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Glycoside Hydrolase Family 23

Activities in Familylysozyme type G (EC 3.2.1.17); peptidoglycan lyase (EC 4.2.2.n1) also known in the literature as peptidoglycan lytic transglycosylase; chitinase (EC 3.2.1.14)
Mechanism Not known
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
NoteCorresponds to family 1 of the peptidoglycan lytic transglycosylases described by N.T. Blackburn and A.J. Clarke (2001) J. Mol. Evol. 52, 78-84; Note that 'peptidoglycan lytic transglycosylases' cleave peptidoglycan without intervention of a water molecule.
External resourcesCAZypedia; PRINTS;
Statistics GenBank accession (52973); Uniprot accession (4531); PDB accession (71); 3D entries (21); cryst (0)
Summary
All (51778) Archaea (7) Bacteria (50620) Eukaryota (170) Viruses (966) unclassified (15) Structure (21) Characterized (31)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 soluble lytic transglycosylase (LT; BD28_04025)   Campylobacter jejuni HF5-5-1 APU80298.1  
6CF8[A] 1.87
6CF9[A] 2.29
6CFC[A] 2.04
 CD0372 / CD630_03720   Clostridioides difficile 630 CAJ67194.1
AJP10066.1		 Q18DB2
4HPE[A,B,C,D,E,F] 2.38
 muramidase / lytic transglycosylase (EtgA) 3.2.1.17_or_4.2.2.n1 Escherichia coli 9812 / EPEC E2348/69 CAR48040.1 Q9AJ25
4XP8[A] 2.03
 exolytic transglycosylase (MltC;BWG_2685) 4.2.2.n1 Escherichia coli BW2952 K-12 ACR63750.1 C5A0N2
4C5F[A,B] 2.34
4CFO[A,B] β-D-GlcpNAc-(1-4)[<C3N1O1>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)[<C3N1O1>-(1-3)]-β-D-GlcpNAc-(1-1)-methyl
 2.90
4CFP[A,B] β-D-GlcpNAc-(1-4)[<C3O2>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)[<C3O2>-(1-3)]-β-D-GlcpNAc-(1-1)-methyl
 2.15
4CHX[A,B] 2.45
 soluble lytic transglycosylase (SLT;SLTY;B4392;Slt70;EO53_18390) 4.2.2.n1 Escherichia coli str. K-12 substr. MG1655 AIZ92838.1
AAA24634.1
AAA97288.1
AAC77345.2
ALI37950.1
AMC97248.1
AUG19070.1
AVI54536.1
NP_418809.1		 P03810
P0AGC3
1QSA[A] 1.65
1QTE[A] 1.90
1SLY[A] 2.80
 lytic transglycosylase (MltE;b1193) 4.2.2.n1 Escherichia coli str. K-12 substr. MG1655 AAC74277.2
AAC74277.1
AIZ91692.1
ALI41030.1
AMC98403.1
AUG15971.1
AVI55710.1
NP_415711.1		 P0C960
P76009
2Y8P[A,B] 2.00
3T1Z[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.40
3T21[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 1.90
3T36[A,B,C,D,E] 2.25
3T4I[A,B,C,D,E] β-D-GlcpNAc-(1-4)[<C6N1O2>-(1-3)]-β-D-GlcpNAc
β-D-GlcpNAc4SO3-(1-1)-<C8N2O5S1>
 2.30
4HJV[A,B,C,D,E] β-D-GlcpNAc-(1-4)[<C3O2>-(1-3)]-β-D-GlcpNAc
β-D-GlcpNAc4SO3-(1-1)-<C8N2O5S1>
 2.30
4HJY[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.40
 resuscitation-promoting factor B (RpfB;Rv1009;RVBD_1009)   Mycobacterium tuberculosis H37Rv AFN48899.1
CAB08136.1
CCP43759.1		  
1XSF[A] NMR
3EO5[A] 1.83
4EMN[A,B,C,D] 1.17
4KL7[A,B,C,D] 1.45
4KPM[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-L-1-deoxy-IdopNAc
 1.33
5E27[A,B] 2.60
 RVBD_1884c / Rv1884c (RpfC)   Mycobacterium tuberculosis H37Rv AFN49813.1
CCP44650.1		  
2N5Z[A] NMR
4OW1[A,B,E,S,T,U,W,X] 1.90
