Glycoside Hydrolase Family 20

Activities in Familyβ-hexosaminidase (EC 3.2.1.52); lacto-N-biosidase (EC 3.2.1.140); β-1,6-N-acetylglucosaminidase) (EC 3.2.1.-); β-6-SO3-N-acetylglucosaminidase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-K
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu
External resourcesCAZypedia; HOMSTRAD; PRINTS; Tay-Sachs Disease;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (4615); Uniprot accession (779); PDB accession (79); 3D entries (18); cryst (1)
All (4333) Archaea (4) Bacteria (4008) Eukaryota (310) Viruses (1) unclassified (10) Structure (18 - 1 cryst) Characterized (124)
| 1 | 2 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 dispersin B / β-1,6-N-acetylglucosaminidase (DspB) 3.2.1.- Actinobacillus pleuropneumoniae IA1 AAT46094.1 Q6GYA5  
 chitobiase (NagA1) 3.2.1.52 Aeromonas caviae CB101 CAH55822.1 Q659J9  
 chitobiase 3.2.1.52 Aeromonas hydrophila AAG28494.1 Q9F9B4  
 β-N-acetylglucosaminidase (NagA;Nag-A) (Nag20A) 3.2.1.52 Aeromonas hydrophila SUWA-9 BAD00143.1 Q75V90  
 β-N-acetylglucosaminidase (NagB;Nag-B) 3.2.1.52 Aeromonas hydrophila SUWA-9 BAF76001.1 A7M7B5  
 β-N-acetylglucosaminidase 3.2.1.52 Aeromonas sp. 10S-24 BAA92145.1 Q9LC82  
 dispersin B / β-1,6-N-acetylglucosaminidase (DspB) 3.2.1.- Aggregatibacter actinomycetemcomitans CU1000 AAP31025.1 Q840G9 1YHT[A]
 chitobiase (Chb;ArChb) 3.2.1.52 Arthrobacter sp. TAD20 CAB72127.1 Q9L448  
 lacto-N-triose II β-N-acetylhexosaminidase (BbhI) 3.2.1.52 Bifidobacterium bifidum JCM 1254 BAI94822.1    
 β-N-acetylhexosaminidase (BbhII) 3.2.1.52 Bifidobacterium bifidum JCM 1254 BAI94823.1    
 lacto-N-biosidase (LnbB) 3.2.1.140 Bifidobacterium bifidum JCM 1254 ABZ78855.1 B3TLD6 4H04[A,B]
4JAW[A,B]
5BXP[A,B]
5BXR[A,B]
5BXS[A,B]
5BXT[A,B]
 β-N-acetylhexosaminidase / β-N-acetylglucosaminidase (Blon_0459) 3.2.1.52 Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ51575.1 B7GN69  
 β-N-acetylhexosaminidase / β-N-acetylglucosaminidase (Blon_0732) 3.2.1.52 Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ51836.1 B7GPV6  
 β-N-acetylhexosaminidase / β-N-acetylglucosaminidase (Blon_2355) 3.2.1.52 Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ53413.1 B7GNQ7  
 β-N-acetylhexosaminidase (Hex20) (Hex20A) 3.2.1.52 Cellulomonas fimi ATCC 484 AAQ05800.1 Q7WUL4  
 β-N-acetylglucosaminidase (Nag1) 3.2.1.52 Enterobacter sp. G-1 BAA74506.1 Q9ZN69  
 endoglycosidase (EndoE;NdoE) 3.2.1.96 Enterococcus faecalis HER1044 AAR20477.1 Q6U890  
 bifunctional endo-β-N-acetylglucosaminidase / exo-β-N-acetylglucosaminidase (EndoE;OG1RF_10107) 3.2.1.52
3.2.1.96
Enterococcus faecalis OG1RF AEA92794.1    
 endo-N-glycosidase (EndoE;EF0114) 3.2.1.52
