Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (834); Uniprot accession (5); PDB accession (12); 3D entries (5); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
β-mannosidase active on Man-β-1,4-GlcNAc (BLD_0195)		Bifidobacterium longum DJO10A	ACD97641.1		6MOY[A,B] β-D-GlcpNAc 2.50 6MP2[A,B] 1.98 6MP7[A,B] β-D-GlcpNAc 1.75 6MPA[A,B] β-D-GlcpNAc 1.90 6MPC[A,B] 1.80	18
Blon_2377		Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	ACJ53432.1		7LQX[A] 1.30	18
β-1,4-mannosidase (BlGH5_18; HMPREF0175_1989)	3.2.1.25	Bifidobacterium longum subsp. longum ATCC 55813	EEI79871.1	C2GY91	7LR1[A,B,C,D] 1.80 7LR2[A,B,C,D] β-D-GlcpNAc 2.40 7LR6[A,B,C,D] β-D-Manp-(1-4)-β-D-GlcpNAc 2.30	18
exo-β-1,4-mannosidase (CaMan5_18; PAZ_c15370)	3.2.1.25	Cutibacterium acnes 266	AEE72695.1	A0A2B7I7A6	6GVB[A,B,C,D] 1.80	18
β-1,4-mannosidase (ScGH5_18; SCATT_p07120)	3.2.1.25	Streptantibioticus cattleyicolor NRRL 8057 = DSM 46488	AEW98905.1	F8JJ04	7LR7[A] β-D-GlcpNAc 1.95 7LR8[A,B] β-D-Manp-(1-4)-β-D-GlcpNAc 1.60	18
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