Glycoside Hydrolase Family 12

Activities in Familyendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
Mechanism Retaining
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (929); Uniprot accession (212); PDB accession (46); 3D entries (16); cryst (1)
All (737) Archaea (81) Bacteria (514) Eukaryota (141) unclassified (1) Structure (16 - 1 cryst) Characterized (68)
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Ahos_1962 (fragment)   Acidianus hospitalis W1 AEE94835.1    
 ASAC_1380   Acidilobus saccharovorans 345-15 ADL19785.1 D9PYZ8  
 ASAC_1386   Acidilobus saccharovorans 345-15 ADL19791.1 D9PZ04  
 ASAC_1415   Acidilobus saccharovorans 345-15 ADL19820.1 D9PZ33  
 SE86_03630   Acidilobus sp. 7A AMD30576.1    
 SE86_03660   Acidilobus sp. 7A AMD30581.1    
 SE86_04245   Acidilobus sp. 7A AMD30662.1    
 Cmaq_0464   Caldivirga maquilingensis IC-167 ABW01309.1    
 Cmaq_0847   Caldivirga maquilingensis IC-167 ABW01682.1 A8MD26  
 Cmaq_0848   Caldivirga maquilingensis IC-167 ABW01683.1 A8MD27  
 cellulase (TCel6;Cmaq_1621) 3.2.1.4 Caldivirga maquilingensis IC-167 ABW02444.1
AEG76945.1
A8M9X3  
 Cmaq_1988   Caldivirga maquilingensis IC-167 ABW02804.1 A8MC20  
 CPM_0130   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK84025.1    
 CPM_0122   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK84017.1    
 HTIA_2118   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ34232.1    
 Igag_0454   Ignisphaera aggregans DSM 17230 ADM27292.1 E0SRL7  
 Igag_0885   Ignisphaera aggregans DSM 17230 ADM27702.1 E0STT6  
 Igag_0638   Ignisphaera aggregans DSM 17230 ADM27471.1 E0SSS1  
 Igag_1802   Ignisphaera aggregans DSM 17230 ADM28599.1 E0SSL4  
 Igag_1811   Ignisphaera aggregans DSM 17230 ADM28608.1 E0SSM3  
 Mcup_0985   Metallosphaera cuprina Ar-4 AEB95090.1    
 PAP_07590   Palaeococcus pacificus DY20341 AIF69907.1    
 PFC_03465   Pyrococcus furiosus COM1 AFN03642.1    
 endo-β-1,4-glucanase A (EglA;EGPf;TCel1;PF0854) (Cel12) 3.2.1.4 Pyrococcus furiosus DSM 3638 AAD54602.1
AAE50601.1
AAL80978.1
AAM56799.1
AAW12536.1
ABJ38334.1
ACM94275.1
ACW20099.1
AEG76943.1
NP_578583.1
E7FHY8
Q9V2T0
3VGI[A]
3WQ0[A]
3WQ1[A]
3WQ7[A,B]
3WR0[A]
3WT3[A,B]
3WXP[A]
3WY6[A]
 Saci_1852   Sulfolobus acidocaldarius DSM 639 AAY81158.1 Q4J7S3  
 ATY89_08850   Sulfolobus acidocaldarius GG12-C01-09 ALU30030.1    
 SacN8_09050   Sulfolobus acidocaldarius N8 AGE71770.1    
 ATZ20_00260   Sulfolobus acidocaldarius NG05B_CO5_07 ALU30720.1    
 SacRon12I_09070   Sulfolobus acidocaldarius Ron12/I AGE74043.1    
 SUSAZ_08935   Sulfolobus acidocaldarius SUSAZ AHC52035.1    
 SiH_0339   Sulfolobus islandicus HVE10/4 ADX81710.1    
 SiH_0385   Sulfolobus islandicus HVE10/4 ADX81754.1    
 LD85_0343   Sulfolobus islandicus L.D.8.5 ADB86136.1 D2PFG3  
 LD85_0905   Sulfolobus islandicus L.D.8.5 ADB86610.1 D2PIB6  
 LS215_0676   Sulfolobus islandicus L.S.2.15 ACP34754.1 C3MMD1  
 LS215_0362   Sulfolobus islandicus L.S.2.15 ACP34505.1 C3MKY0  
 SiL_0318   Sulfolobus islandicus LAL14/1 AGJ61795.1    
 SiL_0366   Sulfolobus islandicus LAL14/1 AGJ61841.1    
 M1425_0923   Sulfolobus islandicus M.14.25 ACP37717.1 C3MX37  
 M1425_0337   Sulfolobus islandicus M.14.25 ACP37218.1 C3MUI4  
 M1627_0990   Sulfolobus islandicus M.16.27 ACP54913.1 C3N4I8  
 M1627_0337   Sulfolobus islandicus M.16.27 ACP54357.1 C3N1U7  
 M164_0932   Sulfolobus islandicus M.16.4 ACR41545.1 C4KG31  
 M164_0358   Sulfolobus islandicus M.16.4 ACR40988.1 C4KL23  
 SiRe_0332   Sulfolobus islandicus REY15A ADX84426.1    
 SiRe_0791   Sulfolobus islandicus REY15A ADX84872.1    
 YG5714_0711   Sulfolobus islandicus Y.G.57.14 ACP45001.1 C3NBL6  
 YG5714_0339   Sulfolobus islandicus Y.G.57.14 ACP44630.1 C3N9U6  
 YN1551_2496   Sulfolobus islandicus Y.N.15.51 ACP49447.1 C3NKX4  
 YN1551_2718   Sulfolobus islandicus Y.N.15.51 ACP49627.1 C3NM45  
 endo-1,4-B-glucanase (SsgluC)   Sulfolobus shibatae B12 CZS63539.1    
 Ssol_0340   Sulfolobus solfataricus 98/2 ACX90632.1 D0KN97  
 Ssol_2755   Sulfolobus solfataricus 98/2 ACX92839.1 D0KPT5  
 SULC_2773   Sulfolobus solfataricus 98/2 SULC AKA77532.1    
 SULC_0332   Sulfolobus solfataricus 98/2 SULC AKA75458.1    
 cellulase (CelS)   Sulfolobus solfataricus MT4 CAC39483.1 Q7LWG2
Q97VS7
 
