Auxiliary Activity Family 10

Activities in FamilyAA10 (formerly CBM33) proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); some proteins have been shown to act on chitin, others on cellulose;
Mechanism monooxygenase
NoteAA10 (formerly CBM33). The enzymes in this family were originally classified as chitin-binding proteins (CBM33); Vaaje-Kolstad et al. have shown that these proteins are in fact oxidative enzymes [PMID - 20929773]. They are now reclassified in the AA category of CAZy. Because a significant literature is associated with the old name CBM33, we recommend to describe these enzymes as "AA10 (formerly CBM33)".
Statistics GenBank accession (3130); Uniprot accession (385); PDB accession (32); 3D entries (16); cryst (0)
All (2989) Archaea (2) Bacteria (2838) Eukaryota (7) Viruses (140) unclassified (2) Structure (16) Characterized (19)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 lytic chitin monooxygenase (ChbB;BaAA10A;BaCBM33;Rbam17540;BAMF_1859) 1.-.-.- Bacillus amyloliquefaciens DSM 7 CBI42985.1 E1UUV3
2YOW[A,B] 1.80
2YOX[A,B] 1.90
2YOY[A,B] 1.70
5IJU[A,B] 1.70
 chitin-active lytic monooxygenase (Lpmo10A;BtLPMO10A) 1.-.-.- Bacillus thuringiensis serovar kurstaki ACCC 10066 AJP62637.1  
5WSZ[A,B,C,D] 2.57
 BURPS1710b_0114 (BpAA10A)   Burkholderia pseudomallei 1710b ABA49030.1 Q3JY22
3UAM[A,B,C,D,E,F] 2.00
 lytic chitin monooxygenase (CjLPMO10A;CJA_2191) (Cbp33A=Lpmo10A) 1.-.-.- Cellvibrio japonicus Ueda107 ACE83992.1 B3PJ79
5FJQ[A,B,C] 1.85
 chitin oxidative-cleaving enzyme (EfAA10A;EF0362;EfCBM33A;EfaCBM33) 1.-.-.- Enterococcus faecalis V583 AAO80225.1
NP_814154.1
Q838S1
4A02[A] 0.95
4ALC[A] 1.49
4ALE[A] 1.48
4ALQ[A,A] 1.48
4ALR[A] 1.49
4ALS[A] 1.47
4ALT[A] 1.49
 lytic chitin monooxygenase / chitinase (Jden_1381)(JdLPMO10A) (LPMO10A) 1.-.-.- Jonesia denitrificans DSM 20603 ACV09037.1 C7R4I0
5AA7[A,B] 1.55
5VG0[A,B] 1.10
5VG1[A,B] 2.10
 LMRG_01781   Listeria monocytogenes 10403S AEO07443.1  
5L2V[A,B] 1.10
 lytic chitin monooxygenase (C1-specific) / chitin-binding protein (Cbp21;CBP21;Cbp;SmAA10A;SmLPMO10A) 1.-.-.- Serratia marcescens BJL200 AAU88202.1 O83009
2BEM[A,B,C] 1.55
2BEN[A,B] 1.8
2LHS[A] NMR
 lytic cellulose monooxygenase (C1/C4-oxidizer) (ScLPMO10B;SCO0643;SCF91.03c) 1.-.-.- Streptomyces coelicolor A3(2) CAB61160.1
NP_624952.1
Q9RJC1
4OY6[A] 1.29
4OY8[A] 1.40
 lytic cellulose monooxygenase (C1-specific) (CelS2;ScLPMO10C;ScAA10C;SCO1188;SCG11A.19) 1.-.-.- Streptomyces coelicolor A3(2) CAB61600.1
AHA82091.1
NP_625478.1
Q9RJY2
4OY7[A,B,C,D,E,F,G,H] 1.50
 chitin-active lytic monooxygenase (SliLPMO10E / SLI_3182 1.-.-.- Streptomyces lividans 1326 EOY47895.1  
5FTZ[A] 1.38
 lytic cellulose monooxygenase (C1/C4-oxidizer) (Tfu_1268;E7;TfLPMO10A) 1.-.-.- Thermobifida fusca YX AAZ55306.1 Q47QG3
4GBO[A,B] 2.00
 lytic chitin monooxygenase / N-acetylglucosamine-binding protein A (GbpA;VcGbpA;VcAA10B;VCA0811) 1.-.-.- Vibrio cholerae O1 biovar El Tor str. N16961 AAF96709.1
ABW34704.1
NP_233197.1
Q9KLD5
2XWX[A,B] 1.80
Viruses
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 fusolin (ACV034) 1.-.-.- Anomala cuprea entomopoxvirus CV6M BAA25629.1
BAO49394.1
 
4YN1[A] 1.90
 fusolin (partial)   unidentified entomopoxvirus    
4YN2[A] 2.02
 fusolin   unidentified entomopoxvirus / Melolontha melolontha entomopoxvirus (MMEV) CAA54706.1
ABE23214.1
Q83389
4OW5[A] 1.90
4X27[A] 2.40
4X29[A] 2.41
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