| Mechanism | Retaining e |
|---|---|
| Clan | GH-E |
| 3D Structure Status | 6-fold β-propeller |
| Catalytic Nucleophile/Base | Tyr+Glu |
| Catalytic Proton Donor | Not known |
| External resources | CAZypedia; ProteinSpotlight; |
| Statistics | GenBank accession (140310); Uniprot accession (49); PDB accession (266); 3D entries (69); cryst (0) |
| Viruses | ||||||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | ||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
H3N2 subtype A/Tanzania/205/2010 H3N2 | K7N5N3 K7N5N8 |
4GZP[A] 4GZQ[A] 4GZS[A,B,C,D] 4GZT[A,B,C,D] 4GZW[A,B,C,D] 4GZX[A,B,C,D] 8G30[C,F,I,L] 8G3M[A,D,G,H] 8G3N[A,D,G,J] 8G3Q[A,B,C,D] 8G3R[A,B,E,F] 4GZO[A] |
|||||
| neuraminidase (A/Hunan/02650/2016 (H7N9)) | 3.2.1.18 | pubmed |
Influenza A virus | 6PZF[A,B] 6Q1Z[B] 6Q1Z[A] |
||||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus (A/American green-winged teal/Washington/195750/2014(H5N1)) | AJM70556.1 | A0A0C5BL75 | 5HUG[A] | ||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus (A/Bayern/62/2009(H1N1)) | ACT33096.1 | C3W6G3 C6KQL9 |
5NZ4[A,B] | ||||
| neuraminidase | 3.2.1.18 | pubmed |
Influenza A virus (A/Brevig Mission/1/1918(H1N1)) | AAF77036.1 | Q9IGQ6 | 3B7E[A,B] 3BEQ[A,B] 3CYE[A,B] 6D96[A,B,C,D,E,F,G,H] 6LXI[A,B] 8E6J[A,D,G,J] 8E6K[A,D,G,J] |
||||
| neuraminidase (pdmNA;NA) | 3.2.1.18 | pubmed |
Influenza A virus (A/California/04/2009(H1N1)) | ACP41107.1 ACP44158.1 AEE69012.1 AJI76397.1 |
A0A0C4ZKQ4 C3W5S3 C7FH46 F8UU09 |
3TI3[A,B] 3TI4[A,B] 3TI5[A,B] 3TI6[A,B] 4B7J[A] 4B7M[A,B] 4B7N[A] 4B7Q[A,B,C,D] 4B7R[A,B,C,D] |
||||
| neuraminidase | 3.2.1.18 | pubmed |
Influenza A virus (A/duck/Alberta/60/1976(H12N5)) | BAF43417.1 ACS94008.1 ACZ45127.1 AGB50974.1 |
A1ILL9 C6KJK4 |
3SAL[A,B] 3SAN[A,B] 3TI8[A,B] 7E6Q[A,B] |
||||
| neuraminidase | 3.2.1.18 | pubmed |
Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) | AAA16234.1 | Q07599 Q0A480 |
2HT5[A] 2HT7[A] 2HT8[A] 2HTQ[A] 2HTR[A] 2HTU[A] 3O9J[A] 3O9K[A] 4D8S[A] 4GB1[A] 4KS1[A] 4KS2[A] 4KS3[A] 4KS4[A] 4KS5[A] 4MJU[A] 4MJV[A] |
||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus (A/environment/Sichuan/NCLL1/2014(H5N6)) | AIK26474.1 | A0A0B4N5Z5 A0A0B4N5Z8 |
5HUM[A,B,C,D] | ||||
| neuraminidase (HumNA;NA) | 3.2.1.18 | pubmed |
