Mechanism	Retaining e
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Asp (experimental);
Catalytic Proton Donor	Glu for hydrolases (experimental); histidine for phosphorylases (experimental)
Note	A recent paper by Macdonald et al. (PMID=25533455) has shown that some enzymes that cleave b-hexosaminides are in fact retaining b-glycoside phosphorylases.
External resources	CAZypedia; PROSITE;
Commercial Enzyme Provider(s)	PROZOMIX ;
Statistics	GenBank accession (79622); Uniprot accession (403); PDB accession (212); 3D entries (63); cryst (3)

Activity Id	EC#	Activity Name	Residue -2	Bond -1	Residue -1	Reacting Bond	Residue +1	Bond +1	Residue +2	Reactant
H5	3.2.1.6	MLG endo-b-1,3/4-glucosidase	bDGlcp	1,3/4	bDGlcp	1,3/4	bDGlcp	1,3/4	bDGlcp	H2O
H7	3.2.1.8	xylan endo-b-1,4-xylosidase	bDXylp	1,4	bDXylp	1,4	bDXylp	1,4	bDXylp	H2O
H15	3.2.1.21	b-glucosidase			[bDGlcp	1,X	alcohol			H2O
H17	3.2.1.23	b-galactosidase			[bDGalp	1,X	alcohol			H2O
H22	3.2.1.31	b-glucuronidase			[bDGlcpA	1,X	alcohol			H2O
H27	3.2.1.37	xylan exo-b-1,4-xylosidase			[bDXylp	1,4	bDXylp	1,4	bDXylp	H2O
H28	3.2.1.38	b-fucosidase			[bDFucp	1,X	alcohol			H2O
H32	3.2.1.45	ceramide b-glucosidase			[bDGlcp	1,X	ceramide			H2O
H38	3.2.1.52	b-N-acetylhexosaminidase			[bDGlcpNAc/bDGalpNAc	1,X	alcohol			H2O
H41	3.2.1.55	a-L-arabinofuranosidase			[aLAraf	1,X	alcohol			H2O
H43	3.2.1.58	glucan exo-b-1,3-glucosidase			[bDGlcp	1,3	bDGlcp	1,3	bDGlcp	H2O
H54	3.2.1.72	xylan exo-b-1,3-xylosidase			[bDXylp	1,3	bDXylp	1,3	bDXylp	H2O
H55	3.2.1.73	MLG endo-b-1,4-glucosidase	bDGlcp	1,3/4	bDGlcp	1,4	bDGlcp	1,3/4	bDGlcp	H2O
H56	3.2.1.74	cellulose exo-b-1,4-glucosidase			[bDGlcp	1,4	bDGlcp	1,4	bDGlcp	H2O
H74	3.2.1.97	protein O endo-a-N-acetylgalactosaminidase	[bDGalp	1,3	aDGalpNAc	1,X	Ser/Thr			H2O
H95	3.2.1.120	xyloglucan exo-b-1,4-glucosidase			[(aDXylp-1,6)bDGlcp	1,4	(aDXylp-1,6)bDGlcp	1,4	(aDXylp-1,6)bDGlcp	H2O
H100	3.2.1.126	coniferin b-glucosidase			[bDGlcp	1,X	coniferol			H2O
H106	3.2.1.132	chitosan endo-b-1,4-N-glucosaminase	bDGlcpN	1,4	bDGlcpN	1,4	bDGlcpN	1,4	bDGlcpN	H2O
H133	3.2.1.168	Flavonoid 6-O-a-L-rhamnosyl-b-glucosidase	[aLRhap	1,6	bDGlcp	1,X	flavonoid			H2O
H149	3.2.1.186	protodioscin 26-O-b-glucosidase			[bDGlcp	1,X	triterpenoid			H2O
H174	3.2.1.-	unsaturated-b-glucuronidase			[bDGlcpA_UNS	1,X	alcohol			H2O
H179	3.2.1.-	MLG exo-b-1,3/4-glucosidase			[bDGlcp	1,3/4	bDGlcp	1,3/4	bDGlcp	H2O
H189	3.2.1.-	avenacin b-1,2-glucosidase			[bDGlcp	1,2	aLArap	1,X	triterpenoid	H2O
H190	3.2.1.-	avenacin b-1,4-glucosidase			[bDGlcp	1,4	aLArap	1,X	triterpenoid	H2O
H198	3.2.1.-	a-L-arabinopyranosidase			[aLArap	1,X	alcohol			H2O
H206	3.2.1.-	xyloglucan exo-b-1,4-glucosidase			[bDGlcp	1,4	(aDXylp-1,6)bDGlcp	1,4	(aDXylp-1,6)bDGlcp	H2O
H208	3.2.1.-	glucan exo-b-1,2-glucosidase			[bDGlcp	1,2	bDGlcp	1,2	bDGlcp	H2O
H215	3.2.1.-	triterpenoid b-1,2-glucosidase			[bDGlcp	1,2	bDGlcp	1,X	triterpenoid	H2O
H232	3.2.1.-	steviol b-1,2-glucosidase			[bDGlcp	1,2	bDGlcp	1,X	steviol	H2O
H234	3.2.1.-	gentiobiose b-1,6-glucosidase			[bDGlcp	1,6	DGlcp]			H2O
H242	3.2.1.-	tomatin b-1,2-glucosidase			[bDGlcp	1,2	bDGlcp	1,4	bDGalp	H2O
H262	3.2.1.-	MLG exo-b-1,4-glucosidase			[bDGlcp	1,4	bDGlcp	1,3/4	bDGlcp	H2O
T296	2.4.1.-	b-glucoside phosphorylase			[bDGlcp	1,X	alcohol			ePi
T297	2.4.1.-	b-N-acteylglucosamine phosphorylase			[bDGlcpNAc	1,X	alcohol			ePi
H412	3.2.1.-	b-D-xylosidase			[bDXylp	1,X	alcohol			H2O
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