Glycoside Hydrolase Family 134

Activities in Familyendo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism inverting
NoteCreated after the work by Shimizu and collaborators. J. Biol. Chem. (2015). [ PMID:26385921 ]. Presents an inverting mechanism in what is a unique feature compared to all other b-mannanases [see Jin et al. ACS Cent. Sci (2016) doi:10.1021/acscentsci.6b00232 ]
External resourcesCAZypedia;
Statistics GenBank accession (139); Uniprot accession (0); PDB accession (8); 3D entries (2); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 β-1,4-mannanase (SsGH134) 3.2.1.78 Streptomyces sp. NRRL B-24484 WP_030268297.1  
5JTS[A] 1.09
5JU9[A] β-D-Manp-(1-4)-β-D-Manp-(1-4)-α-D-Manp
1.18
5JUG[A] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
0.96
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 RMCBS344292_04886   Rhizopus microsporus CEI90564.1  
5XTJ[A,B]
5XTT[A,B]
5XU5[A,B]
5XUG[A,B]
5XUL[A,B]
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