Glycoside Hydrolase Family 26

Activities in Familyβ-mannanase (EC 3.2.1.78); exo-β-1,4-mannobiohydrolase (EC 3.2.1.100); β-1,3-xylanase (EC 3.2.1.32); lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); mannobiose-producing exo-β-mannanase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family I.
External resourcesCAZypedia; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1516); Uniprot accession (309); PDB accession (30); 3D entries (13); cryst (2)
All (1462) Archaea (7) Bacteria (1399) Eukaryota (41) unclassified (15) Structure (13 - 2 cryst) Characterized (72)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 endo-β-1,4-mannanase (ManB;YdhT;BLi00735;BL00606) 3.2.1.78 Bacillus licheniformis DSM 13 = ATCC 14580 AAU39670.1
AAU22320.1
AAU22321.2
Q65MP4
cryst    
 β-mannanase 26A (AmA) (alkaline) (Man26A) 3.2.1.78 Bacillus sp. JAMB750 BAE80444.1 Q2ACI1
4YN5[A] 1.80
 β-mannanase (YdhT;BSU05880) 3.2.1.78 Bacillus subtilis subsp. subtilis str. 168 BAA19712.1
AIY91875.1
AQR80540.1
AQR84753.1
CAB12407.1
CAB12407.2
NP_388469.1
O05512
2WHK[A] 1.70
3CBW[A,B] 1.27
 β-1,4-mannanase (Man;BcMan) 3.2.1.78 Bacillus subtilis Z-2 AAV84100.1 Q5PSP8
2QHA[A,B] 1.45
 exo-β-1,4-mannanase 26A (Mana_1;BoMan26A;Bovatus_02927;BACOVA_02092) (periplasmic) (Man26A) 3.2.1.100 Bacteroides ovatus ATCC 8483 ALJ47536.1  
4ZXO[A] 1.50
 β-mannanase (Man26A) 3.2.1.78 Cellulomonas fimi ATCC 484 AAD42774.1 Q9XCV5
2BVT[A,B] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
2.9
2BVY[A] 2.25
2X2Y[A,B] 2.35
3TP4[A,B] 1.98
 β-1,4-mannanase A (ManA;CjMan26A;CJA_2770;eMAN;E-BMACJ) (Man26A) 3.2.1.78 Cellvibrio japonicus Ueda107 ACE82849.1
CAA57670.2
B3PBK3
P49424
1GVY[A] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp2F-(1-1)-<non_carb>
1.70
1GW1[A] β-D-Manp-(1-4)-β-D-Manp-(1-4)-α-D-Manp2F-(1-4)-GLU
1.65
1J9Y[A] 1.85
1ODZ[A,B] β-D-Manp-(1-4)-α-D-Manp
1.4
2WHM[A] β-D-Manp-(1-4)-α-D-Manp
1.50
 mannobiose-producing exo-β-mannanase (CJA_0236;CjMan26C) (Man26C) 3.2.1.100 Cellvibrio japonicus Ueda107 ACE84009.1 B3PGI1
2VX4[A] 1.70
2VX5[A] β-D-Manp
1.47
2VX6[A] α-D-Galp-(1-6)[β-D-Manp-(1-4)]-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
1.57
2VX7[A] β-D-Manp-(1-4)-β-D-Manp
1.80
4CD4[A] β-D-Manp-(1-1)-<non_carb>
<carb_like_IFM>
1.20
4CD5[A] β-D-Manp-(1-1)-<non_carb>
<carb_like_MVL>
1.10
 endo-β-1,4-glucanase / β-1,3:1,4-glucanase H (CelH) (Lic26A;Cel5E) 3.2.1.4
3.2.1.73
Ruminiclostridium thermocellum NCIB 10682 AAA23225.1 H6SHY4
P16218
2BV9[A] 1.50
2BVD[A] β-D-Glcp-(1-1)-<non_carb>
1.6
2CIT[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-3)-α-D-Glcp2F-(1-4)-GLU
1.40
2V3G[A] β-D-Glcp-(1-1)-<non_carb>
<carb_like_NOY>
1.20
2VI0[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp4SH-(1-4)-β-D-Glcp-(1-1)-methyl
1.51
 endo-β-1,3-xylanase (XylC;TnXyn26A;CTN_0617) (Xyn26A) 3.2.1.32 Thermotoga neapolitana DSM 4359 ACM22793.1
AAB70868.1
B9K760
O33841
cryst    
 β-1,3-xylanase (Xyl4) 3.2.1.32 Vibrio sp. AX-4 BAD51934.1  
2DDX[A] 0.86
3VPL[A] β-D-Xylp-(1-3)-β-D-Xylp-(1-3)-α-D-Xylp2F-(1-4)-GLU
β-D-Xylp-(1-4)-β-D-Xylp-(1-3)-β-D-Xylp2F-(1-1)-<non_carb>
1.20
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 endo-β-1,4-mannanase (PaMan26A;Pa_5_1950) (Man26A) 3.2.1.78 Podospora anserina S mat+ CAP61906.1
ADO14135.1
CDP28981.1
B2AEP0
3ZM8[A] 2.85
 β-mannanase (ManC;RsManC;RsMan26C) (partial) (Man26C) 3.2.1.78 Symbiotic protist of Reticulitermes speratus BAL68133.1  
3WDQ[A] 1.30
3WDR[A] β-D-Glcp-(1-4)-α-D-Manp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Manp
1.40
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