Activities in Family	Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Inverting e
3D Structure Status	lysozyme fold
Note	Created after the work by Shimizu and collaborators. J. Biol. Chem. (2015). [ PMID:26385921 ]. Presents an inverting mechanism in what is a unique feature compared to all other b-mannanases [see Jin et al. ACS Cent. Sci (2016) doi:10.1021/acscentsci.6b00232 ]
External resources	CAZypedia;
Statistics	GenBank accession (125); Uniprot accession (9); PDB accession (9); 3D entries (2); cryst (0)

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Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
232340		Penicillium solitum ITEM 18327 v1.0 (Psol18327_1)
18002		Penicillium solitum ITEM 18327 v1.0 (Psol18327_1)
2165		Penicillium subrubescens (Pensub1)
214250		Penicillium thymicola v1.0 (Penth1)
178938		Penicillium thymicola v1.0 (Penth1)
124523		Penicillium thymicola v1.0 (Penth1)
221249		Penicillium thymicola v1.0 (Penth1)
1832		Penicillium vulpinum IBT 29486 (Penvul1)
8917		Penicillium vulpinum IBT 29486 (Penvul1)
385825		Pilaira anomala RSA1997 v1.0 (Pilano1)
432934		Pilaira anomala RSA1997 v1.0 (Pilano1)
126953		Plectosphaerella cucumerina RP01 v1.0 (Plecuc1)
Lema_p106070.1		Plenodomus lingam JN3 isolate M1	CBX97476.1
V499_06905		Pseudogymnoascus sp. VKM F-103	KFY72999.1
V499_01291		Pseudogymnoascus sp. VKM F-103	KFY79750.1
V490_06010		Pseudogymnoascus sp. VKM F-3557	KFX91241.1
V491_03355		Pseudogymnoascus sp. VKM F-3775	KFY20876.1
V491_05769		Pseudogymnoascus sp. VKM F-3775	KFY15132.1
V491_00893 (fragment)		Pseudogymnoascus sp. VKM F-3775	KFY27465.1
O988_05594		Pseudogymnoascus sp. VKM F-3808	KFX95858.1
V492_05467		Pseudogymnoascus sp. VKM F-4246	KFY09542.1
V492_06650		Pseudogymnoascus sp. VKM F-4246	KFY07977.1
V493_05084		Pseudogymnoascus sp. VKM F-4281 (FW-2241)	KFY24696.1
V495_06073		Pseudogymnoascus sp. VKM F-4514 (FW-929)	KFY39220.1
V496_00343		Pseudogymnoascus sp. VKM F-4515 (FW-2607)	KFY69341.1
V496_07542		Pseudogymnoascus sp. VKM F-4515 (FW-2607)	KFY53482.1
V498_03884		Pseudogymnoascus sp. VKM F-4517 (FW-2822)	KFY94407.1
V498_07457		Pseudogymnoascus sp. VKM F-4517 (FW-2822)	KFY86580.1
V500_08829		Pseudogymnoascus sp. VKM F-4518 (FW-2643)	KFY84966.1
V500_02850		Pseudogymnoascus sp. VKM F-4518 (FW-2643)	KFY95297.1
V501_00483		Pseudogymnoascus sp. VKM F-4519 (FW-2642)	KFZ19809.1
V501_01477		Pseudogymnoascus sp. VKM F-4519 (FW-2642)	KFZ17922.1
V502_10314		Pseudogymnoascus sp. VKM F-4520 (FW-2644)	KFZ04219.1
V502_11421		Pseudogymnoascus sp. VKM F-4520 (FW-2644)	KFZ02892.1
425252		Pyrenochaeta lycopersici ISPaVe ER 1252 v1.0 (Pyrly1)
1214		Pyronema confluens omphalodes (Pyrco1)
288150		Pyronema domesticum DOB7353 v1.0 (Pyrdom1)
PCON_02213		Pyronema omphalodes CBS 100304 CBS100304	CCX33950.1
RO3G_11308		Rhizopus delemar RA 99-880	EIE86597.1
RO3G_00915		Rhizopus delemar RA 99-880	EIE76211.1
RO3G_11298		Rhizopus delemar RA 99-880	EIE86587.1
RO3G_01113		Rhizopus delemar RA 99-880	EIE76409.1
RO3G_12355		Rhizopus delemar RA 99-880	EIE87644.1
RO3G_00568		Rhizopus delemar RA 99-880	EIE75864.1
RO3G_01081		Rhizopus delemar RA 99-880	EIE76377.1
RO3G_12105		Rhizopus delemar RA 99-880	EIE87394.1
RMATCC62417_04585		Rhizopus microsporus	CEG68292.1
