| Activities in Family | UDP-Gal: β-1,3-galactan β-1,6-galactosyltransferase (EC 2.4.1.-); UDP-Gal: β-1,6-galactan β-1,6-galactosyltransferase (EC 2.4.1.-); CMP-NeuAc: α-2,8-polysialyltransferase (EC 2.4.3.-); [inverting] CMP-β-KDO: α-3-deoxy-D-manno-octulosonic-acid (KDO) transferase (EC 2.4.3.-); Sialyltransferase (EC 2.4.3.-); CMP-NeuAc: β-galactoside α-2,6-sialyltransferase (EC 2.4.3.1); CMP-Neu5Ac: α-N-acetylgalactoside α-2,6-sialyltransferase (EC 2.4.3.3); CMP-Neu5Ac: β-galactoside α-2,3-sialyltransferase (EC 2.4.3.4); CMP-Neu5Ac: N-acetyllactoside α-2,3-sialyltransferase (EC 2.4.3.6); α-N-acetylneuraminyl-2,3-β-galactosyl-1,3-N-acetylgalactoside α-2,6-sialyltransferase (EC 2.4.3.7); CMP-Neu5Ac : α-N-acetylneuraminate α-2,8-sialyltransferase (EC 2.4.3.8); Lactosylceramide α-2,3-sialyltransferase (EC 2.4.3.9); Transferring other glycosyl groups (EC 2.4.99.-); |
|---|---|
| Mechanism | Inverting |
| Note | These enzymes use CMP-beta-N-acetylneuraminate as the sugar donor |
| External resources | CFG(Core1); CFG(Glycosphingolipid); CFG(N-linked); CFG(Terminal); Glymap; |
| Statistics | GenBank accession (3110); Uniprot accession (183); PDB accession (16); 3D entries (6); cryst (0) |
| Eukaryota | ||||||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | ||||
| UDP-Gal: β-1,3-galactan/β-1,6-galactan β-1,6-galactosyltransferase (AtGALT29A; At1g08280) (AtGALT29A) | 2.4.1.- 2.4.1.- |
Arabidopsis thaliana | AAF18241.1 AAO42829.1 AEE28269.1 AHL38960.1 BAE99537.1 NP_172305.1 |
A0A178WDI2 Q84W00 Q9SGD2 |
||||||
| CMP-KDO: rhamnogalacturonan-II KDO-transferase (AtRCKT1; MGD2; At1g08660) | 2.4.3.- | pubmed |
Arabidopsis thaliana | AAL36042.1 AAF99778.1 AAM70516.1 AEE28328.1 AEE28329.1 AHL38959.1 ANM57712.1 NP_172342.1 NP_850940.1 |
||||||
| CMP α-2,6-sialyltransferase (ST6Gal I) | 2.4.3.1 | Bos taurus | CAA75385.1 AAI12481.1 NP_803483.1 |
O18974 Q2KIW7 |
||||||
| α-2,8-sialyltransferase (SIAT8A) | 2.4.3.8 | Bos taurus | CAG27880.1 | Q6ZXD2 | ||||||
| CMP-NeuAc: β-galactoside α-2,3-sialyltransferase I/II (ST3Gal I/II;Siat4) | 2.4.3.4 | Ciona intestinalis | CAF25173.1 CAG28326.1 |
Q702S3 | ||||||
| α-2,8-polysialyltransferase IV (ST8Sia IV;PST1;PST-1;SiaT8d) (St8Sia4) | 2.4.3.- | Cricetulus griseus | AAE28634.1 CAA86822.1 |
Q64690 | ||||||
| α-2,6-sialyltransferase (CG4871) ST6Gal I | 2.4.3.1 | Drosophila melanogaster | AAG13185.1 AAF47256.1 AAK92126.1 AAM70791.1 ABC86303.1 NP_523853.1 NP_726474.1 |
Q29QZ9 Q9GU23 Q9W121 |
||||||