Influenza A virus (A/Gansu/Chenguan/1129/2007(H1N1)) | ACF33772.1 | B5AYA6 | |||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus (A/gyrfalcon/Washington/41088-6/2014(H5N8)) | AJE30335.1 | A0A0C4WVM3 | 5HUN[A] | ||||
| neuraminidase | 3.2.1.18 | pubmed |
Influenza A virus (A/Japan/305/1957(H2N2)) | ABI84962.1 ACU79962.1 ACV49603.1 |
C7RWN0 Q0A2X0 Q1K9Q1 |
6Q20[A] | ||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus (A/Mexico/24049/2009(H1N1)) | AGR50232.1 | C3W6G3 S5MC84 |
5NZE[A,B] 5NZF[A,B,C,D] 5NZN[A,B,C,D] |
||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus (A/Mexico/24061/2009(H1N1)) | AGR50353.1 | D5KL82 S5N0T0 |
4QNP[A,B] | ||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus (A/Michigan/45/2015(H1N1)) | AMA11477.1 AMV49036.1 APB91428.1 APC60200.1 |
A0A0X9QTS2 A0A144YDY0 |
7S0I[A] | ||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus (A/Northern pintail/Washington/40964/2014(H5N2)) | AJE30346.1 | A0A0C4WXC5 | 5HUK[A,B,C,D] | ||||
| neuraminidase | 3.2.1.18 | pubmed |
Influenza A virus (A/RI/5+/1957(H2N2)) | ABF82433.1 ABF82434.1 ABF82435.1 |
Q194S9 Q194T0 Q194T1 |
3TIA[A,B,C,D] 3TIB[A,B,C,D] 3TIC[A,B,C,D] 4H52[A,B] 4H53[A,B,C,D] 4K1H[A,B] 4K1I[A,B] 4K1J[A,B] 4K1K[A,B] |
||||
| neuraminidase | 3.2.1.18 | pubmed |
Influenza A virus (A/swine/Missouri/2124514/2006(H2N3)) | ABY40430.1 | A9YN63 | 4HZV[A] 4HZW[A] 4HZX[A] 4HZY[A] 4HZZ[A] 4I00[A] |
||||
| neuraminidase | 3.2.1.18 | pubmed |
Influenza A virus (A/tern/Australia/G70C/1975(H11N9)) | AAA43353.1 | P03472 P05803 |
1A14[N] 1BJI[A] 1F8B[A] 1F8C[A] 1F8D[A] 1F8E[A] 1INY[A] 1L7F[A] 1L7G[A] 1L7H[A] 1MWE[A] 1NCA[N] 1NCB[N] 1NCC[N] 1NCD[A] 1NMA[A] 1NMB[A] 1NMC[A,N] 1NNA[A] 1NNB[A] 1NNC[A] 1XOE[A] 1XOG[A] 2C4A[A] 2C4L[A] 2QWA[A] 2QWB[A] 2QWC[A] 2QWD[A] 2QWE[A] 2QWF[A] 2QWG[A] 2QWH[A] 2QWI[A] 2QWJ[A] 2QWK[A] 3NN9[A] 3W09[A] 4DGR[A] 4NN9[A] 4WEG[A] 5NN9[A] 5W26[A] 5W2U[A] 5W2W[A] 5W2Y[A] 6CRD[A,B,C,D,E,F,G,H] 6D3B[A] 6HCX[A] 6HEB[A] 6MCX[A] 6NN9[A] 7NN9[A] |
||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus (A/Texas/17/2009(H1N1)) | ACS72690.1 | C3W6G3 C6KP13 |
6G01[A,B] 6G02[A,B] 6HP0[A,B,C,D] |
||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus (A/Texas/47/2009(H1N1)) | ACV67206.1 | C3W6G3 C9EKP8 |
5NWE[A,B,C,D] | ||||
| neuraminidase (NA) | 3.2.1.18 | Influenza A virus (A/Tokyo/3/1967(H2N2)) | AAB05621.1 AAO46245.1 |
P06820 | 1ING[A] 1INH[A] 1INW[A] 1INX[A] 1IVC[A] 1IVD[A] 1IVE[A] 1IVF[A] 1IVG[A] 1NN2[A] 2BAT[A] |
|||||
