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Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (18440); Uniprot accession (142); PDB accession (171); 3D entries (62); cryst (1)
Summary
Download CBM13 (22873) Taxonomic display Structure (62 - 1 cryst)
| 1 | ... | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | ... | 173 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 CAP0071   Clostridium acetobutylicum ATCC 824 AAK76817.1
NP_149235.1		    
 CAC0706   Clostridium acetobutylicum ATCC 824 AAK78683.1
NP_347343.1		    
 CAC0706   Clostridium acetobutylicum ATCC 824 AAK78683.1
NP_347343.1		    
 CAC0577   Clostridium acetobutylicum ATCC 824 AAK78555.1
NP_347215.1		    
 SMB_G0591 (YxiA)   Clostridium acetobutylicum DSM 1731 AEI33332.1    
 SMB_P070   Clostridium acetobutylicum DSM 1731 AEI34813.1    
 SMB_P116   Clostridium acetobutylicum DSM 1731 AEI34859.1    
 SMB_G0720 (EglA)   Clostridium acetobutylicum DSM 1731 AEI34191.1    
 SMB_G0720 (EglA)   Clostridium acetobutylicum DSM 1731 AEI34191.1    
 SMB_P117   Clostridium acetobutylicum DSM 1731 AEI34860.1    
 SMB_P118   Clostridium acetobutylicum DSM 1731 AEI34861.1    
 CEA_G0590   Clostridium acetobutylicum EA 2018 ADZ19629.1    
 CEA_P0117   Clostridium acetobutylicum EA 2018 ADZ22900.1    
 CEA_P0119   Clostridium acetobutylicum EA 2018 ADZ22902.1    
 CEA_P0118   Clostridium acetobutylicum EA 2018 ADZ22901.1    
 CEA_G0717   Clostridium acetobutylicum EA 2018 ADZ19756.1    
 CEA_G0717   Clostridium acetobutylicum EA 2018 ADZ19756.1    
 CEA_P0070   Clostridium acetobutylicum EA 2018 ADZ22853.1    
 DK921_09910   Clostridium acetobutylicum LJ4 AWV80402.1    
 DK921_09910   Clostridium acetobutylicum LJ4 AWV80402.1    
 DK921_09260   Clostridium acetobutylicum LJ4 AWV80279.1    
 DK921_19915   Clostridium acetobutylicum LJ4 AWV82362.1    
 DK921_20150   Clostridium acetobutylicum LJ4 AWV82405.1    
 DK921_20160   Clostridium acetobutylicum LJ4 AWV82407.1    
 DK921_20155   Clostridium acetobutylicum LJ4 AWV82406.1    
 haemagglutinin component HA17 (plasmid)   Clostridium argentinense 2740 BBB39294.1    
 hemagglutinin component HA33 (plasmid)   Clostridium argentinense 2740 BBB39292.1    
 hemagglutinin component HA33 (plasmid)   Clostridium argentinense 2740 BBB39292.1    
 RSJ17_00490   Clostridium argentinense 89G ARC83162.1    
 RSJ17_00490   Clostridium argentinense 89G ARC83162.1    
 CLAUR_017140   Clostridium aurantibutyricum DSM 793 URZ01719.1    
 CLAUR_017140   Clostridium aurantibutyricum DSM 793 URZ01719.1    
 CLAUR_018420   Clostridium aurantibutyricum DSM 793 URZ01845.1    
 CLAUR_047300   Clostridium aurantibutyricum DSM 793 URZ04641.1    
 QIT93_09940   Clostridium baratii C110 WWU82648.1    
 QJR28_04920   Clostridium baratii C146 WWU81491.1    
 QJR32_10140   Clostridium baratii C162 WWU71062.1    
 QJR26_06090   Clostridium baratii C202 WWU65932.1    
 CM240_0091   Clostridium bornimense M2/40 CDM67270.1    
 CM240_2499 (YesW)   Clostridium bornimense M2/40 CDM69629.1    
 CM240_2767   Clostridium bornimense M2/40 CDM69884.1    
 CM240_2768 (XynC)   Clostridium bornimense M2/40 CDM69885.1    
 CM240_2769   Clostridium bornimense M2/40 CDM69886.1    
 CM240_1020   Clostridium bornimense M2/40 CDM68184.1    
 CM240_1020   Clostridium bornimense M2/40 CDM68184.1    
 CM240_2770   Clostridium bornimense M2/40 CDM69887.1    
 CM240_3281 (fragment)   Clostridium bornimense M2/40 CDM70398.1    
 CM240_3282   Clostridium bornimense M2/40 CDM70399.1    
 CM240_3282   Clostridium bornimense M2/40 CDM70399.1    
 hemagglutinin component HA33   Clostridium botulinum 003-9 BAM65695.1    
 hemagglutinin component HA33   Clostridium botulinum 003-9 BAM65695.1    
