Auxiliary Activity Family 10

Activities in FamilyAA10 (formerly CBM33) proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); some proteins have been shown to act on chitin, others on cellulose; lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54); lytic cellulose monooxygenase (C4-dehydrogenating)(EC 1.14.99.56); lytic chitin monooxygenase (EC 1.14.99.53); lytic xylan monooxygenase / xylan oxidase (glycosidic bond-cleaving) (EC 1.14.99.-)
Mechanism monooxygenase
NoteAA10 (formerly CBM33). The enzymes in this family were originally classified as chitin-binding proteins (CBM33); Vaaje-Kolstad et al. have shown that these proteins are in fact oxidative enzymes [PMID - 20929773]. They are now reclassified in the AA category of CAZy. Because a significant literature is associated with the old name CBM33, we recommend to describe these enzymes as "AA10 (formerly CBM33)".
Statistics GenBank accession (7794); Uniprot accession (36); PDB accession (40); 3D entries (23); cryst (0)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 lytic chitin monooxygenase (ChbB;BaAA10A;BaCBM33;Rbam17540;BAMF_1859) 1.14.99.53   Bacillus amyloliquefaciens DSM 7 = ATCC 23350 CBI42985.1 E1UUV3 2YOW[A,B]
2YOX[A,B]
2YOY[A,B]
5IJU[A,B]
 lytic chitin monooxygenase (C1-specific) / chitin binding protein (ChbB;Cbp;BliCBP;BlAA10A;BLi00521;BL00145) 1.14.99.53   Bacillus licheniformis DSM 13 = ATCC 14580 AAU39477.1
AAU22121.1
ACW83017.1
D0EW67
Q62YN7
Q65N87
6TWE[A]
 chitin-active lytic monooxygenase (Lpmo10A;BtLPMO10A) 1.14.99.53   Bacillus thuringiensis serovar kurstaki ACCC 10066 AJP62637.1 A0A0C5K362
A0A0F6FRT6
5WSZ[A,B,C,D]
 lytic cellulose monooxygenase (C1/C4-hydroxylating) (CfiLPMO10;Celf_0270) 1.14.99.54
1.14.99.56
  Cellulomonas fimi ATCC 484 AEE44415.1 F4H6A3  
 lytic cellulose monooxygenase (C1-hydroxylating) (CflaLPMO10A;Cfla_0175) 1.14.99.54   Cellulomonas flavigena DSM 20109 ADG73094.1 D5UGB1  
 lytic cellulose monooxygenase (C1/C4-hydroxylating) (CflaLPMO10B;Cfla_0172) 1.14.99.54
1.14.99.56
  Cellulomonas flavigena DSM 20109 ADG73091.1 D5UGA8  
 lytic cellulose monooxygenase (C1/C4-hydroxylating) (CflaLPMO10C;Cfla_0316) 1.14.99.54
1.14.99.56
  Cellulomonas flavigena DSM 20109 ADG73234.1 D5UH31  
 lytic chitin monooxygenase (CjLPMO10A;CJA_2191) (CjLPMO10A) 1.14.99.53   Cellvibrio japonicus Ueda107 ACE83992.1 B3PJ79 5FJQ[A,B,C]
  lytic cellulose monooxygenase (C1-hydroxylating) 10B (CjLPMO10B;CJA_3139) (CjLPMO10B) 1.14.99.54   Cellvibrio japonicus Ueda107 ACE84760.1 B3PDT6  
 chitin oxidative-cleaving enzyme (EfAA10A;EF0362;EfCBM33A;EfaCBM33) 1.14.99.53   Enterococcus faecalis V583 AAO80225.1
NP_814154.1
Q838S1 4A02[A]
4ALC[A]
4ALE[A]
4ALQ[A]
4ALR[A]
4ALS[A]
4ALT[A]
 lytic cellulose monooxygenase (C1-hydroxylating) (HcAA10-2;HCH_00807) 1.14.99.54   Hahella chejuensis KCTC 2396 ABC27701.1 Q2SNS3  
 lytic chitin monooxygenase C1-hydroxylating / chitinase (Jden_1381)(JdLPMO10A) (LPMO10A) 1.14.99.53 pubmed
