Glycoside Hydrolase Family 26

Activities in Familyβ-mannanase (EC 3.2.1.78); exo-β-1,4-mannobiohydrolase (EC 3.2.1.100); β-1,3-xylanase (EC 3.2.1.32); lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); mannobiose-producing exo-β-mannanase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family I.
External resourcesCAZypedia; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1516); Uniprot accession (309); PDB accession (30); 3D entries (13); cryst (2)
All (1462) Archaea (7) Bacteria (1399) Eukaryota (41) unclassified (15) Structure (13 - 2 cryst) Characterized (72)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-1,3-xylanase (TxyA;3xynAlc) 3.2.1.32 Alcaligenes sp. XY-234 BAB88993.1 Q8RS40  
 endo-β-1,4-mannanase 3.2.1.78 Bacillus amyloliquefaciens YB-1402 AIZ00503.1    
 β-mannanase 3.2.1.78 Bacillus circulans NT6.7 AEO19987.1    
 endo-β-1,4-mannanase (ManB;YdhT;BLi00735;BL00606) 3.2.1.78 Bacillus licheniformis DSM 13 = ATCC 14580 AAU39670.1
AAU22320.1
AAU22321.2
Q65MP4 cryst
 β-mannanase (M-I;M-II;M-III) 3.2.1.78 Bacillus mannanilyticus AM-001 AAA22586.1
A37219
P16699  
 endo-β-1,4-mannanase (ManB) 3.2.1.78 Bacillus pumilus Nsic-2 AGI16498.1    
 β-mannanase 3.2.1.78 Bacillus sp. 5H BAA31711.1 O83011  
 endo-β-1,4-mannanase (ManB-1601) 3.2.1.78 Bacillus sp. CFR1601 AIY24429.1    
 β-mannanase 26A (AmA) (alkaline) (Man26A) 3.2.1.78 Bacillus sp. JAMB750 BAE80444.1 Q2ACI1 4YN5[A]
 endo-β-1,4-mannanase (Mans2) (partial) 3.2.1.78 Bacillus sp. SWU60 BAS22086.1    
 endo-β-1,4-mannanase (ManA) 3.2.1.78 Bacillus sp. W-2 BAA21553.1 Q76N66  
 endo-β-1,4-mannanase 3.2.1.78 Bacillus sp. YB-1401 AIZ00502.1    
 β-mannanase (ManB36) 3.2.1.78 Bacillus subtilis B36 ABC73065.1 Q2L7F9  
 endo-β-1,4-mannanase (ManaA) 3.2.1.78 Bacillus subtilis G1 ABC61374.1 Q2LGZ6  
 β-mannanase (Man1) 3.2.1.78 Bacillus subtilis HB002 AAK16706.1 Q9AGZ3  
 β-mannanase 3.2.1.78 Bacillus subtilis MA139 ACH41133.1 B5LX62  
 β-mannanase (MannS) (partial) 3.2.1.78 Bacillus subtilis MAFIC-S11 AFS64032.1    
 β-mannanase (ManA) 3.2.1.78 Bacillus subtilis MUSc-1 / BCC41051 ADZ54787.1    
 β-mannanase 3.2.1.78 Bacillus subtilis NM-39 BAA07178.1 P55278  
 β-mannanase (YdhT;BSU05880) 3.2.1.78 Bacillus subtilis subsp. subtilis str. 168 BAA19712.1
AIY91875.1
AQR80540.1
AQR84753.1
CAB12407.1
CAB12407.2
NP_388469.1
O05512 2WHK[A]
3CBW[A,B]
 β-mannanase (ManA) 3.2.1.78 Bacillus subtilis WL-3 AAZ95239.1 Q3S4E4  
 β-mannanase (ManA) 3.2.1.- Bacillus subtilis WL-7 AAT27435.1 Q6J4L3  
 β-1,4-mannanase (Man;BcMan) 3.2.1.78 Bacillus subtilis Z-2 AAV84100.1 Q5PSP8 2QHA[A,B]
 exo-β-1,4-mannanase (mannobiose-producing) (ManA;BfMan26;BF0771) 3.2.1.100 Bacteroides fragilis NCTC 9343 CAH06517.1 Q5LH69  
 exo-β-1,4-mannanase 26A (Mana_1;BoMan26A;Bovatus_02927;BACOVA_02092) (periplasmic) (Man26A) 3.2.1.100 Bacteroides ovatus ATCC 8483 ALJ47536.1   4ZXO[A]
 β-1,4-mannanase 26B (Mana_2;BoMan26B;Bovatus_02928;BACOVA_02093) (Man26B) 3.2.1.78
3.2.1.100
Bacteroides ovatus ATCC 8483 ALJ47537.1    
 β-mannanase (BaMan26A;BAD_1030) (Man26A) 3.2.1.78 Bifidobacterium adolescentis ATCC 15703 BAF39811.1 A1A278  
 β-1,3-xylanase (XYLII) 3.2.1.32 Brevundimonas vesicularis MA103 AIX87981.1    
 β-mannanase (ManA;CsMan26) 3.2.1.78 Caldicellulosiruptor sp. Rt8B.4 AAC44232.1 P77847  
 β-mannanase (Man26A) 3.2.1.78 Cellulomonas fimi ATCC 484 AAD42774.1 Q9XCV5 2BVT[A,B]
2BVY[A]
2X2Y[A,B]
3TP4[A,B]
 β-1,4-mannanase A (ManA;CjMan26A;CJA_2770;eMAN;E-BMACJ) (Man26A) 3.2.1.78 Cellvibrio japonicus Ueda107 ACE82849.1
CAA57670.2
B3PBK3
P49424
1GVY[A]
1GW1[A]
1J9Y[A]
1ODZ[A,B]
2WHM[A]
 endo-β-1,4-mannanase 26B (CJA_2480) (Man26B) 3.2.1.78 Cellvibrio japonicus Ueda107 ACE85176.1
AAO31762.1
B3PKL2
Q840B9
 
