Mechanism	b-elimination
3D Structure Status	β-jelly roll
External resources	CAZypedia;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (4236); Uniprot accession (59); PDB accession (57); 3D entries (17); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
poly(α-L-guluronate) lyase / G-specific alginate lyase (alyPG; ALY-1)	4.2.2.11	Corynebacterium sp. ALY-1	BAA83339.1 ACK10589.1	Q9RB42	1UAI[A] 1.20	3
alginate lyase (AlgAT5)	4.2.2.11	Defluviitalea phaphyphila	WP_058486006.1		5ZQI[A] 1.50	3
alginate lyase (AlyA; FlAlyA)	4.2.2.3	Flavobacterium sp. UMI-01	BAP05660.1	A0A068PC91	5Y33[A] 1.54 8JSD[A] 1.41 8JT4[A] 1.45
poly(α-L-guluronate) lyase (AlyA)	4.2.2.11	Klebsiella pneumoniae subsp. aerogenes	AAA25049.1 ACK10577.1	Q59478	4OZX[A] 1.88	5
alginate lyase (AlyMc)	4.2.2.-	Microbulbifer sp. Q7	WP_227718076.1		8WOK[A,B] 2.10	5
alginate lyase (AlyQ)	4.2.2.3	Persicobacter sp. CCB-QB2	WP_053404615.1	A0A3B6UEP6	5XNR[A] 2.30	3
poly-MG alginate lyase (PA1167)	4.2.2.- 4.2.2.-	Pseudomonas aeruginosa PAO1	AAG04556.1 NP_249858.1	Q9I4H0	1VAV[A,B] 2.00	1
alginate lyase (AlyC3)	4.2.2.3	Psychromonas sp.		A0A7M4DUG8 A0A7M4DUG9	7C8F[B] β-D-ManpA-(1-4)-β-D-ManpA 1.46 7C8G[A,B] 2.10 7C8F[A] β-D-ManpA-(1-4)-β-D-ManpA 1.46
broad-specificity alginate lyase (A1-II'; Aly)	4.2.2.3 4.2.2.11	Sphingomonas sp. A1	BAD16656.1	Q75WP3	2CWS[A] 1.00 2Z42[A] 1.60 2ZA9[A] 2.10 2ZAA[A] β-D-4-deoxy-ManpA-(1-4)-α-L-GulpA-(1-4)-β-D-ManpA-(1-4)-α-L-GulpA 1.80 2ZAB[A] β-D-4-deoxy-ManpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA 1.66 2ZAC[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-α-L-GulpA 1.50
alginate lyase V (AlyV; VpAly-V; LZI70_13340)	4.2.2.3	Vibrio pelagius WXL662	UTT84646.1 USW90871.1		7W16[A] β-D-ManpA-(1-4)-β-D-ManpA 1.90
alginate lyase (AlyB; VsAlyB)	4.2.2.3 4.2.2.11	Vibrio splendidus OU02			7W12[A] α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA 2.25 5ZU5[A] 1.60	5
exo-alginate lyase (AlyA5;zobellia_4131)	4.2.2.26 4.2.2.26	Zobellia galactanivorans DsijT	CAZ98266.1	G0L2Y1	4BE3[A,B] 1.75	5
endo-guluronate lyase (AlyA1;zobellia_1182)	4.2.2.11	Zobellia galactanivorans DsijT	CAZ95239.1	G0LAE1	3ZPY[A,B] 1.43	3
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
alginate lyase (PsAlg7A)	4.2.2.3	Paradendryphiella salina	VFY81779.1	A0A485PVH1	6YWF[A] 1.90 7NCZ[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.64 7NL3[A] 1.70 7NM6[A] β-D-ManpA-(1-4)-β-D-ManpA 1.78 7NPP[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.45 7NY3[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.82 7O6H[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.66 7OOF[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.30 7ORY[A] α-L-4-deoxy-AllpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.46 7P25[A] β-D-4-deoxy-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.47 7P90[A] β-D-4-deoxy-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.87 7PBF[A] β-D-ManpA-(1-4)-α-D-ManpA 1.54
alginate lyase (PsAlg7C)	4.2.2.- 4.2.2.-	Paradendryphiella salina	CAD6594633.1	A0A7I9C8Z1	8BJO[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.51 8BJR[A] 1.10 8BXZ[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.20 8BZK[A] 1.45 8C0M[A] 1.20 8C3X[A] 0.82 8P6O[A] β-D-ManpA-(1-4)-α-D-ManpA β-D-ManpA-(1-4)-β-D-ManpA 1.05 8PC3[A] β-D-ManpA-(1-4)-α-L-GulpA-(1-4)-β-D-ManpA β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-α-D-ManpA 1.10 8PC8[A] β-D-ManpA-(1-4)-α-L-GulpA-(1-4)-β-D-ManpA β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-α-D-ManpA 1.24 8PCX[A] β-D-ManpA-(1-4)-α-L-GulpA-(1-4)-β-D-ManpA β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-α-D-ManpA 1.14 8PDT[A] β-D-ManpA-(1-4)-α-D-ManpA β-D-ManpA-(1-4)-α-L-GulpA 1.09 8PED[A] β-D-ManpA-(1-4)-α-L-GulpA-(1-4)-β-D-ManpA β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-α-D-ManpA 1.10 8QIZ[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-α-L-GulpA-(1-4)-β-D-ManpA 1.13 8QLI[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.12 8QMJ[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-α-D-ManpA 0.98 8R43[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-α-D-ManpA 0.87 8RBI[A] 0.98 8RBN[A] β-D-4-deoxy-ManpA-(1-4)-β-D-ManpA β-D-ManpA-(1-4)-α-D-ManpA-(1-4)-β-D-ManpA 2.10 8RBR[A] 1.80
alginate lyase (Aly; PyAly)	4.2.2.3	Pyropia yezoensis	BAI66416.1 BAI66417.1	D2KX85	7W13[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.65 7W18[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 1.70
endo-β-1,4-glucuronan lyase (TpPL7A; A9Z42_0012760)	4.2.2.14	Trichoderma parareesei	OTA00986.1	A0A2H2ZFD4	7NDE[A] 1.45	4
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