| neuraminidase | 3.2.1.18 | pubmed |
Influenza A virus (A/Victoria/3/1975(H3N2)) (X-47) | AAB03361.1 AFM71970.1 |
I6S5E0 P03482 |
|||||
| neuraminidase | 3.2.1.18 | pubmed |
Influenza A virus (A/Viet Nam/1203/2004(H5N1)) | AAT73329.1 AAW80723.1 ABP52008.1 ADD97097.1 |
Q6DPL2 | 2HTY[A,B,C,D,E,F,G,H] 2HU0[A,B,C,D,E,F,G,H] 2HU4[A,B,C,D,E,F,G,H] 3CKZ[A] 3CL2[A,B,C,D,E,F,G,H] |
||||
| neuraminidase | 3.2.1.18 | Influenza A virus (A/whale/Maine/1/1984(H13N9)) | AAA43575.1 | P05803 | 2B8H[A] | |||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus A/California/04/2009 | AYV61531.1 QEH91764.1 |
A0A2P1ADF9 C3W5S3 |
6Q23[A,B,C,D] | ||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus A/California/7/2009 | QFR38305.1 | A0A2P1ADF9 C7FH46 |
7U2Q[A,B,C,D] | ||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza A virus A/Michigan/45/2015 | QBL89780.1 | A0A2R4G8D7 C7FH46 |
7U2T[A,B,C,D] | ||||
| neuraminidase | 3.2.1.18 | pubmed |
Influenza B virus (B/BEIJING/1/87) | AAA43733.1 CAB71147.1 |
P27907 Q9IW64 |
1A4G[A,B] 1A4Q[A,B] 1NSB[A,B] 1NSC[A,B] 1NSD[A,B] |
||||
| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza B virus (B/Brisbane/60/2008) | ACN29379.1 ACN29381.1 ADN32819.1 AFH57913.1 |
C0LT34 | 4CPL[A,B] 4CPM[A,B] 4CPN[A,B] |
||||
| neuraminidase | 3.2.1.18 | pubmed |
Influenza B virus (B/Nashville/6/89) | AAA43739.1 AAD42327.2 |
P16199 Q9WPR0 |
|||||
| neuraminidase | 3.2.1.18 | pubmed |
Influenza B virus B/Lee/1940 | AAA43749.1 NP_056663.1 WHU32586.1 WHU32809.1 WHU32853.1 WHU32951.1 WHU33007.1 WHU33563.1 XHV15058.1 XHV15066.1 XHV15083.1 XHV15105.1 XHV15116.1 XHV15127.1 XHV15149.1 XHV15160.1 XHV15171.1 XHV15182.1 XHV15204.1 XHV15215.1 XHV15226.1 XHV15237.1 XHV15259.1 XHV15270.1 XHV15292.1 XHV15336.1 XHV15347.1 XHV15369.1 XHV15380.1 XHV15391.1 XHV15402.1 XHV15424.1 XHV15435.1 XHV15446.1 XHV15468.1 XHV15479.1 XHV15490.1 XHV15501.1 XHV15534.1 XHV15556.1 XHV15567.1 XKI53836.1 XKI53842.1 XKI53873.1 XKI53895.1 XKI53972.1 XKI53983.1 XKI54005.1 XKI54038.1 XKI54049.1 XKI54060.1 XKI54104.1 XKI54115.1 XKI54137.1 XKI54148.1 XKI54159.1 XKR67501.1 XKR72900.1 XKR72911.1 XKS39704.1 XKS39715.1 XLJ77037.1 XLV11691.1 XLV11700.1 XLV11711.1 XME60734.1 XME60743.1 XME60754.1 XME60765.1 XME66267.1 XME66275.1 XMR02419.1 XMR02508.1 XMR02510.1 XMR02514.1 XMR02518.1 XMR02520.1 XMR02524.1 XMR02526.1 XMR02530.1 XMR02532.1 XMR02536.1 XMR02538.1 XMR02540.1 