BAD_1030) (Man26A) 3.2.1.78 pubmed
Bifidobacterium adolescentis ATCC 15703 BAF39811.1 A1A278  
 β-1,3-xylanase (XYLII) 3.2.1.32 doi
Brevundimonas vesicularis MA103 AIX87981.1 A0A0A1C3U6  
 β-mannanase (M-I;M-II;M-III) 3.2.1.78 pubmed
Caldalkalibacillus mannanilyticus AM-001 AAA22586.1
A37219
P16699  
 β-mannanase (ManA;CsMan26) 3.2.1.78 pubmed
Caldicellulosiruptor sp. Rt8B.4 AAC44232.1 P77847  
 β-mannanase (Man26A) 3.2.1.78 pubmed
Cellulomonas fimi ATCC 484 AAD42774.1 Q9XCV5 2BVT[A,B]
2BVY[A]
2X2Y[A,B]
3TP4[A,B]
 β-1,4-mannanase A (ManA; CjMan26A; CJA_2770; eMAN; E-BMACJ) (Man26A) 3.2.1.78 pubmed
Cellvibrio japonicus Ueda107 ACE82849.1
CAA57670.2
B3PBK3
P49424
1GVY[A]
1GW1[A]
1J9Y[A]
1ODZ[A,B]
1R7O[A]
2WHM[A]
 endo-β-1,4-mannanase 26B (CJA_2480) (Man26B) 3.2.1.78 pubmed
Cellvibrio japonicus Ueda107 ACE85176.1
AAO31762.1
B3PKL2
Q840B9
 
 mannobiose-producing exo-β-mannanase (CJA_0236;CjMan26C) (Man26C) 3.2.1.100 pubmed
Cellvibrio japonicus Ueda107 ACE84009.1 B3PGI1 2VX4[A]
2VX5[A]
2VX6[A]
2VX7[A]
4CD4[A]
4CD5[A]
 β-mannanase (Clocel_4124) (Man26E) 3.2.1.78 pubmed
Clostridium cellulovorans 743B ADL53785.1 D9SMC9  
 mannanase B (ManB;NC2;Clocel_2607) 3.2.1.78 pubmed
Clostridium cellulovorans 743B ADL52314.1
YP_003844078.1
D9SQV8  
 β-mannanase (Clocel_4119; Man26A) (Man26A) 3.2.1.78 pubmed
Clostridium cellulovorans 743B ADL53780.1 D9SMC4  
 β-mannanase (ManA) (fragment) 3.2.1.78 pubmed
Dictyoglomus thermophilum RT46B.1 AAB82454.1 O30654  
 Fisuc_0727 / FSU_1165 3.2.1.78 pubmed
Fibrobacter succinogenes subsp. succinogenes S85 ACX74337.1
ADL27067.1
C9RMV9  
 β-mannanase (KMAN; KMAN-3) 3.2.1.78 pubmed
Klebsiella oxytoca KUB-CW2-3 AIT71003.1   7EET[A]
 β-mannanase 3.2.1.78 pubmed
Niallia circulans NT6.7 AEO19987.1 G3FHR2  
 xyloglucanase / β-mannanase (Cel44C-Man26A) 3.2.1.78 pubmed
Paenibacillus polymyxa GS01 AAW12876.1
ABC88431.1
ACE10759.1
Q1A2D0  
 β-1,4-mannanase (Man26B) 3.2.1.78 pubmed
Paenibacillus sp. BME-14 ACS92711.1 C6KL35  
 endo-β-1,4-mannanase (Man26P) 3.2.1.78 doi
Pantoea agglomerans A021 ACN30272.1 C0KZC5  
 β-1,3-xylanase (AxnB) 3.2.1.32 doi
Pseudomonas sp. ND137 BAB79289.1 Q8VUT2  
 β-mannanase (ManA;Rmar_0016) 3.2.1.78 pubmed
Rhodothermus marinus DSM 4252 ACY46925.1
CAA62442.1
P49425  
 endo-β-1,4-mannanase (RiGH26; RIL182_00214; ROSINTL182_07683; ManA) 3.2.1.78 pubmed
Roseburia intestinalis L1-82 VCV20359.1
EEV00397.1
C7GCP5  
 β-mannanase (GH26A;RUM_15270) (Man26A) 3.2.1.78 pubmed
Ruminococcus champanellensis 18P13 = JCM 17042 CBL17621.1 D4LDC6  