| α-2,3-sialyltransferase I (ST3Gal I;St3Gal1;Siat4A) | 2.4.3.4 | Gallus gallus | CAA56666.1 NP_990548.1 |
Q11200 | ||||||
| α-2,6-sialyltransferase I (ST6GalNAcI;Siat7a) | 2.4.3.3 | Gallus gallus | CAA52902.1 AAE68028.1 AAE68029.1 NP_990571.1 |
Q92183 | ||||||
| α-2,6-sialyltransferase II (ST6GalNAcII;Siat7b) | 2.4.3.3 | Gallus gallus | CAA54813.1 AAE68030.1 NP_990564.1 |
Q92184 | ||||||
| α-2,6-sialyltransferase ST6Gal I | 2.4.3.1 | Gallus gallus | CAA53235.1 NP_990572.1 |
Q92182 | ||||||
| α-2,8-sialyltransferase / GD3 Synthase (ST8SiaI;Sial-T2) | 2.4.99.- | Gallus gallus | AAC28888.1 | P79783 | ||||||
| GM3 synthase (SIAT9) | 2.4.3.9 | Gallus gallus | AAS83519.1 AFN40451.1 CAG31234.1 |
I6WCK5 Q5ZM09 Q6R3Q5 |
||||||
| α-2,3-sialyltransferase I (ST3Gal I;Siat4A) | 2.4.3.4 | Homo sapiens | AAG29876.1 AAA36612.1 AAC17874.1 AAC37574.1 AAD39238.1 AAH18357.1 CAS91688.1 NP_003024.1 NP_775479.1 |
A0A024R9L6 Q11201 |
||||||
| α-2,3-sialyltransferase III (ST3Gal III;SiaT6) | 2.4.3.6 | Homo sapiens | CAF25177.1 AAA35778.1 AAH50380.1 AAO13859.1 AAO13861.1 AAO13862.1 AAO13863.1 AAO13864.1 AAO13866.1 AAO13867.1 AAO13869.1 AAO13870.1 AAO13871.1 AAO13872.1 AAO13874.1 AAO38807.1 AAO38808.1 AAO38809.1 AAO38810.1 AAO38811.1 ANZ79617.1 BAG63274.1 CAH71022.1 CAH71023.1 CAH71024.1 CAH71027.1 CAH71028.1 CAH71029.1 CAH71030.1 CAH71031.1 CAH71032.1 CAH71033.1 CAI16785.1 CAI16786.1 CAI16787.1 CAI16790.1 CAI16791.1 CAI16792.1 CAI16793.1 CAI16794.1 CAI16795.1 CAI16796.1 CAI22181.1 CAI22182.1 CAI22183.1 CAI22186.1 CAI22187.1 CAI22188.1 CAI22189.1 CAI22190.1 CAI22191.1 CAI22192.1 CAS91690.1 CAT03463.1 NP_006270.1 NP_777624.1 NP_777626.1 NP_777629.1 NP_777632.1 |
A0A1B2JLU4 D3DPX8 P61132 Q11203 Q11203 Q5T4X0 |
||||||
| α-2,3-sialyltransferase IV (ST3Gal IV;ST3GAL4;Siat4c;STZ) | 2.4.3.4 | Homo sapiens | AAH10645.1 AAA16460.1 AAC14162.1 AAK93790.1 AAM66431.1 AAM66432.1 AAM66433.1 AAM81378.1 ACM84702.1 BAB13940.1 BAF84266.1 BAG37279.1 CAA52662.1 CAE91353.1 CAG33139.1 CAS91691.1 NP_006269.1 |
Q11206 Q6IBE6 Q8N6A6 Q8N6A7 Q8NFD3 Q8NFG7 Q9HAA9 |
||||||
| α-2,3-sialyltransferase II (ST3Gal II;Siat4B;Siat5) | 2.4.3.4 | Homo sapiens | AAH36777.1 AAB40389.1 BAG35855.1 BAG54481.1 CAA65447.1 CAS91689.1 NP_008858.1 |
A0A024QZA4 B2R7K8 B3KXG9 Q16842 |
||||||
| α-2,3-sialyltransferase VI (ST3GalVI;St3Gal6;Siat10) (St3gal6) | 2.4.3.4 | Homo sapiens | AAD39131.1 AAH23312.1 BAA77609.1 BAG50993.1 CAE89895.1 CAF00161.1 CAS91693.1 NP_006091.1 |
B2RCH2 D3DN39 Q9Y274 |
||||||
