Mechanism	Inverting e
3D Structure Status	lysozyme fold
Note	Created after the work by Shimizu and collaborators. J. Biol. Chem. (2015). [ PMID:26385921 ]. Presents an inverting mechanism in what is a unique feature compared to all other b-mannanases [see Jin et al. ACS Cent. Sci (2016) doi:10.1021/acscentsci.6b00232 ]
External resources	CAZypedia;
Statistics	GenBank accession (128); Uniprot accession (9); PDB accession (9); 3D entries (2); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
β-1,4-mannanase (SsGH134)	3.2.1.78	Streptomyces sp. NRRL B-24484	WP_030268297.1	A0A1L1QK12 A0A1L1QK13 A0A1L1QK16	5JTS[A] 1.09 5JU9[A] β-D-Manp-(1-4)-β-D-Manp-(1-4)-α-D-Manp 1.18 5JUG[A] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp 0.96
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
endo-β-1,4-mannanase 134A (RmMan134A; RMCBS344292_04886) (Man134A)	3.2.1.78	Rhizopus microsporus	CEI90564.1	A0A0A1NDE2 A0A2U8ZTY7	5XTJ[A,B] 2.22 5XTT[A,B] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp 1.75 5XU5[A,B] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp 2.02 5XUG[A,B] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp 2.31 5XUL[A,B] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp 1.98 5XXA[A,B] 1.76
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