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Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (18440); Uniprot accession (142); PDB accession (171); 3D entries (62); cryst (1)
Summary
Download CBM13 (22873) Taxonomic display Structure (62 - 1 cryst)
| 1 | ... | 164 | 165 | 166 | 167 | 168 | 169 | 170 | 171 | 172 | 173 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 R8Z52_22770   Vibrio porteresiae DSM 19223 MSSRF30 WPC75746.1    
 R8Z52_22770   Vibrio porteresiae DSM 19223 MSSRF30 WPC75746.1    
 R8Z52_22770   Vibrio porteresiae DSM 19223 MSSRF30 WPC75746.1    
 R8Z52_21815   Vibrio porteresiae DSM 19223 MSSRF30 WPC75566.1    
 R8Z52_11205   Vibrio porteresiae DSM 19223 MSSRF30 WPC72695.1    
 CCZ37_17780   Vibrio qinghaiensis Q67 ASU24297.1    
 RND59_05000   Vibrio ruber HNIBRBA4764 WNJ96457.1    
 RND59_11920   Vibrio ruber HNIBRBA4764 WNJ94835.1    
 RND59_00580   Vibrio ruber HNIBRBA4764 WNJ95652.1    
 J0X00_01130   Vibrio sp. ABG19 WGY45484.1    
 ACOMICROBIO_LKFPLAJE_03804   Vibrio sp. B1FIG11 CAE6942369.1    
 ACOMICROBIO_LKFPLAJE_01803   Vibrio sp. B1FIG11 CAE6907082.1    
 ITG12_01890   Vibrio sp. ED002 UQA52325.1    
 ITG10_18355   Vibrio sp. ED004 UPR59343.1    
 MAO6_37150   Vibrio sp. MAO6 BFG50204.1    
 β-agarase D (AgaD)   Vibrio sp. PO-303 BAF34350.1 Q05KJ8  
 J4N41_07585   Vibrio sp. SCSIO 43139 USD71061.1    
 J4N41_09585   Vibrio sp. SCSIO 43139 USD68650.1    
 J4N45_24355   Vibrio sp. SCSIO 43140 USD62499.1    
 J4N38_07965   Vibrio sp. SCSIO 43145 USD47039.1    
 J4N38_09970   Vibrio sp. SCSIO 43145 USD44571.1    
 J8Z27_09585   Vibrio sp. SCSIO 43186 USD31527.1    
 J8Z27_07580   Vibrio sp. SCSIO 43186 USD33937.1    
 GGC03_05470 (AbfB)   Vibrio sp. THAF191c QGN69270.1    
 GGC03_08100 (Hlya1)   Vibrio sp. THAF191c QGN69791.1    
 GGC04_05470 (AbfB)   Vibrio sp. THAF191d QGM33767.1    
 GGC04_08095 (Hlya1)   Vibrio sp. THAF191d QGM34289.1    
 FIU99_05460 (AbfB)   Vibrio sp. THAF64 QFT35867.1    
 FIU99_08080 (Hlya1)   Vibrio sp. THAF64 QFT36388.1    
 β-agarase (AgaV)   Vibrio sp. V134 ABL06969.1 A1E2B6  
 Vspart_02162 (AbnA)   Vibrio spartinae 3.6 QMV14887.1    
 Vspart_01099 (Lip1_1)   Vibrio spartinae 3.6 QMV13854.1    
 Vspart_00218 (AbfB)   Vibrio spartinae 3.6 QMV13013.1    
 Vspart_04163   Vibrio spartinae 3.6 QMV16758.1    
 VthA   Vibrio tubiashii RE22 ACD87448.1    
 VthA   Vibrio tubiashii X00-12-1(RE98) ACM44932.1    
 cytolysin (partial)   Vibrio vulnificus ACI29376.1    
 hemolysin A, partial (VvhA) (fragment)   Vibrio vulnificus AXG22348.1    
 PVE41_22730   Vibrio vulnificus 1908-10 WHE23828.1    
 H6S61_16275   Vibrio vulnificus 2497-87 QNE03288.1    
 cytotoxin, partial (VvhA) (fragment)   Vibrio vulnificus 628-7 AEI83799.1    
 VV93_v1c39010   Vibrio vulnificus 93U204 AIL72957.1    
 cytotoxin, partial (VvhA) (fragment)   Vibrio vulnificus ATCC 27562 AEI83835.1    
 AL549_05135   Vibrio vulnificus ATL 6-1306 AMG10720.1    
 hemolysin/cytolysin (VvhA)   Vibrio vulnificus CDC B3547 BAC99984.1    
 VVCECT4999_19815   Vibrio vulnificus CECT 4999 ASJ40904.1    
 cytolysin (VvhA) (fragment)   Vibrio vulnificus CIP 75.4T ATCC 27562 AAM97564.1    
 hemolysin/cytolysin β-trefoil lectin (VV20404)   Vibrio vulnificus CMCP6 AAO07360.2
AAO07360.1
NP_762370.1		   4OWJ[A,B,C,D,E,F,G]
4OWK[A,B,C,D,E,F,G]
4OWL[A,B,C,D,E,F,G]