 SSOP1_1266   Sulfolobus solfataricus P1 SAI84820.1    
 SSOP1_1471   Sulfolobus solfataricus P1 SAI85025.1    
 SSOP1_2656   Sulfolobus solfataricus P1 SAI86210.1    
 SSOP1_2078   Sulfolobus solfataricus P1 SAI85632.1    
 cellulase (CelB;SSO2534) 3.2.1.4 Sulfolobus solfataricus P2 CAC24331.1
AAK42663.1
NP_343873.1
   
 endo-β-1,4-glucanase (SSO1949)   Sulfolobus solfataricus P2 AAK42142.1
NP_343352.1
Q97X08  
 endoglucanase / xylanase (SSO1354) 3.2.1.4
3.2.1.8
Sulfolobus solfataricus P2 AAK41590.1
NP_342800.1
Q97YG7  
 SULA_2775   Sulfolobus solfataricus SULA AKA80222.1    
 SULA_0332   Sulfolobus solfataricus SULA AKA78151.1    
 SULB_2776   Sulfolobus solfataricus SULB AKA74836.1    
 SULB_0334   Sulfolobus solfataricus SULB AKA72759.1    
 BFU36_00630   Sulfolobus sp. A20 AOL15484.1    
 BFU36_07185   Sulfolobus sp. A20 AOL16515.1    
 BFU36_07415   Sulfolobus sp. A20 AOL16553.1    
 CHITON_0818   Thermococcus chitonophagus DSM 10152 CUX77597.1    
 A3L04_07960   Thermococcus chitonophagus GC74 ASJ17009.1    
 ADU37_CDS22600   Thermococcus sp. 2319x1 ALV63957.1    
 ADU37_CDS22600   Thermococcus sp. 2319x1 ALV63957.1    
 TAM4_1337   Thermococcus sp. AM4 EEB73588.2    
 Tpen_1681   Thermofilum pendens Hrk 5 ABL79076.1 A1S0U6  
 TTX_0363   Thermoproteus tenax Kra 1 CCC81038.1    
 TUZN_1301   Thermoproteus uzoniensis 768-20 AEA12777.1    
 TUZN_1431   Thermoproteus uzoniensis 768-20 AEA12904.1    
 Sequence 2 from patent US 6329187 (fragment)   unidentified archaeon AEPII1a AAQ77850.1    
 Vdis_1604   Vulcanisaeta distributa DSM 14429 ADN50982.1 E1QTR5  
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