Glycoside Hydrolase Family 123

Activities in Familyβ-N-acetyl-4-sulfo-galactosaminidase (EC 3.2.1.-);
Endo-β-1,3-N-acetylgalactosaminidase (EC 3.2.1.-);
Endo-β-1,4-N-acetylgalactosaminidase (EC 3.2.1.-);
Exo-β-1,3-N-acetylgalactosaminidase (EC 3.2.1.-);
Exo-β-1,4-N-acetylgalactosaminidase (EC 3.2.1.-);
Glycosphingolipid β-N-acetylgalactosaminidase (EC 3.2.1.-);
β-N-acetylgalactosaminidase (EC 3.2.1.53);
Mechanism Retaining e
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu
NoteCreated after Sumida T, Fujimoto K, Ito M. (2011) J Biol Chem. 286:14065-14072 [PMID: 21297160]
External resourcesCAZypedia;
Statistics GenBank accession (1621); Uniprot accession (6); PDB accession (19); 3D entries (8); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 glycolipid exo-β-N-acetylgalactosaminidase (CpNga123;CPF_1473) 3.2.1.53
3.2.1.-
Clostridium perfringens ATCC 13124 ABG82546.1 A0A0H2YNR7
5FQE[A,B] 1.53
5FQF[A,B] β-D-GalpNAc
2.15
5FQG[A] β-D-GalpNAc-(1-3)-β-D-Galp
2.30
5FQH[A] β-D-GalpNAc-(1-4)-β-D-Galp-(1-4)-β-D-Glcp
2.10
5FR0[A] <non_carb>-(1-2)-β-D-GalpN
1.75
1
 β-N-acetylgalactosaminidase (NgaCa;KCTCHS21_21730) 3.2.1.53 Cohnella abietis HS21 BBI32774.1 A0A3T1D3V8
8K2F[A] 1.75
8K2G[A,B] 1.75
4
 exo-β-N-acetylgalactosaminidase (NgaLy) 3.2.1.-
3.2.1.-
Lacticaseibacillus yichunensis WP_125696777.1  
8K2N[A,B,C,D] 2.50
2
 β-N-acetylgalactosaminidase (NaNga) (DUF4091 domain-containing protein) 3.2.1.53 Niabella aurantiaca DSM 17617 WP_018628640.1  
8P4L[A,B,C,D,E,F,G,H,I,J, 2.79
8Q8H[A,B,C,D] 2.50
2
 exo-β-N-acetylgalactosaminidase (NgaP2) 3.2.1.-
3.2.1.-
Paenibacillus sp. TS12 BEL01682.1  
8K2L[A] 1.95
8K2M[A] D-1,2-deoxy-Galp
1.65
2
 N-acetyl-β-galactosaminidase / β-N-acetylgalactosaminidase (BvGH123;BVU_2198) 3.2.1.53 Phocaeicola vulgatus ATCC 8482 ABR39859.1 A6L2E5
5L7R[A,B] 1.85
5L7U[A,B] β-D-GalpNAc
2.10
5L7V[A,B] D-1,2-deoxy-Galp
2.30
1
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 exo-β-1,3-N-acetylgalactosaminidase (NgaAt) 3.2.1.- Arabidopsis thaliana AEE32084.1
Q7Y231
 
8K2H[A,B] D-1,2-deoxy-Galp
2.20
8K2I[A,B] 2.50
5
unclassified
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 β-N-acetylgalactosaminidase (NgaDssm) 3.2.1.53
3.2.1.-
unidentified    
8K2J[A] 1.76
8K2K[A] D-1,2-deoxy-Galp
1.75
3
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