Glycoside Hydrolase Family 134

Activities in FamilyEndo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism Inverting e
3D Structure Statuslysozyme fold
NoteCreated after the work by Shimizu and collaborators. J. Biol. Chem. (2015). [ PMID:26385921 ]. Presents an inverting mechanism in what is a unique feature compared to all other b-mannanases [see Jin et al. ACS Cent. Sci (2016) doi:10.1021/acscentsci.6b00232 ]
External resourcesCAZypedia;
Statistics GenBank accession (127); Uniprot accession (9); PDB accession (9); 3D entries (2); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 β-1,4-mannanase (SsGH134) 3.2.1.78 Streptomyces sp. NRRL B-24484 WP_030268297.1 A0A1L1QK12
A0A1L1QK13
A0A1L1QK16
5JTS[A] 1.09
5JU9[A] β-D-Manp-(1-4)-β-D-Manp-(1-4)-α-D-Manp
1.18
5JUG[A] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
0.96
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 endo-β-1,4-mannanase (RMCBS344292_04886) 3.2.1.78 Rhizopus microsporus CEI90564.1 A0A0A1NDE2
A0A2U8ZTY7
5XTJ[A,B] 2.22
5XTT[A,B] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
1.75
5XU5[A,B] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
2.02
5XUG[A,B] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
2.31
5XUL[A,B] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
1.98
5XXA[A,B] 1.76
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