Activities in Sub Family	[retaining] α-amylase (EC 3.2.1.1);
Mechanism	Retaining a
Clan	GH-H
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Asp (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	New: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resources	CAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX;
Statistics	GenBank accession (1); Uniprot accession (52); PDB accession (85); 3D entries (5); cryst (0)

Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
α-amylase I (Amy I; Ef-Amy I)	3.2.1.1	Eisenia fetida	BAV13234.1	A0A173N065	6M4K[A] 1.30 6M4L[A] 1.60 6M4M[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 1.70	24
α-amylase (Amy2A) (pancreatic)	3.2.1.1	Homo sapiens	AAA51724.1 AAA51723.1 AAA51725.1 AAA52280.1 AAH07060.1 AAI46998.1 BAD97183.1 CAA30099.1 CAA30100.1 CAN87444.1 NP_000690.1	P04746 P04746 P19961 Q53F26	1B2Y[A] α-D-6-deoxy-Glcp-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-β-D-Glcp 3.20 1BSI[A] 2.00 1CPU[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp 2.00 1HNY[A] 1.80 1KB3[A] 2.10 1KBB[A] 1.90 1KBK[A] D-1-deoxy-GlcpNAc 1.90 1KGU[A] 2.00 1KGW[A] 2.10 1KGX[A] 2.00 1U2Y[A] <carb_like_GOX> 1.95 1U30[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-1)-<non_carb> <carb_like_GOX> 1.90 1U33[A] α-D-Glcp4Me-(1-4)-α-D-Glcp-(1-1)-<non_carb> 1.95 1XCW[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp 2.00 1XCX[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-6)-β-D-Glcp 1.90 1XD0[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp 2.00 1XD1[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-6)-β-D-Glcp 2.20 1XGZ[A] 2.00 1XH0[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 2.00 1XH1[A] 2.03 1XH2[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp 2.20 2CPU[A] 2.00 2QMK[A] 2.30 2QV4[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N 1.97 3BAI[A] 1.90 3BAJ[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp 2.10 3BAK[A] 1.90 3BAW[A] 2.00 3BAX[A] 1.90 3BAY[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp 1.99 3CPU[A] α-D-Glcp-(1-4)-α-D-Glcp 2.00 3IJ7[A] α-D-Glcp4Me-(1-4)-α-D-Glcp-(1-4)-α-L-Idop5F-(1-4)-ASP α-D-Glcp4Me-(1-4)-α-D-Glcp1F 2.00 3IJ8[A] α-L-Idop5F-(1-4)-ASP β-L-Idop1,5F 1.43 3IJ9[A] α-D-Glcp-(1-4)-α-L-Idop5F-(1-4)-ASP β-L-Idop1,5F 1.85 3OLD[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp 2.00 3OLE[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp 1.55 3OLG[A] <acarbose_derivative> unknown-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp α-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.30 3OLI[A] <acarbose_derivative> unknown-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp β-D-Glcp 1.50 4GQQ[A] 1.35 4GQR[A] 1.20 4W93[A] β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-α-L-Rhap-(1-1)-<non_carb> 1.35 4X9Y[A] 1.07 5E0F[A] β-D-Glcp-(1-2)-α-L-Rhap-(1-1)-<non_carb> 1.40 5EMY[A] 1.23 5KEZ[A] 1.83 5TD4[A] α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 2.30 5U3A[A] 0.95 5VA9[A,B] 2.55 6OBX[A] 1.30 6OCN[A] 1.15 6Z8L[A] α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp 1.40	24
α-amylase (salivary) (Amy1A;Amy1;HSA)	3.2.1.1	Homo sapiens	AAH63129.1 AAA16183.1 AAA52279.1 AAA57345.1 AAA58368.1 AAH69347.1 AAH69463.1 AAH70302.1 AAH92444.1 AAI32986.1 AAI32988.1 AAI32996.1 AAI32998.1 AAI44453.1 BAF85030.1 NP_004029.2	B7ZMD7 P04745 P0DTE7 P0DTE8 P0DUB6 Q6NSB3	1C8Q[A] 2.30 1JXJ[A] 1.99 1JXK[A] 1.90 1MFU[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp D-1-deoxy-Glcp α-D-Glcp-(1-4)-D-1-deoxy-Glcp 2.00 1MFV[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp 2.00 1NM9[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 2.10 1Q4N[X] 2.07 1SMD[A] 1.60 1XV8[A,B] 3.00 1Z32[X] β-D-Glcp-(1-4)-<non_carb>-(0-4)-D-1,6-deoxy-Glcp4N 1.60 3BLK[A] α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp 2.00 3BLP[X] α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp 1.60 3DHP[A] α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp 1.50	24
α-amylase (partial)	3.2.1.1	Oryzias latipes		H2N0D4	3VM5[A] 2.85	24
α-amylase (Ppa;PPA) (pancreatic)	3.2.1.1	Sus scrofa	AAF02828.1	P00690	1BVN[P] 2.50 1DHK[A] 1.85 1HX0[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-1)-<non_carb> 1.38 1JFH[A] α-D-Glcp-(1-4)-α-D-Glcp4S1S α-D-Glcp4SMe-(1-4)-α-D-Glcp4S-(1-1)-methyl 2.03 1KXQ[A] 1.60 1KXT[A] 2.00 1KXV[A] 1.60 1OSE[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-β-D-Glcp β-D-Glcp 2.30 1PIF[A] 2.30 1PIG[A] α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp β-D-Glcp β-D-Glcp-(1-4)-α-D-Glcp 2.20 1PPI[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-β-D-Glcp 2.20 1UA3[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp α-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp 2.01 1VAH[A] 2.40 1WO2[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp α-D-Glcp-(1-4)-β-D-Glcp 2.01 3L2L[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)[α-D-Glcp-(1-6)]-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp β-D-Glcp 2.11 3L2M[A] 1.97 4X0N[A] 2.60	24
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