Glycoside Hydrolase Family 123

Activities in Familyβ-N-acetylgalactosaminidase (EC 3.2.1.53); glycosphingolipid β-N-acetylgalactosaminidase (EC 3.2.1.-)
Mechanism Retaining
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu
NoteCreated after Sumida T, Fujimoto K, Ito M. (2011) J Biol Chem. 286:14065-14072 [PMID: 21297160]
External resourcesCAZypedia;
Statistics GenBank accession (172); Uniprot accession (2); PDB accession (8); 3D entries (2); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 N-acetyl-β-galactosaminidase / β-N-acetylgalactosaminidase (BvGH123;BVU_2198) 3.2.1.53 Bacteroides vulgatus ATCC 8482 ABR39859.1  
5L7R[A,B] 1.85
5L7U[A,B] β-D-GalpNAc
2.10
5L7V[A,B] D-1,2-deoxy-Galp
2.30
 glycolipid exo-β-N-acetylgalactosaminidase (CpNga123;CPF_1473) 3.2.1.53
3.2.1.-
Clostridium perfringens ATCC 13124 ABG82546.1  
5FQE[A,B] 1.53
5FQF[A,B] β-D-GalpNAc
2.15
5FQG[A] β-D-GalpNAc-(1-3)-β-D-Galp
2.30
5FQH[A] β-D-GalpNAc-(1-4)-β-D-Galp-(1-4)-β-D-Glcp
2.10
5FR0[A] <non_carb>-(1-2)-β-D-GalpN
1.75
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