Glycoside Hydrolase Family 20

Known Activitiesβ-hexosaminidase (EC 3.2.1.52); lacto-N-biosidase (EC 3.2.1.140); β-1,6-N-acetylglucosaminidase) (EC 3.2.1.-); β-6-SO3-N-acetylglucosaminidase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-K
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu
External resourcesHEXAdb; HEXBdb; HOMSTRAD; InterPro; PFAM; PRINTS; Tay-Sachs Disease;
Statistics GenBank accession (1007); Uniprot accession (419); PDB accession (27); 3D entries (7); cryst (0)
All (771) Archaea (3) Bacteria (616) Eukaryota (152) Structure (7 ) Characterized (89)
Bacteria
Protein Name EC#OrganismGenBankUniprotPDB/3D
 dispersin B / β-1,6-N-acetylglucosaminidase (DspB) 3.2.1.- Actinobacillus pleuropneumoniae IA1 AAT46094.1 Q6GYA5  
 chitobiase 3.2.1.52 Aeromonas hydrophila AAG28494.1 Q9F9B4  
 β-N-acetylglucosaminidase (NagB;Nag-B) 3.2.1.52 Aeromonas hydrophila SUWA-9 BAF76001.1 A7M7B5  
 β-N-acetylglucosaminidase (NagA;Nag-A) (Nag20A) 3.2.1.52 Aeromonas hydrophila SUWA-9 BAD00143.1 Q75V90  
 chitobiase (NagA1) 3.2.1.52 Aeromonas punctata CB101 CAH55822.1 Q659J9  
 β-N-acetylglucosaminidase 3.2.1.52 Aeromonas sp. 10S-24 BAA92145.1 Q9LC82  
 dispersin B / β-1,6-N-acetylglucosaminidase (DspB) 3.2.1.- Aggregatibacter actinomycetemcomitans CU1000 AAP31025.1 Q840G9 1YHT[A]
 chitobiase (Chb;ArChb) 3.2.1.52 Arthrobacter sp. TAD20 CAB72127.1 Q9L448  
 lacto-N-triose II β-N-acetylhexosaminidase (BbhI) 3.2.1.52 Bifidobacterium bifidum JCM 1254 BAI94822.1    
 β-N-acetylhexosaminidase (BbhII) 3.2.1.52 Bifidobacterium bifidum JCM 1254 BAI94823.1    
 lacto-N-biosidase (LnbB) 3.2.1.140 Bifidobacterium bifidum JCM 1254 ABZ78855.1 B3TLD6  
 β-N-acetylhexosaminidase (Hex20) (Hex20A) 3.2.1.52 Cellulomonas fimi ATCC 484 AAQ05800.1 Q7WUL4  
 β-N-acetylglucosaminidase (Nag1) 3.2.1.52 Enterobacter sp. G-1 BAA74506.1 Q9ZN69  
 endoglycosidase (EndoE;NdoE) 3.2.1.96 Enterococcus faecalis HER1044 AAR20477.1 Q6U890  
 endo-N-glycanase (EF0114) 3.2.1.96 Enterococcus faecalis V583 AAO79989.1
AAR59794.1
AAR59795.1
NP_813917.1
   
