Polysaccharide Lyase Family 24

Mechanism b-elimination
3D Structure Status7-bladed β-propeller
NoteFamily created after Kopel et al. (2016) J. Biol. Chem., 291, 5871-5878 [PMID=26763234]. Ulvan lyases cleave the bond between 3-sulfated rhamnose (Rha3S) linked to either D-glucuronic acid (GlcA) or L-iduronic acid (IduA) in the marine polysaccharide ulvan. Members of this family are known to specifically cleave the b(1,4) glycosidic bond between GlcUA and R3S residues by b-elimination.
External resourcesCAZypedia;
Statistics GenBank accession (80); Uniprot accession (6); PDB accession (6); 3D entries (2); cryst (0)
Activity IdEC#Activity NameResidue -2Bond -1Residue -1 Reacting BondResidue +1Bond +1Residue +2Reactant
L389 4.2.2.- b-D-glucuronate ulvan lyase bDGlcpA 1,4 aLRhap_3S 1,4 bDGlcpA 1,4 aLRhap_3S
L390 4.2.2.- a-L-iduronate ulvan lyase aLIdopA 1,4 aLRhap_3S 1,4 aLIdopA 1,4 aLRhap_3S
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