XOI46006.1 XOI46116.1 XOI46127.1 XOI46138.1 XOI46160.1 XOI46182.1 XOI46193.1 XOI46259.1 XOI46281.1 XOI46303.1 XOI46380.1 XOI46402.1 XOI46413.1 XOI46424.1 XOI46457.1 XOI46468.1 XOI46479.1 XOT60959.1 XOT60981.1 XOT61014.1 XOT61025.1 XOT61036.1 XOT61047.1 XOT61069.1 XOT61080.1 XOT61091.1 XOT61113.1 XOT61157.1 XOT61190.1 XOT61201.1 XOT61267.1 XOT61278.1 XOT61311.1 XOT61333.1 XOT61344.1 XOT61355.1 XOT61377.1 XOT61432.1 XOT61443.1 XOT61454.1 XOT61476.1 XOT61509.1 XOT61542.1 XOT61553.1 XOT61597.1 XOT61608.1 XOT61619.1 XOT61652.1 XOT61674.1 XOT61707.1 XOT61718.1 XOT61729.1 XOT61740.1 XOT61762.1 XOT61773.1 XOT61784.1 XOT61795.1 XOT61806.1 XOT61850.1 XOT61861.1 XOT61905.1 XOT62026.1 XOT62037.1 XOT62048.1 XOT62059.1 XOT62103.1 XOT62114.1 XOT62147.1 XOT62169.1 XOT62180.1 XOT62202.1 XOT62213.1 XOT62224.1 XOT62235.1 XOT62246.1 XOT62257.1 XOT62268.1 XOT62279.1 XOT62312.1 XOT62345.1 XOT62356.1 XOT62367.1 XOT62389.1 XOT62411.1 XOT62422.1 XOT62433.1 XOT62466.1 XOT62510.1 XOT62532.1 XOT62554.1 XOT62598.1 XOT62620.1 XOT81564.1 XOT81575.1 XOT81597.1 XOT81608.1 XOT81652.1 XOT81685.1 XOT81696.1 XOT81707.1 XOT81718.1 XPB67480.1 XPB67502.1 XPB67513.1 XPB67524.1 XPB67557.1 XPB67568.1 XPB67579.1 XPB67590.1 XPB67601.1 XPB67623.1 XPB67689.1 XPB67700.1 XPB69540.1 XPB69551.1 XPK61618.1 XPK61628.1 XPK61638.1 XPK61649.1 XPK61677.1 XPK61681.1 XPK61696.1 XPK61708.1 XPK61722.1 XPK61733.1 XPK61744.1 XPK61755.1 XPK61795.1 XPK61861.1 XPK61877.1 XPK61892.1 XPK61903.1 XPK61964.1 XPK61975.1 XPK61986.1 XPK61997.1 XPK62019.1 XPK62074.1 XPK62096.1 XPO15062.1 XPO15103.1 XPO15114.1 XPO15145.1 XPO15152.1 XPO15161.1 XPO15256.1 XPO15274.1 XPO15285.1 XPO15875.1 XPO15886.1 XPO15894.1 XPO15913.1 XPO15942.1 XPO16000.1 XPO16011.1 XPO16022.1 XPO16055.1 XPO16082.1 XPO16090.1 XPO73115.1 XPO73159.1 XPO73180.1 XPO83148.1 XPO83159.1 XPO86654.1 XPO86687.1 XPO86697.1 XPO86707.1 XPO86732.1 XPO86761.1 XPO86780.1 XPO86791.1 XPO86802.1 XPO86813.1 XPO86877.1 XPO86891.1 XPY67184.1 XPY67194.1 XPY67205.1 XPY67216.1 XQH92237.1 XQH92246.1 XQH92251.1 XQH92299.1 XQH92332.1 XQH92354.1 XQH92365.1 XQH92376.1 XQH92387.1 XQH92398.1 XQH92486.1 XQH92552.1 XQH92607.1 XQH92629.1 XQH92640.1 XQH92673.1 XQH92695.1 XQH92717.1 XQH92728.1 XQH92750.1 XQH92761.1 XQH92772.1 XQH92805.1 XQH92827.1 XQH92871.1 XQH92882.1 XQH92904.1 XQH92926.1 XQH92948.1 XQH92970.1 XQH93014.1 XQH93047.1 XQH93080.1 XQH93091.1 