Glycoside Hydrolase Family 23

Activities in Familylysozyme type G (EC 3.2.1.17); peptidoglycan lyase (EC 4.2.2.n1) also known in the literature as peptidoglycan lytic transglycosylase; chitinase (EC 3.2.1.14)
Mechanism Not known
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
NoteCorresponds to family 1 of the peptidoglycan lytic transglycosylases described by N.T. Blackburn and A.J. Clarke (2001) J. Mol. Evol. 52, 78-84; Note that 'peptidoglycan lytic transglycosylases' cleave peptidoglycan without intervention of a water molecule.
External resourcesCAZypedia; PRINTS;
Statistics GenBank accession (41765); Uniprot accession (4532); PDB accession (56); 3D entries (19); cryst (0)
All (40668) Archaea (7) Bacteria (39829) Eukaryota (158) Viruses (659) unclassified (15) Structure (19) Characterized (31)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 bifunctional N-acetylmuramidase / D-,L-endopeptidase (CwlT;YddH;BSU04970) 3.2.1.17 Bacillus subtilis subsp. subtilis str. 168 CAB12304.1
AIY91781.1
AQR80443.1
AQR84656.1
NP_388378.1
P96645  
 bifunctional muramidase DD-endopeptidase (CwlP;YomI;BSU21350) 3.2.1.17 Bacillus subtilis subsp. subtilis str. 168 CAB14053.2
AAQ80336.1
AIY93456.1
AQR82141.1
AQR86355.1
CAB14053.1
NP_390018.1
O31976  
 bifunctional muramidase soluble-lytic transglycosylase (CwlQ;YjbJ;BSU11570) 4.2.2.n1
3.2.1.17
Bacillus subtilis subsp. subtilis str. 168 AIY92440.1
AQR81111.1
AQR85325.1
CAB09517.1
CAB13014.1
NP_389039.1
O31608  
 muramidase / lytic transglycosylase (EtgA) 3.2.1.17_or_4.2.2.n1 Escherichia coli 9812 / EPEC E2348/69 CAR48040.1 Q9AJ25 4XP8[A]
 exolytic transglycosylase (MltC;BWG_2685) 4.2.2.n1 Escherichia coli BW2952 K-12 ACR63750.1 C5A0N2 4C5F[A,B]
4CFO[A,B]
4CFP[A,B]
4CHX[A,B]
 soluble lytic transglycosylase (SLT;SLTY;B4392;Slt70;EO53_18390) 4.2.2.n1 Escherichia coli str. K-12 substr. MG1655 AIZ92838.1
AAA24634.1
AAA97288.1
AAC77345.2
ALI37950.1
AMC97248.1
NP_418809.1
P03810
P0AGC3
1QSA[A]
1QTE[A]
1SLY[A]
 lytic transglycosylase (MltE;b1193) 4.2.2.n1 Escherichia coli str. K-12 substr. MG1655 AAC74277.2
AAC74277.1
AIZ91692.1
ALI41030.1
AMC98403.1
NP_415711.1
P0C960
P76009
2Y8P[A,B]
3T1Z[A,B]
3T21[A,B]
3T36[A,B,C,D,E]
3T4I[A,B,C,D,E]
4HJV[A,B,C,D,E]
4HJY[A,B]
 lytic murein transglycosylase (YfhD;MltF) 4.2.2.n1 Escherichia coli str. K-12 substr. W3110 BAE76734.1    
 lytic transglycosylase (MltD;HP1572) 4.2.2.n1 Helicobacter pylori 26695 AAD08609.1
AFV42796.1
NP_208363.1
O26092  
 peptidoglycan lytic transglycosylase (Slt;HP0645) 4.2.2.n1 Helicobacter pylori 26695 AAD07706.1
AFV41866.1
NP_207439.1
O25362  
 peptidoglycan lytic transglycosylase (MltF;PA3764) 4.2.2.n1 Pseudomonas aeruginosa PAO1 AAG07151.1
NP_252453.1
Q9HXN1 4OWD[A]
4OXV[A]
4OYV[A]
4OZ9[A]
4P0G[A]
4P11[A]
5A5X[A,B]
5AA1[A,B,C,D]
5AA2[A,B,C,D]
5AA3[A,B,C,D,E,F,G,H,I,J,K,L]
5AA4[A,B,C,D]
 chitinase (ChiC;Rα-ChiC) 3.2.1.14 Ralstonia sp. A-471 BAH10650.1   3W6B[A,B,C,D]
3W6C[A,B,C,D]
3W6D[A,B,C,D]
3W6E[A,B,C,D]
3W6F[A,B,C,D]
 lytic transglycosylase (MltC;SL1344_3087) 4.2.2.n1 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 CBW19186.1 E1WHQ1  
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 lysozyme G (GEL) 3.2.1.17 Anser anser anser   P00718 153L[A]
154L[A]
 g-lysozyme (AmphiLysG) 3.2.1.17 Branchiostoma japonicum AFJ15537.1    
 goose-type lysozyme (LysG;CfLysG) 3.2.1.17 Chlamys farreri ABB53641.1
AGA95494.1
Q075V3  
 lysozyme G 3.2.1.17 Cygnus atratus   P00717 1LSP[A]
1GBS[A]
 lysozyme g 3.2.1.17 Dicentrarchus labrax CBJ56263.1
AIE45885.1
   
