Carbohydrate-Binding Module Family 94

Activities in Family	N-Acetylglucosamine binding
Mechanism
Note	Created after Oka et al. 2022 [PMID=36106687] who demonstrated the N-Acetylglucosamine binding properties of the CBM94 module in two proteins of Homo sapiens and Bombyx mori. The CBM94 is the C-terminal domain of GnT-IV which is an N-acetylglucosaminyltransferase (GT54) involved in N-glycosylation. Modules of approx. 150 residues found at the C-terminus of the GT54 in eukaryotes. Involved in N-glycosylation by the binding of N-Acetylglucosamine.
External resources	CAZypedia;
Statistics	GenBank accession (596); Uniprot accession (12); PDB accession (4); 3D entries (3); cryst (0)

Eukaryota

Protein Name

EC#

Organism

GenBank

Uniprot

PDB/3D

Carbohydrate Ligands

Resolution (Å)

UDP-GlcNAc: α-1,3-D-mannoside β-1,4-N-acetylglucosaminyltransferase (GnT-IV; GlcNAcT-IV; Mgat4)

BDI24347.2
BDI24347.1
XP_028034380.1

7XTM[A,B]		1.47
7XTN[A,B]	β-D-GlcpNAc	1.15

UDP-GlcNAc: α-1,3-D-mannoside β-1,4-N-acetylglucosaminyltransferase 4A (GnT-IVa; GlcNAcT-IVa; Mgat4A)

Homo sapiens

BAA86388.1
AAI27108.1
AAI27109.1
AAY14976.1
BAF84222.1
BAG65228.1
NP_036346.1

1.97

α-1,3-mannoside β-1,4-N-acetylglucosaminyltransferase IVa (GnT-IVa; GlcNAcT-IVa; Mgat4a)

Mus musculus

BAC55018.1
BAC55085.1
BAE37301.1
NP_776295.1

1.95