| α-2,8-polysialyltransferase IV (ST8Sia IV;Siat8d;PST-1) | 2.4.3.- | Homo sapiens | AAH53657.1 AAC41775.1 AAH27866.1 ACM85043.1 BAF85561.1 CAN37586.1 CAS91698.1 NP_005659.1 |
A8KA07 Q8N1F4 Q92187 |
6AHZ[A] | |||||
| α-2,8-sialyltransferase I (ST8Sia I;Siat8a;SAT-II;GD3 synthase) | 2.4.3.8 | Homo sapiens | AAC37586.1 AAA62366.1 AAH31081.1 AAI17286.1 AAI26163.1 AAQ53140.1 ABN29101.1 ACM80809.1 ACM82503.1 BAA05391.1 BAF83630.1 BAG59776.1 CAA54891.1 CAS91695.1 NP_003025.1 |
A8K4H6 B4DM64 Q92185 |
||||||
| CMP-NeuAc: β-galactoside α-2,6-sialyltransferase I (ST6GAL1;ST6Gal I;Siat1;Siat-1;ST6N) | 2.4.3.1 | Homo sapiens | CAA01327.1 AAH31476.1 AAH40009.1 ACM80808.1 ACM85639.1 ACQ18409.1 BAF85568.1 BAG34960.1 CAA01686.1 CAA35111.1 CAA38246.1 CAA44634.1 CAS91678.1 NP_003023.1 NP_775323.1 |
A8KA14 D3DNV3 P15907 |
4JS1[A] 4JS2[A] 6QVS[A,B] 6QVT[A,B] |
|||||
| lactosylceramide α-2,3-sialyltransferase V (ST3Gal V;Siat9) | 2.4.3.9 | Homo sapiens | AAD14634.1 AAF66146.1 AAH65936.2 AAO16866.1 AAO16866.2 AAP65066.1 AAQ89463.1 AAY24147.1 ABI12336.1 ABX94074.1 ABX96367.1 ABX96677.1 ABY05141.1 ABY16080.1 ABY18877.1 ACC23222.1 ACE08868.1 ACG89779.1 ACK00075.1 ACM84564.1 ACM95185.1 ACP58739.1 ACP73940.1 ACP88674.1 ACS06566.1 ACW23933.1 ALQ33905.1 ALQ33906.1 BAA33950.1 BAG50894.1 CAE89320.1 CAJ44921.1 CAS91692.1 NP_003887.2 |
A0A0S2Z4Q7 A0A0S2Z4S6 B3KM82 Q9UNP4 |
||||||
| CMP-NeuAc:N-acetylgalactosaminide α-2,6-sialyltransferase II (ST6GalNAc II;Sia7b;SThM) | 2.4.3.3 | Homo sapiens | AAH40455.1 AAA52228.1 AAV38775.1 CAB61434.1 CAS91683.1 NP_006447.1 |
A0A024R8M1 Q9UJ37 |
6APJ[A,B,C,D,E,F] 6APL[A,B,C,D,E,F] |
|||||
| N-acetylgalactosaminide α-2,6-sialyltransferase IV (ST6GalNAcIV;Siat7d;Siat3c) (St6galnac4) | 2.4.3.7 | Homo sapiens | BAA87034.1 AAF00102.1 AAH36705.1 AAP63349.1 ACG89841.1 ACH33352.1 BAA91281.1 BAF84738.1 CAB44353.1 CAB44354.1 CAC07404.1 CAC24981.1 CAC27250.1 CAF14360.1 CAI12613.1 CAS91685.1 CAX11911.1 NP_055218.3 NP_778204.1 |
A0A024R881 A8K7N4 Q5T9D0 Q9H4F1 |
||||||
| N-acetylgalactosaminide α-2,6-sialyltransferase I (Siat7A;Sia7a;ST6GALNAC1;ST6GalNAc I) | 2.4.3.3 | Homo sapiens | CAA72179.2 AAH22462.1 AAM22800.1 AAQ89277.1 ABA13600.1 ABA33477.1 ABC03856.1 ABC04774.1 ABC15951.1 ABE24539.1 ABE25352.1 ABH65894.1 ABH72000.1 ABH72444.1 ABH72821.1 ABH75559.1 ABH83062.1 ABH93236.1 ABH98460.1 ABI01924.1 ABI02448.1 ABI11364.1 ABI12733.1 ABJ18775.1 ABJ30959.1 ABJ35147.1 ABJ39089.1 ABJ41693.1 ABL13582.1 ABN30350.1 ABX91728.1 ABX92004.1 ABX92280.1 ABX92556.1 ABX92832.1 ABX93266.1 ABX93773.1 ABX94507.1 ABX95514.1 ABX95790.1 ABX96066.1 ABY04288.1 ABY04564.1 ABY04840.1 ABY16532.1 ABY18024.1 ABY18300.1 ABY18576.1 ACC00203.1 ACC25401.1 ACC26418.1 ACC36990.1 ACE07635.1 ACE09473.1 ACE10685.1 ACG89184.1 ACJ96248.1 ACN02514.1 ACN06924.1 ACP58316.1 ACP73639.1 ACP89167.1 ACR89117.1 ACR89669.1 ACW28759.1 BAA90953.1 CAS91682.1 NP_060884.1 |