3.2.1.96
Enterococcus faecalis V583 AAO79989.1
AAR59794.1
AAR59795.1
NP_813917.1
Q839P8  
 β-N-acetylglucosaminidase 3.2.1.52 Lactobacillus casei ATCC 27092 BAA76352.1 Q9WXH9  
 β-N-acetylglucosaminidase (GlcNAcase;LCABL_02860) 3.2.1.52 Lactobacillus casei BL23 CAQ65412.1 B3W8P4  
 β-N-acetylhexosaminidase (LnbA;L126168) 3.2.1.52 Lactococcus lactis subsp. lactis Il1403 AAK05592.1
NP_267650.1
Q9CFI2  
 β-hexosaminidase (Hex1T) 3.2.1.52 Paenibacillus sp. TS12 BAI63641.1 D2KW09 3GH4[A]
3GH5[A]
3GH7[A]
3SUR[A]
3SUS[A]
3SUT[A]
3SUU[A]
3SUV[A]
3SUW[A]
 β-N-acetylglucosaminidase (NahA;PG0043) 3.2.1.52 Porphyromonas gingivalis W83 CAA55582.1
AAQ65295.1
NP_904396.1
P49008  
 mucin-desulfating glycosidase / sulfoglycosidase / β-6-SO3-N-acetylglucosaminidase (Sgl) 3.2.1.- Prevotella sp. RS2 AAW30398.1 Q5MAH5  
 β-N-acetylhexosaminidase 3.2.1.52 proteobacterium AI21 ABE96869.1 A1XNE6  
 β-N-acetylglucosaminidase B (Nag096) 3.2.1.52 Pseudoalteromonas piscicida O-7 BAA06136.1 P49007  
 β-N-acetylhexosaminidase (Hex86) 3.2.1.52 Pseudoalteromonas piscicida O-7 BAB84321.1 Q8VUM1  
 transglycosylative enzyme (Hex99) 2.4.1.- Pseudoalteromonas piscicida O-7 BAA84281.1 Q9R6Y9  
 β-N-acetylglucosaminidase A (NagA) 3.2.1.52 Pseudoalteromonas piscicida O-7 BAB17855.1 Q9FAC5  
 β-N-acetylglucosaminidase (ChiP) 3.2.1.52 Pseudoalteromonas sp. S9 / S91 AAC83238.1 Q9ZH38  
 β-N-acetylglucosaminidase 20B (HexB;Sde_3271) (Hex20B) 3.2.1.52 Saccharophagus degradans 2-40 DAA01339.1
ABD82526.1
ACG81707.1
Q7PC48  
 β-N-acetylglucosaminidase 20A (HexA; Sde_3037) (Hex20A) 3.2.1.52 Saccharophagus degradans 2-40 DAA01338.1
ABD82294.1
ACG81706.1
Q7PC49  
 chitobiase (Chb;Ctb;SmCHB;SmGH20A) 3.2.1.52 Serratia marcescens 2170 AAB03808.1 Q54468 1C7S[A]
1C7T[A]
1QBA[A]
1QBB[A]
 β-N-acetylhexosaminidase (Hex;StmHex;Smlt4027) 3.2.1.52 Stenotrophomonas maltophilia K279a CAQ47422.1 B2FUR2  
 β-N-acetylglucosaminidase (GcnA) 3.2.1.52 Streptococcus gordonii FSS2 AAS02154.1 Q6ST21 2EPK[X]
2EPL[X]
2EPM[X]
2EPN[A,B]
2EPO[A,B]
 β-N-acetylglucosaminidase (StrH) 3.2.1.52 Streptococcus pneumoniae ATCC 12213 AAC41450.1 P49610  
 β-N-acetylglucosaminidase (StrH) 3.2.1.52 Streptococcus pneumoniae ATCC 12213 AAC41450.1 P49610  
 β-N-acetylhexosaminidase (StrH;spr0057) 3.2.1.52 Streptococcus pneumoniae R6 AAK98861.1
NP_357651.1
Q8DRL6 3RPM[A]
 β-N-acetylhexosaminidase (StrH;spr0057) 3.2.1.52 Streptococcus pneumoniae R6 AAK98861.1
NP_357651.1
Q8DRL6 3RPM[A,B]
 β-N-acetylhexosaminidase (GH20C;SP2141;SP_2141) 3.2.1.52 Streptococcus pneumoniae TIGR4 AAK76198.1   5A69[A]
5A6A[A,B]
5A6B[A,B,C,D]
5A6J[A,B,C,D]
5A6K[A,B]
5AC4[A,B]
5AC5[A,B]
 β-N-acetylglucosaminidase (StrH;SP0057;SP_0057) 3.2.1.52 Streptococcus pneumoniae TIGR4 AAK74246.1
