Known Activities	β-hexosaminidase (EC 3.2.1.52); lacto-N-biosidase (EC 3.2.1.140); β-1,6-N-acetylglucosaminidase) (EC 3.2.1.-); β-6-SO3-N-acetylglucosaminidase (EC 3.2.1.-)
Mechanism	Retaining
Clan	GH-K
3D Structure Status	( β / α ) 8
Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton Donor	Glu
External resources	CAZypedia; HEXAdb; HEXBdb; HOMSTRAD; InterPro; PFAM; PRINTS; Tay-Sachs Disease;
Statistics	GenBank accession (1335); Uniprot accession (725); PDB accession (40); 3D entries (12); cryst (1)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
dispersin B / β-1,6-N-acetylglucosaminidase (DspB)	3.2.1.-	Aggregatibacter actinomycetemcomitans CU1000	AAP31025.1	Q840G9	1YHT[A]
β-N-acetylhexosaminidase (AAur_4089)		Arthrobacter aurescens TC1	ABM09106.1	A1RBZ5	3RCN[A]
β-hexosaminidase (Hex1T)	3.2.1.52	Paenibacillus sp. TS12	BAI63641.1	D2KW09	3GH4[A] 3GH5[A] 3GH7[A]
chitobiase (Chb;Ctb;SmCHB)	3.2.1.52	Serratia marcescens 2170	AAB03808.1	Q54468	1C7S[A] 1C7T[A] 1QBA[A] 1QBB[A]
β-N-acetylglucosaminidase (GcnA)	3.2.1.52	Streptococcus gordonii FSS2	AAS02154.1	Q6ST21	2EPK[X] 2EPL[X] 2EPM[X] 2EPN[A,B] 2EPO[A,B]
β-N-acetylhexosaminidase (StrH;spr0057)	3.2.1.52	Streptococcus pneumoniae R6	AAK98861.1 NP_357651.1	Q8DRL6	3RPM[A,B]
β-N-acetylhexosaminidase (StrH;spr0057)	3.2.1.52	Streptococcus pneumoniae R6	AAK98861.1 NP_357651.1	Q8DRL6	3RPM[A,B]
β-N-acetylglucosaminidase (StrH;SP0057;SP_0057)	3.2.1.52	Streptococcus pneumoniae TIGR4	AAK74246.1 NP_344606.1	P49610	2YL6[A] 2YL8[A] 2YLL[A]
β-N-acetylglucosaminidase (StrH;SP0057;SP_0057)	3.2.1.52	Streptococcus pneumoniae TIGR4	AAK74246.1 NP_344606.1	P49610	2YL5[A,B,C,D] 2YL9[A,B,C,D] 2YLA[A,B,C,D]
β-N-acetylglucosaminidase (Hex;SpHex)	3.2.1.52	Streptomyces plicatus	AAC38798.3	O85361	1HP4[A] 1HP5[A] 1JAK[A] 1M01[A] 1M03[A] 1M04[A]
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
β-N-acetylhexosaminidase (HexA)	3.2.1.52	Aspergillus oryzae CCF 1066	AAM13977.1		cryst
β-N-acetylglucosaminidase / β-hexosaminidase A (α-chain) (HexA)	3.2.1.52	Homo sapiens	AAA51827.1 AAB00965.1 AAD13932.1 AAH01138.2 AAH18927.1 AAH21030.1 AAH84537.1 AAQ70000.1 ACM85216.1 BAD96222.1 BAG59159.1 BAG60039.1 BAG62619.1 BAG62730.1 CAH10482.1 NP_000511.1	P06865.1 Q9BVJ8	2GJX[A,D,E,H] 2GK1[A,C,E,G]
β-N-acetylglucosaminidase B (β-chain) (HexB)	3.2.1.52	Homo sapiens	AAA51828.1 AAA51829.1 AAA52645.1 AAA68620.1 AAH17378.1 AAM46114.1 AAP88921.1 AAV48875.1 NP_000512.1	P07686.3	1NOU[A,B] 1NOW[A,B] 1NP0[A,B] 1O7A[A,B,C,D,E,F] 2GJX[B,C,F,G] 2GK1[B,D,F,H] 3LMY[A,B]
β-N-acetylhexosaminidase (Hex1;OfHex1)	3.2.1.52	Ostrinia furnacalis	ABI81756.1	Q06GJ0	3NSM[A] 3NSN[A] 3OZO[A] 3OZP[A]

Last update: 2012-01-31 © Copyright 1998-2012
AFMB - CNRS - Universités Aix-Marseille I & II