Glycoside Hydrolase Family 109

Mechanism	Other a,e
3D Structure Status	Rossmann fold
Catalytic Nucleophile/Base	Not applicable
Catalytic Proton Donor	None
Note	Created following Liu et al. (2007) Nature Biotechnol 25:454-64 (PMID: 17401360); the enzymes in this family display an unusual mechanism involving NAD+
External resources	CAZypedia;
Statistics	GenBank accession (2902); Uniprot accession (9); PDB accession (3); 3D entries (2); cryst (0)

Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
α-N-acetylgalactosaminidase (AmGH109B;Amuc_0017)	3.2.1.49	doi	Akkermansia muciniphila ATCC BAA-835	ACD03864.1 QTD80695.1	B2UL75
a/β-N-acetylgalactosaminidase (AmGH109A;Amuc_0920)	3.2.1.49 3.2.1.52	doi doi	Akkermansia muciniphila ATCC BAA-835	ACD04752.1 QTD81538.1	B2UQL7	6T2B[A,B,C,D]
N-acetylgalactosaminidase	3.2.1.49	pubmed	Arenibacter latericius KMM426	ADM26828.1	E1AXI3
[mucin] α-N-acetylgalactosaminidase (BT4243; BT_4243)	3.2.1.217	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO79348.1 NP_813154.1
α-N-acetylgalactosaminidase (NagA)	3.2.1.49	pubmed	Elizabethkingia meningoseptica ATCC 13253	CAJ01375.1	A2AWV6
α-N-acetylgalactosaminidase (NagA)	3.2.1.49	pubmed	Elizabethkingia meningoseptica ATCC 33958	CAJ01376.1	A4Q8F7	2IXA[A] 2IXB[A]
α-N-acetylgalactosaminidase (BvGH109_1)	3.2.1.49	pubmed	Phocaeicola vulgatus	WP_005848863.1	A0A0N7J713 I9J6R7
α-N-acetylgalactosaminidase (NagA)	3.2.1.49	pubmed	Shewanella oneidensis ATCC70050	CAJ01377.1	Q8ECL7
α-N-acetylgalactosaminidase	3.2.1.49	pubmed	Tannerella forsythia ATCC43037	CAJ01380.1	A4Q8G1
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