Auxiliary Activity Family 10

Activities in FamilyAA10 (formerly CBM33) proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); some proteins have been shown to act on chitin, others on cellulose;
Mechanism monooxygenase
NoteAA10 (formerly CBM33). The enzymes in this family were originally classified as chitin-binding proteins (CBM33); Vaaje-Kolstad et al. have shown that these proteins are in fact oxidative enzymes [PMID - 20929773]. They are now reclassified in the AA category of CAZy. Because a significant literature is associated with the old name CBM33, we recommend to describe these enzymes as "AA10 (formerly CBM33)".
Statistics GenBank accession (3130); Uniprot accession (385); PDB accession (32); 3D entries (16); cryst (0)
All (2989) Archaea (2) Bacteria (2838) Eukaryota (7) Viruses (140) unclassified (2) Structure (16) Characterized (19)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 lytic chitin monooxygenase (ChbB;BaAA10A;BaCBM33;Rbam17540;BAMF_1859) 1.-.-.- Bacillus amyloliquefaciens DSM 7 CBI42985.1 E1UUV3 2YOW[A,B]
2YOX[A,B]
2YOY[A,B]
5IJU[A,B]
 lytic chitin monooxygenase (C1-specific) / chitin binding protein (ChbB;Cbp;BliCBP;BlAA10A;BLi00521;BL00145) 1.-.-.- Bacillus licheniformis DSM 13 = ATCC 14580 AAU39477.1
AAU22121.1
ACW83017.1
Q62YN7
Q65N87
 
 chitin-active lytic monooxygenase (Lpmo10A;BtLPMO10A) 1.-.-.- Bacillus thuringiensis serovar kurstaki ACCC 10066 AJP62637.1   5WSZ[A,B,C,D]
 β-1,4-mannanase (ManA) 3.2.1.78 Caldibacillus cellulovorans AAF22274.1 Q9RFX5  
 lytic chitin monooxygenase (CjLPMO10A;CJA_2191) (Cbp33A=Lpmo10A) 1.-.-.- Cellvibrio japonicus Ueda107 ACE83992.1 B3PJ79 5FJQ[A,B,C]
 lytic cellulose monooxygenase 10B (C1-specific) (CjLPMO10B;CJA_3139) (cbp33/10B=Lpmo10B) 1.-.-.- Cellvibrio japonicus Ueda107 ACE84760.1 B3PDT6  
 chitin oxidative-cleaving enzyme (EfAA10A;EF0362;EfCBM33A;EfaCBM33) 1.-.-.- Enterococcus faecalis V583 AAO80225.1
NP_814154.1
Q838S1 4A02[A]
4ALC[A]
4ALE[A]
4ALQ[A,A]
4ALR[A]
4ALS[A]
4ALT[A]
 lytic cellulose monooxygenase (HcAA10-2;HCH_00807) 1.-.-.- Hahella chejuensis KCTC 2396 ABC27701.1 Q2SNS3  
 lytic chitin monooxygenase / chitinase (Jden_1381)(JdLPMO10A) (LPMO10A) 1.-.-.- Jonesia denitrificans DSM 20603 ACV09037.1 C7R4I0 5AA7[A,B]
5VG0[A,B]
5VG1[A,B]
 lytic chitin monooxygenase / GlcNAc binding protein A (GbpA;LmLPMO10;Lmo2467) 1.-.-.- Listeria monocytogenes EGD-e CAD00545.1
NP_465990.1
Q8Y4H4  
 lytic chitin monooxygenase (C1-specific) / chitin-binding protein (Cbp21;CBP21;Cbp;SmAA10A;SmLPMO10A) 1.-.-.- Serratia marcescens BJL200 AAU88202.1 O83009 2BEM[A,B,C]
2BEN[A,B]
2LHS[A]
 lytic cellulose monooxygenase (C1/C4-oxidizer) (ScLPMO10B;SCO0643;SCF91.03c) 1.-.-.- Streptomyces coelicolor A3(2) CAB61160.1
NP_624952.1
Q9RJC1 4OY6[A]
4OY8[A]
 lytic cellulose monooxygenase (C1-specific) (CelS2;ScLPMO10C;ScAA10C;SCO1188;SCG11A.19) 1.-.-.- Streptomyces coelicolor A3(2) CAB61600.1
AHA82091.1
NP_625478.1
Q9RJY2 4OY7[A,B,C,D,E,F,G,H]
 lytic chitin monooxygenase (SGR_6855;SgLPMO10F) 1.-.-.- Streptomyces griseus subsp. griseus NBRC 13350 BAG23684.1 B1VN59  
 chitin-active lytic monooxygenase (SliLPMO10E / SLI_3182 1.-.-.- Streptomyces lividans 1326 EOY47895.1   5FTZ[A]
 lytic cellulose monooxygenase (C1/C4-oxidizer) (Tfu_1268;E7;TfLPMO10A) 1.-.-.- Thermobifida fusca YX AAZ55306.1 Q47QG3 4GBO[A,B]
 lytic cellulose monooxygenase (C1-specific) (E8;TfAA10B;Tfu_1665) 1.-.-.- Thermobifida fusca YX AAZ55700.1 Q47PB9  
 lytic chitin monooxygenase / N-acetylglucosamine-binding protein A (GbpA;VcGbpA;VcAA10B;VCA0811) 1.-.-.- Vibrio cholerae O1 biovar El Tor str. N16961 AAF96709.1
ABW34704.1
NP_233197.1
Q9KLD5 2XWX[A,B]
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 fusolin (ACV034) 1.-.-.- Anomala cuprea entomopoxvirus CV6M BAA25629.1
BAO49394.1
  4YN1[A]
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