Activities in Family	endoglucanase (EC 3.2.1.4); endo-β-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6); β-glucosidase (EC 3.2.1.21); lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); cellobiohydrolase (EC 3.2.1.91); xyloglucan-specific endo-β-1,4-glucanase / endo-xyloglucanase (EC 3.2.1.151); exo-β-glucosaminidase (EC 3.2.1.165); endo-β-1,4-glucanase (xanthanase) (EC 3.2.1.-)
Mechanism	Inverting
3D Structure Status	( α / α ) 6
Catalytic Nucleophile/Base	Asp (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	formerly known as cellulase family E.
External resources	CAZypedia; HOMSTRAD; PROSITE;
Statistics	GenBank accession (4602); Uniprot accession (658); PDB accession (47); 3D entries (20); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
cellulase (CelA;Ac_Cel9A;AaCel9A;Aaci_2475) (Cel9A)	3.2.1.4	Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446	ACV59481.1 CAC34051.1	C8WSJ6 Q9AJS0	3EZ8[A] 2.30 3GZK[A] 1.80 3H2W[A] β-D-Glcp β-D-Glcp-(1-4)-α-D-Glcp 2.66 3H3K[A] β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp 2.10 3RX5[A] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb> 1.99 3RX7[A] β-D-Glcp-(1-1)-<non_carb> β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb> 2.02 3RX8[A] β-D-Glcp-(1-1)-<non_carb> 2.56 5E2J[A,B] 2.10
endo-xyloglucanase (CelD;BoGH9A;BACOVA_02649;Bovatus_03068)	3.2.1.151	Bacteroides ovatus ATCC 8483	ALJ47676.1		6DHT[A] 1.42
cellulase (CelA;CbCelA;Athe_1867;Cbes1867;Cbes_1867;CbCBH48A) (Cel9A+Cbh48A)	3.2.1.176 3.2.1.4	Caldicellulosiruptor bescii DSM 6725	ACM60955.1 CAB06786.1	B9MKU7 P96311	4DOD[A] 1.70 4DOE[A] β-D-Glcp-(1-4)-α-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.56
cellobiohydrolase (CbhA;Cthe_0413) (Cbh9A)	3.2.1.91	Hungateiclostridium thermocellum ATCC 27405	ABN51651.1 AAR87745.1	A3DCH2 Q6RSN8	1RQ5[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp 2.40 1UT9[A] 2.1
endo-β-1,4-glucanase T (CelT;Cthe_2812) (Cel9T)	3.2.1.4	Hungateiclostridium thermocellum ATCC 27405	ABN54011.1	A3DJ82	2YIK[A] 2.10
endoglucanase Q (CelQ) (Cel9I)	3.2.1.4	Hungateiclostridium thermocellum F1	BAB33148.1	Q9AJF8	5GXX[A,B] 1.50 5GXY[A,B] β-D-Glcp-(1-4)-β-D-Glcp 1.70 5GXZ[A,B] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.05 5GY0[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.74 5GY1[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.99
endo-β-1,4-glucanase D (CelD) (Cel9A)	3.2.1.4	Hungateiclostridium thermocellum NCIB 10682	CAA28255.1	P04954	1CLC[A] 1.90 4CJ0[A] 1.10 4CJ1[A] 1.63
endo-β-1,4-glucanase I (CelI;CMC) (Cel9C=Cel9I)	3.2.1.4	Hungateiclostridium thermocellum NCIB10682 / F7	AAA20892.1 CAB76932.1	Q02934 Q9L3J8	2XFG[A] 1.68
xanthanase GH9 (Xan9)	3.2.1.-	Paenibacillus nanensis 62047	AXR85426.1		6FHJ[A] 2.04
exo-β-glucosaminidase (GlcNase;PpGlcNase;PBPRA0520)	3.2.1.165	Photobacterium profundum SS9	CAG18943.1		5DGQ[A,B] 1.90 5DGR[A,B] β-D-GlcpN 1.90
endo-β-1,4-glucanase G (CelG;Ccel_0731) (Cel9G)	3.2.1.4	Ruminiclostridium cellulolyticum H10	ACL75110.1 AAA73868.1	P37700	1G87[A,B] 1.60 1GA2[A,B] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.70 1K72[A,B] α-D-Glcp β-D-Glcp-(1-4)-α-D-Glcp 1.80 1KFG[A,B] β-D-Glcp4S-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp1S 1.90
cellulase M (CelM;Ccel_0737) (Cel9M)	3.2.1.4	Ruminiclostridium cellulolyticum H10	ACL75116.1 AAG45160.1	B8I7V9 Q9EYQ2	1IA6[A] 1.80 1IA7[A] β-D-Glcp-(1-4)-β-D-Glcp 2.00
Theco_0555		Thermobacillus composti KWC4	AGA56765.1		5U0H[A] 1.70 5U2O[A] 1.46
endo/exo-β-1,4-glucanase 9A (E4;CelD;TfCel9A;Tfu_2176) (processive) (Cel9A)	3.2.1.4	Thermobifida fusca YX	AAB42155.1 AAA27397.1 AAZ56209.1	P26221 Q47MW0	1JS4[A,B] β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.00 1TF4[A,B] 1.90 3TF4[A,B] β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.20 4TF4[A,B] β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp 2.00
cellulase (Lc-CelG)	3.2.1.4	uncultured bacterium	AHL27900.1		3X17[A,B] 2.15
β-glucosidase/β-glucosaminidase (BglA;VC0615)	3.2.1.165 3.2.1.21	Vibrio cholerae O1 biovar El Tor str. N16961	AAF93781.1 NP_230264.1	Q9KUA8	6GDT[A,B,C,D,E] 3.17
VP2484		Vibrio parahaemolyticus RIMD 2210633 O3:K6	BAC60747.1 NP_798863.1		3H7L[A,B,C] 2.30
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
endo-β-1,4-glucanase (Eg2;EF-EG2)	3.2.1.4	Eisenia fetida	BAM14716.1		3WC3[A] 1.50
endo-β-1,4-glucanase (NtEG;EGA)	3.2.1.4	Nasutitermes takasagoensis	BAA33708.1 BAA76619.1	O77044	1KS8[A] 1.40 1KSC[A] 1.55 1KSD[A] 1.60
endo-β-1,4-glucanase (PnbEG)	3.2.1.4	Perinereis nuntia brevicirris	BAK20401.1		4ZG8[A,B] 1.39 4ZH5[A,B] β-D-Glcp-(1-4)-β-D-Glcp 1.35
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