 β-mannanase (GH26B;RUM_21270) (Man26B) 3.2.1.78 pubmed
Ruminococcus champanellensis 18P13 = JCM 17042 CBL18146.1 D4LEV1  
 β-1,4-mannanase (ManA;ManAGN25) 3.2.1.78 pubmed
Sphingobacterium sp. GN25 AGC01502.1 A0A0N6X4Z9  
 endo-β-1,4-mannanase (ManA;ManAJB13) 3.2.1.78 pubmed
Sphingomonas sp. JB13 AFE82293.1 I3PQX2  
 β-mannanase 26A (Man26A; Mana1; Cst_c11340) 3.2.1.78 pubmed
Thermoclostridium stercorarium subsp. stercorarium DSM 8532 AGC68130.1
AGI39156.1
L7VJA2  
 endo-β-1,3-xylanase (XylC;TnXyn26A;CTN_0617) (Xyn26A) 3.2.1.32 pubmed
Thermotoga neapolitana DSM 4359 ACM22793.1
AAB70868.1
B9K760
O33841
cryst
 bifunctional mannanase-xyloglucanase (MNXEG) 3.2.1.78 pubmed
uncultured bacterium ADA62505.1 D2KKK4  
 endoglycosidase (GH6248) (Cel5A) 3.2.1.78 pubmed
uncultured bacterium ABB46200.1 Q283N5  
 exo-β-mannanase (GH26_i) 3.2.1.100 pubmed
uncultured Bacteroidetes bacterium AIT97142.1 A0A097KUR5  
 endomannanase (Man1; GC_Man1) 3.2.1.78 pubmed
uncultured Dictyoglomus sp. QRN45945.1 A0A891XKI6  
 β-1,3-xylanase (Xyl4) 3.2.1.32 pubmed
Vibrio sp. AX-4 BAD51934.1 D5MP61 2DDX[A]
3VPL[A]
 endo-1,3-β-xylanase (TxyA) 3.2.1.32 pubmed
Vibrio sp. XY-214 BAA94698.1 Q9LCB9  
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 endo-β-1,4-mannanase (AnMan26A;AN7413.2) (Man26A) 3.2.1.78 doi
Aspergillus nidulans FGSC A4 EAA61784.1 C8VCC9
Q5AWB7
 
 endo-β-1,4-mannanase (An15g07760) (Man26A) 3.2.1.78 pubmed
Aspergillus niger CBS 513.88 CAK42663.1 A2R6F5  
 β-mannanase A (ManA) 3.2.1.78 pubmed
Piromyces sp. CAA62968.1 P55296  
 β-mannanase B (ManB) 3.2.1.78 pubmed
Piromyces sp. CAA66061.1 P55297  
 β-mannanase C (ManC) 3.2.1.78 pubmed
Piromyces sp. CAA66134.1 P55298  
 endo-β-1,4-mannanase (PaMan26A;Pa_5_1950) (Man26A) 3.2.1.78 pubmed
Podospora anserina S mat+ CAP61906.1
ADO14135.1
CDP28981.1
B2AEP0
E2GHW2
3ZM8[A]
 β-mannanase (ManC;RsManC;RsMan26C) (Man26C) 3.2.1.78 pubmed
Symbiotic protist of Reticulitermes speratus BAL68133.1 H7CGE2 3WDQ[A]
3WDR[A]
 β-mannanase (mannobiose-producing) (RsManH;RsMan26H) (fragment) 3.2.1.100 pubmed
Symbiotic protist of Reticulitermes speratus BAN57513.1 A0A060N6J6  
 endo-β-1,4-mannanase 26A (WspMan26A) 3.2.1.78 pubmed
Westerdykella sp. AXG24385.1 A0A345F7H7  
 endo-β-1,4-mannanase 26A (YpenMan26A) 3.2.1.78 pubmed
Yunnania penicillata Man26A AYU65281.1 A0A3G4RHU4 6HPF[A]
unclassified
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 endo-β-1,4-glucanase (SARM_0007 / 3811766_160700 / TW-10) 3.2.1.4 pubmed
uncultured organism ADX05678.1 E9NSI3  
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