NP_344606.1
P49610 2YL6[A]
2YL8[A]
2YLL[A]
4AZ5[A]
4AZ6[A]
4AZ7[A]
4AZB[A]
 β-N-acetylglucosaminidase (StrH;SP0057;SP_0057) 3.2.1.52 Streptococcus pneumoniae TIGR4 AAK74246.1
NP_344606.1
P49610 2YL5[A,B,C,D]
2YL9[A,B,C,D]
2YLA[A,B,C,D]
4AZC[A,B,C,D]
4AZG[A,B]
4AZH[A,B,C,D]
4AZI[A,B]
 β-N-acetylhexosaminidase (HexA;SCO2786) 3.2.1.52 Streptomyces coelicolor A3(2) CAB87223.1
NP_627016.1
Q9L068 4C7D[A,B]
4C7F[A,B]
4C7G[A]
 β-N-acetylhexosaminidase (SGR_4591) 3.2.1.52 Streptomyces griseus subsp. griseus NBRC 13350 BAG21420.1 B1VVQ9  
 β-N-acetylhexosaminidase (Hex56) 3.2.1.52 Streptomyces olivaceoviridis CAC34802.1 Q9ACN7  
 β-N-acetylglucosaminidase (Hex;SpHex) 3.2.1.52 Streptomyces plicatus AAC38798.3 O85361 1HP4[A]
1HP5[A]
1JAK[A]
1M01[A]
1M03[A]
1M04[A]
5FCZ[A]
5FD0[A]
 lacto-N-biosidase 3.2.1.140 Streptomyces sp. 142 AAD10478.1
AAE24545.1
Q9Z4I7  
 β-N-acetylglucosaminidase C (NagC) 3.2.1.52 Streptomyces thermoviolaceus OPC-520 BAC76622.1 Q83WL6  
 N-acetyl β-glucosaminidase (NagB) 3.2.1.52 Streptomyces thermoviolaceus OPC-520 BAA88762.2 Q9RHV6  
 β-N-acetylglucosaminidase (HexA;NABGLU;TF2925;BFO_1923) 3.2.1.52 Tannerella forsythia 92A2 ATCC 43037 AEW20137.1
AAO33832.1
Q84FS9  
 β-N-acetylhexosaminidase (Hex1;SoMe-cHEX1) 3.2.1.52 uncultured Actinomycetales bacterium AKC34128.1    
 β-N-acetylhexosaminidase (Hex2;SoMe-cHEX2) (fragment) 3.2.1.52 uncultured Bacteroidetes bacterium AKC34129.1    
 N-acetylhexosaminidase (ExoI) 3.2.1.52 Vibrio furnissii AAC44672.1
AAE36540.1
P96155  
 β-N-acetylglucosaminidase (Nag1;VhNag1) 3.2.1.52 Vibrio harveyi 650 ADJ68332.1 D9ISD9  
 β-N-acetylglucosaminidase (Nag2;VhNag2) 3.2.1.52 Vibrio harveyi 650 ADJ68333.1 D9ISE0  
 N-acetyl β-glucosaminidase (Chb) 3.2.1.52 Vibrio harveyi B392 AAA88682.1
AAR60429.1
AAX00633.1
CAD26692.1
P13670  
 N-acetyl β-glucosaminidase (Chb) 3.2.1.52 Vibrio parahaemolyticus ATCC 27969 AAA65915.1 Q60081  
 exo-β-N-acetylglucosaminidase (NixG;NahA;XCC2890) 3.2.1.52 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42162.1
NP_638238.1
Q8P6S5  
 β-N-acetylglucosaminidase (NagA;YPTB1123) 3.2.1.52 Yersinia pseudotuberculosis IP 32953 CAH20363.1    
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 processing β-N-acetylglucosaminidase / α-subunit (Fdl;AmFDL) (partial) 3.2.1.52 Apis mellifera AIZ97749.1    
 β-N-acetylhexosaminidase 2 (Hexo2;AtHex1;At1g05590) (plasma membrane) 3.2.1.52 Arabidopsis thaliana AAD30612.1
AEE27861.1
ANM60833.1
ANM60834.1
NP_172050.1
Q9SYK0  
 β-N-acetylhexosaminidase (Hexo3;AtHex3;At1g65590) (plasma membrane) 3.2.1.52 Arabidopsis thaliana AAM91092.1
AAB60911.1
AAN33206.1
AEE34399.1
NP_176737.2
O04477
Q8L7S6
 
