GlycosylTransferase Family 109

Activities in FamilyUDP-GalNAc: β-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.-)
Mechanism inverting (inferred)
3D Structure StatusGT-A
NoteFamily created after Hirata et al., 2018 (PMID=29374258) who have shown that the human enzyme probably is a b-1,4-N-acetylgalactosaminyltransferase that adds GalNAc to the first mannose residue of GPI anchors; the GTs of this family are characterized by the presence of two transmembrane domains inserted in the GT-A fold; very distant relatedness to GT54
Statistics GenBank accession (172); Uniprot accession (1);
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 β-1,4-GalNAc transferase (TMEM246; C9orf125) 2.4.1.-   Homo sapiens AAH06115.1
AAH33550.1
Q9BRR3  
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