Activities in Family	lysozyme type G (EC 3.2.1.17); peptidoglycan lyase (EC 4.2.2.n1) also known in the literature as peptidoglycan lytic transglycosylase; chitinase (EC 3.2.1.14)
Mechanism	Unknown
3D Structure Status	lysozyme fold
Catalytic Nucleophile/Base	Not known
Catalytic Proton Donor	Glu
Note	Corresponds to family 1 of the peptidoglycan lytic transglycosylases described by N.T. Blackburn and A.J. Clarke (2001) J. Mol. Evol. 52, 78-84; Note that 'peptidoglycan lytic transglycosylases' cleave peptidoglycan without intervention of a water molecule.
External resources	CAZypedia; PRINTS;
Statistics	GenBank accession (113948); Uniprot accession (57); PDB accession (71); 3D entries (21); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
peptidoglycan lytic transglycosylase (RC10_04025)	4.2.2.n1	Campylobacter jejuni CJ677CC047	ALW37381.1	Q0PA47	7LAM[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.31 7LAQ[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.58
soluble lytic transglycosylase (LT; BD28_04025)		Campylobacter jejuni HF5-5-1	APU80298.1		6CF8[A] 1.87 6CF9[A] 2.29 6CFC[A] 2.04
CD0372 / CD630_03720		Clostridioides difficile 630	CAJ67194.1 AJP10066.1		4HPE[A,B,C,D,E,F] 2.38
muramidase / lytic transglycosylase (EtgA)		Escherichia coli 9812 / EPEC E2348/69	CAR48040.1		4XP8[A] 2.03
exolytic transglycosylase (MltC;BWG_2685)	4.2.2.n1	Escherichia coli BW2952 K-12	ACR63750.1	C5A0N2 P0C066	4C5F[A,B] 2.34 4CFO[A,B] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)[<C3N1O1>-(1-3)]-β-D-GlcpNAc-(1-1)-methyl 2.90 4CFP[A,B] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)[<C3O2>-(1-3)]-β-D-GlcpNAc-(1-1)-methyl 2.15 4CHX[A,B] 2.45
soluble lytic transglycosylase (SLT;SLTY;B4392;Slt70;EO53_18390)	4.2.2.n1	Escherichia coli str. K-12 substr. MG1655	AIZ92838.1 AAA24634.1 AAA97288.1 AAC77345.2 ALI37950.1 AMC97248.1 AUG19070.1 AVI54536.1 AYG20839.1 NP_418809.1	P03810 P0AGC3	1QSA[A] 1.65 1QTE[A] 1.90 1SLY[A] 2.80
lytic transglycosylase (MltE;b1193)	4.2.2.n1	Escherichia coli str. K-12 substr. MG1655	AAC74277.2 AAC74277.1 AIZ91692.1 ALI41030.1 AMC98403.1 AUG15971.1 AVI55710.1 AYG19721.1 NP_415711.1	P0C960 P76009	2Y8P[A,B] 2.00 3T1Z[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.40 3T21[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 1.90 3T36[A,B,C,D,E] 2.25 3T4I[A,B,C,D,E] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc β-D-GlcpNAc4SO3-(1-1)-<non_carb> 2.30 4HJV[A,B,C,D,E] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc β-D-GlcpNAc4SO3-(1-1)-<non_carb> 2.30 4HJY[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.40 6GHY[A,B] 2.12 6GHZ[A,B] 2.33 6GI3[B] 1.38 6GI4[B] 1.35
bifunctional peptidoglycan/chitin lytic transglycosylase (NMB1949)		Neisseria meningitidis MC58	AAF42278.1 NP_274943.1		5MPQ[A] 1.78 5O1J[A] 1.90 5O24[A] 1.43 5O29[A] 1.38 5O2N[A] β-D-GlcpNAc β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc 1.51 5O2O[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 1.43 6FPN[B] 1.44 6H5F[A] 2.00
Lytic transglycosylase		Neisseria meningitidis NM422	ELK56709.1		4YP4[A] 2.00
AOY09_04369 (SlT)		Pseudomonas aeruginosa N15-01092	ALV79406.1		5OHU[A] 2.20 6FBT[A] 2.50 6FC4[A] 3.05 6FCQ[A] β-D-GlcpNAc4SO3-(1-1)-<non_carb> 3.10 6FCR[A] 2.75 6FCS[A] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-1)-methyl 2.90 6FCU[A] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-1)-methyl 3.20
peptidoglycan lytic transglycosylase (MltF;PA3764)	4.2.2.n1	Pseudomonas aeruginosa PAO1	AAG07151.1 NP_252453.1	A0A0J9X1Z1 A0A1I9GEN8 A0A1I9GEN9 Q9HXN1	4OWD[A] 2.21 4OXV[A] 2.20 4OYV[A] 2.31 4OZ9[A] 2.24 4P0G[A] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc 1.65 4P11[A] 1.89 5A5X[A,B] 1.80 5AA1[A,B,C,D] 2.89 5AA2[A,B,C,D] 2.80 5AA3[A,B,C,D,E,F,G,H,I,J, 3.20 5AA4[A,B,C,D] 2.40
chitinase (ChiC;Rα-ChiC)	3.2.1.14	Ralstonia sp. A-471	BAH10650.1	B7XCV4	3W6B[A,B,C,D] 1.90 3W6C[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.00 3W6D[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.15 3W6E[A,B,C,D] 2.15 3W6F[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.10
SAV0400		Staphylococcus aureus subsp. aureus Mu50	BAB56562.1		4FDY[A,B] 2.23
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
lysozyme G (GEL)	3.2.1.17	Anser anser anser		P00718	153L[A] 1.60 154L[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 1.60
lysozyme G	3.2.1.17	Cygnus atratus		P00717	1LSP[A] β-D-GlcpNAc4SO3-(1-1)-<non_carb> 2.45 1GBS[A] 1.50
goose-type lysozyme 1 (lysozyme1)	3.2.1.17	Gadus morhua	CAL18269.1 ACB20803.1 ACB20805.1	A6PYF4 B9TU22 Q1M163	3GXK[A,B,C,D] 1.90 3GXR[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 1.70
G-type lysozyme (SalG;LysG;LyG)	3.2.1.17	Salmo salar	CAM35431.1 ACI67565.1 ACI67766.1 ACI67904.1 ACI68608.1 ACI68650.1 ACI69019.1 ACI69359.1 ACN09851.1 ACN10201.1 ACN12198.1 ACN12555.1 CAJ90904.1	A6PZ97 B5X9P5 B5XA96 B5XAN4 B5XCN8 B5XCT0 B5XDU9 B5XET9 Q0KFS4	3MGW[A] 1.75 4G9S[A] 0.95
lysozyme G (OEL)	3.2.1.17	Struthio camelus	BAL03620.1	P00719	3WYH[A,B] 1.77
Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
gene 16		Escherichia phage T7	CAA24434.1 AAP33956.1 ACY75871.1 CAA6798315.1 CAA6799914.1 CAA6800612.1 CAA6800702.1 CAA6830980.1 NP_042004.1		7EYB[Q,R,S,T] 3.70
T7delholinF1_51		Escherichia phage T7	QWY13924.1		6YT5[G,H,I,J,K,L] 3.00
peptidoglycan lytic transglycosylase (PHIKZ144;gp144;Orf144)	4.2.2.n1	Phikzvirus phiKZ	AAL83045.1	Q8SD18	3BKH[A] 2.50 3BKV[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.60
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