 peptidoglycan hydrolase (RpfE;Rv2450c;RVBD_2450c)   Mycobacterium tuberculosis H37Rv CCP45243.1
AFN50416.1		 O53177
4CGE[A,B,C,D,E,F] 2.76
 bifunctional peptidoglycan/chitin lytic transglycosylase (NMB1949)   Neisseria meningitidis MC58 AAF42278.1
NP_274943.1		 Q9JXP1
5O1J[A] 1.90
5O24[A] 1.43
5O29[A] 1.38
5O2N[A] β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc
 1.51
5O2O[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 1.43
6FPN[B] 1.44
 Lytic transglycosylase   Neisseria meningitidis NM422 ELK56709.1  
4YP4[A] 2.00
4YIB[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 1.51
 AOY09_04369 (SlT)   Pseudomonas aeruginosa N15-01092 ALV79406.1  
5OHU[A] 2.20
6FBT[A] 2.50
6FC4[A] 3.05
6FCQ[A] β-D-GlcpNAc4SO3-(1-1)-<C8N2O5S1>
 3.10
6FCR[A] 2.75
6FCS[A] β-D-GlcpNAc-(1-4)[<C3N1O1>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)[ALA-(0-17)--(1-3)]-β-D-GlcpNAc-(1-1)-methyl
β-D-GlcpNAc-(1-4)[<C6N2O2>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-1)-methyl
 2.90
6FCU[A] β-D-GlcpNAc-(1-4)[<C3N1O1>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)[ALA-(0-17)--(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)[<C3O1>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-1)-methyl
 3.20
 peptidoglycan lytic transglycosylase (MltF;PA3764) 4.2.2.n1 Pseudomonas aeruginosa PAO1 AAG07151.1
NP_252453.1		 Q9HXN1
4OWD[A] 2.21
4OXV[A] 2.20
4OYV[A] 2.31
4OZ9[A] 2.24
4P0G[A] β-D-GlcpNAc-(1-4)[<C3O2>-(1-3)]-β-D-GlcpNAc
 1.65
4P11[A] 1.89
5A5X[A,B] 1.80
5AA1[A,B,C,D] 2.89
5AA2[A,B,C,D] 2.80
5AA3[A,B,C,D,E,F,G,H,I,J, 3.20
5AA4[A,B,C,D] 2.40
 chitinase (ChiC;Rα-ChiC) 3.2.1.14 Ralstonia sp. A-471 BAH10650.1  
3W6B[A,B,C,D] 1.90
3W6C[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.00
3W6D[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.15
3W6E[A,B,C,D] 2.15
3W6F[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.10
 SAV0400   Staphylococcus aureus subsp. aureus Mu50 BAB56562.1 Q932I6
4FDY[A,B] 2.23
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 lysozyme G (GEL) 3.2.1.17 Anser anser anser   P00718
153L[A] 1.60
154L[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 1.60
 lysozyme G 3.2.1.17 Cygnus atratus   P00717
1LSP[A] β-D-GlcpNAc4SO3-(1-1)-<C8N2O5S1>
 2.45
1GBS[A] 1.50
 goose-type lysozyme 1 (lysozyme1) 3.2.1.17 Gadus morhua CAL18269.1
ACB20803.1
ACB20805.1		 A6PYF4
3GXK[A,B,C,D] 1.90
3GXR[A,B,C,D] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 1.70
 G-type lysozyme (SalG;LysG;LyG) 3.2.1.17 Salmo salar CAM35431.1
ACI67565.1
ACI67766.1
ACI67904.1
ACI68608.1
ACI68650.1
ACI69019.1
ACI69359.1
ACN09851.1
ACN10201.1
ACN12198.1
ACN12555.1
CAJ90904.1		 A6PZ97
3MGW[A] 1.75
4G9S[A] 0.95
 lysozyme G (OEL) 3.2.1.17 Struthio camelus BAL03620.1 P00719
3WYH[A,B] 1.77
Viruses
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 peptidoglycan lytic transglycosylase (PHIKZ144;gp144;Orf144) 4.2.2.n1 Pseudomonas virus phiKZ AAL83045.1 Q8SD18
3BKH[A] 2.50
3BKV[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.60
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