Q8TBJ6 Q9NSC7 |
||||||
| α-2,6-sialyltransferase 2 (ST6GAL2;ST6Gal II;KIAA1877) | 2.4.3.1 | Homo sapiens | BAB47506.1 AAH08680.1 AAY15022.1 BAB47506.2 BAC24793.1 CAD54408.1 CAE48260.1 CAE48261.1 CAS91680.1 NP_115917.1 |
D3DVK3 Q86Y44 Q96HE4 Q96JF0 |
||||||
| N-acetylgalactosaminide α-2,6-sialyltransferase III (ST6GalNAc III;Sia7c) | 2.4.3.7 | Homo sapiens | CAD45371.1 AAH59363.1 AAQ88904.1 ABA66708.1 ABI12351.1 ABX96382.1 ABX96692.1 ABY05156.1 ABY16095.1 ABY18892.1 ACC23237.1 ACC35997.1 ACC36307.1 ACE08883.1 ACH32638.1 ACK00090.1 ACM95200.1 ACP73955.1 ACS06581.1 ACW23948.1 BAC03611.1 BAG59810.1 CAK32360.1 CAS91684.1 NP_694541.1 |
B4DM98 Q8NDV1 Q8NDV1 |
||||||
| polysialyltransferase (ST8Sia IV) | 2.4.3.- | Mesocricetus auratus | CAB53396.1 | Q9QXF4 | ||||||
| Gal β-1,3/4-GlcNAc α-2,3-sialyltransferase (ST3Gal IV) | 2.4.3.6 | Mesocricetus auratus | CAB53395.1 | Q9QXF5 | ||||||
| Gal β-1,3/4-GlcNAc α-2,3-sialyltransferase (ST3Gal III) | 2.4.3.6 | Mesocricetus auratus | CAB53394.1 CAM14706.1 CAM14708.1 |
Q9QXF6 | ||||||
| α-2,3-sialyltransferase I (ST3GalI;Siat4A;Sait4;St3gal-1) (St3gal1) | 2.4.3.4 | Mus musculus | AAH84730.1 AAF60973.1 AAH99670.1 AAH99693.1 BAC27356.1 BAC37290.1 BAE23767.1 CAA51919.1 NP_033203.1 |
P54751 Q3UU61 Q544T4 Q8BJX5 Q9JL30 |
||||||
| α-2,3-sialyltransferase IV (ST3GalIV;Siat4c) (St3gal4) | 2.4.3.4 | Mus musculus | AAH50773.1 AAH11121.1 BAA06068.1 BAB25732.1 BAB47508.1 BAE20844.1 CAA65076.1 NP_033204.2 |
P97354 Q3V2F4 Q91Y74 Q921R5 Q9CVE8 |
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| α-2,3-sialyltransferase II (ST3GalII;Siat4b;Siat5) (St3gal2) | 2.4.3.4 | Mus musculus | AAH15264.1 AAH66064.1 BAC28752.1 BAC28859.1 BAC35543.1 BAE20742.1 BAE22346.1 CAA54294.1 NP_033205.1 NP_835149.1 |
Q11204 Q8BPL0 Q8BSA0 Q8BSE9 Q91WH6 |
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| α-2,8-sialyltransferase I / GD3 synthase (ST8SiaI;Siat8a;Siat8;GD3S) (St8sia1) | 2.4.3.8 | Mus musculus | AAH24821.1 AAA91869.1 ABK96807.1 BAC32625.1 BAC34994.1 BAE20627.1 CAA59014.1 NP_035504.1 |
A1E2I1 Q3V3B1 Q64468 Q64687 Q8BL76 Q8BWI0 Q8K1C1 |
||||||