 33 KD haemagglutinin component (Ha33)   Clostridium botulinum 111 BAF91949.1
BAP25801.1		    
 33 KD haemagglutinin component (Ha33)   Clostridium botulinum 111 BAF91949.1
BAP25801.1		    
 IRP61_10930   Clostridium botulinum 1873 QPW56556.1    
 IRP61_10930   Clostridium botulinum 1873 QPW56556.1    
 hemagglutinin component HA33   Clostridium botulinum 348 BAM65701.1    
 hemagglutinin component HA33   Clostridium botulinum 348 BAM65701.1    
 IRP63_14350   Clostridium botulinum 3859/11 QPW59224.1    
 IRP63_14350   Clostridium botulinum 3859/11 QPW59224.1    
 Ha33 (HA-33;Ha34)   Clostridium botulinum 62A AAM75951.1
AAM75958.1
AAQ06328.1
ABD65469.1
ABE20280.1
ACQ22029.1
ACS02888.1		   1YBI[A,B]
4LO0[A,B]
4LO1[A,B]
4LO2[A,B]
4LO3[A,B]
4LO7[B,D,F,H]
5BP5[A,B]
5BQU[A,B]
 Ha33 (HA-33;Ha34)   Clostridium botulinum 62A AAM75951.1
AAM75958.1
AAQ06328.1
ABD65469.1
ABE20280.1
ACQ22029.1
ACS02888.1		   1YBI[A,B]
4LO0[A,B]
4LO1[A,B]
4LO2[A,B]
4LO3[A,B]
4LO7[B,D,F,H]
5BP5[A,B]
5BQU[A,B]
 Ha33   Clostridium botulinum 657BA ABY56320.1
ACW83611.1		    
 Ha33   Clostridium botulinum 657BA ABY56320.1
ACW83611.1		    
 HA-33   Clostridium botulinum 667AB CAA61129.1    
 HA-33   Clostridium botulinum 667AB CAA61129.1
ABC05321.1		    
 HA33   Clostridium botulinum A Hall AIR72301.1    
 HA33   Clostridium botulinum A Hall AIR72301.1    
 CLB_0845   Clostridium botulinum A str. ATCC 19397 ABS34221.1    
 CLB_0845   Clostridium botulinum A str. ATCC 19397 ABS34221.1    
 CBO0803   Clostridium botulinum A str. ATCC 3502 CAL82357.1    
 CBO0803   Clostridium botulinum A str. ATCC 3502 CAL82357.1    
 CLC_0859 (HA33)   Clostridium botulinum A str. Hall ABS38942.1   4QD2[C,D,H,I]
 CLC_0859 (HA33)   Clostridium botulinum A str. Hall ABS38942.1   4QD2[C,D,H,I]
 RSJ11_01045   Clostridium botulinum AM1195 AUM93823.1    
 RSJ11_01045   Clostridium botulinum AM1195 AUM93823.1    
 RSJ11_05560   Clostridium botulinum AM1195 AUM94646.1    
 RSJ10_3974   Clostridium botulinum AM282 APQ78750.1    
 RSJ10_3974   Clostridium botulinum AM282 APQ78750.1    
 CB17B_P049 (CntC)   Clostridium botulinum B str. Eklund 17B (NRP) CDH92507.1    
 CB17B_P049 (CntC)   Clostridium botulinum B str. Eklund 17B (NRP) CDH92507.1    
 CLL_0035   Clostridium botulinum B str. Eklund 17B (NRP) ACD14182.1    
 CLL_0035   Clostridium botulinum B str. Eklund 17B (NRP) ACD14182.1    
 HA1   Clostridium botulinum B1 str. Okra BAE48261.1    
 HA1   Clostridium botulinum B1 str. Okra BAE48261.1    
 neurotoxin type B progenitor toxin complex subunit (Ha1;Ha33;CLD_A0071)   Clostridium botulinum B1 str. Okra ACA46991.1
BAE48261.1		   3WIN[A,B]
4OUJ[A,B]
 neurotoxin type B progenitor toxin complex subunit (Ha1;Ha33;CLD_A0071)   Clostridium botulinum B1 str. Okra ACA46991.1
BAE48261.1		   3WIN[A,B]
4OUJ[A,B]
 RSJ6_04405   Clostridium botulinum B305 AUN09773.1    
 RSJ6_04405   Clostridium botulinum B305 AUN09773.1    
 RSJ21_04850   Clostridium botulinum B515 AUN24601.1    
 RSJ21_04850   Clostridium botulinum B515 AUN24601.1    
 RSJ22_04985   Clostridium botulinum B609 AUN20817.1    
 RSJ22_04985   Clostridium botulinum B609 AUN20817.1    
 RSJ15_04425   Clostridium botulinum B742 AUM86966.1    
 RSJ15_04425   Clostridium botulinum B742 AUM86966.1    
 CLJ_0136 (Ha33)   Clostridium botulinum Ba4 str. 657 ACQ51131.1    
 CLJ_0136 (Ha33)   Clostridium botulinum Ba4 str. 657 ACQ51131.1    
 CbC4_4094   Clostridium botulinum BKT015925 AEB77294.1    
 CbC4_4094   Clostridium botulinum BKT015925 AEB77294.1    
 IG390_13945   Clostridium botulinum BKT2873 QPW62151.1    
 IG390_13945   Clostridium botulinum BKT2873 QPW62151.1    
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