Carbohydrate-Binding Module Family 47

Activities in Family	Modules of approx 150 residues. Fucose-binding activity demonstrated
Mechanism
3D Structure Status	β-sandwich
Note	Created from Boraston, Wang and Burke (2006) J. Biol. Chem., 281:35263-71 (PMID: 16987809)
External resources	CAZypedia;
Statistics	GenBank accession (1747); Uniprot accession (3); PDB accession (14); 3D entries (7); cryst (0)

Bacteria

Protein Name

EC#

Organism

GenBank

Uniprot

PDB/3D

Carbohydrate Ligands

Resolution (Å)

lectinolysin / human platelet aggregation factor (LLY;Sm-hPAF;samhpaf)

BAE72438.1
BBA91466.1

4GWI[A]	α-L-Fucp-(1-2)-β-D-Galp-(1-4)[α-L-Fucp-(1-3)]-β-D-GlcpNAc	1.60
4GWJ[A]	α-L-Fucp-(1-2)-β-D-Galp-(1-3)[α-L-Fucp-(1-4)]-β-D-GlcpNAc	1.60

endo-β-1,4-galactosidase (SP_2159; SP2159; Sp4GH98) (LewisY-specific)

AAK76213.1
NP_346573.1

1.8

endo-β-1,4-galactosidase (SP_2159; SP2159; Sp4GH98) (LewisY-specific)

AAK76213.1
AAY71778.1
NP_346573.1

2J1R[A,B]		1.54
2J1S[A,B]	β-L-Fucp	1.5
2J1T[A,B]	α-L-Fucp-(1-2)-β-D-Galp-(1-4)[α-L-Fucp-(1-3)]-β-D-GlcpNAc	1.6
2J1U[A,B]	α-D-GalpNAc-(1-3)[α-L-Fucp-(1-2)]-β-D-Galp-(1-4)-β-D-Glcp	1.8
2J1V[A,B]	α-L-Fucp-(1-2)-β-D-Galp-(1-4)-β-D-GlcpNAc	1.45

lectinolysin (Lly)

3LE0[A]		1.91
3LEG[A]	α-L-Fucp-(1-2)-β-D-Galp-(1-4)[α-L-Fucp-(1-3)]-β-D-GlcpNAc	2.01
3LEI[A]	β-L-Fucp	1.90
3LEK[A]	α-L-Fucp-(1-2)-β-D-Galp-(1-3)[α-L-Fucp-(1-4)]-α-D-GlcpNAc	2.00