| Activities in Family | α-mannosyltransferase (EC 2.4.1.-); Glucuronyl-galactosyl-proteoglycan 4-α-N-acetylglucosaminyltransferase (EC 2.4.1.223); Glucuronosyl-N-acetylglucosaminyl-proteoglycan α-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.224); |
|---|---|
| Mechanism | Retaining |
| 3D Structure Status | GT-A |
| Note | The long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs have a single domain. |
| External resources | Glymap; |
| Statistics | GenBank accession (1094); Uniprot accession (31); PDB accession (20); 3D entries (4); cryst (0) |
| Eukaryota | ||||||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | ||||
| GlcA-IPC α-mannosyltransferase (AtGMT1; Epc1; AtEPC1; F27K19_10; At3g55830) | 2.4.1.- | pubmed |
Arabidopsis thaliana | CAB87837.1 AEE79446.1 AHL38727.1 BAF00425.1 NP_191142.1 |
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| β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (exostosin-2) (Ext2) | 2.4.1.224 | Bos taurus | AAC35386.1 AAI26571.1 NP_803462.1 |
A0JN91 O77783 |
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| β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (Ext1) | 2.4.1.224 | Cricetulus griseus | AAF71276.1 | Q9JK82 | ||||||
| heparan sulfate α-1,4-N-acetylglucosaminyltransferase-I/II (CG15110;Dext3;botv) | 2.4.1.224 | Drosophila melanogaster | AAD34749.1 AAF57601.1 BAB89399.1 NP_523790.1 |
Q9XZ08 | ||||||
| UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2) | 2.4.1.224 | Homo sapiens | AAB07008.1 AAB62718.1 AAC50764.1 AAC51219.1 AAH10058.1 AAH68545.1 NP_000392.1 |
B2R5Z6 Q6NUL1 Q93063 |
7SCH[B] 7SCJ[B] 7SCK[B] 7UQX[B] 7UQY[B] 7ZAY[B] |
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| UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-1;Ext1) | 2.4.1.224 | Homo sapiens | AAB62283.1 AAH01174.1 ACS08204.1 AGV77097.1 AHB20150.1 BAG35949.1 NP_000118.1 |
B2R7V2 Q16394 |
7SCH[A] 7SCJ[A] 7SCK[A] 7UQX[A] 7UQY[A] 7ZAY[A] |
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| exostosin-like 3 (Extl3;Extr1) | 2.4.1.223 | Homo sapiens | AAC39598.1 AAB67602.1 AAD01877.1 AAD42041.1 AAH06363.1 AAP36017.1 AAW12588.1 AAW12594.1 ACW32787.1 ADO22448.1 BAA24080.1 BAA25445.2 BAA25445.3 BAG57702.1 NP_001431.1 |
A0A384NPY9 D3DST8 O43909 Q53XT3 |
7AU2[A,B] 7AUA[A,B] 8OG1[A] 8OG4[A,B] |
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| exostosin-like 1 (Extl1) | 2.4.1.224 | Homo sapiens | AAC51141.1 AAD02840.1 AAF73172.1 AAH65528.1 AAW12597.1 CAI17130.1 NP_004446.1 |
Q92935 | ||||||
| UDP-GlcNAc: α-1,4-N-acetylglucosaminyltransferase (Exotosin-like 2) (Extl2;EXTL2;Extr2) | 2.4.1.223 | Homo sapiens | AAC02898.1 AAH14910.1 AAH36015.1 AAH45681.1 AAR61360.1 AAW12598.1 BAA24081.1 BAC04893.1 BAG60404.1 NP_001430.1 |
B2R795 B4DNZ2 D3DT60 Q05DH5 Q49A43 Q8IYF4 Q8N8F1 Q9UBQ6 |
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| α-1,4-N-acetylglucosaminyltransferase-I/II / exostosin-like 3 (Extl3) | 2.4.1.224 | Mus musculus | AAD42040.1 AAH65073.1 AAW12587.1 BAE23506.1 NP_061258.2 |
Q3UUW7 Q6P1H4 Q9WVL6 |
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| UDP-GlcNAc: α-1,4-N-acetylglucosaminyltransferase (Extl2) | 2.4.1.223 | Mus musculus | AAG17542.1 AAH31438.1 AAH94444.1 BAB31683.2 BAC26062.1 BAC27649.1 BAE34959.1 BAE36615.1 BAM48568.1 BAM48569.1 NP_067363.1 |
K0J1C6 Q3TSR0 Q3TXF7 Q8C089 Q8C197 Q9ES89 |
1OMX[A,B] 1OMZ[A,B] 1ON6[A,B] 1ON8[A,B] |
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