 E2I22_22900   Vibrio vulnificus CMCP6 QBN16941.1    
 cytolysin (VvhA) (fragment)   Vibrio vulnificus CNRVC 970121 AAM97566.1    
 BJD94_15020   Vibrio vulnificus Env1 AVX01199.1    
 FOB71_03515   Vibrio vulnificus FDAARGOS_663 QET74083.1    
 hemolysin/cytolysin A (VvhA)   Vibrio vulnificus FJ03-X2 AGL46605.1    
 FORC9_3806   Vibrio vulnificus FORC_009 ALM73323.1    
 FORC16_3801   Vibrio vulnificus FORC_016 ANH65684.1    
 FORC17_3853   Vibrio vulnificus FORC_017 ANN28916.1    
 FORC36_3773   Vibrio vulnificus FORC_036 ARN68290.1    
 FORC37_3714   Vibrio vulnificus FORC_037 ASC59408.1    
 FORC54_3902   Vibrio vulnificus FORC_054 AUL98047.1    
 FORC77_3619   Vibrio vulnificus FORC_077 QBH29342.1    
 RI132_18175   Vibrio vulnificus GCU-01 WNJ73073.1    
 cytolysin (VvhA) (fragment)   Vibrio vulnificus IF VV10 IFREMER AAM97569.1    
 cytolysin (VvhA) (fragment)   Vibrio vulnificus IF VV11 IFREMER AAM97570.1    
 cytolysin (VvhA) (fragment)   Vibrio vulnificus IF VV18 IFREMER AAM97567.1    
 cytolysin (VvhA) (fragment)   Vibrio vulnificus IF VV24 IFREMER AAM97568.1    
 hemolysin/cytolysin (VvhA)   Vibrio vulnificus L-180 BAC99982.1    
 cytolysin, partial (VvhA)   Vibrio vulnificus MO6 AMH86056.1    
 VVM_01835   Vibrio vulnificus MO6-24/O ADV88903.1    
 AOT11_04970   Vibrio vulnificus NBRC 15645 = ATCC 27562 ASM98807.1    
 AABD45_19340   Vibrio vulnificus Per1 WYZ03239.1    
 cytolysin, partial (VvhA) (fragment)   Vibrio vulnificus SAP027 WGT83872.1    
 cytolysin (VvhA) (fragment)   Vibrio vulnificus VV1 AGS13677.1    
 F6X00_20065   Vibrio vulnificus Vv180806 QMV38693.1    
 VV208B2_29030   Vibrio vulnificus VV20-8B-2 BDP31823.1    
 BWZ32_19695   Vibrio vulnificus VV2014DJH AUJ37047.1    
 QPX65_18195   Vibrio vulnificus VV2018 WIL77004.1    
 VVA0965   Vibrio vulnificus YJ016 BAC96991.1
NP_937021.1		    
 pectin lyase   Vibrio ziniensis QOT69934.1    
 G5S32_16340   Vibrio ziniensis ZWAL4003 QIH43562.1    
 NF212_18970   Vibrionaceae bacterium SE-01 WWE61469.1    
 H9Q79_17380   Wansuia hejianensis NSJ-29 QNM08600.1    
 H9Q79_17380   Wansuia hejianensis NSJ-29 QNM08600.1    
 LJE71_08965   Xanthobacter autotrophicus GJ10 UDQ91104.1    
 Xaut_1731   Xanthobacter autotrophicus Py2 ABS66976.1    
 EZH22_20890 (fragment)   Xanthobacter dioxanivorans YN2 QRG05509.1    
 D7006_21030   Xanthobacter sp. YC-JY1 UJX46943.1    
 X12_001332   Xanthomonas arboricola isolate Xanthomonas sp. CPBF 122 CAD2245012.1    
 X12_001332   Xanthomonas arboricola isolate Xanthomonas sp. CPBF 122 CAD2245012.1    
 JH280_21070   Xanthomonas campestris 5053 WDI93666.1    
 JH280_21070   Xanthomonas campestris 5053 WDI93666.1    
 R5577_15210   Xanthomonas euvesicatoria T0319-01 WOP55593.1    
 R5577_15210   Xanthomonas euvesicatoria T0319-01 WOP55593.1    
 R5576_06245   Xanthomonas euvesicatoria XpT32 WOP53497.1    
 R5576_06245   Xanthomonas euvesicatoria XpT32 WOP53497.1    
 R2B60_15150   Xanthomonas euvesicatoria XpT39 WOP47083.1    
 R2B60_15150   Xanthomonas euvesicatoria XpT39 WOP47083.1    
 PG878_04400   Xanthomonas sp. A6251 WNH45713.1    
 PG878_04400   Xanthomonas sp. A6251 WNH45713.1    
 OEG85_17075 (fragment)   Xanthomonas hortorum Oregano 108 WAH63190.1    
 OEG85_17075 (fragment)   Xanthomonas hortorum Oregano 108 WAH63190.1    
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