Jonesia denitrificans DSM 20603 ACV09037.1 C7R4I0 5AA7[A,B]
5VG0[A,B]
5VG1[A,B]
 lytic chitin monooxygenase / GlcNAc binding protein A (GbpA;LmLPMO10;Lmo2467) 1.14.99.53   Listeria monocytogenes EGD-e CAD00545.1
NP_465990.1
Q8Y4H4  
 lytic chitin monooxygenase (CbpL;plu2352) 1.14.99.53   Photorhabdus laumondii subsp. laumondii TTO1 CAE14645.1
NP_929598.1
Q7N4I5 6T5Z[A,B,C]
 lytic chitin monooxygenase (C1-specific) / chitin-binding protein (Cbp21;CBP21;Cbp;SmAA10A;SmLPMO10A) 1.14.99.53   Serratia marcescens BJL200 AAU88202.1 O83009 2BEM[A,B,C]
2BEN[A,B]
2LHS[A]
 22kDa protein 1.14.99.53 pubmed
Serratia marcescens KCTC2172 AAC37123.1    
 lytic chitin monooxygenase (SAML0570; SamLPMO10B) (SamLPMO10B) 1.14.99.53   Streptomyces ambofaciens ATCC 23877 CAJ89556.1 A3KIM2  
 lytic cellulose monooxygenase (C1-hydroxylating) (SAML1174) (SamLPMO10C) 1.14.99.54   Streptomyces ambofaciens ATCC 23877 CAJ90160.1 A3KKC4  
 lytic cellulose monooxygenase (C1-hydroxylating/C4-dehydrogenating) (ScLPMO10B;SCO0643;SCF91.03c) 1.14.99.54
1.14.99.56
  Streptomyces coelicolor A3(2) CAB61160.1
NP_624952.1
Q9RJC1 4OY6[A]
4OY8[A]
 lytic cellulose monooxygenase (C1-hydroxylating) (CelS2;ScLPMO10C;ScAA10C;SCO1188;SCG11A.19) 1.14.99.54   Streptomyces coelicolor A3(2) CAB61600.1
AHA82091.1
NP_625478.1
Q9RJY2
V5N5H9
4OY7[A,B,C,D,E,F,G,H]
 lytic chitin monooxygenase (SGR_199;SgLPMO10A) 1.14.99.53   Streptomyces griseus subsp. griseus NBRC 13350 BAG17028.1 B1VNK5  
 lytic chitin monooxygenase (SGR_6855;SgLPMO10F) 1.14.99.53   Streptomyces griseus subsp. griseus NBRC 13350 BAG23684.1 B1VN59  
 chitin-active lytic monooxygenase (SliLPMO10E / SLI_3182 1.14.99.53   Streptomyces lividans 1326 EOY47895.1 A0A7U9DRA2
D6EWM4
5FTZ[A]
 lytic polysaccharide monooxygenase (Sfla_0248) 1.14.99.53
1.14.99.-
1.14.99.54
1.14.99.56
  Streptomyces pratensis ATCC 33331 ADW01716.1 C9N838 6NDQ[A,B]
 TtAA10A (TERTU_0046) 1.14.99.54
1.14.99.56
pubmed
pubmed
Teredinibacter turnerae T7901 ACR14100.1 C5BKQ9 6RW7[A]
 lytic cellulose monooxygenase (C1-hydroxylating/C'-dehydrogenating) (Tfu_1268;E7;TfLPMO10A) 1.14.99.54
1.14.99.56
  Thermobifida fusca YX AAZ55306.1 Q47QG3 B[nd]
4GBO[A,B]
5UIZ[A]
 lytic cellulose monooxygenase (C1-hydroxylating) (E8;TfAA10B;Tfu_1665) 1.14.99.54   Thermobifida fusca YX AAZ55700.1 Q47PB9  
 lytic chitin monooxygenase / N-acetylglucosamine-binding protein A (GbpA;VcGbpA;VcAA10B;VCA0811) 1.14.99.53   Vibrio cholerae O1 biovar El Tor str. N16961 AAF96709.1
ABW34704.1
NP_233197.1
A9Y370
Q9KLD5
2XWX[A,B]
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 lytic chitin monooxygenase 1.14.99.53 pubmed
Tectaria macrodonta AFR32946.1 W5QLL4 6IF7[A]
Viruses
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 fusolin (ACV034) 1.14.99.53   Anomala cuprea entomopoxvirus CV6M BAA25629.1
BAO49394.1
O70709 4YN1[A]
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