Mechanism	Retaining e
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu
Catalytic Proton Donor	Glu
Note	formerly known as cellulase family J. Note that the stereochemistry of the reaction has recently been corrected : Kitago et al., J. Biol. Chem. 282(2007)35703-11 (PMID: 17905739)
External resources	CAZypedia;
Statistics	GenBank accession (503); Uniprot accession (15); PDB accession (14); 3D entries (4); cryst (0)

Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
broad substrate-specificity xyloglucanase J / processive endoglucanase (CelJ;Cthe_0624) (Cel9D/Cel9J+Cel44A)	3.2.1.151	pubmed	Acetivibrio thermocellus ATCC 27405	ABN51859.1	A3DD30
endoglucanase J (CelJ) (Cel9D-Cel44A)	3.2.1.4	pubmed	Acetivibrio thermocellus F1	BAA12070.1	A3DD30 P71140	2D8G[nd] 2E0P[A] 2E4T[A] 2EEX[A] 2EJ1[A] 2EO7[A] 2EQD[A]
bifunctional mannanase / endoglucanase (CelB; CbMan5A/Cel44A; Athe_1859; Cbes_1859; ORF1946) (Man5A-Cel44A)	3.2.1.4	pubmed	Caldicellulosiruptor bescii DSM 6725	ACM60947.1	B9MKT9
multifunctional glycoside hydrolase (Cmor_0545; OTK00_002181)	3.2.1.4 3.2.1.73		Caldicellulosiruptor morganii DSM 8990	WAM33659.1 WP_045168810.1
multifunctional glycoside hydrolase (Cmor_0943; OTK00_000772)	3.2.1.4	doi	Caldicellulosiruptor morganii DSM 8990	WAM34557.1 WP_045169127.1
bifunctional β-mannanase / endo-β-1,4-glucanase (ManA)	3.2.1.4	pubmed	Caldicellulosiruptor saccharolyticus	AAA71887.1	P22533
endoglucanase/xylanase (EG;CAC0915)	3.2.1.4 3.2.1.8	pubmed pubmed	Clostridium acetobutylicum ATCC 824	AAK78891.1 NP_347551.1	Q977Y3	3IK2[A]
endo-β-1,4-glucanase / endo-b1,4-xylosidase 44A (CelA2; GH44A; Cspa_c18620) (Xyn44A)	3.2.1.4 3.2.1.8	pubmed pubmed	Clostridium saccharoperbutylacetonicum N1-4(HMT)	AGF55632.1 WP_015391953.1	M1MVU0
endo-β-1,4-glucanase A (CelA)	3.2.1.4	pubmed	Paenibacillus lautus PL236	AAA22303.1 CAA01933.1	P29719
xyloglucanase / β-mannanase (Cel44C-Man26A)	3.2.1.4 3.2.1.151	pubmed pubmed	Paenibacillus polymyxa GS01	AAW12876.1 ABC88431.1 ACE10759.1	Q1A2D0	2YIH[A] 2YJQ[A,B] 2YKK[A] 3ZQ9[A]
xyloglucanase 44O (P99; Ccel_0429) (Cel44O)	3.2.1.151	pubmed	Ruminiclostridium cellulolyticum H10	ACL74812.1	B8I5Z5
xyloglucanase (GH44A;RUM_05910) (Xeg44A)	3.2.1.151	pubmed	Ruminococcus champanellensis 18P13 = JCM 17042	CBL16808.1	D4LB13
cellulase (EndB)	3.2.1.4	pubmed	Ruminococcus flavefaciens 17	CAC83072.1	Q934F9
xyloglucanase / endo-β-1,4-glucanase B (CelB)	3.2.1.4 3.2.1.151	pubmed pubmed	Ruminococcus flavefaciens FD-1	WP_009985075.1 AAA95959.1	Q52743
cellulose endo-β-1,4-glucosidase (CelM2)	3.2.1.4	pubmed	uncultured bacterium	ABL11223.1	A1E9A6	3FW6[A] 3II1[A]
cellulase (Lc-CelH)	3.2.1.4	pubmed	uncultured bacterium	AHL27901.1	W8PBJ3
unclassified
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
endoglucanase (MgCel44) (Cel44)	3.2.1.4	pubmed	uncultured microorganism	AGZ87466.1	U5YC86
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