Carbohydrate-Binding Module Family 94

Activities in FamilyN-Acetylglucosamine binding
Mechanism
NoteCreated after Oka et al. 2022 [PMID=36106687] who demonstrated the N-Acetylglucosamine binding properties of the CBM94 module in two proteins of Homo sapiens and Bombyx mori. The CBM94 is the C-terminal domain of GnT-IV which is an N-acetylglucosaminyltransferase (GT54) involved in N-glycosylation. Modules of approx. 150 residues found at the C-terminus of the GT54 in eukaryotes. Involved in N-glycosylation by the binding of N-Acetylglucosamine.
External resourcesCAZypedia;
Statistics GenBank accession (342); Uniprot accession (12); PDB accession (4); 3D entries (3); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 UDP-GlcNAc: α-1,3-D-mannoside β-1,4-N-acetylglucosaminyltransferase (GnT-IV; GlcNAcT-IV; Mgat4)   Bombyx mandarina BDI24347.2
BDI24347.1
XP_028034380.1
A0A6J2JXS5
7XTM[A,B] 1.47
7XTN[A,B] β-D-GlcpNAc
1.15
 UDP-GlcNAc: α-1,3-D-mannoside β-1,4-N-acetylglucosaminyltransferase 4A (GnT-IVa; GlcNAcT-IVa; Mgat4A)   Homo sapiens BAA86388.1
AAI27108.1
AAI27109.1
AAY14976.1
BAF84222.1
BAG65228.1
NP_036346.1
A8K668
D3DVH6
Q9UM21
7XTL[A,B] 1.97
 α-1,3-mannoside β-1,4-N-acetylglucosaminyltransferase IVa (GnT-IVa; GlcNAcT-IVa; Mgat4a)   Mus musculus BAC55018.1
BAC55085.1
BAE37301.1
NP_776295.1
Q812G0
7VMT[A,B,C,D,E,F] 1.95
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