 mannobiose-producing exo-β-mannanase (CJA_0236;CjMan26C) (Man26C) 3.2.1.100 Cellvibrio japonicus Ueda107 ACE84009.1 B3PGI1 2VX4[A]
2VX5[A]
2VX6[A]
2VX7[A]
4CD4[A]
4CD5[A]
 β-mannanase (Clocel_4124) (Man26E) 3.2.1.78 Clostridium cellulovorans 743B ADL53785.1 D9SMC9  
 mannanase B (ManB;NC2;Clocel_2607) 3.2.1.78 Clostridium cellulovorans 743B ADL52314.1
YP_003844078.1
D9SQV8  
 Clocel_4119 (Man26A) 3.2.1.78 Clostridium cellulovorans 743B ADL53780.1 D9SMC4  
 β-mannanase (ManA) (fragment) 3.2.1.78 Dictyoglomus thermophilum RT46B.1 AAB82454.1 O30654  
 Fisuc_0727 / FSU_1165 3.2.1.78 Fibrobacter succinogenes subsp. succinogenes S85 ACX74337.1
ADL27067.1
C9RMV9  
 mannanase (KMAN) (probable fragment) 3.2.1.78 Klebsiella oxytoca KUB-CW2-3 AIT71003.1    
 xyloglucanase 3.2.1.151 Paenibacillus polymyxa AAW12877.1
ACE10760.1
   
 xyloglucanase / β-mannanase (Cel44C-Man26A) 3.2.1.151
3.2.1.4
3.2.1.78
Paenibacillus polymyxa GS01 AAW12876.1
ABC88431.1
ACE10759.1
   
 β-1,4-mannanase (Man26B) 3.2.1.78 Paenibacillus sp. BME-14 ACS92711.1 C6KL35  
 endo-β-1,4-mannanase (Man26P) 3.2.1.78 Pantoea agglomerans A021 ACN30272.1 C0KZC5  
 mixed-linkage β-glucanase/xyloglucanase (Orf4;CMCase;PBR_0368) (Cel5A) 3.2.1.151
3.2.1.73
Prevotella bryantii B14 AAC97596.1
AAA22909.1
AAB20175.1
O06842
Q44878
 