| α-2,8-sialyltransferase IV (ST8SiaIV;SiaT8d;PST-1) (St8sia4) | 2.4.3.- | Mus musculus | CAA11685.1 AAH60112.1 BAB22941.1 BAC31044.1 CAA59992.1 CAA70692.1 NP_033209.1 |
Q53WR7 Q64692 Q6PAS1 Q8BY70 |
||||||
| α-2,6-sialyltransferase I (ST6GalI;Siat1) (St6gal1) | 2.4.3.1 | Mus musculus | BAA03680.1 AAE68031.1 AAH27833.1 AAH92222.1 AAH96026.1 BAC28828.1 BAC39120.1 NP_666045.1 |
Q64685 Q8BM62 Q8K1L1 |
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| α-2,8-sialyltransferase V (ST8SiaV;Siat8e) (St8sia5) | 2.4.3.8 | pubmed |
Mus musculus | CAA66642.1 AAH34855.1 BAC37354.1 BAE36964.1 CAA66643.1 CAA66644.1 NP_038694.1 NP_694764.1 NP_803135.1 |
P70126 Q3TRR3 Q8BJW0 Q8JZQ3 |
|||||
| N-acetylgalactosaminide α-2,6-sialyltransferase VI (ST6GalNAcVI;Siat7f) (St6galnac6) | 2.4.3.7 | Mus musculus | CAM16606.1 AAH22924.1 AAH36985.1 BAA87036.1 BAA95940.1 BAC27064.1 CAM16604.1 CAM16605.1 CAM16607.1 CAM16609.1 CAM16610.1 CAM16611.1 NP_058669.1 |
Q8JZW3 Q9JM95 Q9R0G9 |
||||||
| α-2,6-sialyltransferase I (ST6GalNAcI;Siat7a) (St6galnac1) | 2.4.3.3 | Mus musculus | CAA72137.1 AAI41096.1 AAI45374.1 AAI45375.1 CAM25276.1 CAM25277.1 NP_035501.1 |
B7ZNQ3 Q9QZ39 |
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| α-2,6-sialyltransferase II (ST6GalNAcII;Siat7b;Siat7) (St6galnac2) | 2.4.3.3 | Mus musculus | NP_033206.1 AAH10208.1 BAB00637.1 BAB23410.1 BAE22955.1 CAA63821.1 CAM20516.1 NP_033206.2 |
A2A7Y2 P70277 P70277 Q9JJM5 |
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| α-2,3-sialyltransferase VI (St3galVI;Siat10) (St3gal6) | 2.4.3.4 | Mus musculus | BAB79494.1 AAD39130.1 AAH52338.1 BAC28360.1 BAC30851.1 BAE36994.1 CAO78161.1 NP_061254.1 |
A6X951 Q8BLV1 Q8VIB3 Q8VIB3 |
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| α-2,3-sialyltransferase III (ST3GalIII;Siat6) (St3gal3) | 2.4.3.6 | Mus musculus C57BL/6J | BAB23779.1 AAH06710.1 BAB28598.1 BAE22980.1 CAA59013.1 CAM14710.1 CAM14711.1 CAM26719.1 CAM26720.1 CAM26721.1 CAM26722.1 CAM27381.1 CAM27383.1 CAM27384.1 NP_033202.2 |
P97325 Q3UWD5 Q922X5 Q9CZ48 Q9DBB6 |
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| α-2,6-sialyltransferase IV (ST6GalNAcIV;Siat7d) (St6galnac4) | 2.4.3.7 | Mus musculus ICR | CAB43514.1 AAH56451.1 AAH56451.2 AAH86784.1 BAC39523.1 BAE26116.1 BAE31668.1 BAE35308.1 BAE36463.1 CAA07446.1 CAB43507.1 CAB43508.1 CAB93946.1 CAB93948.1 CAM16603.1 NP_035503.1 |
Q3TT62 Q3U6Q6 Q3UMI2 Q8C3J2 Q9JHP2 Q9R2B6 |
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| α-2,3-sialyltransferase V / GM3 synthase (ST3GalV;St3GA;Siat9) (St3gal5) | 2.4.3.9 | Mus musculus ICR | CAA75235.1 AAF66147.1 AAP65063.1 BAA33491.1 BAA76467.1 BAB28571.1 BAE34763.1 BAE38355.1 CAA75236.1 CAJ44922.1 NP_035505.1 |
