Glycoside Hydrolase Family 23

Known Activities	lysozyme type G (EC 3.2.1.17); peptidoglycan lyase (EC 4.2.2.-) also known in the literature as peptidoglycan lytic transglycosylase
Mechanism	Not known
Catalytic Nucleophile/Base	Not known
Catalytic Proton Donor	Glu
Note	Corresponds to family 1 of the peptidoglycan lytic transglycosylases described by N.T. Blackburn and A.J. Clarke (2001) J. Mol. Evol. 52, 78-84; Note that 'peptidoglycan lytic transglycosylases' cleave peptidoglycan without intervention of a water molecule.
External resources	CAZypedia; PRINTS;
Statistics	GenBank accession (7380); Uniprot accession (4324); PDB accession (15); 3D entries (8); cryst (0)

Summary

All (6801) Bacteria (6646) Eukaryota (56) Viruses (90) unclassified (9) Structure (8 ) Characterized (21)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
bifunctional N-acetylmuramidase / D-,L-endopeptidase (CwlT;YddH;BSU04970)	3.2.1.17	Bacillus subtilis subsp. subtilis str. 168	CAB12304.1 NP_388378.1
bifunctional muramidase DD-endopeptidase (CwlP;YomI;BSU21350)	3.2.1.17	Bacillus subtilis subsp. subtilis str. 168	AAQ80336.1 CAB14053.1 CAB14053.2 NP_390018.1
bifunctional muramidase soluble-lytic transglycosylase (CwlQ;YjbJ;BSU11570)	3.2.1.- 3.2.1.17	Bacillus subtilis subsp. subtilis str. 168	CAB13014.1 NP_389039.1	O31608
soluble lytic transglycosylase (SLT;SLTY;B4392;Slt70)	3.2.1.-	Escherichia coli K-12 MG1655	AAA24634.1 AAA97288.1 AAC77345.2 NP_418809.1	P03810 P0AGC3	1QSA[A] 1QTE[A] 1SLY[A]
lytic transglycosylase (MltE;b1193)	3.2.1.-	Escherichia coli K-12 MG1655	AAC74277.1 AAC74277.2 NP_415711.1	P0C960 P76009	2Y8P[A,B]
lytic murein transglycosylase (YfhD;MltF)	3.2.1.-	Escherichia coli str. K-12 substr. W3110	BAE76734.1
lytic transglycosylase (MltD;HP1572)	3.2.1.-	Helicobacter pylori 26695	AAD08609.1 NP_208363.1	O26092
peptidoglycan lytic transglycosylase (Slt;HP0645)	3.2.1.-	Helicobacter pylori 26695	AAD07706.1 NP_207439.1	O25362
chitinase (ChiC)	3.2.1.14	Ralstonia sp. A-471	BAH10650.1
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
lysozyme G (GEL)	3.2.1.17	Anser anser anser		P00718.1	153L[A] 154L[A]
goose-type lysozyme (LysG;CfLysG)	3.2.1.17	Chlamys farreri	ABB53641.1	Q075V3
lysozyme G	3.2.1.17	Cygnus atratus		P00717.1	1GBS[A] 1LSP[A]
lysozyme	3.2.1.17	Epinephelus coioides	AAL08021.2 AEA39740.1	Q90X99
goose-type lysozyme 1 (lysozyme1)	3.2.1.17	Gadus morhua	ACB20803.1 ACB20805.1 CAL18269.1	A6PYF4	3GXK[A,B,C,D] 3GXR[A,B,C,D]
lysozyme G	3.2.1.17	Gallus gallus	AAR81315.1 CAA43319.1 CAA43320.1 CAB37929.1	P27042.1
lysozyme G2 (LysG2;Lig2;LygH;HLysG2)	3.2.1.17	Homo sapiens	AAI00883.1 AAI00884.1 AAI00885.1 AAI00886.1 AAK16605.1 AAO32945.1 AAX93255.1 ABA68300.1 NP_783862.2	Q86SG7
lysozyme B (G-type) (Lyz;RBgLyz)	3.2.1.17	Oplegnathus fasciatus	ADZ44622.1
lysozyme G	3.2.1.17	Paralichthys olivaceus	BAB62406.1 BAB62407.1	Q90VZ3
G-type lysozyme (LysG;SmLysG)	3.2.1.17	Scophthalmus maximus	ADN06441.1
lysozyme G (OEL)	3.2.1.17	Struthio camelus	BAL03620.1	P00719.1
Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
peptidoglycan lytic transglycosylase (PHIKZ144;gp144;Orf144)	3.2.1.-	Pseudomonas phage phiKZ	AAL83045.1	Q8SD18	3BKH[A] 3BKV[A]

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.