 β-1,3-xylanase (AxnB) 3.2.1.32 Pseudomonas sp. ND137 BAB79289.1 Q8VUT2  
 β-mannanase (ManA;Rmar_0016) 3.2.1.78 Rhodothermus marinus DSM 4252 ACY46925.1
CAA62442.1
P49425  
 β-mannanase (Man;CtMan;CtManf;Cthe_0032) 3.2.1.78 Ruminiclostridium thermocellum ATCC 27405 ABN51273.1 A3DBE4  
 bifunctional endo-β-1,4-glucanase / β-1,4-xylanase H (CelH;EgH;CtCelH;CtCel5E;Cthe_1472) (Lic26A;Cel5E) 3.2.1.4
3.2.1.8
Ruminiclostridium thermocellum ATCC 27405 ABN52701.1
CCF82162.1
P16218  
 β-mannanase (ManA;ManB;Cthe_2811) (Man26B) 3.2.1.78 Ruminiclostridium thermocellum ATCC 27405 ABN54010.1 A3DJ81  
 β-mannanase 26B (Man26B) 3.2.1.78 Ruminiclostridium thermocellum F1 BAB19050.1 Q9F1T9  
 endo-β-1,4-glucanase / β-1,3:1,4-glucanase H (CelH) (Lic26A;Cel5E) 3.2.1.4
3.2.1.73
Ruminiclostridium thermocellum NCIB 10682 AAA23225.1 H6SHY4
P16218
2BV9[A]
2BVD[A]
2CIT[A]
2V3G[A]
2VI0[A]
 β-mannanase A (ManA) (Man26A) 3.2.1.78 Ruminiclostridium thermocellum YS CAB52403.1 Q9REC7  
 β-mannanase (GH26A;RUM_15270) (Man26A) 3.2.1.78 Ruminococcus champanellensis 18P13 = JCM 17042 CBL17621.1 D4LDC6  
 β-mannanase (GH26B;RUM_21270) (Man26B) 3.2.1.78 Ruminococcus champanellensis 18P13 = JCM 17042 CBL18146.1 D4LEV1  
 β-1,4-mannanase (ManA;ManAGN25) 3.2.1.- Sphingobacterium sp. GN25 AGC01502.1    
 endo-β-1,4-mannanase (ManA;ManAJB13) 3.2.1.- Sphingomonas sp. JB13 AFE82293.1    
 endo-β-1,3-xylanase (XylC;TnXyn26A;CTN_0617) (Xyn26A) 3.2.1.32 Thermotoga neapolitana DSM 4359 ACM22793.1
AAB70868.1
B9K760
O33841
cryst
 bifunctional mannanase-xyloglucanase (MNXEG) 3.2.1.73
3.2.1.78
uncultured bacterium ADA62505.1 D2KKK4  
 endoglycosidase (GH6248) (Cel5A) 3.2.1.4
3.2.1.73
3.2.1.78
3.2.1.8
uncultured bacterium ABB46200.1 Q283N5  
 exo-β-mannanase (GH26_i) 3.2.1.100 uncultured Bacteroidetes bacterium AIT97142.1    
 β-1,3-xylanase (Xyl4) 3.2.1.32 Vibrio sp. AX-4 BAD51934.1   2DDX[A]
3VPL[A]
 endo-1,3-β-xylanase (TxyA) 3.2.1.32 Vibrio sp. XY-214 BAA94698.1 Q9LCB9  
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 endo-β-1,4-mannanase (AnMan26A;AN7413.2) (Man26A) 3.2.1.78 Aspergillus nidulans FGSC A4 EAA61784.1 C8VCC9
Q5AWB7
 
 endo-β-1,4-mannanase (An15g07760) (Man26A) 3.2.1.78 Aspergillus niger CBS 513.88 CAK42663.1 A2R6F5  
 β-mannanase 3.2.1.78 Humicola insolens AAQ31840.1    
 β-mannanase A (ManA) 3.2.1.78 Piromyces sp. CAA62968.1 P55296  
 β-mannanase B (ManB) 3.2.1.78 Piromyces sp. CAA66061.1 P55297  
 β-mannanase C (ManC) 3.2.1.78 Piromyces sp. CAA66134.1 P55298  
 endo-β-1,4-mannanase (PaMan26A;Pa_5_1950) (Man26A) 3.2.1.78 Podospora anserina S mat+ CAP61906.1
ADO14135.1
CDP28981.1
B2AEP0 3ZM8[A]
 β-mannanase (ManC;RsManC;RsMan26C) (partial) (Man26C) 3.2.1.78 Symbiotic protist of Reticulitermes speratus BAL68133.1   3WDQ[A]
3WDR[A]
 β-mannanase (mannobiose-producing) (RsManH;RsMan26H) (fragment) 3.2.1.100 Symbiotic protist of Reticulitermes speratus BAN57513.1    
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 SARM_0007 / 3811766_160700 / TW-10 3.2.1.- uncultured organism ADX05678.1    
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