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Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (18440); Uniprot accession (142); PDB accession (171); 3D entries (62); cryst (1)
Summary
Download CBM13 (22873) Taxonomic display Structure (62 - 1 cryst)
| 1 | ... | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | ... | 56 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 CKF44_000508   Cryptococcus neoformans var. grubii KN99 AUB22179.1    
 CKF44_002384   Cryptococcus neoformans var. grubii KN99 AUB23598.1    
 CKF44_000509   Cryptococcus neoformans var. grubii KN99 AUB22180.1    
 CKF44_004391   Cryptococcus neoformans var. grubii KN99 AUB27334.1    
 CKF44_000704   Cryptococcus neoformans var. grubii KN99 AUB22412.1    
 CNK01820   Cryptococcus neoformans var. neoformans JEC21 AAW46144.1    
 CNJ03160   Cryptococcus neoformans var. neoformans JEC21 AAW45878.1    
 CNA05720   Cryptococcus neoformans var. neoformans JEC21 AAW41073.1    
 CNA07770   Cryptococcus neoformans var. neoformans JEC21 AAW41305.1    
 CNA05710   Cryptococcus neoformans var. neoformans JEC21 AAW41423.1
AAW41423.2		    
 LQV05_006603   Cryptococcus neoformans VNII UOH83865.1    
 LQV05_000555   Cryptococcus neoformans VNII UOH79548.1    
 LQV05_000766   Cryptococcus neoformans VNII UOH79756.1    
 LQV05_000554   Cryptococcus neoformans VNII UOH79547.1    
 IAR50_007289   Cryptococcus sp. DSM 104548 WVQ77601.1    
 IAR50_001738   Cryptococcus sp. DSM 104548 WVQ72192.1    
 IAR50_003013   Cryptococcus sp. DSM 104548 WVQ73441.1    
 IAR50_005202   Cryptococcus sp. DSM 104548 WVQ75575.1    
 IAR50_007290   Cryptococcus sp. DSM 104548 WVQ77602.1    
 IAR50_000115   Cryptococcus sp. DSM 104548 WVQ70596.1    
 IAR50_004634   Cryptococcus sp. DSM 104548 WVQ75025.1    
 IAR50_001737   Cryptococcus sp. DSM 104548 WVQ72191.1    
 IAT38_002177   Cryptococcus sp. DSM 104549 WVQ80076.1    
 IAT38_002175   Cryptococcus sp. DSM 104549 WVQ80074.1    
 IAT38_002175   Cryptococcus sp. DSM 104549 WVQ80074.1    
 IAT38_001929   Cryptococcus sp. DSM 104549 WVQ79829.1    
 IAT38_001928   Cryptococcus sp. DSM 104549 WVQ79828.1    
 IAT38_001930   Cryptococcus sp. DSM 104549 WVQ79830.1    
 IAT38_004995   Cryptococcus sp. DSM 104549 WVQ82860.1    
 IAT38_004995   Cryptococcus sp. DSM 104549 WVQ82860.1    
 IAT38_002178   Cryptococcus sp. DSM 104549 WVQ80077.1    
 IAT38_008011   Cryptococcus sp. DSM 104549 WVQ85843.1    
 GalNAc transferase T1   Cryptosporidium hominis AGL80529.1    
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T3   Cryptosporidium parvum AAQ95175.1
AAQ95175.2		 Q6TBQ9  
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T1   Cryptosporidium parvum AAQ95174.2
AAQ95174.1		 Q6TBR0  
 cpbgf_500690   Cryptosporidium parvum IOWA WRK32213.1    
 cpbgf_7004160   Cryptosporidium parvum IOWA WRK33595.1    
 CPATCC_002066   Cryptosporidium parvum IOWA-ATCC QOY41502.1    
 CPATCC_003629   Cryptosporidium parvum IOWA-ATCC QOY40739.1    
 CPCDC_7g4160   Cryptosporidium sp. 43IA8 WKS79106.1    
 CPCDC_5g690   Cryptosporidium sp. 43IA8 WKS77723.1    
 hemolytic lectin (Cel3;CEL-III)   Cucumaria echinata BAC75827.1
BAK19472.1
BAK19473.1
BAK19476.1		   1VCL[A,B]
2Z48[A,B]
2Z49[A,B]
3W9T[A,B,C,D,E,F,G]
 hemolytic lectin (Cel3;CEL-III)   Cucumaria echinata BAC75827.1
BAK19472.1
BAK19473.1
BAK19476.1		   1VCL[A,B]
2Z48[A,B]
2Z49[A,B]
3W9T[A,B,C,D,E,F,G]
 hemolytic lectin-L1 (Lecl1)   Cucumaria echinata BAK19474.1    
 hemolytic lectin-L1 (Lecl1)   Cucumaria echinata BAK19474.1    
 hemolytic lectin-L2 (Lecl2)   Cucumaria echinata BAK19475.1    
 hemolytic lectin-L2 (Lecl2)   Cucumaria echinata BAK19475.1    
 Agglutinin   Cucumis melo XP_016903609.1   8R8A[A]
8R8C[A]
 Agglutinin   Cucumis melo XP_016903609.1    
 lectin XSP30   Cucumis sativus BAA88294.1    