A0A0R4J1J3 B2RRS1 O88829 Q9CZ65 Q9QWF9 |
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| CMP-NeuAc: [asialofetuin] sialyltransferase (OsSTLP3;Os04g0506800) | 2.4.3.- | Oryza sativa Japonica Group | CAD41185.1 BAF15173.1 BAG92108.1 BAG96936.1 BAS89985.1 CAE04714.1 |
Q7FA29 | ||||||
| CMP-NeuAc: LacNac/glycoprotein sialyltransferase (OsSTLP1;Os01g0858900) | 2.4.3.- | Oryza sativa Japonica Group | BAB63715.1 BAB90552.1 BAF06777.1 BAS75321.1 NP_915574.1 |
Q94DD4 | ||||||
| β-galactosamide α-2,6-sialyltransferase I (ST6Gal I; Siat1) | 2.4.3.1 | Pan troglodytes | CAF29492.1 | Q701R5 | ||||||
| α-2,8-sialyltransferase 8A (Siat8A) | 2.4.3.8 | Pan troglodytes | CAG26896.1 | P61642 | ||||||
| α-2,3-sialyltransferase III (ST3GalIII;ST3N;Siat6) (St3gal3) | 2.4.3.6 | Rattus norvegicus | AAA42146.1 CAS91694.1 NP_113885.1 |
Q02734 | ||||||
| α-2,8-sialyltransferase 1 / GD3 synthase (ST8SiaI;Siat8a;Siat8) (St8sia1) | 2.4.3.8 | Rattus norvegicus | AAC27541.1 BAA08213.1 |
P70554 Q78EI9 |
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| β-galactoside α-2,6-sialyltransferase I (ST6GalI;ST6Gal1;Siat1) | 2.4.3.1 | Rattus norvegicus | AAA41196.1 AAB07233.1 NP_671738.1 |
F2Z3S3 P13721 |
4MPS[A,B] | |||||
| α-2,6-sialyltransferase II (ST3GalII;Siat5;Siat4c) (St3gal2) | 2.4.3.4 | Rattus norvegicus | CAA54293.1 NP_113883.1 |
A6IZ75 G3V8B2 Q11205 |
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| α-2,8-sialyltransferase (Siat8D;ST8Sia IV) | 2.4.3.- | Rattus norvegicus | AAB49989.1 CAL91579.1 |
A0A9K3Y707 A1KQY6 O08563 |
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| α-2,6-sialyltransferase IV (Siat7b;ST6GalNAc IV) | 2.4.3.7 | Sus scrofa | CAF05851.1 ACD10538.1 |
A0A4X1U3T7 B2ZCZ7 Q704X3 |
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| CMP-Neu5Ac: α-2,3-sialyltransferase (ST3Gal I) | 2.4.3.4 | Sus scrofa | AAA31125.1 | Q02745 | 2WML[A] 2WNB[A] 2WNF[A] |
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| CMP-NeuAc: β-galactoside α-2,3-sialyltransferase II (ST3Gal II;Siat5) (partial) | 2.4.3.4 | Takifugu rubripes | CAF25175.1 CAG29191.1 |
Q50J63 Q702S1 |
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| α-2,8-sialyltransferase (ST8Siα-I;Siat8A;GD3 synthase) | 2.4.3.8 | Xenopus laevis | CAG28695.1 AAQ16162.1 AAQ16163.1 ABK58605.1 |
Q6ZXA0 | ||||||
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