XQH93146.1 XQH93168.1 XQH93179.1 XQH93234.1 XQH93267.1 XQH93300.1 XQH93388.1 XQH93421.1 XQH93443.1 XQH93487.1 XQH93509.1 XQH93932.1 XQH94030.1 XQH94052.1 XQH94063.1 XQH94085.1 XQH94107.1 XQH95655.1 XQH95665.1 XQH95703.1 XQH95733.1 XQH95809.1 XQH95825.1 XQH95844.1 XQH95887.1 XQH95918.1 XQH95957.1 XQH95983.1 XQH95994.1 XQH96071.1 XQH96082.1 XQH96126.1 XQH96159.1 XQH96214.1 XQH96247.1 XQH96258.1 XQH96291.1 XQH96302.1 XQH96335.1 XQH96379.1 XQH96390.1 XQH96445.1 XQH96467.1 XQH96500.1 XQH96522.1 XQH96544.1 XQH96588.1 XQH96610.1 XQH96687.1 XQH96852.1 XQH96863.1 XQH96885.1 XQH96907.1 XQH96973.1 XQH96995.1 XQH97006.1 XQH97050.1 XQH97072.1 XQH97138.1 XQH97160.1 XQH97171.1 XQH97193.1 XQH97270.1 XQH97292.1 XQH97325.1 XQH97347.1 XQH97380.1 XQH97435.1 XQJ32881.1 XQJ32892.1 XQJ32903.1 XQM66085.1 XQN12731.1 XQN12742.1 XQN12764.1 XQN12775.1 XQS35257.1 XQS35279.1 XQS35312.1 XQS35323.1 XQS35334.1 XRA29418.1 XRA29428.1 XRM23303.1 XRM23338.1 XRM23355.1 XRM23363.1 XRQ51630.1 XRQ51641.1 XRQ51703.1 XRQ51710.1 XRQ51718.1 XRQ51724.1 XRQ51748.1 XRQ51787.1 XRQ51810.1 XRQ51832.1 XRQ51865.1 XRQ51887.1 XRQ51920.1 XRQ51953.1 XRQ51964.1 XRQ51986.1 XRQ52062.1 XRQ52073.1 XRQ52095.1 XRQ52117.1 XRQ52128.1 XRQ52139.1 XRQ52150.1 XRQ52172.1 XRQ52183.1 XRQ52194.1 XRQ52216.1 XRQ52227.1 XRQ52238.1 XRQ52249.1 XRQ52271.1 XRQ52282.1 XRQ52315.1 XRQ52326.1 XRQ52337.1 XRQ52348.1 XRQ52370.1 XRQ52403.1 XRQ52414.1 XRQ52425.1 XRQ52458.1 XRQ52469.1 XRQ52524.1 XRQ52546.1 XRQ52568.1 XRQ52590.1 XRQ52612.1 XRQ52689.1 XRQ52711.1 XRT74570.1 XRT74581.1 XTP38677.1 XTP38688.1 XTR47945.1 XTR47949.1 XTZ52410.1 XTZ52421.1 XUB15699.1 XUB15818.1 XUB15854.1 XUB15967.1 XUB15980.1 XUB16040.1 XUB16055.1 XUB16078.1 XUB16745.1 XUB16869.1 XUB16916.1 XUB16960.1 XUB16994.1 XUB17006.1 XUB17216.1 XUB17258.1 XUB17274.1 XUB17290.1 XUB17391.1 XUB17413.1 XUB17486.1 XUM62126.1 XWX49368.1 XXH80454.1 XXH80459.1 XXH80504.1 XXH80619.1 XXH80704.1 XXH80746.1 XXH80772.1 |
P03474 | 1B9S[A] 1INF[A] 1INV[A] 1IVB[A] 1VCJ[A] |
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| neuraminidase (NA) | 3.2.1.18 | pubmed |
Influenza B virus B/Lyon/CHU/15.216/2011 | 4CPO[B] 4CPY[A,B] 4CPZ[A,B,C,D,E,F,G,H] 4CPO[A] |
||||||
| neuraminidase | 3.2.1.18 | pubmed |
Wuhan spiny eel influenza virus WHQSR4065 | AVM87625.1 | A0A2P1GNP4 | 7XVR[A,B] 7XVU[A,B] 7XVV[A,B] 7XVW[A,B] |
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