Mechanism	Retaining a
Clan	GH-D
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Asp
Catalytic Proton Donor	Asp
Note	Subfamily classification initiated by Arumapperuma et al. 2023 [PMID:36806678]
External resources	CAZypedia; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (3615); Uniprot accession (119); PDB accession (77); 3D entries (12); cryst (0)

Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
α-glucosidase with α-mannosidase activity (MalA;SsMalA;Sso1_0793)	3.2.1.20 3.2.1.24	Saccharolobus solfataricus 98/2	AAC38215.1 ACX91047.1 AET42970.1	D0KQM8 G8GCW5 O59645 P0CD66	2G3M[A,B,C,D,E,F] 2.55 2G3N[A,B,C,D,E,F] β-D-Glcp-(1-1)-ethyl 2.55	1
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
α-glucosidase (BT3299;BT_3299)	3.2.1.20	Bacteroides thetaiotaomicron VPI-5482	AAO78405.1 NP_812211.1	Q8A2K6	5DJW[A,B] 2.70	1
α-glucosidase / maltase-glucoamylase (Ro-aG1;RUMOBE_03919)	3.2.1.20	Blautia obeum ATCC 29174	ZP_01966167.1	A5ZY13	3FFJ[A,B] 1.94 3M46[A,B] 2.66 3M6D[A,B] 2.90 3MKK[A,B] α-D-Glcp-(1-6)-β-D-Glcp 1.91 3N04[A,B] 2.02 3NQQ[A,B] α-D-Glcp <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Manp 1.99 3NSX[A,B] 1.57 3NUK[A,B] 2.06 3NXM[A,B,C,D] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 2.17 3PHA[A,B,C,D] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 2.17 3POC[A,B] α-D-Glcp <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 1.99 6C9X[A,B] 1.46 6C9Z[A,B] 2.10 6CA1[A,B] <carb_like_MIG> 1.95 6CA3[A,B] <carb_like_MIG> 1.74	1
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
α-glucosidase (AgdL; AsojAgdL)	3.2.1.20	Aspergillus sojae NBRC 4239		A0A5N6DPG0 A0A5N6EXS6	7XOI[A,C,E,G,I,K,M,O,B,D, α-D-Glcp α-D-Glcp-(1-1)-α-D-Glcp 2.30	1
α-glucosidase (Agl;SBG)	3.2.1.20	Beta vulgaris	BAM74081.1 BAM72724.1	L0N1H0 L0N7E5	3W37[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 1.70 3W38[A] 2.79 3WEL[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 1.84 3WEM[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 2.59 3WEN[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 2.59 3WEO[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 1.45	1
α-glucosidase A (GAA) (lysosomal)	3.2.1.20	Homo sapiens	CAA68763.1 AAA52506.1 AAB33842.1 AAH40431.1 ABI53718.1 ACM80396.1 ACM84029.1 BAH13042.1 CAA38907.1 CAA68764.1 CAC12967.1 CAE85448.1 NP_000143.1 SJX48026.1	B7Z5V6 P10253 P10253 Q8IWE7	5KZW[A] α-D-Glcp-(1-6)-β-D-Glcp 2.00 5KZX[A] α-D-Glcp-(1-6)-β-D-Glcp 2.00 5NN3[A] 1.90 5NN4[A] 1.83 5NN5[A] <carb_like_NOJ> 2.00 5NN6[A] <carb_like_MIG> 2.00 5NN8[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 2.45 7P2Z[A,B] 7P32[A] 8CB1[B] 1.75 8CB6[B] 1.90	1
α-glucosidase II (GanAB;G2AN;KIAA0088 )	3.2.1.20 3.2.1.207	Homo sapiens	AAF66685.1 AAH17433.2 AAH17435.2 AAH65266.1 ACJ13667.1 BAA07642.1 BAG58624.1 BAG58692.1 BAG61688.1 BAG63965.1 CAA04006.1 SJX47948.1 XP_043268.1	B4DIW2 B4DJ30 B4DSM6 B4DZ53 Q14697 Q14697 V9HWJ0	8D43[A] 2.88 8EMR[A] 2.92	1
maltase-glucoamylase (MgaM; Mga; MGAML)	3.2.1.20	Homo sapiens	AAC39568.2 AAI20873.1 AAL83560.1 NP_004659.1	O43451 Q8TE24	3TON[A,B] 2.95 3TOP[A,B] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 2.88	1
maltase-glucoamylase (MgaM; Mga; MGAML)	3.2.1.20	Homo sapiens	AAC39568.2 AAI20873.1 AAL83560.1 AAP21875.1 NP_004659.1	O43451 Q86UM5 Q8TE24	2QLY[A] 2.00 2QMJ[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 1.90 3CTT[A] <carb_like_3CU> 2.10 3L4T[A] <carb_like_BJ1> 1.90 3L4U[A] <carb_like_DSK> 1.90 3L4V[A] <carb_like_KTL> 2.10 3L4W[A] <carb_like_MIG> 2.00 3L4X[A] <carb_like_NR3> 1.90 3L4Y[A] <carb_like_NR4> 1.80 3L4Z[A] <carb_like_SSD> 2.00	1
sucrase-isomaltase (SI)	3.2.1.10	Homo sapiens	AAT19036.1 AAA60551.1 AAI15035.1 AAI16453.1 AAI16454.1 AAI32835.1 AAI32861.1 AAT18166.1 ABH87017.1 ACM85129.1 ACP58672.1 CAA45140.1 NP_001032.1	P14410	3LPO[A,B,C,D] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-β-D-Manp-(1-4)-β-D-GlcpNAc-(1-4)-D-1-deoxy-GlcpNAc 3.20 3LPP[A,B,C,D] <carb_like_KTL> 2.15	1
α-glucosidase II (α-GluII;AB;GanAB;GANAB;G2an;Kiaa0088 )		Mus musculus	AAC53182.1 AAH94437.1 AAI17889.1 AAI17890.1 AAI28070.1 BAB30982.1 BAC27099.1 BAC38370.1 BAC65483.1 BAE29025.1 NP_032086.1		5F0E[A] 1.74 5H9O[A,C] α-D-Glcp 2.37 5HJO[A,C] α-D-2-deoxy-Glcp-(1-3)-D-1,2-deoxy-Glcp D-1,2-deoxy-Glcp 2.29 5HJR[A,C] β-D-Glcp5F-(1-4)-ASP 2.40 5IED[A] <carb_like_CTS> 1.81 5IEE[A] <carb_like_NOJ> 1.92 5IEF[A] <carb_like_NBV> 2.38 5IEG[A] 1.82 7JTY[A,C] 2.21 7K9N[A,C] 2.07 7K9O[A,C] 2.30 7K9Q[A,C] 2.30 7K9T[A,C] 2.10 7KAD[A,C] 2.51 7KB6[A,C] 2.20 7KB8[A,C] 2.39 7KBJ[C,G] 2.21 7KBR[C,G] 2.09 7KRY[A,C] 2.55 7L9E[C,G] 2.29	1
α-1,3-glucosidase II α-subunit (GIIa;CTHT_0064960)	3.2.1.84	Thermochaetoides thermophila DSM 1495	EGS17181.1	G0SG42	5DKX[A] 1.40 5DKY[A] <carb_like_NOJ> 1.60 5DKZ[A] α-D-Glcp-(1-3)-α-D-Glcp 2.40 5DL0[A] α-D-Glcp-(1-3)-α-D-Manp 2.30 5JQP[A] 2.20	1
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