 lysozyme g (LZG) 3.2.1.17 Dromaius novaehollandiae BAL03618.1
BAL03619.1
G3XDD8  
 lysozyme 3.2.1.17 Epinephelus coioides AAL08021.2
AEA39740.1
Q90X99  
 GB-type lysozyme (Ec-lysG) 3.2.1.17 Epinephelus coioides AHN09799.1
AHN09800.1
   
 goose-type lysozyme 1 (lysozyme1) 3.2.1.17 Gadus morhua CAL18269.1
ACB20803.1
ACB20805.1
A6PYF4 3GXK[A,B,C,D]
3GXR[A,B,C,D]
 lysozyme G 3.2.1.17 Gallus gallus AAR81315.1
CAA43319.1
CAA43320.1
CAB37929.1
P27042  
 goose-type lysozyme (LysG;abLysG) 3.2.1.17 Haliotis discus discus AGQ50335.1
AGQ50337.1
   
 lysozyme G2 (LysG2;Lig2;LygH;HLysG2) 3.2.1.17 Homo sapiens AAX93255.1
AAI00883.1
AAI00884.1
AAI00885.1
AAI00886.1
AAK16605.1
AAO32945.1
ABA68300.1
NP_783862.2
Q86SG7  
 lysozyme B (G-type) (Lyz;RBgLyz) 3.2.1.17 Oplegnathus fasciatus ADZ44622.1    
 lysozyme G 3.2.1.17 Paralichthys olivaceus BAB62407.1
BAB62406.1
Q90VZ3  
 G-type lysozyme (SalG;LysG;LyG) 3.2.1.17 Salmo salar CAM35431.1
ACI67565.1
ACI67766.1
ACI67904.1
ACI68608.1
ACI68650.1
ACI69019.1
ACI69359.1
ACN09851.1
ACN10201.1
ACN12198.1
ACN12555.1
CAJ90904.1
A6PZ97 3MGW[A]
4G9S[A]
 G-type lysozyme (LysG;SmLysG) 3.2.1.17 Scophthalmus maximus ADN06441.1    
 lysozyme G (OEL) 3.2.1.17 Struthio camelus BAL03620.1 P00719 3WYH[A,B]
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 peptidoglycan lytic transglycosylase (PHIKZ144;gp144;Orf144) 4.2.2.n1 Pseudomonas phage phiKZ AAL83045.1 Q8SD18 3BKH[A]
3BKV[A]
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