 N-acetyl β-glucosaminidase 3.2.1.52 Lactobacillus casei ATCC 27092 BAA76352.1 Q9WXH9  
 β-hexosaminidase 3.2.1.52 Paenibacillus sp. TS12 BAI63641.1   3GH4[A]
3GH5[A]
3GH7[A]
 β-N-acetylglucosaminidase (NahA;PG0043) 3.2.1.52 Porphyromonas gingivalis W83 AAQ65295.1
CAA55582.1
NP_904396.1
P49008  
 mucin-desulfating glycosidase / sulfoglycosidase / β-6-SO3-N-acetylglucosaminidase (Sgl) 3.2.1.- Prevotella sp. RS2 AAW30398.1 Q5MAH5  
 β-N-acetylhexosaminidase 3.2.1.52 proteobacterium AI21 ABE96869.1 A1XNE6  
 β-N-acetylglucosaminidase B (Nag096) 3.2.1.52 Pseudoalteromonas piscicida BAA06136.1 P49007  
 β-N-acetylhexosaminidase (Hex86) 3.2.1.52 Pseudoalteromonas piscicida BAB84321.1 Q8VUM1  
 β-N-acetylglucosaminidase A (NagA) 3.2.1.52 Pseudoalteromonas piscicida BAB17855.1 Q9FAC5  
 transglycosylative enzyme (Hex99) 2.4.1.- Pseudoalteromonas piscicida BAA84281.1 Q9R6Y9  
 β-N-acetylglucosaminidase (ChiP) 3.2.1.52 Pseudoalteromonas sp. S9 / S91 AAC83238.1 Q9ZH38  
 N-acetyl-β-glucosaminidase (HexB; Sde_3271) 3.2.1.52 Saccharophagus degradans 2-40 ABD82526.1
ACG81707.1
DAA01339.1
Q7PC48  
 N-acetyl-β-glucosaminidase (HexA; Sde_3037) 3.2.1.52 Saccharophagus degradans 2-40 ABD82294.1
ACG81706.1
DAA01338.1
Q7PC49  
 chitobiase (Chb;Ctb) 3.2.1.52 Serratia marcescens 2170 AAB03808.1 Q54468 1C7S[A]
1C7T[A]
1QBA[A]
1QBB[A]
 β-N-acetylglucosaminidase (GcnA) 3.2.1.52 Streptococcus gordonii FSS2 AAS02154.1 Q6ST21 2EPK[X]
2EPL[X]
2EPM[X]
2EPN[A,B]
2EPO[A,B]
 β-N-acetylglucosaminidase (StrH) 3.2.1.52 Streptococcus pneumoniae ATCC 12213 AAC41450.1 P49610  
 β-N-acetylglucosaminidase (StrH) 3.2.1.52 Streptococcus pneumoniae ATCC 12213 AAC41450.1 P49610  
 β-N-acetylhexosaminidase (Hex56) 3.2.1.52 Streptomyces olivaceoviridis CAC34802.1 Q9ACN7  
 β-N-acetylglucosaminidase (Hex) 3.2.1.52 Streptomyces plicatus AAC38798.3 O85361 1HP4[A]
1HP5[A]
1JAK[A]
1M01[A]
1M03[A]
1M04[A]
 lacto-N-biosidase 3.2.1.140 Streptomyces sp. 142 AAD10478.1
AAE24545.1
Q9Z4I7  
 N-acetyl β-glucosaminidase (NagB) 3.2.1.52 Streptomyces thermoviolaceus OPC-520 BAA88762.2 Q9RHV6  
 β-N-acetylglucosaminidase C (NagC) 3.2.1.52 Streptomyces thermoviolaceus OPC-520 BAC76622.1 Q83WL6  
 β-N-acetylglucosaminidase (HexA) 3.2.1.52 Tannerella forsythia ATCC 43037 AAO33832.1 Q84FS9  
 N-acetylhexosaminidase (ExoI) 3.2.1.52 Vibrio furnissii AAC44672.1
AAE36540.1
P96155  
 N-acetyl β-glucosaminidase (Chb) 3.2.1.52 Vibrio harveyi B392 AAA88682.1
AAR60429.1
AAX00633.1
CAD26692.1
P13670.1  
 N-acetyl β-glucosaminidase (Chb) 3.2.1.52 Vibrio parahaemolyticus ATCC 27969 AAA65915.1 Q60081  
 N-acetyl β-glucosaminidase (Hex) 3.2.1.52 Vibrio vulnificus ATCC 27562 AAA27527.1 Q04786  
 β-N-acetylglucosaminidase (NagA;YPTB1123) 3.2.1.52 Yersinia pseudotuberculosis IP 32953 CAH20363.1    
Eukaryota
Protein Name EC#OrganismGenBankUniprotPDB/3D
 β-N-acetylhexosaminidase 2 (Hexo2;AtHex1;At1g05590) (plasma membrane) 3.2.1.52 Arabidopsis thaliana AAD30612.1
NP_172050.1
Q9SYK0  
 β-N-acetylhexosaminidase (Hexo3;AtHex3;At1g65590) (plasma membrane) 3.2.1.52 Arabidopsis thaliana AAB60911.1
AAM91092.1
AAN33206.1
NP_176737.2
O04477
Q8L7S6
 
 β-N-acetylhexosaminidase 1 (Hexo1;AtHex2;At3g55260) (vacuolar) 3.2.1.52 Arabidopsis thaliana AAM61367.1
AAN41320.1
BAE99290.1
CAB75760.1
CAM35467.1
NP_191086.1
NP_567017.1
Q0WUA8
Q8LFK0
Q9M3C5
 
