Glycoside Hydrolase Family 5 / Subf 25

Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) ₈ barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (581); Uniprot accession (19); PDB accession (24); 3D entries (6); cryst (0)

Summary

Download GH5_25 (567) Taxonomic display Structure (6) Characterized (17) Activities in Sub Family (3)

Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
bifunctional endo-β-1,4-glucanase / β-1,4-xylanase H (CelH;EgH;CtCelH;CtCel5E;Cthe_1472) (Lic26A;Cel5E)	3.2.1.4 3.2.1.8	pubmed pubmed	Acetivibrio thermocellus ATCC 27405	ABN52701.1 CCF82162.1	H6SHY4 P16218	4U3A[A,B] 4U5I[A,B] 4U5K[A,B] 5BYW[A,B,C,D,E]	25
endo-β-1,4-glucanase / β-1,3:1,4-glucanase H (CelH) (Lic26A;Cel5E)	3.2.1.4	pubmed	Acetivibrio thermocellus NCIB 10682	AAA23225.1	H6SHY4 P16218		25
cellulose endo-β-1,4-glucosidase (Caul_1283) (Cel5A)	3.2.1.4	pubmed	Caulobacter sp. K31	ABZ70413.1	B0SYT2		25
cellulose endo-β-1,4-glucosidase (CcsZ; CDIF28668_02723)	3.2.1.4	pubmed	Clostridioides difficile DSM 28668	AXU72614.1	A0A5Q9L120	6UJE[A] 6UJF[A]	25
cellulose endo-β-1,4-glucosidase (DICTH_0008) (Cel5A)	3.2.1.4	pubmed	Dictyoglomus thermophilum H-6-12	ACI18520.1	B5YAS2		25
endoglucanase (LC1; CelA; Dtur_0670) (Cel5B)	3.2.1.4	pubmed	Dictyoglomus turgidum DSM 6724	ACK41955.1	B8DZM2		25
endo-β-1,4-glucanase (FnCel5A;Fnod_1560) (Cel5A)	3.2.1.4	doi	Fervidobacterium nodosum Rt17-B1	ABS61403.1 ADD73709.1	A7HNC0 D4PEB3	3NCO[A,B] 3RJX[A] 3RJY[A]	25
endoglucanase (BcelFp; Ferpe_1841)	3.2.1.4	pubmed	Fervidobacterium pennivorans DSM 9078	AFG35892.1	H9UEE9	6KDD[A]	25
endo-β-1,4-glucanase (MtGlu5; Mtai_v1c27890)	3.2.1.4	pubmed	Meiothermus taiwanensis WR-220	AWR88013.1	A0A399DY85	7VT4[A,B] 7VT5[A] 7VT6[A] 7VT7[A] 7VT8[A]	25
endo-β-1,4-glucanase D (CelD;CelCCD;EGCCD;Ccel_0840) (Cel5D)	3.2.1.4	pubmed	Ruminiclostridium cellulolyticum H10	ACL75216.1 BAA14354.1 P25472.1	P25472		25
endoglucanase / β-mannanase (Tm_Cel5A; TmCel5A; TM1751) (Cel5A)	3.2.1.4 3.2.1.78	pubmed pubmed	Thermotoga maritima MSB8	AAD36816.1 AGL50683.1 AHD18355.1 AKE29506.1 NP_229549.1	Q9X273 R4P461	3AMC[A,B] 3AMD[A,B,C,D] 3AMG[A,B] 3AOF[A,B] 3AZR[A,B] 3AZS[A,B] 3AZT[A,B,C,D] 3MMU[A,B,C,D,E,F,G,H] 3MMW[A,B,C,D]	25
endo-β-1,4-glucanase (Cel; CelH; CelRH5)	3.2.1.4	pubmed	uncultured bacterium	QCI34346.1 QCI34340.1 VIO51607.1	A0A4D6Z3S6		25
endo-β-1,4-glucanase (UmCel5L) (Cel5A)	3.2.1.4	pubmed	uncultured bacterium	ABE60714.1	Q1PDD8		25
cellulase (C2P3)	3.2.1.4	pubmed	uncultured bacterium	BAO65808.1	X5IY83		25
endoglucanase (CellMM5.1;Cell5.1_3)	3.2.1.4	pubmed	uncultured bacterium	AID57617.1	A0A068F0I2		25
endoglucanase (EglDG) (fragment)	3.2.1.4	doi	uncultured Dictyoglomus sp.	ARO76321.1	A0A1W6S733		25
endoglucanase (Cel4; GC_Cel4)	3.2.1.4	pubmed	uncultured Dictyoglomus sp.	QRN45943.1	A0A891XJK4		25
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