Mechanism	Inverting a
Clan	GH-N
3D Structure Status	parallel β-helix
Catalytic Nucleophile/Base	Asp
Catalytic Proton Donor	Asp
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (22469); Uniprot accession (211); PDB accession (25); 3D entries (20); cryst (3)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
polygalacturonase (PehA)	3.2.1.15	Agrobacterium vitis CG49	AAB51699.1	P77818	1ZFW[nd]
homogalacturonan specific α-galacturonidase / exo-polygalacturonase (BT4155;BT_4155)	3.2.1.67	Bacteroides thetaiotaomicron VPI-5482	AAO79260.1 NP_813066.1	Q8A066	5OLP[A,B] 2.00
PARMER_00599 (fragment)		Parabacteroides merdae ATCC 43184	EDN88021.1		4MXN[A,B,C,D] 1.95
polygalacturonase-2 (PehA)	3.2.1.15	Pectobacterium carotovorum SCC3193	CAA35998.1	P26509	1BHE[A] 1.90
exo-polygalacturonase (GalU; PelB; ExoPG; TM0437; TM_0437; Tmari_0434)	3.2.1.67	Thermotoga maritima MSB8	AAD35522.1 AGL49359.1 AHD17805.1 AKE28230.1 NP_228247.1	G4FE33 Q9WYR8	3JUR[A,B,C,D] 2.05
exo-polygalacturonosidase (PehX) (YeGH28)	3.2.1.82	Yersinia enterocolitica ATCC 9610D	AAC15064.1	O68975	2UVE[A,B] 2.19 2UVF[A,B] α-D-GalpA-(1-4)-α-D-GalpA 2.1
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
endo-polygalacturonase (ADPG2; At2g41850)	3.2.1.15	Arabidopsis thaliana	AAL84942.1 AAC02763.1 AAN60351.1 AEC10040.1	Q8RY29	7B8B[A,B] 2.03
endo-polygalacturonase (PGLR; At5g14650)	3.2.1.15	Arabidopsis thaliana	CAB87632.1 AED92058.1 ANM69799.1 NP_196969.1	A0A1P8BDY0 Q9LYJ5	7B7A[A] 1.30 8IKX[A] 1.50
polygalacturonase (Pga1)	3.2.1.15	Aspergillus aculeatus KSM 510	AAC23565.1	O74213	1IA5[A] 2.00 1IB4[A,B] 2.00
rhamnogalacturonase A (RhgA)	3.2.1.171	Aspergillus aculeatus KSM 510 / CBS 115.80	AAA64367.1 AAB35485.1 CAA58507.2 CAB58937.1 CAB58938.1	Q00001	1RMG[A] 2.00
endopolygalacturonase-1 / I (PgaI;PgaA;AnPGI)	3.2.1.15	Aspergillus niger CBS 120.49 / N400	CAA41693.1	P26213	1NHC[A,B,C,D,E,F] 1.70
endopolygalacturonase-2 / II (PgaII; PgaB; AnPGII)	3.2.1.15	Aspergillus niger CBS 120.49 / N400	CAA41694.1	P26214	1CZF[A,B] 1.68
xylogalacturonan hydrolase (XghA)	3.2.1.-	Aspergillus tubingensis	CAB65657.1 CAC07733.1	Q9UUZ2	4C2L[A] 1.75
endopolygalacturonase I (Pg1;endoPG I)	3.2.1.15	Chondrostereum purpureum	BAA08102.1 BAA96351.1	P79074	1K5C[A] 0.96 1KCC[A] β-D-GalpA 1.00 1KCD[A] β-D-GalfA β-D-GalpA 1.15
endopolygalacturonase (Pg1)	3.2.1.15	Colletotrichum lupini var. setosum (nom. inval.) SHK788	ABL01533.1	A1E266	2IQ7[A,B,C,D,E,F,G] 1.94
endo-polygalacturonase (TlpgA)		Evansstolkia leycettana JCM 12802	QKK82827.1		6KVE[A] 1.32 6KVH[A] 1.20 7E56[A] 1.40
polygalacturonase (PgA;PgI;FmPG)	3.2.1.15	Fusarium verticillioides FC-10	AAA74586.1	A0A8H5NAM9 Q07181	1HG8[A] 1.73 8IKW[B,F,G,H] 1.94
endopolygalacturonase (PPSX1;SX1)	3.2.1.15	Geotrichum klebahnii ATCC 42397	AAE82584.1		cryst
polygalacturonase (PSE3;SE3)	3.2.1.15	Geotrichum klebahnii B2	BAA20427.1 AAB46926.1	P87217	cryst
polygalacturonase 2	3.2.1.15	Solanum lycopersicum	AAB09575.1 AAC28904.1 CAX05861.1 CBD29102.1	Q96487	cryst
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