 N-acetylglucosaminidase (NagA;AN1502.2) 3.2.1.52 Aspergillus nidulans FGSC A4 BAB13330.1
EAA63815.1
C8VMN3  
 β-N-acetylglucosaminidase (NagA;HexA;AO090005000639) 3.2.1.52 Aspergillus oryzae RIB40 AAM13977.1
BAC41255.1
BAE55679.1
Q8J2T0  
 N-acetyl-β-D-glucosaminidase (Nag1;Cr-Nag1) 3.2.1.52 Bionectria ochroleuca IK726 IBT 9371 ABC73393.1 A2SW08  
 β-N-acetylglucosaminidase 3.2.1.52 Bombyx mandarina AAG48701.1 Q9GPG8  
 chitooligosaccharidolytic β-N-acetylglucosaminidase 3.2.1.52 Bombyx mori AAC60521.1 P49010  
 processing β-N-acetylglucosaminidase (Fdl) 3.2.1.52 Bombyx mori Qiufeng/Baiyu hybrid ACV89847.1    
 β-N-acetylglucosaminidase 1 (GlcNAcase1) 3.2.1.52 Bombyx mori W1-PND BAF52531.1 A4PHN6  
 β-N-acetylglucosaminidase 2 (GlcNAcase2) 3.2.1.52 Bombyx mori W1-PND BAF52532.1 A4PHN7  
 processing β-N-acetylhexosaminidase (Hex-4;Y51F10.5) 3.2.1.52 Caenorhabditis elegans Bristol N2 AAL35732.2
CAO72177.1
A7DY68  
 processing β-N-acetylhexosaminidase (Hex-1;T14F9.3) 3.2.1.52 Caenorhabditis elegans Bristol N2 AAA91263.1
CAO72174.1
NP_508409.1
Q22492  
 processing β-N-acetylhexosaminidase (Hex-5;Y70D2A.2) 3.2.1.52 Caenorhabditis elegans Bristol N2 CAA22078.2
CAO72178.1
Q9XW90  
 processing β-N-acetylhexosaminidase (Hex-3;Y39A1C.4) 3.2.1.52 Caenorhabditis elegans Bristol N2 CAA19506.2
CAA19506.3
CAI06053.1
CAI06053.2
CAO72176.1
Q9XXE8  
 processing β-N-acetylhexosaminidase (Hex-2;C14C11.3) 3.2.1.52 Caenorhabditis elegans Bristol N2 AAA96105.3
CAO72175.1
CAO72175.2
Q17977  
 N-acetyl β-glucosaminidase (Hex1) 3.2.1.52 Candida albicans A72 AAA34346.2 P43077  
 β-N-acetylglucosaminidase 3.2.1.52 Choristoneura fumiferana AAX94571.1 Q52H16  
 N-acetyl β-glucosaminidase (α-chain) (NagA) 3.2.1.52 Dictyostelium discoideum AAA33230.1 P13723.1  
 processing β-N-acetylglucosaminidase / α-subunit (Fdl;CG8824;Dmel_CG8824) 3.2.1.52 Drosophila melanogaster AAF58500.2
AAL55992.1
AAM29423.1
AAM68691.1
AAM68691.2
AAM68692.1
AAM68693.1
ABY20426.1
NP_610790.1
NP_725178.2
NP_725179.1
NP_725180.1
Q8WSF3.1  
 β-N-acetylglucosaminidase A (Hex-A;Bex-1) 3.2.1.52 Entamoeba histolytica HM-1:IMSS AAA80165.1
CAE46968.1
CAG23943.1
P49009  
 N-acetyl β-glucosaminidase (β-chain) 3.2.1.52 Felis catus AAB30707.2
AAB67612.1
O18795
P49614
 
