Glycoside Hydrolase Family 136

Activities in Familylacto-N-biosidase (EC 3.2.1.140); Lacto-N-biosidase (Lewis antigen a/b specificity) (EC 3.2.1.-)
Mechanism Retaining
3D Structure Statusparallel β-helix
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteCreated after Yamada et al. (2017) Cell Chem Biol 24:515-524 (PMID=28392148)
External resourcesCAZypedia;
Statistics GenBank accession (861); Uniprot accession (4); PDB accession (7); 3D entries (4); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 lacto-N-biosidase (LnbX;BLLJ_1505) 3.2.1.140 Bifidobacterium longum subsp. longum JCM 1217 BAJ67172.1 A0A024QYS6
5GQC[A,B,C,D,E,F,G,H] 2.36
5GQF[A,B] β-D-Galp-(1-3)-β-D-GlcpNAc
1.82
5GQG[A,B] β-D-Galp-(1-3)-β-D-GalpNAc
2.70
 lacto-N-biosidase (BsaXc;BSD967_02910) 3.2.1.140 Bifidobacterium saguini DSMZ 23967 QTB91395.1  
7V6I[A] β-D-Galp-(1-3)-β-D-GlcpNAc
2.51
 lacto-N-biosidase (HMPREF0373_02965) 3.2.1.140 Eubacterium ramulus ATCC 29099 ERK42296.1 U2PDT9
6KQS[A] β-D-Galp-(1-3)-β-D-GlcpNAc
1.40
6KQT[A] β-D-Galp-(1-3)-β-D-GlcpNAc
2.00
  lacto-N-biosidase (TnXc;CLONEX_02542) 3.2.1.140 Tyzzerella nexilis DSM 1787 EEA81577.1  
7V6M[A] β-D-Galp-(1-3)-β-D-GlcpNAc
1.92
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