Activities in Family	Modules of approx. 200 residues, found at the N-terminus of GH33 sialidases. Can also be found inserted in the β-propeller of GH33 sialidases. The sialic acid binding function has been demonstrated for the N-terminal CBM40 of Vibrio cholerae sialidase (Moustafa et al. (2004) J Biol Chem 279:40819-26) (PMID: 15226294).
3D Structure Status	lectin-like
Statistics	GenBank accession (1060); Uniprot accession (26); PDB accession (69); 3D entries (8); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
sialidase NanI (CpNanI;CPF_0721)		Clostridium perfringens ATCC 13124	ABG83208.1	A0A0H2YQR1 Q0TT67	5FRA[A,B,C,D,E,F] α-D-Neup5Ac α-D-Neup5Ac-(2-6)-β-D-Galp 2.00 5FRE[A,B,C] α-D-Neup5Ac-(2-3)-β-D-Galp 1.90
exo-α-sialidase (NanJ;CPE0553)		Clostridium perfringens str. 13	BAB80259.1 NP_561469.1		2V73[A,B] α-D-Neup5Ac 2.2
anhydrosialidase (RgNanH;HMPREF1201_01421) (intramolecular)		Mediterraneibacter gnavus	ETD19277.1	A0A829NK98 A7B557	6ER2[A,B] 1.73 6ER3[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp 1.37 6ER4[A,B] α-D-Neup5Ac-(2-6)-β-D-Galp-(1-4)-β-D-Glcp 1.30
sialidase A (NanA)		Streptococcus pneumoniae 6	CAA51473.1 ACJ76903.1	B8XTT3 P62575 Q59959	4C1W[A] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-α-D-Glcp 1.84 4C1X[A] α-D-Neup5Ac-(2-6)-β-D-Galp-(1-4)-β-D-Glcp 1.84 4ZXK[A,B] 1.84
neuraminidase (NanC)		Streptococcus pneumoniae G54	ACF56230.1	A0A0B7LH44 A0A0H2UQE4 A0A182DW00 B5E561	4YW0[A,B] 2.05 4YW1[A,B] α-D-Neup5Ac <carb_like_DAN> 2.25 4YW2[A,B] α-D-Neup5Ac-(2-6)-β-D-Galp 2.00 4YW3[A,B] α-D-Neup5Ac <carb_like_DAN> 2.05 4YW4[A,B] 2.20 4YW5[A,B] <carb_like_G39> 2.30 4YZ1[A,B] 1.97 4YZ2[A,B] <carb_like_DAN> 2.06 4YZ3[A,B] <carb_like_G39> 2.38 4YZ4[A,B] α-D-Neup5Ac 2.15 4YZ5[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp <carb_like_DAN> 2.27 5F9T[A,B] α-L-Manp3F5Ac-(2-0)-TYR 2.05
intramolecular trans-sialidase B (NanB;SP_1687)		Streptococcus pneumoniae TIGR4	AAK75766.1 NP_346126.1	Q54727	2JKB[A] 1.54 2VW0[A] 2.3 2VW1[A] <carb_like_DAN> 2.39 2VW2[A] 1.7 4FOQ[A] 1.99 4FOV[A] 2.29 4FOW[A] 2.10 4FOY[A] 1.84 4FP2[A] 2.05 4FP3[A] 2.74 4FPC[A] 2.32 4FPE[A] 2.18 4FPF[A] 2.23 4FPG[A] 2.58 4FPH[A] 1.94 4FPJ[A] 1.98 4FPK[A] 2.40 4FPL[A] 2.10 4FPO[B] 2.59 4FPY[A] 2.18 4FQ4[A] 1.84 4XE9[A] 1.84 4XHB[A] 1.88 4XHX[A] 2.10 4XIK[A] 1.91 4XIL[A] 1.90 4XIO[A] 1.80 4XJ8[A] 2.75 4XJ9[A] 1.98 4XJA[A] 1.98 4XJU[A] 1.94 4XJW[A] 1.53 4XJZ[A] 1.56 4XMA[A] 2.09 4XMI[A] 1.97 4XOG[A] <carb_like_DAN> 2.09 4XYX[A] 2.10
sialidase / neuraminidase (NanH;VcNA;VCSA)		Vibrio cholerae 569B 395	AAA27546.1 AAA27547.1	A5F7A4 P0C6E9 P37060	1KIT[A] 2.30 1W0O[A] α-D-Neup5Ac <carb_like_DAN> 1.9 1W0P[A] α-D-Neup5Ac 1.6 2W68[A,B,C] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-Glcp 2.50 6EKS[A] <carb_like_G39> 1.87 6EKU[A] <carb_like_ZMR> 1.75
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
intramolecular trans-sialidase L (MDSA)		Macrobdella decora	AAC47263.1	Q27701	1SLI[A] <carb_like_DAN> 2.00 1SLL[A] 2.00 2SLI[A] 1.80 3SLI[A] 1.80 4SLI[A] <carb_like_CNP> 1.80
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