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Glycoside Hydrolase Family 23

Activities in FamilyChitinase (EC 3.2.1.14);
Lysozyme (EC 3.2.1.17);
Peptidoglycan lytic transglycosylase / peptidoglycan lyase (EC 4.2.2.29);
Mechanism Unknown e
3D Structure Statuslysozyme fold
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
NoteCorresponds to family 1 of the peptidoglycan lytic transglycosylases described by N.T. Blackburn and A.J. Clarke (2001) J. Mol. Evol. 52, 78-84; Note that 'peptidoglycan lytic transglycosylases' cleave peptidoglycan without intervention of a water molecule.
External resourcesCAZypedia; PRINTS;
Statistics GenBank accession (128573); Uniprot accession (60); PDB accession (91); 3D entries (22); cryst (0)
Summary
Download GH23 (127282) Taxonomic display Structure (22) Characterized (34)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 peptidoglycan lytic transglycosylase (RC10_04025) 4.2.2.29 Campylobacter jejuni CJ677CC047 ALW37381.1 Q0PA47
7LAM[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.31
7LAQ[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.58
8GEZ[A] β-D-GlcpNAc-(1-1)-<non_carb>
 1.99
8GF0[A] β-D-GlcpNAc-(1-1)-<non_carb>
 1.89
8GF1[A] β-D-GlcpNAc-(1-1)-<non_carb>
 1.92
8GFB[A] β-D-GlcpNAc6Me-(1-1)-<non_carb>
 2.17
8GFC[A] β-D-GlcpNAc4N-(1-1)-<non_carb>
 2.48
8GFD[A] β-D-GlcpNAc-(1-1)-<non_carb>
 1.86
8GFE[A] β-D-GlcpNAc-(1-1)-<non_carb>
 2.42
8GFF[A] β-D-GlcpNAc-(1-1)-<non_carb>
 1.90
8GFG[A] β-D-GlcpNAc-(1-1)-<non_carb>
 2.48
8GFH[A] β-D-GlcpNAc-(1-1)-<non_carb>
 1.83
8GFI[A] β-D-GlcpNAc-(1-1)-<non_carb>
 2.15
8GFJ[A] 2.20
8GFL[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-1)-<non_carb>
 2.36
8GFM[A] <carb_like_4AM>
 2.38
8GFP[A] <carb_like_DAN>
 2.07
8GFQ[A] <carb_like_9AM>
 2.30
8GFS[A] 2.38
 soluble lytic transglycosylase (LT; BD28_04025)   Campylobacter jejuni HF5-5-1 APU80298.1  
6CF8[A] 1.87
6CF9[A] 2.29
6CFC[A] 2.04
 CD0372 / CD630_03720   Clostridioides difficile 630 CAJ67194.1
AJP10066.1		  
4HPE[A,B,C,D,E,F] 2.38
 PS051_21525 (EtgA)   Escherichia albertii BIA_36 WDB90621.1  
8URN[A] 2.01
 muramidase / lytic transglycosylase (EtgA)   Escherichia coli 9812 / EPEC E2348/69 CAR48040.1  
4XP8[A] 2.03
 exolytic transglycosylase (MltC;BWG_2685) 4.2.2.29 Escherichia coli BW2952 K-12 ACR63750.1 C5A0N2
P0C066
4C5F[A,B] 2.34
4CFO[A,B] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)[<C3N1O1>-(1-3)]-β-D-GlcpNAc-(1-1)-methyl
 2.90
4CFP[A,B] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)[<C3O2>-(1-3)]-β-D-GlcpNAc-(1-1)-methyl
 2.15
4CHX[A,B] 2.45
 soluble lytic transglycosylase (SLT;SLTY;B4392;Slt70;EO53_18390) 4.2.2.29 Escherichia coli str. K-12 substr. MG1655 AIZ92838.1
AAA24634.1
AAA97288.1
AAC77345.2
ALI37950.1
AMC97248.1
AUG19070.1
AVI54536.1
AYG20839.1
NP_418809.1		 P03810
P0AGC3
1QSA[A] 1.65
1QTE[A] 1.90
1SLY[A] 2.80
 lytic transglycosylase (MltE;b1193) 4.2.2.29 Escherichia coli str. K-12 substr. MG1655 AAC74277.2
AAC74277.1
AIZ91692.1
ALI41030.1
AMC98403.1
AUG15971.1
AVI55710.1
AYG19721.1
NP_415711.1		 P0C960
P76009
2Y8P[A,B] 2.00
3T1Z[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.40
3T21[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 1.90
3T36[A,B,C,D,E] 2.25
3T4I[A,B,C,D,E] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc
β-D-GlcpNAc4SO3-(1-1)-<non_carb>