 β-N-acetylglucosaminidase (α-chain) (HexA) 3.2.1.52 Homo sapiens AAA51827.1
AAB00965.1
AAD13932.1
AAH01138.2
AAH18927.1
AAH21030.1
AAH84537.1
AAQ70000.1
ACM85216.1
BAD96222.1
BAG59159.1
BAG60039.1
BAG62619.1
BAG62730.1
CAH10482.1
NP_000511.1
P06865.1
Q9BVJ8
2GJX[A,D,E,H]
2GK1[A,C,E,G]
 β-N-acetylglucosaminidase B (β-chain) (HexB) 3.2.1.52 Homo sapiens AAA51828.1
AAA51829.1
AAA52645.1
AAA68620.1
AAH17378.1
AAM46114.1
AAP88921.1
AAV48875.1
NP_000512.1
P07686.3 1NOU[A,B]
1NOW[A,B]
1NP0[A,B]
1O7A[A,B,C,D,E,F]
2GJX[B,C,F,G]
2GK1[B,D,F,H]
 exo-chitinase 1 (Exc1) 3.2.1.52 Hypocrea lixii AAB47060.1 P78738  
 exo-chitinase 2 (Exc2) 3.2.1.52 Hypocrea lixii AAB47061.1 P78739  
 hexosaminidase (Exc1y) 3.2.1.52 Hypocrea lixii T-Y CAC85402.1 Q8NIN7  
 hexosaminidase (Exc2y) 3.2.1.52 Hypocrea lixii T-Y CAC85401.1 Q8NIN6  
 β-hexosaminidase (fragment) 3.2.1.52 Lagenorhynchus acutus AAF98706.1
AAF98707.1
Q9GJW3  
 β-hexosaminidase (fragment) 3.2.1.52 Lagenorhynchus obliquidens AAF98688.1
AAF98689.1
AAF98690.1
AAF98691.1
AAF98692.1
AAF98693.1
AAF98694.1
AAF98695.1
AAF98696.1
Q9GJW1  
 β-hexosaminidase (fragment) 3.2.1.52 Lagenorhynchus obscurus AAF98697.1
AAF98698.1
AAF98699.1
AAF98700.1
AAF98701.1
AAF98702.1
AAF98703.1
AAF98704.1
AAF98705.1
Q9GJW2  
 β-N-acetylglucosaminidase 3.2.1.52 Litopenaeus vannamei ACR23316.1    
 β-N-acetylglucosaminidase 3.2.1.52 Manduca sexta AAQ97603.1 Q6UJX7  
 N-acetyl β-glucosaminidase (α-chain) 3.2.1.52 Mus musculus AAA18775.1
AAA18777.1
AAC53246.1
AAH10755.1
BAC36036.1
BAC36049.1
BAC38018.1
BAE25744.1
BAE29566.1
BAE30831.1
BAE34808.1
BAE35394.1
BAE35457.1
BAE35636.1
BAE39189.1
BAE40146.1
CAA45615.1
NP_034551.1
P29416.1
Q8BNS6
Q91XG3
 
 N-acetyl β-glucosaminidase (β-chain) 3.2.1.52 Mus musculus AAA18776.1
AAA74738.1
AAB60667.1
BAE30155.1
BAE34846.1
BAE34877.1
BAE35874.1
BAE40652.1
CAA68781.1
NP_034552.1
P20060.2
Q3TXR9
 
 N-acetylglucosaminidase 3.2.1.52 Neotyphodium sp. FCB-2004 AAU29327.1 Q643Y1  
 β-N-acetylhexosaminidase (OfHex1) 3.2.1.52 Ostrinia furnacalis ABI81756.1 Q06GJ0  
 β-N-acetylhexosaminidase (NagA;Hex) 3.2.1.52 Penicillium chrysogenum AAF00010.1
AAP66194.1
AAQ80154.1
Q9URR8  
 processing β-N-acetylglucosaminidase (Fdl) 3.2.1.52 Spodoptera frugiperda ACA30398.1 B1P868  
 β-N-acetylglucosaminidase 1 3.2.1.52 Spodoptera frugiperda ABB76924.1 Q2Q1D3  
 β-N-acetylglucosaminidase 3 (HexA;Hex) 3.2.1.52 Spodoptera frugiperda ABA27426.1
ABB76926.1
ABY57947.1
Q3LS76  
 β-N-acetylglucosaminidase 2 (HexB;Hex) 3.2.1.52 Spodoptera frugiperda ABA27427.1
ABB76925.1
Q3LS75  
 β-N-acetylhexosaminidase (HexB) 3.2.1.52 Sus scrofa BAI47712.1
CAA63123.1
Q29548  
 β-hexosaminidase (Bhex) 3.2.1.52 Tetrahymena thermophila CAD55811.1 Q8IEV5  
 β-N-acetylglucosaminidase (Nag2) (fragment) 3.2.1.52 Trichoderma atroviride P1 ABC95196.1 Q0ZLH7  
 β-N-acetylglucosaminidase (Nag1;Chit73) 3.2.1.52 Trichoderma atroviride P1 AAB50829.1 P87258  
 exochitinase 2 (Zm.15748;ZmExo2;LOC100280178;ZM_BFb0204B20) 3.2.1.52 Zea mays B73 ACF87335.1
ACG29631.1
ACL54323.1
B4FYZ2  

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.