 β-N-acetylhexosaminidase 1 (Hexo1;AtHex2;At3g55260) (vacuolar) 3.2.1.52 Arabidopsis thaliana BAE99290.1
AAM61367.1
AAN41320.1
AEE79360.1
CAB75760.1
CAM35467.1
NP_191086.1
NP_567017.1
A7WM73
Q0WUA8
Q8LFK0
Q9M3C5
 
 N-acetylglucosaminidase (NagA;AN1502.2) 3.2.1.52 Aspergillus nidulans FGSC A4 EAA63815.1
BAB13330.1
C8VMN3
G5EB27
 
 β-N-acetylhexosaminidase (HexA) 3.2.1.52 Aspergillus oryzae CCF 1066 AAM13977.1 Q8J2T0 cryst
 β-N-acetylglucosaminidase (NagA;HexA;AO090005000639) 3.2.1.52 Aspergillus oryzae RIB40 BAC41255.1
BAE55679.1
Q2URY6
Q8J2T0
 
 β-N-acetylglucosaminidase 3.2.1.52 Bombyx mandarina AAG48701.1 Q9GPG8  
 [N-glycan specific] processing β-N-acetylglucosaminidase (Fdl;BmFDL) 3.2.1.52 Bombyx mori ACV89846.1
ACV89847.1
BAJ20189.1
D3GGI8  
 β-N-acetylglucosaminidase 3 / A (GlcNAcase3;BmGlcNAcase3) 3.2.1.52 Bombyx mori AAT99455.1 Q3L6N4  
 chitooligosaccharidolytic β-N-acetylglucosaminidase (BmChiGlcNAcase) 3.2.1.52 Bombyx mori AAC60521.1 P49010  
 β-N-acetylglucosaminidase 1 (GlcNAcase1;BmGlcNAcase1;BmHex3) 3.2.1.52 Bombyx mori W1-PND BAF52531.1 A4PHN6  
 β-N-acetylglucosaminidase 2 (GlcNAcase2;BmGlcNAcase2) 3.2.1.52 Bombyx mori W1-PND BAF52532.1 A4PHN7  
 processing β-N-acetylhexosaminidase (Hex-1;T14F9.3) 3.2.1.52 Caenorhabditis elegans Bristol N2 AAA91263.1
CAO72174.1
CCD68941.1
NP_508409.1
Q22492  
 processing β-N-acetylhexosaminidase (Hex-2;CeHEX-2;C14C11.3) 3.2.1.52 Caenorhabditis elegans Bristol N2 AAA96105.3
CAO72175.1
CAO72175.2
CCD64497.1
G5EFL1
Q17977
 
 processing β-N-acetylhexosaminidase (Hex-4;CeHEX-4;Y51F10.5) 3.2.1.52 Caenorhabditis elegans Bristol N2 CCD73477.2
AAL35732.2
CAO72177.1
A7DY68  
 processing β-N-acetylhexosaminidase (Hex-5;CeHEX-5;Y70D2A.2) 3.2.1.52 Caenorhabditis elegans Bristol N2 CAA22078.2
CAO72178.1
G5EEC8
Q9XW90
 
 processing β-N-acetylhexosaminidase (Hex-3;CeHEX-3;Y39A1C.4) 3.2.1.52 Caenorhabditis elegans Bristol N2 CAA19506.3
CAA19506.2
CAI06053.1
CAI06053.2
CAO72176.1
Q9XXE8  
 β-N-acetylglucosaminidase (Hex1) 3.2.1.52 Candida albicans A72 AAA34346.2 P43077  
 β-D-N-acetylhexosaminidase 1 (β-Hex) 3.2.1.52 Capsicum annuum ADU20405.1    
 β-N-acetylglucosaminidase 3.2.1.52 Choristoneura fumiferana AAX94571.1 Q52H16  
 N-acetyl-β-D-glucosaminidase (Nag1;Cr-Nag1) 3.2.1.52 Clonostachys rosea IK726 IBT 9371 ABC73393.1 A2SW08  
 β-N-acetylhexosaminidase / chitobiase (Hex1;CpHEX1) 3.2.1.52 Coccidioides posadasii SILVEIRA ABB18373.1 Q309C3  
 N-acetyl β-glucosaminidase (α-chain) (NagA) 3.2.1.52 Dictyostelium discoideum AAA33230.1 P13723  
 β-N-acetylhexosaminidase 2 / b(2)-subunit (Hexo2;Hex2;CG1787) 3.2.1.52 Drosophila melanogaster AAF46406.1
AAM48390.1
NP_525081.1
Q9W3C4  
 β-N-acetylhexosaminidase 1 / b(1)-subunit (Hexo1;Hex1;CG1318) 3.2.1.52 Drosophila melanogaster AAF47881.1
AAG22248.1
AAG22248.2
AAL28566.1
AAM49995.1
AAN11596.1
AAN11597.1
AAN11597.2
ACU43551.1
NP_523924.1
NP_728974.1
NP_728975.1
NP_728976.1
Q0E8H9
Q8IRB6
Q8MSS9
Q95S03
Q9VZE3
 
