GlycosylTransferase Family 81

Activities in FamilyHexosyltransferases (EC 2.4.1.-);
Mannosyl-3-phosphoglycerate synthase / [retaining] GDP-Man: 3-phosphoglycerate α-mannosyltransferase (EC 2.4.1.217);
NDP-Glc: glucosyl-3-phosphoglycerate synthase (EC 2.4.1.266);
UDP-Glc: glucosyl-3-phosphoglycerate synthase (EC 2.4.1.266);
[retaining] ADP-Glc: glucosylglycerate synthase (EC 2.4.1.270);
Mechanism Retaining
3D Structure StatusGT-A
NoteCreated after reading Costa et al. (2006) J. Bacteriol. 188:1022-1030; updated to include mycobacterial,enzymes after reading Empadinhas et al. (2008) FEMS Microbiol Lett 280:195�202; distantly related to family GT2
Statistics GenBank accession (3941); Uniprot accession (13); PDB accession (35); 3D entries (4); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 UDP-Glc: glucosyl-3-phosphoglycerate synthase (MAP2569c;GpgS;MaGpgS) 2.4.1.266 Mycobacterium avium subsp. paratuberculosis K-10 AAS04886.1
NP_961503.1
Q73WU1
3CKJ[A] 1.80
3CKN[A] 2.20
3CKO[A] 2.50
3CKQ[A] 3.00
3CKV[A] 2.00
 UDP-Glc: glucosyl-3-phosphoglycerate synthase (Rv1208;GpgS;MtGpgS;MTCI364.20) 2.4.1.266 Mycobacterium tuberculosis H37Rv CAB07831.1
AFN49112.1
CCP43964.1
NP_215724.1
A5U1Q6
O05309
P9WMW9
Q7U0E1
3E25[A] 2.70
3E26[A] 2.50
4DDZ[A] 2.60
4DE7[A] 3.00
4DEC[A] 1.98
4Y6N[A] 2.35
4Y6U[A] 2.27
4Y7F[A] 3.23
4Y7G[A] 2.59
4Y9X[A] 2.64
5JQQ[A] 2.60
5JQX[A,B,C,D] 2.82
5JSX[A] 2.81
5JT0[A] α-D-Glcp-(1-1)-<non_carb>
2.80
5JUC[A] α-D-Glcp-(1-1)-<non_carb>
2.80
5JUD[A] 2.59
 MHAS_02845 (GpgS)   Mycolicibacterium hassiacum DSM 44199 VCT91131.1  
7P5L[A,B] 1.22
7P8G[A] β-D-Glcp
2.13
7PD5[A] 1.95
7PDO[A] 1.97
7PE4[A] 2.05
7PHO[A,B] 1.27
7PVL[A,B] 1.43
7QCP[A,B] 1.11
7QI9[A,B] 1.23
7QIB[A,B] 1.60
7QOQ[A,B] 1.93
 GDP-Man: mannosyl-3-phosphoglycerate synthase (MpgS) 2.4.1.217 Rubrobacter xylanophilus PRD-1 ACJ24528.1 B7SY86
3F1Y[A,C] 2.20
3KIA[A,C] 2.80
3O3P[A,B] 2.53
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