 lectin XSP30   Cucumis sativus BAA88294.1    
 274019   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 265180   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 183933   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 250245   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 172418   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 272137   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 104121   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 104121   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 104121   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 104121   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 168982   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 227857   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 185510   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 273237   Cunninghamella echinulata NRRL 1382 v1.0 (Cunech1)      
 CcaverHIS002_0700540 (fragment)   Cutaneotrichosporon cavernicola HIS002 BEI86708.1    
 CcaverHIS002_0705570   Cutaneotrichosporon cavernicola HIS002 BEI87211.1    
 CcaverHIS002_0705580   Cutaneotrichosporon cavernicola HIS002 BEI87212.1    
 CcaverHIS002_0700520   Cutaneotrichosporon cavernicola HIS002 BEI86706.1    
 CcaverHIS002_0700070   Cutaneotrichosporon cavernicola HIS002 BEI86661.1    
 CcaverHIS002_0101530   Cutaneotrichosporon cavernicola HIS002 BEI79624.1    
 CcaverHIS002_0206660 (fragment)   Cutaneotrichosporon cavernicola HIS002 BEI81506.1    
 CcaverHIS002_0301210   Cutaneotrichosporon cavernicola HIS002 BEI82253.1    
 CcaverHIS002_0306020 (fragment)   Cutaneotrichosporon cavernicola HIS002 BEI82734.1    
 CcaverHIS002_0108600   Cutaneotrichosporon cavernicola HIS002 BEI80331.1    
 CcaverHIS002_0400720   Cutaneotrichosporon cavernicola HIS002 BEI83468.1    
 CcaverHIS002_0500300   Cutaneotrichosporon cavernicola HIS002 BEI84629.1    
 CcaverHIS002_0400710   Cutaneotrichosporon cavernicola HIS002 BEI83467.1    
 CcaverHIS002_0400710   Cutaneotrichosporon cavernicola HIS002 BEI83467.1    
 CcaverHIS002_0400710   Cutaneotrichosporon cavernicola HIS002 BEI83467.1    
 CcaverHIS002_0206650   Cutaneotrichosporon cavernicola HIS002 BEI81505.1    
 CcaverHIS002_0309720   Cutaneotrichosporon cavernicola HIS002 BEI83104.1    
 CcaverHIS002_0108740   Cutaneotrichosporon cavernicola HIS002 BEI80345.1    
 CcaverHIS002_0505900   Cutaneotrichosporon cavernicola HIS002 BEI85189.1    
 CcaverHIS002_0309890   Cutaneotrichosporon cavernicola HIS002 BEI83121.1    
 CcaverHIS002_0105890   Cutaneotrichosporon cavernicola HIS002 BEI80060.1    
 CcaverHIS019_0206640 (fragment)   Cutaneotrichosporon cavernicola HIS019 BEI89302.1    
 CcaverHIS019_0309560   Cutaneotrichosporon cavernicola HIS019 BEI90886.1    
 CcaverHIS019_0206630   Cutaneotrichosporon cavernicola HIS019 BEI89301.1    
 CcaverHIS019_0400680   Cutaneotrichosporon cavernicola HIS019 BEI91248.1    
 CcaverHIS019_0400680   Cutaneotrichosporon cavernicola HIS019 BEI91248.1    
 CcaverHIS019_0101500   Cutaneotrichosporon cavernicola HIS019 BEI87432.1    
 CcaverHIS019_0305970   Cutaneotrichosporon cavernicola HIS019 BEI90527.1    
 CcaverHIS019_0108540   Cutaneotrichosporon cavernicola HIS019 BEI88136.1    
 CcaverHIS019_0105830   Cutaneotrichosporon cavernicola HIS019 BEI87865.1    
 CcaverHIS019_0301170   Cutaneotrichosporon cavernicola HIS019 BEI90047.1    
 CcaverHIS019_0108680   Cutaneotrichosporon cavernicola HIS019 BEI88150.1    
 CcaverHIS019_0705620   Cutaneotrichosporon cavernicola HIS019 BEI94981.1    
 CcaverHIS019_0506420   Cutaneotrichosporon cavernicola HIS019 BEI93014.1    
 CcaverHIS019_0600300   Cutaneotrichosporon cavernicola HIS019 BEI93571.1    
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