 2.30
4HJV[A,B,C,D,E] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc
β-D-GlcpNAc4SO3-(1-1)-<non_carb>
 2.30
4HJY[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.40
6GHY[A,B] 2.12
6GHZ[A,B] 2.33
6GI3[B] 1.38
6GI4[B] 1.35
 bifunctional peptidoglycan/chitin lytic transglycosylase (NMB1949)   Neisseria meningitidis MC58 AAF42278.1
NP_274943.1		  
5MPQ[A] 1.78
5O1J[A] 1.90
5O24[A] 1.43
5O29[A] 1.38
5O2N[A] β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc
 1.51
5O2O[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 1.43
6FPN[B] 1.44
6H5F[A] 2.00
 AOY09_04369 (SlT)   Pseudomonas aeruginosa N15-01092 ALV79406.1  
5OHU[A] 2.20
6FBT[A] 2.50
6FC4[A] 3.05
6FCQ[A] β-D-GlcpNAc4SO3-(1-1)-<non_carb>
 3.10
6FCR[A] 2.75
6FCS[A] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-1)-methyl
 2.90
6FCU[A] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-1)-methyl
 3.20
 NCTC9433_03378 (Mltd_1)   Pseudomonas aeruginosa NCTC9433 SQK97194.1  
8RHE[A,B] β-D-GlcpNAc4SO3-(1-1)-<non_carb>
 1.95
8RHF[A,B] β-D-GlcpNAc4SO3-(1-1)-<non_carb>
 1.95
8RHI[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc4SO3-(1-1)-<non_carb>
 1.98
 peptidoglycan lytic transglycosylase (MltF;PA3764) 4.2.2.29 Pseudomonas aeruginosa PAO1 AAG07151.1
NP_252453.1		 A0A0J9X1Z1
A0A1I9GEN8
A0A1I9GEN9
Q9HXN1
4OWD[A] 2.21
4OXV[A] 2.20
4OYV[A] 2.31
4OZ9[A] 2.24
4P0G[A] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc
 1.65
4P11[A] 1.89
5A5X[A,B] 1.80
5AA1[A,B,C,D] 2.89
5AA2[A,B,C,D] 2.80
5AA3[A,B,C,D,E,F,G,H,I,J, 3.20
5AA4[A,B,C,D] 2.40
 chitinase (ChiC;Rα-ChiC) 3.2.1.14 Ralstonia sp. A-471 BAH10650.1 B7XCV4
3W6B[A,B,C,D] 1.90
3W6C[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.00
3W6D[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.15
3W6E[A,B,C,D] 2.15
3W6F[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.10
 SAV0400   Staphylococcus aureus subsp. aureus Mu50 BAB56562.1  
4FDY[A,B] 2.23
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 lysozyme G (GEL) 3.2.1.17 Anser anser anser   P00718
153L[A] 1.60
154L[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 1.60
 lysozyme G 3.2.1.17 Cygnus atratus   P00717
1LSP[A] β-D-GlcpNAc4SO3-(1-1)-<non_carb>
 2.45
1GBS[A] 1.50
 goose-type lysozyme 1 (lysozyme1) 3.2.1.17 Gadus morhua CAL18269.1
ACB20803.1
ACB20805.1		 A6PYF4
B9TU22
Q1M163
3GXK[A,B,C,D] 1.90
3GXR[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 1.70
 G-type lysozyme (SalG;LysG;LyG) 3.2.1.17 Salmo salar CAM35431.1
ACI67565.1
ACI67766.1
ACI67904.1
ACI68608.1
ACI68650.1
ACI69019.1
ACI69359.1
ACN09851.1
ACN10201.1
ACN12198.1
ACN12555.1
CAJ90904.1		 A6PZ97
B5X9P5
B5XA96
B5XAN4
B5XCN8
B5XCT0
B5XDU9
B5XET9
Q0KFS4
3MGW[A] 1.75
4G9S[A] 0.95
 lysozyme G (OEL) 3.2.1.17 Struthio camelus BAL03620.1 P00719
3WYH[A,B] 1.77
Viruses
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 gene 16   Escherichia phage T7 CAA24434.1
AAP33956.1
ACY75871.1
CAA6798315.1
CAA6799914.1
CAA6800612.1
CAA6800702.1
CAA6830980.1
NP_042004.1		  
7EYB[Q,R,S,T] 3.70
 T7delholinF1_51   Escherichia phage T7 QWY13924.1  
6YT5[G,H,I,J,K,L] 3.00
 peptidoglycan lytic transglycosylase (PHIKZ144;gp144;Orf144) 4.2.2.29 Phikzvirus phiKZ AAL83045.1 Q8SD18
3BKH[A] 2.50
3BKV[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.60
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