endo-β-1,4-mannanase (RMCBS344292_04886)	3.2.1.78	Rhizopus microsporus	CEI90564.1	A0A0A1NDE2 A0A2U8ZTY7	5XTJ[A,B] 5XTT[A,B] 5XU5[A,B] 5XUG[A,B] 5XUL[A,B] 5XXA[A,B]
RMATCC62417_15903		Rhizopus microsporus	CEG81741.1
RMATCC62417_16090		Rhizopus microsporus	CEG81953.1
RMATCC62417_06891		Rhizopus microsporus	CEG71106.1
RMATCC62417_15902 (fragment)		Rhizopus microsporus	CEG81740.1
RMATCC62417_11464		Rhizopus microsporus	CEG76584.1
RMATCC62417_04622		Rhizopus microsporus	CEG68339.1
7138		Rhizopus microsporus var. chinensis CCTCC M201021 (Rhich1)
12780		Rhizopus microsporus var. chinensis CCTCC M201021 (Rhich1)
1793		Rhizopus microsporus var. chinensis CCTCC M201021 (Rhich1)
1794		Rhizopus microsporus var. chinensis CCTCC M201021 (Rhich1)
7501		Rhizopus microsporus var. chinensis CCTCC M201021 (Rhich1)
209690		Rhizopus microsporus var. microsporus ATCC52813 v1.0 (Rhimi1_1)
295460		Rhizopus microsporus var. microsporus ATCC52813 v1.0 (Rhimi1_1)
188864		Rhizopus microsporus var. microsporus ATCC52813 v1.0 (Rhimi1_1)
274066		Rhizopus microsporus var. microsporus ATCC52813 v1.0 (Rhimi1_1)
241866		Rhizopus microsporus var. microsporus ATCC52813 v1.0 (Rhimi1_1)
234929		Rhizopus microsporus var. microsporus ATCC52814 v1.0 (Rhimi_ATCC52814_1)
291808		Rhizopus microsporus var. microsporus ATCC52814 v1.0 (Rhimi_ATCC52814_1)
318789		Rhizopus microsporus var. microsporus ATCC52814 v1.0 (Rhimi_ATCC52814_1)
313680		Rhizopus microsporus var. microsporus ATCC52814 v1.0 (Rhimi_ATCC52814_1)
Man134A		Rhizopus microsporus var. rhizopodiformis F518	AWO12178.1
671859		Rhizoscyphus ericae UAMH 7357 v1 (Rhier1)
247043		Sphaerobolus stellatus SS14 (Sphst1)
S40288_09926		Stachybotrys chartarum IBT 40288	KFA70873.1
11153		Stachybotrys chartarum IBT 40288 (Stach1)
10924		Stachybotrys chartarum IBT 40288 (Stach1)
S40293_01173		Stachybotrys chartarum IBT 40293	KFA56552.1
S7711_00292		Stachybotrys chartarum IBT 7711	KEY72294.1
S7711_06146		Stachybotrys chartarum IBT 7711	KEY73073.1
S40285_08660		Stachybotrys chlorohalonata IBT 40285	KFA69873.1
782		Stachybotrys chlorohalonata IBT 40285 (Stachl1)
512737		Stachybotrys elegans LAHC-LSPK-M15 v1.0 (Stael1)
42829		Staphylotrichum longicolle CBS 103.79 v1.0 (Stalo1)
47983		Staphylotrichum longicolle CBS 103.79 v1.0 (Stalo1)
35257		Staphylotrichum longicolle CBS 103.79 v1.0 (Stalo1)
TW65_03794		Stemphylium lycopersici CIDEFI 216	KNG49621.1
3421		Stemphylium lycopersici CIDEFI-216 (Stely1)
2042		Talaromyces borbonicus CBS 141340 (Talabor1)
TRUGW13939_08114		Talaromyces rugulosus W13939	QKX60968.1
482		Talaromyces stipitatus ATCC 10500 (Talst1_2)
497346		Thamnidium elegans v1.0 (Thaele1)
433		Trichoderma gamsii T6085 (Trigam1)
832727		Trichophaea hybrida UTF0779 v1.0 (Trihyb1)
523023		Truncatella angustata MPI-SDFR-AT-0073 v1.0 (Truan1)
8628		Verticillium alfalfae VaMs.102 (Veral1)
114416		Volvariella volvacea V23 (Volvo1)
580147		Wilcoxina mikolae CBS 423.85 (Wilmi1)
525665		Xylaria acuta CBS 122032 v1.0 (Xylacu1)
549967		Xylaria cf. castorea CBS 124033 v1.0 (Xylcas124033_1)
517469		Xylaria cf. heliscus FL0509 v2.0 (Xylhel2)
486675		Xylaria cubensis CBS 116.85 v1.0 (Xylcube1)
516014		Xylaria digitata CBS 161.22 v1.0 (Xyldig1)
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