 processing β-N-acetylglucosaminidase / α-subunit (Fdl;DmFDL;CG8824;Dmel_CG8824) 3.2.1.52 Drosophila melanogaster AAM29423.1
AAF58500.2
AAL55992.1
AAM68691.1
AAM68691.2
AAM68692.1
AAM68693.1
ABY20426.1
AFC17499.1
AHN56148.1
AHN56149.1
NP_610790.1
NP_725178.2
NP_725179.1
NP_725180.1
Q8WSF3  
 β-N-acetylglucosaminidase A / α-subunit (HexA;Hex-A;Bex-1;EHI_148130) 3.2.1.52 Entamoeba histolytica HM-1:IMSS CAE46968.1
AAA80165.1
CAG23943.1
EAL52144.2
P49009  
 N-acetyl β-glucosaminidase (β-chain) 3.2.1.52 Felis catus AAB30707.2
AAB67612.1
AEP60131.1
O18795
P49614
 
 β-N-acetylglucosaminidase / β-hexosaminidase A (α-chain) (HexA) 3.2.1.52 Homo sapiens AAB00965.1
AAA51827.1
AAD13932.1
AAH01138.2
AAH18927.1
AAH21030.1
AAH84537.1
AAQ70000.1
ACM85216.1
ALQ33567.1
ALQ33569.1
ALQ33570.1
BAD96222.1
BAG59159.1
BAG60039.1
BAG62619.1
BAG62730.1
CAH10482.1
NP_000511.1
P06865
Q9BVJ8
2GJX[A,D,E,H]
2GK1[A,C,E,G]
 β-N-acetylglucosaminidase B (β-chain) (HexB) 3.2.1.52 Homo sapiens AAA52645.1
AAA51828.1
AAA51829.1
AAA68620.1
AAH17378.1
AAM46114.1
AAP88921.1
AAV48875.1
ACI46028.1
ACV87197.1
NP_000512.1
P07686 1NOU[A,B]
1NOW[A,B]
1NP0[A,B]
1O7A[A,B,C,D,E,F]
2GJX[B,C,F,G]
2GK1[B,D,F,H]
3LMY[A,B]
5BRO[A]
 β-hexosaminidase (short fragment) 3.2.1.52 Lagenorhynchus acutus AAF98707.1
AAF98706.1
Q9GJW3  
 β-hexosaminidase (short fragment) 3.2.1.52 Lagenorhynchus obliquidens AAF98696.1
AAF98688.1
AAF98689.1
AAF98690.1
AAF98691.1
AAF98692.1
AAF98693.1
AAF98694.1
AAF98695.1
Q9GJW1  
 β-hexosaminidase (short fragment) 3.2.1.52 Lagenorhynchus obscurus AAF98705.1
AAF98697.1
AAF98698.1
AAF98699.1
AAF98700.1
AAF98701.1
AAF98702.1
AAF98703.1
AAF98704.1
Q9GJW2  
 β-N-acetylhexosaminidase (LeHex20B) 3.2.1.52 Lentinula edodes BAQ21906.1    
 N-acetylhexosaminidase (LeHex20A) (Hex20A) 3.2.1.52 Lentinula edodes H600 BAM42836.1    
 β-N-acetylglucosaminidase 3.2.1.52 Litopenaeus vannamei ACR23316.1 C4P6W6  
 β-N-acetylglucosaminidase (Nag1;LmNAG1) 3.2.1.52 Locusta migratoria AFZ76982.1    
 β-N-acetylglucosaminidase 3.2.1.52 Manduca sexta AAQ97603.1 Q6UJX7  
 β-N-acetylglucosaminidase (α-chain) / β-hexosaminidase A (HexA) 3.2.1.52 Mus musculus AAC53246.1
AAA18775.1
AAA18777.1
AAH10755.1
BAC36036.1
BAC36049.1
BAC38018.1
BAE25744.1
BAE29566.1
BAE30831.1
BAE34808.1
BAE35394.1
BAE35457.1
BAE35636.1
BAE39189.1
BAE40146.1
CAA45615.1
NP_034551.1
P29416
Q8BNS6
Q91XG3
 
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