Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 abrin isoform G   Abrus precatorius AAL77434.1 Q8SA43  
 abrin isoform G   Abrus precatorius AAL77434.1 Q8SA43  
 abrin-a B chain (galactose-specific lectin) (partial)   Abrus precatorius AAB23029.1    
 abrin-a B chain (galactose-specific lectin) (partial)   Abrus precatorius AAB23029.1    
 abrin-b B-chain (toxic lectin)   Abrus precatorius AAB25435.1    
 abrin-b B-chain (toxic lectin)   Abrus precatorius AAB25435.1    
 agglutinin (AAG)   Abrus precatorius AAF28309.1 Q9M6E9 2AMZ[B]
2Q3N[B]
2ZR1[B,D]
 agglutinin (AAG)   Abrus precatorius AAF28309.1 Q9M6E9 2AMZ[B]
2Q3N[B]
2ZR1[B,D]
 pulchelin B-chain (PBC)   Abrus pulchellus subsp. tenuiflorus AAM19073.1 Q7Y0V1  
 pulchelin B-chain (PBC)   Abrus pulchellus subsp. tenuiflorus AAM19073.1 Q7Y0V1  
 prepropulchellin I   Abrus pulchellus subsp. tenuiflorus ABW23503.1 B1NQB9  
 prepropulchellin I   Abrus pulchellus subsp. tenuiflorus ABW23503.1 B1NQB9  
 prepropulchellin II   Abrus pulchellus subsp. tenuiflorus ABW23504.1 B1NQC0  
 prepropulchellin II   Abrus pulchellus subsp. tenuiflorus ABW23504.1 B1NQC0  
 prepropulchellin III   Abrus pulchellus subsp. tenuiflorus ABW23505.1 B1NQC1  
 prepropulchellin III   Abrus pulchellus subsp. tenuiflorus ABW23505.1 B1NQC1  
 prepropulchellin IV   Abrus pulchellus subsp. tenuiflorus ABW23506.1 B1NQC2  
 prepropulchellin IV   Abrus pulchellus subsp. tenuiflorus ABW23506.1 B1NQC2  
 secreted protein   Achlya hypogyna ATCC 48635 AIG56318.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56318.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55846.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55846.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55915.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55915.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55926.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55960.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55960.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55969.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55969.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56029.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56029.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56030.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56030.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56036.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56170.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56170.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56171.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56171.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56197.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56197.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56198.1    
 secreted protein (fragment)   Achlya hypogyna ATCC 48635 AIG56230.1    
 secreted protein (fragment)   Achlya hypogyna ATCC 48635 AIG56230.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56231.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56276.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56276.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56282.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56282.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56285.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56285.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56438.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56439.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56439.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56445.1    
 [Blood group A] α-N-acetylgalactosaminidase (NagA) 3.2.1.49 Acremonium sp. No.413 BAB08149.1 Q9HFB1  
 A036-E7   Acropora millepora ACJ64656.1 B7T136  
 A049-E7   Acropora millepora ACJ64657.1 B7T137  
 A049-E7   Acropora millepora ACJ64657.1 B7T137  
 Volkensin (Volk38)   Adenia volkensii CAD61022.1 Q70US9  
 Volkensin (Volk38)   Adenia volkensii CAD61022.1 Q70US9  
 glycoside hydrolase 10 (Cbh-2)   Adineta ricciae AKC91351.1    
 glycoside hydrolase 10 (Cbh-1)   Adineta ricciae AKC91350.1    
 ORF   Agaricus bisporus ACN56442.1 C0LAM1  
 ORF   Agaricus bisporus ACN56442.1 C0LAM1  
 ACCB14679 (fragment)   Apis cerana AEY61935.1    
 pierisin-4   Aporia crataegi BAH96563.1 C6L2F6  
 pierisin-4   Aporia crataegi BAH96563.1 C6L2F6  
 pierisin-4   Aporia crataegi BAH96563.1 C6L2F6  
 pierisin-4   Aporia crataegi BAH96563.1 C6L2F6  
 EGX43760.1   Arthrobotrys oligospora ATCC 24927 EGX43760.1    
 EGX45292.1   Arthrobotrys oligospora ATCC 24927 EGX45292.1    
 EGX44261.1   Arthrobotrys oligospora ATCC 24927 EGX44261.1    
 EGX52451.1   Arthrobotrys oligospora ATCC 24927 EGX52451.1    
 EGX50856.1   Arthrobotrys oligospora ATCC 24927 EGX50856.1    
 EGX50094.1   Arthrobotrys oligospora ATCC 24927 EGX50094.1    
 EGX48470.1   Arthrobotrys oligospora ATCC 24927 EGX48470.1    
 ORF   Ascaris suum ADY42538.1    
 ORF   Ascaris suum ADY42754.1    
 ORF   Ascaris suum ADY43175.1    
 ORF   Ascaris suum ADY41481.1    
 ORF   Ascaris suum ADY43296.1    
 ORF   Ascaris suum ADY44456.1    
 ORF (fragment)   Ascaris suum ADY47570.1    
 ORF (fragment)   Ascaris suum ADY47590.1    
 ORF (fragment)   Ascaris suum ADY48063.1    
 α-galactosidase A (AglA;AFUA_5G13830;Afu5g13830)   Aspergillus fumigatus Af293 EAL91233.1 Q4WVZ3  
 α-N-acetylgalactosaminidase / α-galactosidase (AglA;An06g00170) 3.2.1.22
3.2.1.49
Aspergillus niger CBS 513.88 CAK44933.1 A2QL72  
 α-galactosidase A (Ag1A;AglA) 3.2.1.22 Aspergillus niger N402 CAA44950.1
AAE69559.1
P28351  
 AO090005000217   Aspergillus oryzae RIB40 BAE55309.1 Q2UT06  
 AO090138000159   Aspergillus oryzae RIB40 BAE64529.1 Q2U1N6  
 crybg3 (fragment)   Astyanax mexicanus AIW06993.1    
 ORF (fragment)   Belgica antarctica ABF72913.1 Q19PZ9  
 UDP-GalNAc: [mucin] polypeptide α-N-acetylgalactosaminyltransferase (ppGalNAcT) 2.4.1.41 Biomphalaria glabrata AGS17229.1    
 N-acetylgalactosaminyltransferase (GalNAc-T) (partial)   Bombyx mori AGC81884.1    
 UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 1 (GalNT1;ppGalNAcT1;GalNAc-T1) 2.4.1.41 Bos taurus AAA30532.1
AAA68489.1
AAE24810.1
AAE24816.1
NP_803485.1
Q07537  
 GALNT6   Bos taurus AAX08745.1
AAI46056.1
Q5EA41  
 Unknown (protein for MGC:139629)   Bos taurus AAI22598.1 Q0IIK7  
 Unknown (protein for MGC:143063)   Bos taurus AAI23663.1 Q08DM9  
 Unknown (protein for IMAGE:8475367) (fragment)   Bos taurus AAI26726.1 A0JNJ8  
 ORF (protein for MGC:148786)   Bos taurus AAI48122.1 A6QLX6  
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