Mechanism	Retaining e
3D Structure Status	( β / α ) 7 barrel
Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton Donor	Glu
External resources	CAZypedia; PRINTS;
Statistics	GenBank accession (763); Uniprot accession (63); PDB accession (7); 3D entries (4); cryst (0)

Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
hyaluronidase (HYA;Api m 2;Apim2;LOC406146)	3.2.1.35	Apis mellifera	AAA27730.1 AAB45920.1 AAR78242.1 ABH87698.1 NP_001011619.1	Q08169	1FCQ[A] 1.60 1FCU[A] 2.10 1FCV[A] β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-α-D-GlcpNAc 2.65 2J88[A] 2.6
hyaluronidase (SPAM1) (sperm)	3.2.1.35	Homo sapiens	AAH26163.1 AAC16482.1 AAC60607.2 AAQ96882.1 AAX13985.1 AAX13986.1 AAX13987.1 AAX13988.1 AAY03322.1 ABJ38775.1 ACJ13740.1 ACM84481.1 BAF84918.1 CAA59086.1 NP_003108.2 NP_694859.1	P38567 Q5D1J4 Q8TC30	9JUB[A] 3.10
chondroitin sulfate hydrolase / hyaluronidase 1 (HYAL1;Hyal-1;LUCA1;LUCA-1)	3.2.1.35 3.2.1.-	Homo sapiens	AAD09137.2 AAB67046.1 AAC02730.1 AAD04190.1 AAD53277.1 AAE60457.1 AAE60459.1 AAH25774.1 AAH35695.1 AAM60770.1 AAM60771.1 AAM60772.1 AAM60773.1 AAM60774.1 ABJ38770.1 ABJ38772.1 ACK03148.1 ALQ33600.1 ALQ33601.1 BAF83505.1 BAG53447.1 CAC60225.1 CAG46731.1 NP_009296.1 NP_149349.2 NP_695013.1 NP_695014.1 NP_695015.1 NP_695016.1 NP_695017.1 NP_695018.1	A0A024R2X3 A0A0S2Z3Q0 A8K451 B3KUI5 Q12794 Q6FH23	2PE4[A] 2.00
hyaluronidase (Ves v 2 allergen)	3.2.1.35	Vespula vulgaris	AAB48073.1 AAR78244.1 ABH87700.1	P49370	2ATM[A] 2.00
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