Glycoside Hydrolase Family 136

Activities in Familylacto-N-biosidase (EC 3.2.1.140); Lacto-N-biosidase (Lewis antigen a/b specificity) (EC 3.2.1.-)
Mechanism Retaining
3D Structure Statusparallel β-helix
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteCreated after Yamada et al. (2017) Cell Chem Biol 24:515-524 (PMID=28392148)
External resourcesCAZypedia;
Statistics GenBank accession (861); Uniprot accession (4); PDB accession (7); 3D entries (4); cryst (0)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 lacto-N-biosidase (LnbX;BLLJ_1505) 3.2.1.140 pubmed
Bifidobacterium longum subsp. longum JCM 1217 BAJ67172.1 A0A024QYS6 5GQC[A,B,C,D,E,F,G,H]
5GQF[A,B]
5GQG[A,B]
 lacto-N-biosidase (BsaXc;BSD967_02910) 3.2.1.140 pubmed
Bifidobacterium saguini DSMZ 23967 QTB91395.1   7V6I[A]
 lacto-N-biosidase (HMPREF0373_02965) 3.2.1.140 pubmed
Eubacterium ramulus ATCC 29099 ERK42296.1 U2PDT9 6KQS[A]
6KQT[A]
 lacto-N-biosidase (RhLnb136II; RHOM_04115) (possible fragment) 3.2.1.140 pubmed
Roseburia hominis A2-183 AEN95945.1 G2T0V1  
 Lacto-N-biosidase (Lewis antigen a/b specificity) (RiLea/b136) 3.2.1.- pubmed
Roseburia inulinivorans WP_007885622.1 C0FT31  
 lacto-N-biosidase (RlXc;RUMLAC_RS05545) 3.2.1.140 pubmed
Ruminococcus lactaris WP_005610277.1    
  lacto-N-biosidase (TnXc;CLONEX_02542) 3.2.1.140 pubmed
Tyzzerella nexilis DSM 1787 EEA81577.1   7V6M[A]
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